Octanoic acid promotes clearance of antibiotic-tolerant cells and eradicates biofilms of Staphylococcus aureus isolated from recurrent bovine mastitis

Gomes, 2016, Control of bovine mastitis: old and recent therapeutic approaches, Curr Microbiol, 72, 377, 10.1007/s00284-015-0958-8 Tenhagen, 2006, Prevalence of mastitis pathogens and their resistance against antimicrobial agents in dairy cows in Brandenburg, Germany, J Dairy Sci, 89, 2542, 10.3168/jds.S0022-0302(06)72330-X Krömker, 2017, Mastitis treatment-Reduction in antibiotic usage in dairy cows, Reprod Domest Anim, 52, 21, 10.1111/rda.13032 Fisher, 2017, Persistent bacterial infections and persister cells, Nat Rev Microbiol, 15, 453, 10.1038/nrmicro.2017.42 Peyrusson, 2020, Intracellular Staphylococcus aureus persisters upon antibiotic exposure, Nat Commun, 11, 2200, 10.1038/s41467-020-15966-7 Hossain, 2017, Bovine mastitis and its therapeutic strategy doing antibiotic sensitivity test, Austin. J. Vet. Sci. & Anim. Husb., 4, 1030 Cheng, 2020, Bovine mastitis: risk factors, therapeutic strategies, and alternative treatments - a review, Asian-Australas J Anim Sci, 33, 1699, 10.5713/ajas.20.0156 Atulya, 2014, Influence of milk components in establishing biofilm mediated bacterial mastitis infections in cattle: a fractional factorial approach, Res Vet Sci, 96, 25, 10.1016/j.rvsc.2013.12.001 Bosch, 2020, Staphylococcus aureus ATP synthase promotes biofilm persistence by influencing innate immunity, mBio, 11, 10.1128/mBio.01581-20 Zebari, 2019, Fatty acid profile of milk for determining reproductive status in lactating Holstein Friesian cows, Anim Reprod Sci, 202, 26, 10.1016/j.anireprosci.2019.01.004 Desbois, 2010, Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential, Appl Microbiol Biotechnol, 85, 1629, 10.1007/s00253-009-2355-3 Lee, 2021, Antibiofilm and antifungal activities of medium-chain fatty acids against Candida albicans via mimicking of the quorum-sensing molecule farnesol, Microb Biotechnol, 14, 1353, 10.1111/1751-7915.13710 Nair, 2005, Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens, J Dairy Sci, 88, 3488, 10.3168/jds.S0022-0302(05)73033-2 Royce, 2013, The damaging effects of short chain fatty acids on Escherichia coli membranes, Appl Microbiol Biotechnol, 97, 8317, 10.1007/s00253-013-5113-5 Rani, 2022, Efficacy and mechanism of carvacrol with octanoic acid against mastitis causing multi-drug-resistant pathogens, Braz J Microbiol, 53, 385, 10.1007/s42770-021-00639-4 Zhang, 2019, Antimicrobial action of octanoic acid against Escherichia coli O157:H7 during washing of baby spinach and grape tomatoes, Food Res Int, 125, 10.1016/j.foodres.2019.108523 Kumar, 2020, Fatty acids as antibiofilm and antivirulence agents, Trends Microbiol, 28, 753, 10.1016/j.tim.2020.03.014 Zhang, 2019, Caprylic acid suppresses inflammation via TLR4/NF-κB signaling and improves atherosclerosis in ApoE-deficient mice, Nutr Metab, 16, 40, 10.1186/s12986-019-0359-2 Zhang, 2022, Caprylic acid improves lipid metabolism, suppresses the inflammatory response and activates the ABCA1/p-JAK2/p-STAT3 signaling pathway in C57bl/6J mice and RAW264.7 cells, Biomed Environ Sci, 35, 95 Dong, 2014, In vitro activities of rifampin, colistin, sulbactam and tigecycline tested alone and in combination against extensively drug-resistant Acinetobacter baumannii, J Antibiot (Tokyo), 67, 677, 10.1038/ja.2014.99 Lin, 2022, A cationic amphipathic Tilapia piscidin 4 peptide-based antimicrobial formulation promotes eradication of bacterial vaginosis-associated bacterial biofilms, Front Microbiol, 13 Haney, 2021, Microtiter plate assays to assess antibiofilm activity against bacteria, Nat Protoc, 16, 2615, 10.1038/s41596-021-00515-3 Proctor, 2006, Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections, Nat Rev Microbiol, 4, 295, 10.1038/nrmicro1384 Vulin, 2018, Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters, Nat Commun, 9, 4074, 10.1038/s41467-018-06527-0 Balaban, 2019, Definitions and guidelines for research on antibiotic persistence [published correction appears in Nat Rev Microbiol. 2019 Apr 29], Nat Rev Microbiol, 17, 441, 10.1038/s41579-019-0196-3 Ali, 2021, Prevalence of mastitis pathogens and antimicrobial susceptibility of isolates from cattle and buffaloes in northwest of Pakistan, Front Vet Sci, 8, 10.3389/fvets.2021.746755 Dufour, 2019, The mastitis pathogens culture collection, Microbiol Resour Announc, 8, 10.1128/MRA.00133-19 Putz, 2020, Case report: characterization of a persistent, treatment-resistant, novel Staphylococcus aureus infection causing chronic mastitis in a Holstein dairy cow, BMC Vet Res, 16, 336, 10.1186/s12917-020-02528-8 Mirani, 2015, Small colony variants have a major role in stability and persistence of Staphylococcus aureus biofilms, J Antibiot (Tokyo), 68, 98, 10.1038/ja.2014.115 Thoendel, 2011, Peptide signaling in the staphylococci, Chem Rev, 111, 117, 10.1021/cr100370n Ganesh, 2022, Biofilm-associated agr and sar quorum sensing systems of Staphylococcus aureus are inhibited by 3-hydroxybenzoic acid derived from Illicium verum, ACS Omega, 7, 14653, 10.1021/acsomega.1c07178 Jenul, 2019, Regulation of Staphylococcus aureus virulence, Microbiol Spectr, 7, 10.1128/microbiolspec.GPP3-0031-2018 Herman-Bausier, 2018, Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion, Proc Natl Acad Sci U S A, 115, 5564, 10.1073/pnas.1718104115 Foster, 2019, Surface proteins of Staphylococcus aureus, Microbiol Spectr, 7, 10.1128/microbiolspec.GPP3-0046-2018 Shinji, 2011, Role of fibronectin-binding proteins A and B in in vitro cellular infections and in vivo septic infections by Staphylococcus aureus, Infect Immun, 79, 2215, 10.1128/IAI.00133-11 Tuchscherr, 2015, Sigma factor SigB is crucial to mediate Staphylococcus aureus adaptation during chronic infections, PLoS Pathog, 11, 10.1371/journal.ppat.1004870 Kwiecinski, 2021, Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection, Cell Rep, 36, 10.1016/j.celrep.2021.109462 Cue, 2009, Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC, J Bacteriol, 191, 6363, 10.1128/JB.00913-09 Manasherob, 2021, Tolerant small-colony variants form prior to resistance within a Staphylococcus aureus biofilm based on antibiotic selective pressure, Clin Orthop Relat Res, 479, 1471, 10.1097/CORR.0000000000001740 Sachi, 2019, Antibiotic residues in milk: past, present, and future, J Adv Vet Anim Res, 6, 315, 10.5455/javar.2019.f350 Angelopoulou, 2019, Non-antibiotic microbial solutions for bovine mastitis - live biotherapeutics, bacteriophage, and phage lysins, Crit Rev Microbiol, 45, 564, 10.1080/1040841X.2019.1648381 Gruet, 2001, Bovine mastitis and intramammary drug delivery: review and perspectives, Adv Drug Deliv Rev, 50, 245, 10.1016/S0169-409X(01)00160-0 Pellegrino, 2017, Bovine mastitis prevention: humoral and cellular response of dairy cows inoculated with lactic acid bacteria at the dry-off period, Benef Microbes, 8, 589, 10.3920/BM2016.0194 Rainard, 2018, Knowledge gaps and research priorities in Staphylococcus aureus mastitis control, Transbound Emerg Dis, 65, 149, 10.1111/tbed.12698 Côté-Gravel, 2019, Symposium review: features of Staphylococcus aureus mastitis pathogenesis that guide vaccine development strategies, J Dairy Sci, 102, 4727, 10.3168/jds.2018-15272 Sharun, 2021, Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review, Vet Q, 41, 107, 10.1080/01652176.2021.1882713 Wente, 2020, Recurrent mastitis-persistent or new infections?, Vet Microbiol, 244, 10.1016/j.vetmic.2020.108682 Zaatout, 2020, Staphylococcus aureus persistence properties associated with bovine mastitis and alternative therapeutic modalities, J Appl Microbiol, 129, 1102, 10.1111/jam.14706 Campos, 2022, Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives, BMC Vet Res, 18, 115, 10.1186/s12917-022-03197-5 Pumipuntu, 2019, Staphylococcus spp. associated with subclinical bovine mastitis in central and northeast provinces of Thailand, PeerJ, 7, 10.7717/peerj.6587 Belfield, 2017, Evaluation of combinations of putative anti-biofilm agents and antibiotics to eradicate biofilms of Staphylococcus aureus and Pseudomonas aeruginosa, J Antimicrob Chemother, 72, 2531, 10.1093/jac/dkx192