Oestrogen treatment of constitutionally tall girls with 0.1 mg/day ethinyl oestradiol
Tóm tắt
For the treatment of tall stature in girls, oestrogens are usually given in high doses. In this study, growth data of 35 constitutionally tall girls treated with only 0.1 mg/day ethinyl oestradiol (EE) are reported (Group 1). The data were compared with those of 23 untreated girls with comparable bone ages and growth potential (Group 2), and with those of 5 girls treated with 0.3 mg/day EE (Group 3). All groups were followed until cessation of growth. In group 1, the median bone age at the onset of treatment was 12.50 years (Greulich-Pyle, range 10.50–13.75), and the median height prediction was calculated to be 184.4 cm (Bayley-Pinneau, range 179.5–191.5). Following oestrogen treatment of 21 months duration (range 10–37) the median adult height was reduced by 4.3 cm (range 0.0–9.0), or 3.9 cm if corrected for the error of prediction in the control group. The effect was greater in those girls with bone ages below 12.5 years at the onset of treatment (6.7 cm/corrected value 7.4 cm) than in the older girls (4.2 cm/3.6 cm). In Group 2 (controls) the median final adult height was over-estimated by 0.4 cm (range-4.9 to 4.9), but was under-estimated by 0.7 cm in those girls with bone ages below 12.5 years. In girls of comparable bone age similar reductions were obtained whether 0.3 mg/day EE (Group 3) or 0.1 mg/day was given (4.4 vs. 4.2 cm). A comparison of these results with published data indicates that higher EE doses (0.3–0.5 mg/day) have only little, if any, greater effect on the growth of girls than the dosage of 0.1 mg/day EE used in this study.
Tài liệu tham khảo
Bailey JD, Park E, Cowell C (1981) Estrogen treatment of girls with constitutionally tall stature. Pediatr Clin North Am 28:501–512
Bayley N, Pinneau SR (1952) Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr 40:423–441
Bierich JR (1982) Hochwuchstherapie. Monatsschr Kinderheilkd 130:372–378
Bierich JR, Blunck W, Prader A, Steendijk R (1975) Podiumsdiskussion zum Thema: Therapie des konstitutionellen Hochwuchses. Monatsschr Kinderheilkd 123:324–330
Conte FA, Grumbach MM (1978) Estrogen use in children and adolescents: a survey. Pediatrics [Suppl] 62:1091–1097
Crawford JD (1978) Treatment of tall girls with estrogens. Pediatrics [Suppl] 621:1189–1195
Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist, 2nd edn. Stanford University Press, Stanford, Calif
Hoepffner E, Keller E, Willgerodt H (1981) Erfahrungen mit der Therapie des konstitutionellen Hochwuchses bei Knaben und Mädchen. In: Hochwuchs im Kindesalter, Symposium der AG Pädiatrische Endokrinologie der Gesellschaft für Pädiatrie der DDR, Mai 1979. Friedrich-Schiller-Universität, Jena
John G, Schellong G (1980) Östrogentherapie hochwüchsiger Mädchen. Monatsschr Kinderheikd 128:545–550
Kuhn N, Blunck W, Stahnke N, Wiebel J, Willig RP (1977) Estrogen treatment in tall girls. Acta Paediatr Scand 66:161–167
Puttkamer K v, Bierich JR, Brugger F, Hirche W, Schönberg D (1977) Östrogentherapie bei Mädchen mit konstitutionellem Hochwuchs. Dtsch Med Wochenschr 102:983–988
Reeser HM, Heremans GF, v Gelderen HH (1979) Reduction of adult height in tall girls. Eur J Pediatr 132:37–41
Schambach H (1981) 12-jährige Erfahrungen mit der Behandlung des weiblichen Hochwuchses mit Ovulationshemmern. In: Hochwuchs im Kindesalter, Symposium der AG Pädiatrische Endokrinologie der Gesellschaft für Pädiatrie der DDR, Mai 1979. Friedrich-Schiller-Universität, Jena
Schoen EJ, Solomon IL, Warner O, Wingerd J (1973) Estrogen treatment of tall girls. Am J Dis Child 125:71–74
Tanner JM, Whitehouse RH, Marshall WA, Healy MJ, Goldstein H (1975) Assessment of skeletal maturity and prediction of adult height (TW2 method). Academic Press, London
Willig RP, Christiansen D, Kuhn N, Schaefer E, Stahnke N (1980) Voraussetzungen und Ergebnisse der Östrogenbehandlung extrem großer Mädchen. Monatsschr Kinderheilkd 128:787–788
Zachmann M, Ferrandez A, Mürset G, Prader A (1975) Estrogen treatment of excessively tall girls. Helv Pediatr Acta 30:11–30