Odontogenic Carcinoma with Dentinoid: A New Odontogenic Carcinoma
Tóm tắt
Dentinoid is an integral part of some odontogenic tumors. This article describes the clinico-pathological features of three cases of odontogenic carcinomas with dentinoid (OCD). A comparison of these with previously reported cases of dentinoid-producing epithelial odontogenic tumors allowed us to identify another six cases that may be considered as examples of OCD. Six cases occurred in the mandible and three in the maxilla, all developing behind the canines. There was no sex predilection (five men and four women; age range 14–61 years, mean 38.1). Pain or discomfort was mentioned in five cases, four of which showed tooth resorption. All cases appeared initially as well-defined radiolucencies, five of which showed variable amounts of calcified material. Recurrences were recorded in three instances, but no evidence of metastasis has been found. Seven cases were composed predominantly or entirely of clear cells, usually with minimal cellular atypia and variable mitotic activity; however, in all cases there was evidence of tumor infiltration into adjacent tissues, including the presence of perineural invasion in two tumors. Those cases in which no reference was made to the presence of clear cells exhibited evident mitotic activity and cellular pleomorphism. The epithelium in OCD does not produce buds or enamel organ-like structures such as those found in ameloblastic fibro-dentinoma and this tumor does not contain a mesenchyme-like connective tissue resembling dental papilla as observed in several mixed odontogenic tumors. Based on the existing data and the present series of cases, OCD appears to represent a distinct entity.
Tài liệu tham khảo
Gardner DG, Farquhar DA. A classification of dysplastic forms of dentin. J Oral Pathol. 1979;8:28–46.
Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.
Pindborg JJ. On dentinomas. Acta Pathol Microbiol Scand Suppl. 1955;105:135–44.
Anker AH, Radden BG. Dentinoma of the mandible. Oral Surg Oral Med Oral Pathol. 1989;67:731–3.
Lukinmaa PL, Hietanen J, Laitinen J-M, Malmström M. Mandibular dentinoma. J Oral Maxillofac Surg. 1987;45:60–4.
Takeda Y. So-called, “immature dentinoma”: a case presentation and histological comparison with ameloblastic fibrodentinoma. J Oral Pathol Med. 1994;23:92–6.
Minamizato T, I T, Ikeda H, Fujita S, Asahina I. Peripheral-type ameloblastic fibro-dentinoma with features of so-called “immature dentinoma”. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:e61–4.
Slabbert H, Altini M, Crooks J, Uys P. Ameloblastoma with dentinoid induction: dentinoameloblastoma. J Oral Pathol Med. 1992;21:46–8.
Matsumoto Y, Mizoue K, Seto K. Atypical plexiform ameloblastoma with dentinoid: adenoid ameloblastoma with dentinoid. J Oral Pathol Med. 2001;30:251–4.
Evans BL, Carr RF, Phillipe LJ. Adenoid ameloblastoma with dentinoid: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:583–8.
Ide F, Mishima K, Saito I, Kusama K. Diagnostically challenging epithelial odontogenic tumors: a selective review of 7 jawbone lesions. Head Neck Pathol. 2009;3:18–26.
Saxena K, Jose M, Chatra LK, Sequiera J. Adenoid ameloblastoma with dentinoid. J Oral Maxillofac Pathol. 2012;16:272–6.
Allen CM, Neville BW, Hammond HL. Adenomatoid dentinoma. Report of four cases of an unusual odontogenic lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:313–7.
Kemp S, Gallagher G, Kabani S, Todd R. Adenomatoid dentinoma: case report and review of a rare odontogenic lesion. J Oral Maxillofac Surg. 2008;66:1489–91.
Sawyer DR, Nwoku AL, Mosadomi A, Kekere-Ekun AT. Odontogenic carcinoma with dentinoid. Int J Oral Maxillofac Surg. 1986;15:105–7.
Miyauchi M, Ogawa I, Takata T, Ito H, Nikai H, Ijuhin N, Tanimoto K, Itoh Y. Clear cell odontogenic tumour: a case with induction of dentin-like structures? J Oral Pathol Med. 1998;27:220–4.
Kumamoto H, Yamazaki S, Sato A, Yamaguchi T, Tezuka F, Ooya K. Clear cell odontogenic tumor in the mandible: report of a case with duct-like appearances and dentinoid induction. J Oral Pathol Med. 2000;29:43–7.
Ariyoshi Y, Shimahara M, Miyauchi M, Nikai H. Clear cell odontogenic carcinoma with ghost cells and inductive dentin formation-report of a case in the mandible. J Oral Pathol Med. 2002;31:181–3.
Punnya A, Kumar GS, Rekha K, Vandana R. Primary intraosseous odontogenic carcinoma with osteoid/dentinoid formation. J Oral Pathol Med. 2004;33:121–4.
Waldron CA, Small IA, Silverman H. Clear cell ameloblastoma—an odontogenic carcinoma. J Oral Maxillofac Surg. 1985;43:707–17.
Hansen LS, Eversole LR, Green TL, Powell NB. Clear cell odontogenic tumor—a new histologic variant with aggressive potential. Head Neck Surg. 1985;8:115–23.
Bang G, Koppang HS, Hansen LS, Gilhuus-Moe O, Aksdal E, Persson PG, et al. Clear cell odontogenic carcinoma: report of three cases with pulmonary and lymph node metastases. J Oral Pathol Med. 1989;18:113–8.