Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment

Water Research - Tập 46 - Trang 4790-4802 - 2012
Marco Scheurer1,2, Amandine Michel1, Heinz-Jürgen Brauch1, Wolfgang Ruck2, Frank Sacher1
1DVGW-Technologiezentrum Wasser (TZW), Karlsruher Str. 84, 76139 Karlsruhe, Germany
2Leuphana Universität Lüneburg, Scharnhorststr. 1, 21335 Lüneburg, Germany

Tài liệu tham khảo

Bader, 1981, Determination of ozone in water by the indigo method, Water Research, 15, 449, 10.1016/0043-1354(81)90054-3 Blatchley, 2010, Reaction mechanism for chlorination of urea, Environmental Science & Technology, 44, 8529, 10.1021/es102423u Caminada, 2006, Cytotoxicity of pharmaceuticals found in aquatic systems: comparison of PLHC-1 and RTG-2 fish cell lines, Aquatic Toxicology, 79, 114, 10.1016/j.aquatox.2006.05.010 ChemAxon Ltd., 2012. http://intro.bio.umb.edu/111-112/OLLM/111F98/newclogp.html (accessed 20.05.12). Collin, 2004, Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of metformin in aqueous solutions, Journal of Mass Spectrometry, 39, 890, 10.1002/jms.656 DVGW, 1998 EN ISO 7393-2, 2000. Water Quality — Determination of Free Chlorine and Total Chlorine — Part 2: Colorimetric Method Using N, N-diethyl-1,4-phenylenediamine for Routine Control Purposes. ISO 7393-2:1985. Gartiser, 2012, Mutagenicity of biodegraded and ozonated pharmaceuticals, related metabolites and their transformation products, Environmental Science and Pollution Research, 10.1007/s11356-012-0925-x Greenstone LLC, 2009 Haag, 1992, Rate constants for reaction of hydroxyl radicals with several drinking water contaminants, Environmental Science & Technology, 26, 1005, 10.1021/es00029a021 Haist-Gulde, 1998, Removal of organic micropollutants by activated carbon, vol. 5, 103 Happel, O., Graf, C., Mertineit, S., Brauch, H.-J., 2009. Small scale filter test with activated carbon for the assessment of the removability of organic trace pollutants in drinking water production. In: Conference Proceedings of the Annual Conference of the Water Chemical Society (Branch of the German Chemical Society), May 18–20, 2009 (Stralsund, Germany), pp. 202–206. HLUG Hormazabal, 2010, Determination of metformin in cultivated plant species and soil by liquid chromatography–mass spectrometry, Journal of Liquid Chromatography & Related Technologies, 33, 1630, 10.1080/10826076.2010.519242 Huber, 2003, Oxidation of pharmaceuticals during ozonation and advanced oxidation processes, Environmental Science & Technology, 37, 1016, 10.1021/es025896h IDF, 2011 Karrenbrock, 1999, Development of a standardized testfilter for the determination of microbial degradability of single compounds, Vom Wasser, 92, 361 Khouri, 2004, Radical-induced oxidation of metformin, European Journal of Biochemistry, 271, 4745, 10.1111/j.1432-1033.2004.04438.x Knepper, 1999, Metabolism studies of phenylsulfonamides relevant for water works, Environmental Science & Technology, 33, 945, 10.1021/es980712d Knepper, 1999, Detection of polar organic substances relevant for drinking water, Waste Management, 19, 77, 10.1016/S0956-053X(99)00003-3 Kolpin, 2002, Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999–2000: a national reconnaissance, Environmental Science & Technology, 36, 1202, 10.1021/es011055j Liebl, 2005 Marcus, P., 2005. Development and validation of a rapid laboratory test for assessment of the adsorbability of organic single substances onto activated carbon. Thesis, Technical University Dresden (in German). Maruthamuthu, 1995, Rate constants for some reactions of free radicals with haloacetates in aqueous solution, International Journal of Chemical Kinetics, 27, 605, 10.1002/kin.550270610 Mengel, 2011, Antidiabetika, 343 OECD, 2000 Ottmar, 2010, Development and application of a model to estimate wastewater treatment plant prescription pharmaceutical influent loadings and concentrations, Bulletin of Environmental Contamination and Toxicology, 84, 507, 10.1007/s00128-010-9990-3 Pentikäinen, 1979, Pharmacokinetics of metformin after intravenous and oral-administration to man, European Journal of Clinical Pharmacology, 16, 195, 10.1007/BF00562061 Richardson, 2009, Water analysis: emerging contaminants and current issues, Analytical Chemistry, 81, 4645, 10.1021/ac9008012 Richardson, 2011, Water analysis: emerging contaminants and current issues, Analytical Chemistry, 83, 4614, 10.1021/ac200915r RIVM, 2005 Scheurer, 2009, Occurrence of the antidiabetic drug metformin in sewage and surface waters in Germany, Journal of Environmental Monitoring, 11, 1608, 10.1039/b909311g Scheurer, 2010, Performance of conventional multi-barrier drinking water treatment plants for the removal of four artificial sweeteners, Water Research, 44, 3573, 10.1016/j.watres.2010.04.005 Seitz, 2006, Removal of iodinated X-ray contrast media during drinking water treatment, Environmental Chemistry, 3, 35, 10.1071/EN05036 Trautwein, 2011, Incomplete aerobic degradation of the antidiabetic drug metformin and identification of the bacterial dead-end transformation product guanylurea, Chemosphere, 85, 765, 10.1016/j.chemosphere.2011.06.057 van Nuijs, 2010, Optimization and validation of a hydrophilic interaction liquid chromatography–tandem mass spectrometry method for the determination of 13 top-prescribed pharmaceuticals in influent wastewater, Analytical and Bioanalytical Chemistry, 398, 2211, 10.1007/s00216-010-4101-1 von Gunten, 2003, Ozonation of drinking water: Part I. Oxidation kinetics and product formation, Water Research, 37, 1443, 10.1016/S0043-1354(02)00457-8 Vulliet, 2011, Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption, Environmental Pollution, 159, 2929, 10.1016/j.envpol.2011.04.033 WHO, 2012. http://www.whocc.no/atcddd/ (accessed 31.01.12).