Ocular syphilis

Survey of Ophthalmology - Tập 67 - Trang 440-462 - 2022
João M. Furtado1, Milena Simões1, Daniel Vasconcelos-Santos2, Genevieve F. Oliver3, Mudit Tyagi4, Heloisa Nascimento5,6, David L. Gordon3,7, Justine R. Smith3
1Divisão de Oftalmologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil
2Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
3Flinders University College of Medicine and Public Health, Adelaide, Australia
4Ocular Inflammation and Immunology Services, LV Prasad Eye Institute, Hyderabad, India
5Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
6Instituto Paulista de Estudos e Pesquisas em Oftalmologia-IPEPO, São Paulo, Brazil
7SA Pathology, Microbiology and Infectious Diseases, Flinders Medical Centre, Bedford Park, South Australia

Tài liệu tham khảo

Abreu, 1980, Domingues Neto S. Uveítes em São Paulo: estudo epidemiológico, clínico e terapêutico, J Arq Bras Oftalmol, 43, 10 Agostini, 2018, Intravenous ceftriaxone for syphilitic uveitis, Ocul Immunol Inflamm, 26, 1059, 10.1080/09273948.2017.1311926 Akpek, 2004, Evaluation of patients with scleritis for systemic disease, Ophthalmology, 111, 501, 10.1016/j.ophtha.2003.06.006 Albini, 2017, Trends in hospitalization and incidence rate for syphilitic uveitis in the United States from 1998 to 2009, Am J Ophthalmol, 180, 133, 10.1016/j.ajo.2017.05.013 Alexander, 2012, Visual evoked potential (VEP) and multifocal electroretinogram (mfERG) in ocular syphilitic posterior segment inflammation, Doc Ophthalmol, 125, 169, 10.1007/s10633-012-9339-9 Amaratunge, 2010, Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus-positive and negative patients, Clin Exp Ophthalmol, 38, 68, 10.1111/j.1442-9071.2010.02203.x Amode, 2018, Oral doxycycline for syphilitic uveitis: a case report highlighting potential efficacy, J Antimicrob Chemother, 73, 1999, 10.1093/jac/dky102 Ang, 2012, Interferon-gamma release assay as a diagnostic test for tuberculosis-associated uveitis, Eye, 26, 658, 10.1038/eye.2012.1 Anshu, 2008, Syphilitic uveitis: an Asian perspective, Br J Ophthalmol, 92, 594, 10.1136/bjo.2007.133843 Arriola-Villalobos, 2018, Vision-related quality of life in patients with non-infectious uveitis: a cross-sectional study, Ocul Immunol Inflamm, 26, 717, 10.1080/09273948.2017.1285034 Balaskas, 2011, Analysis of significant factors influencing visual acuity in ocular syphilis, Br J Ophthalmol, 95, 1568, 10.1136/bjo.2010.194498 Becerra, 1989, Syphilitic uveitis in human immunodeficiency virus-infected and noninfected patients, Ophthalmology, 96, 1727, 10.1016/S0161-6420(89)32657-1 Berkenstock, 2020, Analysis of new cases of uveitis at academic and community settings, Br J Ophthalmol Berkowitz, 1990, False-negative syphilis screening: the prozone phenomenon, nonimmune hydrops, and diagnosis of syphilis during pregnancy, Am J Obs Gynecol, 163, 975, 10.1016/0002-9378(90)91107-N Beymer, 2018, Does HIV pre-exposure prophylaxis use lead to a higher incidence of sexually transmitted infections? A case-crossover study of men who have sex with men in Los Angeles, California, Sex Transm Infect, 94, 457, 10.1136/sextrans-2017-053377 Bharadwaj, 2013, Role of the retinal vascular endothelial cell in ocular disease, Prog Retin Eye Res, 32, 102, 10.1016/j.preteyeres.2012.08.004 Bialasiewicz, 1988, Bilateral diffuse choroiditis and exudative retinal detachments with evidence of Lyme disease, Am J Ophthalmol, 105, 419, 10.1016/0002-9394(88)90310-8 Binnicker, 2012, Which algorithm should be used to screen for syphilis?, Curr Opin Infect Dis, 25, 79, 10.1097/QCO.0b013e32834e9a3c Blodi, 1968, Syphilitic chorioretinitis. A histologic study, Arch Ophthalmol, 79, 294, 10.1001/archopht.1968.03850040296013 Bollemeijer, 2016, Clinical manifestations and outcome of syphilitic uveitis, Invest Ophthalmol Vis Sci, 57, 404, 10.1167/iovs.15-17906 Borges, 2018, Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series, Arq Neuropsiquiatr, 76, 373, 10.1590/0004-282x20180054 Bosch-Driessen, 2002, Ocular toxoplasmosis: clinical features and prognosis of 154 patients, Ophthalmology, 109, 869, 10.1016/S0161-6420(02)00990-9 Brown, 1921, Experimental syphilis in the rabbit : vii. Affections of the eyes, J Exp Med, 34, 167, 10.1084/jem.34.2.167 Browning, 2000, Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy, and the influence of human immunodeficiency virus status on response, Ophthalmology, 107, 2015, 10.1016/S0161-6420(00)00457-7 Butler, 2013, Ocular toxoplasmosis II: Clinical features, pathology and management, Clin Exp Ophthalmol, 41, 10.1111/j.1442-9071.2012.02838.x Butler, 2012, Current status of HIV infection and ocular disease, Curr Opin Ophthalmol, 23, 517, 10.1097/ICU.0b013e328358ba85 Centers for Disease Control and Prevention. 2015 sexually transmitted diseases treatment guidelines: syphilis. Published 2015. https://www.cdc.gov/std/tg2015/syphilis.htm. 2011, Discordant results from reverse sequence syphilis screening–five laboratories, United States, 2006-2010, MMWR Morb Mortal Wkly Rep, 60, 133 Centers for Disease Control and Prevention. Sexually Transmitted Diseases (STDs): Clinical Advisory: Ocular Syphilis in the United States. Published 2016. https://www.cdc.gov/std/syphilis/clinicaladvisoryos2015.htm, updated March 24, 2016. Centers for Disease Control and Prevention. Sexually Transmitted Diseases (STDs): Syphilis Statistics. Published 2016. https://www.cdc.gov/std/syphilis/stats.htm 2017, Sexually Transmitted Diseases (STDs): What health care providers can do, Published Chan, 2006, Ophthalmic complications of dengue, Emerg Infect Dis, 12, 285, 10.3201/eid1202.050274 Chao, 2006, Syphilis: reemergence of an old adversary, Ophthalmology, 113, 2074, 10.1016/j.ophtha.2006.05.048 Cillino, 2012, Chancre of the eyelid as manifestation of primary syphilis, and precocious chorioretinitis and uveitis in an HIV-infected patient: a case report, BMC Infect Dis, 12, 226, 10.1186/1471-2334-12-226 Cnossen, 1995, Ceftriaxone treatment of penicillin resistant neurosyphilis in alcoholic patients, J Neurol Neurosurg Psychiatry, 59, 194, 10.1136/jnnp.59.2.194 Cochrane, 2012, Acute retinal necrosis in the United Kingdom: results of a prospective surveillance study, Eye, 26, 370, 10.1038/eye.2011.338 Cope, 2019, Ocular syphilis and human immunodeficiency virus coinfection among syphilis patients in North Carolina, 2014-2016, Sex Transm Dis, 46, 80, 10.1097/OLQ.0000000000000910 Crouch, 1975, Retinal periarteritis secondary to syphilis, Arch Ophthalmol, 93, 384, 10.1001/archopht.1975.01010020396017 Cunningham, 2014, Syphilitic uveitis, Ocul Immunol Inflamm, 22, 2, 10.3109/09273948.2014.883236 Curi AL, Sarraf D, Cunningham Jr. ET. Multimodal imaging of syphilitic multifocal retinitis. Retin Cases Br Rep. 2015;9(4):277-280. doi:10.1097/icb.0000000000000186. Currie, 1988, Chronic syphilitic meningitis resulting in superior orbital fissure syndrome and posterior fossa gumma. A report of two cases followed for 20 years, J Clin Neuroophthalmol, 8, 145 Dai, 2016, Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-Negative patients, BMC Infect Dis, 16, 245, 10.1186/s12879-016-1586-z Danesh-Meyer, 1999, Not so slowly progressive visual loss, Surv Ophthalmol, 10.1016/S0039-6257(99)00099-5 Davis, 2014, Ocular syphilis, Curr Opin Ophthalmol, 25, 513, 10.1097/ICU.0000000000000099 DeLuise, 1982, Syphilitic retinal detachment and uveal effusion, Am J Ophthalmol, 94, 757, 10.1016/0002-9394(82)90300-2 DeVience, 2020, Syphilitic retinitis presentations: punctate inner retinitis and posterior placoid chorioretinitis, Int Ophthalmol Diaz-Valle, 2005, Simultaneous bilateral exudative retinal detachment and peripheral necrotizing retinitis as presenting manifestations of concurrent HIV and syphilis infection, Ocul Immunol Inflamm, 13, 459, 10.1080/09273940490912353 Dogru, 2007, Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis, Curr Eye Res, 32, 863, 10.1080/02713680701624705 Dutta Majumder, 2019, Ocular syphilis: an update, Ocul Immunol Inflamm, 27, 117, 10.1080/09273948.2017.1371765 Eandi, 2012, Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature, Retina, 32, 1915, 10.1097/IAE.0b013e31825f3851 Eaton, 2018, Reverse syphilis screening algorithm fails to demonstrate cost effectiveness in persons living with HIV, Int J STD AIDS, 29, 563, 10.1177/0956462417743409 Edmondson, 2018, Long-term in vitro culture of the syphilis spirochete Treponema pallidum subsp. pallidum, MBio, 9, e01153, 10.1128/mBio.01153-18 Elsas, 1972, Treponeme-like forms in chimpanzee aqueous humor and cerebrospinal fluid, Arch Ophthalmol, 87, 333, 10.1001/archopht.1972.01000020335019 Engstrom, 1994, The progressive outer retinal necrosis syndrome. A variant of necrotizing herpetic retinopathy in patients with AIDS, Ophthalmology, 101, 1488, 10.1016/S0161-6420(94)31142-0 Eslami, 2020, Resurgence of ocular syphilis in British Columbia between 2013-2016: a retrospective chart review, Can J Ophthalmol, 55, 179, 10.1016/j.jcjo.2019.11.002 Evans, 2007, Differences in clinical findings between Caucasians and African Americans with biopsy-proven sarcoidosis, Ophthalmology, 114, 325, 10.1016/j.ophtha.2006.05.074 Fenolland, 2016, Syphilitic scleritis, Ocul Immunol Inflamm, 24, 93, 10.3109/09273948.2014.916307 Fisher, 1982, The acute retinal necrosis syndrome. Part 1: Clinical manifestations, Ophthalmology, 89, 1309, 10.1016/S0161-6420(82)34628-X Folk, 1983, Syphilitic neuroretinitis, Am J Ophthalmol, 95, 480, 10.1016/0002-9394(83)90268-4 Fonollosa, 2016, Clinical manifestations and outcomes of syphilis-associated uveitis in northern Spain, Ocul Immunol Inflamm, 24, 147 Forster, 1990, Rapidly progressive outer retinal necrosis in the acquired immunodeficiency syndrome, Am J Ophthalmol, 110, 341, 10.1016/S0002-9394(14)77012-6 Fu, 2010, Superficial retinal precipitates in patients with syphilitic retinitis, Retina, 30, 1135, 10.1097/IAE.0b013e3181cdf3ae Fujikawa, 1990, Immunopathology of vitreous and retinochoroidal biopsy in posterior uveitis, Ophthalmology, 97, 1644, 10.1016/S0161-6420(90)32357-6 Furtado, 2018, Clinical manifestations and ophthalmic outcomes of ocular syphilis at a time of re-emergence of the systemic infection, Sci Rep, 8 Furtado, 2016, Uveitis associated with zika virus infection, N Engl J Med, 375, 10.1056/NEJMc1603618 Furtado, 2013, Ocular toxoplasmosis I: Parasitology, epidemiology and public health, Clin Exp Ophthalmol, 41, 10.1111/j.1442-9071.2012.02821.x Garnett, 1997, The natural history of syphilis. Implications for the transmission dynamics and control of infection, Sex Transm Dis, 24, 185, 10.1097/00007435-199704000-00002 Gass, 1990, Acute syphilitic posterior placoid chorioretinitis, Ophthalmology, 97, 1288, 10.1016/S0161-6420(90)32418-1 Gentile, 1998, Syphilitic meningomyelitis treated with ceftriaxone: case report, Clin Infect Dis, 26, 528, 10.1086/517112 Ghanem, 2010, Review: Neurosyphilis: A historical perspective and review, CNS Neurosci Ther, 16, e157, 10.1111/j.1755-5949.2010.00183.x Ghanimi Zamli, 2019, Clinical profile and visual outcomes of ocular syphilis: a 5-year review in Hospital Universiti Sains, Malaysia, Cureus, 11, e4015 Gonzalez Fernandez, 2017, Uveitis in Sao Paulo, Brazil: 1053 new patients in 15 months, Ocul Immunol Inflamm, 25, 382, 10.3109/09273948.2015.1132741 Grange, 2014, Neoplastic masquerade syndromes in patients with uveitis, Am J Ophthalmol, 157, 526, 10.1016/j.ajo.2013.11.002 Gu, 2020, The importance of proper and prompt treatment of ocular syphilis: a lesson from permanent vision loss in 52 eyes, J Eur Acad Dermatol Venereol, 34, 1569, 10.1111/jdv.16347 Gupta, 2015, Clinics of ocular tuberculosis, Ocul Immunol Inflamm, 23, 14, 10.3109/09273948.2014.986582 Hamze, 2020, Human immunodeficiency virus seropositivity and early syphilis stage associated with ocular syphilis diagnosis: a case-control study in British Columbia, Canada, 2010-2018, Clin Infect Dis, 71, 259, 10.1093/cid/ciz794 Harman, 2013, Viscous dynamics of Lyme disease and syphilis spirochetes reveal flagellar torque and drag, Biophys J, 105, 2273, 10.1016/j.bpj.2013.10.004 Hart, 1986, Syphilis tests in diagnostic and therapeutic decision making, Ann Intern Med, 104, 368, 10.7326/0003-4819-104-3-368 Holland, 2003, Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease, Am J Ophthalmol, 136, 973, 10.1016/j.ajo.2003.09.040 Holland, 1994, The progressive outer retinal necrosis syndrome, Int Ophthalmol, 18, 163, 10.1007/BF00915966 Holland, 2008, Characteristics of untreated AIDS-related cytomegalovirus retinitis. I. Findings before the era of highly active antiretroviral therapy (1988 to 1994), Am J Ophthalmol, 145, 5, 10.1016/j.ajo.2007.09.023 Holland, 2008, Characteristics of untreated AIDS-related cytomegalovirus retinitis. II. Findings in the era of highly active antiretroviral therapy (1997 to 2000), Am J Ophthalmol, 145, 12, 10.1016/j.ajo.2007.09.040 Hoogewoud, 2017, Prognostic factors in syphilitic uveitis, Ophthalmology, 124, 1808, 10.1016/j.ophtha.2017.06.003 Hook 3rd, 1988, Ceftriaxone therapy for incubating and early syphilis, J Infect Dis, 158, 881, 10.1093/infdis/158.4.881 Hook, 1992, Acquired syphilis in adults, N Engl J Med, 10.1056/NEJM199204163261606 Houston, 2015, Conservation of the host-interacting proteins Tp0750 and pallilysin among treponemes and restriction of proteolytic capacity to Treponema pallidum, Infect Immun, 83, 4204, 10.1128/IAI.00643-15 Huang, 2018, Acute syphilitic posterior placoid chorioretinopathy mimicking central serous chorioretinopathy: A case report, Taiwan J Ophthalmol, 8, 176, 10.4103/tjo.tjo_18_18 Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science (80- ). 1991;254(5035):1178-1181. doi:10.1126/science.1957169. Hughes, 2010, Syphilitic retinitis and uveitis in HIV-positive adults, Clin Exp Ophthalmol, 38, 851, 10.1111/j.1442-9071.2010.02383.x Hussnain, 2016, Ocular syphilis presenting as bilateral acute retinal necrosis in an immunocompetent host, Conn Med, 80, 533 2014, International Team for the Revision of the International Criteria for Behçet's Disease (ITR-ICBD). The International Criteria for Behcet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria, J Eur Acad Dermatol Venereol, 28, 338, 10.1111/jdv.12107 Jabs, 2011, Cytomegalovirus retinitis and the acquired immunodeficiency syndrome–bench to bedside: LXVII Edward Jackson Memorial Lecture, Am J Ophthalmol, 151, 198, 10.1016/j.ajo.2010.10.018 Jabs, 2005, Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy, Ophthalmology, 112, 771, 10.1016/j.ophtha.2004.10.049 Jabs, 2000, Episcleritis and scleritis: clinical features and treatment results, Am J Ophthalmol, 130, 469, 10.1016/S0002-9394(00)00710-8 Jabs, 2005, Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop, Am J Ophthalmol, 140, 509, 10.1016/j.ajo.2005.03.057 Jeyakumar, 1989, Primary syphilis of the eyelid: case report, Genitourin Med, 65, 192 Joseph, 2007, Syphilitic acute posterior placoid chorioretinitis in nonimmuno-compromised patients, Eye, 21, 1114, 10.1038/sj.eye.6702504 Jumper, 2012, Imaging syphilis uveitis, Int Ophthalmol Clin, 52, 121, 10.1097/IIO.0b013e3182691388 Kao, 2017, Identification of Tp0751 (pallilysin) as a Treponema pallidum vascular adhesin by heterologous expression in the Lyme disease spirochete, Sci Rep, 7, 1538, 10.1038/s41598-017-01589-4 Kim, 2014, A case of syphilitic outer retinitis mimicking acute zonal occult outer retinopathy, Korean J Ophthalmol, 28, 497, 10.3341/kjo.2014.28.6.497 Kim, 2016, Non-human immunodeficiency virus-related ocular syphilis in a Korean population: clinical manifestations and treatment outcomes, Korean J Ophthalmol, 30, 360, 10.3341/kjo.2016.30.5.360 Klein, 2019, The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis, Acta Ophthalmol, 97, e641, 10.1111/aos.13963 van Kooij, 2006, The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema, Ocul Immunol Inflamm, 14, 73, 10.1080/09273940500545684 Kunimi, 2020, Changes in etiology of uveitis in a single center in Japan, Ocul Immunol Inflamm, 1 Kunkel, 2009, Ocular syphilis - indicator of previously unknown HIV-infection, J Infect, 58, 32, 10.1016/j.jinf.2008.11.004 Lafond, 2006, Biological basis for syphilis, Clin Microbiol Rev, 19, 29, 10.1128/CMR.19.1.29-49.2006 Landry, 2019, Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017, BMJ Open, 9, 10.1136/bmjopen-2018-025995 Lapere, 2019, Clinical manifestations and cerebrospinal fluid status in ocular syphilis, Ocul Immunol Inflamm, 27, 126, 10.1080/09273948.2018.1521436 Lee, 1989, Syphilitic interstitial keratitis, Jama, 262, 2921, 10.1001/jama.1989.03430200169047 Lee, 2013, Ocular syphilis characterised by severe scleritis in a patient infected with HIV, Lancet Infect Dis, 13, 994, 10.1016/S1473-3099(13)70198-1 Lee, 2015, Clinical and laboratory characteristics of ocular syphilis: a new face in the era of HIV co-infection, J Ophthalmic Inflamm Infect, 5, 56, 10.1186/s12348-015-0056-x Li, 2010, Ocular syphilis among HIV-infected individuals, Clin Infect Dis, 51, 468, 10.1086/654797 Lima, 2014, Syphilitic outer retinopathy, Ocul Immunol Inflamm, 22, 4, 10.3109/09273948.2013.841960 Lima, 2017, Multimodal imaging analyses of hyperreflective dot-like lesions in acute syphilitic posterior placoid chorioretinopathy, J Ophthalmic Inflamm Infect, 7, 1, 10.1186/s12348-016-0119-7 Liu, 2010, Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography, J Mol Biol, 403, 546, 10.1016/j.jmb.2010.09.020 Lobes, 1981, Syphilitic phlebitis simulating branch vein occlusion, Ann Ophthalmol, 13, 825 Lobo, 2018, Association between eye diagnosis and positive syphilis test results in a large, urban sexually transmitted infection/primary care clinic population, Int J STD AIDS, 29, 357, 10.1177/0956462417726700 Lotery, 1996, Pseudoretinitis pigmentosa due to sub-optimal treatment of neurosyphilis, Eye, 10, 759, 10.1038/eye.1996.182 Mabey, 2012, Point-of-care tests to strengthen health systems and save newborn lives: the case of syphilis, PLoS Med, 9, 10.1371/journal.pmed.1001233 Macfaul, 1971, Acute choroido-retinitis in secondary syphilis. Presence of spiral organisms in the aqueous humour, Br J Vener Dis, 47, 159 Mahendradas, 2008, Ocular manifestations associated with chikungunya, Ophthalmology, 115, 287, 10.1016/j.ophtha.2007.03.085 Marcus, 2016, Preexposure prophylaxis for HIV prevention in a large integrated health care system: adherence, renal safety, and discontinuation, J Acquir Immune Defic Syndr, 73, 540, 10.1097/QAI.0000000000001129 Margo, 1992, Ocular syphilis, Surv Ophthalmol, 37, 203, 10.1016/0039-6257(92)90138-J Marks, 2018, Diagnostic performance of PCR assays for the diagnosis of neurosyphilis: a systematic review, Sex Transm Infect, 94, 585, 10.1136/sextrans-2018-053666 Marra, 1991, An experimental model of early central nervous system syphilis, J Infect Dis, 163, 825, 10.1093/infdis/163.4.825 Marra, 2010, Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis, J Infect Dis, 202, 1380, 10.1086/656533 Marra, 2004, Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features, J Infect Dis, 189, 369, 10.1086/381227 Martin-Ezquerra, 2009, Treponema pallidum distribution patterns in mucocutaneous lesions of primary and secondary syphilis: an immunohistochemical and ultrastructural study, Hum Pathol, 40, 624, 10.1016/j.humpath.2008.10.017 Marx, 2016, Variations in clinical presentation of ocular syphilis: case series reported from a growing epidemic in the United States, Sex Transm Dis, 43, 519, 10.1097/OLQ.0000000000000477 Mathew, 2020, Clinical and laboratory characteristics of ocular syphilis and neurosyphilis among individuals with and without HIV infection, Br J Ophthalmol Mathew, 2014, British Ocular Syphilis Study (BOSS): 2-year national surveillance study of intraocular inflammation secondary to ocular syphilis, Invest Ophthalmol Vis Sci, 55, 5394, 10.1167/iovs.14-14559 Meira-Freitas, 2009, Optical coherence tomography and indocyanine green angiography findings in acute syphilitic posterior placoid choroidopathy: case report, Arq Bras Oftalmol, 72, 832, 10.1590/S0004-27492009000600019 Mendelsohn, 1984, Syphilitic retinitis. A cause of necrotizing retinitis, Retina, 4, 221, 10.1097/00006982-198400440-00002 Menon, 2005, Clinical and electrophysiological course of acute syphilitic posterior placoid chorioretinitis, Klin Monbl Augenheilkd, 222, 261, 10.1055/s-2005-857998 Mochizuki, 2019, Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis, Br J Ophthalmol, 103, 1418, 10.1136/bjophthalmol-2018-313356 Mochizuki, 2013, Immunological homeostasis of the eye, Prog Retin Eye Res, 33, 10, 10.1016/j.preteyeres.2012.10.002 Moloney, 2004, Syphilis presenting as scleritis in an HIV-positive man undergoing immune reconstitution, Clin Exp Ophthalmol, 32, 526, 10.1111/j.1442-9071.2004.00871.x Montenegro, 1969, Histopathologic demonstration of spirochetes in the human eye, Am J Ophthalmol, 67, 335, 10.1016/0002-9394(69)92042-X Mora, 2005, Indocyanine green angiography anomalies in ocular syphilis, Retina, 25, 171, 10.1097/00006982-200502000-00010 Moradi, 2015, Clinical features and incidence rates of ocular complications in patients with ocular syphilis, Am J Ophthalmol, 159, 334, 10.1016/j.ajo.2014.10.030 Moramarco, 2020, Clinical features of ocular syphilis: a retrospective clinical study in an Italian referral centre, Semin Ophthalmol, 35, 50, 10.1080/08820538.2020.1723651 Muccioli, 2000, Hypopyon in a patient with presumptive diffuse unilateral subacute neuroretinitis, Ocul Immunol Inflamm, 8, 119, 10.1076/0927-3948(200006)821-0FT119 Naik, 2013, Normative comparison of patient-reported outcomes in patients with noninfectious uveitis, JAMA Ophthalmol, 131, 219, 10.1001/2013.jamaophthalmol.102 Nair, 2020, Utility of treponemal testing from aqueous fluid in the diagnosis of ocular syphilis in patients with HIV/AIDS, Ocul Immunol Inflamm, 1 Newman, 2015, Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting, PLoS One, 10, 10.1371/journal.pone.0143304 Nguyen, 2018, Historical and current trends in the epidemiology of early syphilis in San Francisco, 1955 to 2016, Sex Transm Dis, 45, S55, 10.1097/OLQ.0000000000000870 Northey, 2015, Syphilitic uveitis and optic neuritis in Sydney, Australia, Br J Ophthalmol, 99, 1215, 10.1136/bjophthalmol-2014-306168 Oliver, 2019, Current ophthalmology practice patterns for syphilitic uveitis, Br J Ophthalmol, 103, 10.1136/bjophthalmol-2018-313207 Oliver, 2016, Molecular typing of Treponema pallidum in ocular syphilis, Sex Transm Dis, 43, 524, 10.1097/OLQ.0000000000000478 Oliver, 2016, Ocular syphilis - eight jurisdictions, United States, 2014-2015, MMWR Morb Mortal Wkly Rep, 65, 1185, 10.15585/mmwr.mm6543a2 Oliver, 2017, Increases in ocular syphilis-North Carolina, 2014-2015, Clin Infect Dis, 65, 1676, 10.1093/cid/cix604 Ong, 2017, Keeping an eye on syphilis, Aust Fam Physician, 46, 401 Onoda, 1979, Therapeutic effect of oral doxycycline on syphilis, Br J Vener Dis, 55, 110 Page, 1982, Vertical supranuclear gaze palsy with secondary syphilis, J Neurol Neurosurg Psychiatry, 45, 86, 10.1136/jnnp.45.1.86 Pan, 2010, Syphilitic uveitis: report of 3 cases, Int J Ophthalmol, 3, 361 Park, 2019, Performance of treponemal tests for the diagnosis of syphilis, Clin Infect Dis, 68, 913, 10.1093/cid/ciy558 Parker, 1972, Uncommon complications of early syphilis. Hepatitis, periostitis, iritis with papillitis, and meningitis, Br J Vener Dis, 48, 32 Peeling, 2017, Syphilis, Nat Rev Dis Prim, 3, 17073, 10.1038/nrdp.2017.73 Peng, 2011, Molecular typing of Treponema pallidum: a systematic review and meta-analysis, PLoS Negl Trop Dis, 5, e1273, 10.1371/journal.pntd.0001273 Peterman, 2015, Public health interventions to control syphilis, Sex Heal, 12, 126, 10.1071/SH14156 Pichi, 2014, Spectral domain optical coherence tomography findings in patients with acute syphilitic posterior placoid chorioretinopathy, Retina, 34, 373, 10.1097/IAE.0b013e3182993f11 Pichi, 2020, Multimodal imaging patterns of posterior syphilitic uveitis: a review of the literature, laboratory evaluation and treatment, Int Ophthalmol, 40, 1319, 10.1007/s10792-020-01285-9 Pillay, 2018, Centers for Disease Control and Prevention Syphilis Summit-diagnostics and laboratory issues, Sex Transm Dis, 45, S13, 10.1097/OLQ.0000000000000843 Pospisilova, 2018, Multi-locus sequence typing of Treponema pallidum subsp. pallidum present in clinical samples from France: Infecting treponemes are genetically diverse and belong to 18 allelic profiles, PLoS One, 13, 10.1371/journal.pone.0201068 Pratas, 2018, Increase in ocular syphilis cases at ophthalmologic reference center, France, 2012-2015, Emerg Infect Dis, 24, 193, 10.3201/eid2402.171167 Puech, 2010, Ocular manifestations of syphilis: recent cases over a 2.5-year period, Graefes Arch Clin Exp Ophthalmol, 248, 1623, 10.1007/s00417-010-1481-z Queiroz, 2019, The ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis, J Ophthalmic Inflamm Infect, 9, 2, 10.1186/s12348-019-0169-8 Quilter, 2020, Prevalence of self-reported neurologic and ocular symptoms in early syphilis cases, Clin Infect Dis Radolf, 1996, Treponema Read, 2001, Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature, Am J Ophthalmol, 131, 647, 10.1016/S0002-9394(01)00925-4 Reddy, 2006, Syphilitic retinitis with focal inflammatory accumulations, Ophthalmic Surg Lasers Imaging, 37, 429, 10.3928/15428877-20060901-13 Reekie, 2018, Use of lumbar punctures in the management of ocular syphilis, Semin Ophthalmol, 33, 271 Riedner, 2005, Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis, N Engl J Med, 353, 1236, 10.1056/NEJMoa044284 Riley, 1992, Virulent Treponema pallidum activates human vascular endothelial cells, J Infect Dis, 165, 484, 10.1093/infdis/165.3.484 Riley, 1994, Virulent Treponema pallidum promotes adhesion of leukocytes to human vascular endothelial cells, Infect Immun, 62, 4622, 10.1128/iai.62.10.4622-4625.1994 Rodrigues, 2014, Yellowish dots in the retina: a finding of ocular syphilis?, Arq Bras Oftalmol, 77, 324, 10.5935/0004-2749.20140081 Rolfs, 1997, A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group, N Engl J Med, 337, 307, 10.1056/NEJM199707313370504 Romao, 2016, Ocular syphilis in a kidney transplant recipient, Rev Inst Med Trop Sao Paulo, 58, 10.1590/S1678-9946201658046 Ross, 1980, Acquired syphilitic uveitis, Arch Ophthalmol, 98, 496, 10.1001/archopht.1980.01020030492011 Runkle, 2011, The blood-retinal barrier: structure and functional significance, Methods Mol Biol, 686, 133, 10.1007/978-1-60761-938-3_5 Rush, 1981, Syphilitic optic perineuritis, Am J Ophthalmol, 91, 404, 10.1016/0002-9394(81)90298-1 Russell, 2020, Masqueraders of multiple evanescent white dot syndrome (MEWDS), Int Ophthalmol, 40, 627, 10.1007/s10792-019-01223-4 Sacks, 1983, Progressive visual loss in syphilitic optic atrophy, J Clin Neuroophthalmol, 3, 5 Sahin, 2016, Clinical and laboratory characteristics of ocular syphilis, co-infection, and therapy response, Clin Ophthalmol, 10, 13 Saidel, 2005, Cytomegalovirus retinitis after intravitreous triamcinolone in an immunocompetent patient, Am J Ophthalmol, 140, 1141, 10.1016/j.ajo.2005.06.058 Saleh, 2017, Ultra-wide-field fundus autofluorescence and spectral-domain optical coherence tomography findings in syphilitic outer retinitis, Ophthalmic Surg Lasers Imaging Retin, 48, 208, 10.3928/23258160-20170301-03 Sara, 2016, Three cases of ocular syphilis and the resurgence of the disease in Queensland, Int Med Case Rep J, 9, 279, 10.2147/IMCRJ.S111349 Scattergood, 1983, Scrolls of Descemet's membrane in healed syphilitic interstitial keratitis, Ophthalmology, 90, 1518, 10.1016/S0161-6420(83)34354-2 Schlaegel, 1982, A review (1970-1980) of 28 presumptive cases of syphilitic uveitis, Am J Ophthalmol, 93, 412, 10.1016/0002-9394(82)90129-5 Schmidt, 1972, Demonstration of motile treponemes in the aqueous humour in secondary syphilis, Br J Vener Dis, 48, 400 Schoenberger, 2017, Diagnosis and treatment of acute retinal necrosis: a report by the American Academy of Ophthalmology, Ophthalmology, 124, 382, 10.1016/j.ophtha.2016.11.007 Schwartz, 1980, Secondary syphilis with iris papules, Am J Ophthalmol, 90, 380, 10.1016/S0002-9394(14)74921-9 Sekine, 2015, Multimodal imaging of a case of acute syphilitic posterior placoid chorioretinitis, Nihon Ganka Gakkai Zasshi, 119, 266 Shaikh, 2015, Nodular syphilitic scleritis masquerading as an ocular tumor, J Ophthalmic Inflamm Infect, 5, 8, 10.1186/s12348-015-0040-5 Shalaby, 1997, Syphilitic uveitis in human immunodeficiency virus-infected patients, Arch Ophthalmol, 115, 469, 10.1001/archopht.1997.01100150471003 Silveira, 2001, A follow-up study of Toxoplasma gondii infection in southern Brazil, Am J Ophthalmol, 131, 351, 10.1016/S0002-9394(00)00830-8 Smith, 1969, Late ocular syphilis: transfer of infection from man to experimental animals, Trans Am Ophthalmol Soc, 67, 658 Smith, 1968, Treponemes in aqueous humor in late seronegative syphilis, Trans Am Acad Ophthalmol Otolaryngol, 72, 63 Smith, 1968, Recovery of Treponema pallidum from aqueous humor removed at cataract surgery in man by passive transfer to rabbit testis, Am J Ophthalmol, 65, 242, 10.1016/0002-9394(68)93595-2 Smith, 1965, Experimental ocular syphilis and neurosyphilis, Br J Vener Dis, 41, 15 Smith, 2007, Unique gene expression profiles of donor-matched human retinal and choroidal vascular endothelial cells, Invest Ophthalmol Vis Sci, 48, 2676, 10.1167/iovs.06-0598 Smith, 2018, Angiogenic and immunologic proteins identified by deep proteomic profiling of human retinal and choroidal vascular endothelial cells: potential targets for new biologic drugs, Am J Ophthalmol, 193, 197, 10.1016/j.ajo.2018.03.020 Smolak, 2018, Trends and predictors of syphilis prevalence in the general population: global pooled analyses of 1103 prevalence measures including 136 million syphilis tests, Clin Infect Dis, 66, 1184, 10.1093/cid/cix975 Soheilian, 1996, Intermediate uveitis and retinal vasculitis as manifestations of cat scratch disease, Am J Ophthalmol, 122, 582, 10.1016/S0002-9394(14)72125-7 Song, 2008, Acute syphilitic posterior placoid chorioretinitis following intravitreal triamcinolone acetonide injection, Graefes Arch Clin Exp Ophthalmol, 246, 1775, 10.1007/s00417-008-0928-y Sood, 2019, Combined intravitreal and systemic antibiotic therapy in a patient with syphilitic uveitis, Ocul Immunol Inflamm, 27, 131, 10.1080/09273948.2017.1385817 de Souza, 1988, Unusual central chorioretinitis as the first manifestation of early secondary syphilis, Am J Ophthalmol, 105, 271, 10.1016/0002-9394(88)90009-8 Spoor, 1983, Ocular syphilis. Acute and chronic, J Clin Neuroophthalmol, 3, 197 Stoltey, 2015, Syphilis transmission: a review of the current evidence, Sex Heal, 12, 103, 10.1071/SH14174 Sudharshan, 2020, Ocular syphilis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy, Indian J Ophthalmol, 68, 1887, 10.4103/ijo.IJO_1070_20 Tamai, 2007, Possible requirement of intercellular adhesion molecule-1 for invasion of gingival epithelial cells by Treponema medium, Can J Microbiol, 53, 1232, 10.1139/W07-094 Tamesis, 1990, Ocular syphilis, Ophthalmology, 97, 1281, 10.1016/S0161-6420(90)32419-3 Tan, 2012, Evaluation of the impact of uveitis on visual-related quality of life, Ocul Immunol Inflamm, 20, 453, 10.3109/09273948.2012.723781 Tanizaki, 2015, High-dose oral amoxicillin plus probenecid is highly effective for syphilis in patients with HIV infection, Clin Infect Dis, 61, 177, 10.1093/cid/civ270 2000, Survival after introduction of HAART in people with known duration of HIV-1 infection, Lancet, 355, 1158, 10.1016/S0140-6736(00)02069-9 Thomas, 1989, Interactions of Treponema pallidum with endothelial cell monolayers, Eur J Epidemiol, 5, 15, 10.1007/BF00145039 Thomas, 1988, Treponema pallidum invades intercellular junctions of endothelial cell monolayers, Proc Natl Acad Sci U S A, 85, 3608, 10.1073/pnas.85.10.3608 Tipple, 2015, Syphilis testing, typing, and treatment follow-up: a new era for an old disease, Curr Opin Infect Dis, 28, 53, 10.1097/QCO.0000000000000124 Tramont, 1995, Neurosyphilis in patients with human immunodeficiency virus infection, N Engl J Med, 332, 1169, 10.1056/NEJM199504273321712 Tran, 2005, Syphilitic uveitis in patients infected with human immunodeficiency virus, Graefes Arch Clin Exp Ophthalmol, 243, 863, 10.1007/s00417-005-1137-6 Tsuboi, 2016, Prognosis of ocular syphilis in patients infected with HIV in the antiretroviral therapy era, Sex Transm Infect, 92, 605, 10.1136/sextrans-2016-052568 Tsui, 2018, Multimodal imaging adds new insights into acute syphilitic posterior placoid chorioretinitis, Retin Cases Br Rep, 12, S3, 10.1097/ICB.0000000000000645 Tucker, 2011, Ocular syphilis among HIV-infected patients: a systematic analysis of the literature, Sex Transm Infect, 87, 4, 10.1136/sti.2010.043042 Tuddenham, 2016, Ocular syphilis: opportunities to address important unanswered questions, Sex Transm Infect, 92, 563, 10.1136/sextrans-2016-052570 Tugal-Tutkun, 2004, Uveitis in Behcet disease: an analysis of 880 patients, Am J Ophthalmol, 138, 373, 10.1016/j.ajo.2004.03.022 Tyagi, 2020, Clinical manifestations and outcomes of ocular syphilis in Asian Indian population: analysis of cases presenting to a tertiary referral center, Indian J Ophthalmol, 68, 1881, 10.4103/ijo.IJO_809_20 Vadboncoeur, 2020, Ocular syphilis: case series (2000-2015) from 2 tertiary care centres in Montreal, Canada, Can J Ophthalmol, 55, 30, 10.1016/j.jcjo.2019.05.009 Villanueva, 2000, Posterior uveitis in patients with positive serology for syphilis, Clin Infect Dis, 30, 479, 10.1086/313689 Volk, 2015, No new HIV infections with increasing use of HIV preexposure prophylaxis in a clinical practice setting, Clin Infect Dis, 61, 1601, 10.1093/cid/civ778 Watson, 1976, Scleritis and episcleritis, Br J Ophthalmol, 60, 163, 10.1136/bjo.60.3.163 Wells, 2018, Ocular syphilis: the re-establishment of an old disease, Eye, 32, 99, 10.1038/eye.2017.155 Wells, 1967, Experimental ocular and neurosyphilis in the primate, Br J Vener Dis, 43, 10 Wickremasinghe, 2009, Syphilitic punctate inner retinitis in immunocompetent gay men, Ophthalmology, 116, 1195, 10.1016/j.ophtha.2008.12.055 Widdrington, 2017, Missed opportunities to diagnose syphilis prior to the development of sight-losing uveitis, J R Coll Physicians Edinb, 47, 129, 10.4997/JRCPE.2017.204 Wilhelmus, 1987, Syphilitic episcleritis and scleritis, Am J Ophthalmol, 104, 595, 10.1016/0002-9394(87)90170-X Wong, 2005, Risk factors for early syphilis among gay and bisexual men seen in an STD clinic: San Francisco, 2002-2003, Sex Transm Dis, 32, 458, 10.1097/01.olq.0000168280.34424.58 Woolston, 2015, A Cluster of ocular syphilis cases - Seattle, Washington, and San Francisco, California, 2014-2015, MMWR Morb Mortal Wkly Rep, 64, 1150, 10.15585/mmwr.mm6440a6 Workowski, 2015, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015, MMWR Recomm Rep, 64, 1 Wroblewski, 2011, Ocular tuberculosis: a clinicopathologic and molecular study, Ophthalmology, 118, 772, 10.1016/j.ophtha.2010.08.011 Yang, 2012, Ocular manifestations of syphilitic uveitis in Chinese patients, Retina, 32, 1906, 10.1097/IAE.0b013e3182509796 Yap, 2014, Syphilitic uveitis in a Singaporean population, Ocul Immunol Inflamm, 22, 9, 10.3109/09273948.2013.829106 Yim, 1985, Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis, Antimicrob Agents Chemother, 28, 347, 10.1128/AAC.28.2.347 Yoon, 2005, Neurosyphilitic episcleritis, Acta Ophthalmol Scand, 83, 265, 10.1111/j.1600-0420.2005.00394.x Zett, 2018, En-face optical coherence tomography of acute syphilitic posterior placoid chorioretinopathy, Ocul Immunol Inflamm, 26, 1264, 10.1080/09273948.2017.1347265 Zhang, 2014, Recombinant Treponema pallidum protein Tp0965 activates endothelial cells and increases the permeability of endothelial cell monolayer, PLoS One, 9 Zhang, 2017, Clinical features and treatments of syphilitic uveitis: a systematic review and meta-analysis, J Ophthalmol, 2017, 10.1155/2017/6594849 Zhang, 2017, Characteristics of syphilitic uveitis in northern China, BMC Ophthalmol, 17, 95, 10.1186/s12886-017-0491-6 Zhu, 2017, Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: a retrospective case study, Medicine (Baltimore), 96, e8376, 10.1097/MD.0000000000008376 Zinsser, 1916, Studies on Treponema pallidum and syphilis : III. The individual fluctuations in virulence and comparative virulence of Treponema pallidum strains passed through rabbits, J Exp Med, 23, 329, 10.1084/jem.23.3.329