Occupational exposure to anticancer drugs — Potential and real hazards

Mutation Research/Reviews in Genetic Toxicology - Tập 154 - Trang 135-149 - 1985
Marja Sorsa1, Kari Hemminki1, Harri Vainio2
1Institute of Occupational Health, Helsinki, Finland
2International Agency for Research on Cancer, Lyon, France

Tài liệu tham khảo

Anderson, 1982, Risk of handling injectable antineoplastic agents, Am. J. Hosp. Pharm., 39, 1881 Apelt, 1981, Azathioprine, a clastogen in human somatic cells?, Mutation Res., 88, 61, 10.1016/0165-1218(81)90090-2 Aronson, 1982, Acute and long-term cytogenetic effects of treatment of childhood cancer: Sister-chromatid exchanges and chromosome aberrations, Mutation Res., 92, 291, 10.1016/0027-5107(82)90232-9 Barale, 1985, Sister chromatid exchanges in lymphocytes and mutagenicity in urine of nurses handling cytostatic drugs, Mutation Res., 10.1016/0165-1218(85)90121-1 Barber, 1981, Fetal and neonatal effects of cytotoxic agents, Obstet. Gynecol., 51, 415 Bennet, 1981, Alkylation of DNA in rat tissues following administration of streptozotocin, Cancer Res., 41, 2786 1985 Boice, 1983, Leukemia and preleukemia after adjuvant treatment of gastrointestinal cancer with semustine (methyl-CCNU), N. Engl. J. Med., 309, 1079, 10.1056/NEJM198311033091802 Bos, 1982, Mutagenicity of urine from nurses handling cytostatic drugs, influence of smoking, Int. Arch. Occup. Environ. Health, 50, 359, 10.1007/BF00377832 1982, 580 Chun, 1969, Differences in the in vivo alkylation and cross-linking of nitrogen mustard-sensitive and -resistant lines of Lettrè-Ehrlich ascites tumors, Cancer Res., 29, 1184 Clark, 1981, The potassium iodide method for determining protection factors in openfronted microbiological safety cabinets, J. Appl. Biol., 51, 461 Dobos, 1974, Cyclophosphamide-induced chromosomal aberrations in nontumorous patients, Hum. Genet., 22, 221, 10.1007/BF00284825 Einhorn, 1982, Late side effects of chemotherapy in ovarian carcinoma, Cancer, 459, 2234, 10.1002/1097-0142(19820601)49:11<2234::AID-CNCR2820491106>3.0.CO;2-Q Einistö, 1984, Mutagenic activity in urine of active and passive smokers, 174 Einistö, 1986, Urinary mutagenicity related to histidine in urine concentrates among passive and active cigarette smokers, Arch. Toxicol. Falck, 1979, Mutagenicity in urine of nurses handling cytostatic drugs, Lancet, i, 1250, 10.1016/S0140-6736(79)91939-1 Falck, 1981, Use of the bacterial fluctuation test to detect mutagenicity in urine of nurses handling cytostatic drugs (abstract), Mutation Res., 85, 236, 10.1016/0165-1161(81)90083-2 Fedortzeva, 1973, Cytogenetical analysis of the effect of 6-mercaptopurine on human chromosomes, I. Effects on blood cells of acute leukemia patients (in Russian), Cytologia, 15, 1172 Forni, 1985, Chromosomal aberrations in monitoring exposure to mutagens-carcinogens Gebhart, 1981, Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing, Hum. Genet., 58, 235, 10.1007/BF00294917 Gebhart, 1980, Chromosome studies on lymphocytes of patients under cytostatic therapy, I. Conventional chromosome studies in cytostatic interval therapy, Hum. Genet., 55, 53, 10.1007/BF00329127 Gebhart, 1980, Chromosome studies on lymphocytes of patients under cytostatic therapy, II. Studies using the BUDR-labelling technique in cytostatic interval therapy, Hum. Genet., 56, 157, 10.1007/BF00295688 Gibson, 1983, Urinary mutagenicity assays: a problem arising from the proesence of histidine associated growth factors in XAD-2 prepared urine concentrates, with particular relevance to assays carried out using the bacterial fluctuation test, Carcinogenesis, 4, 1471, 10.1093/carcin/4.11.1471 Gibson, 1984, Mutagenicity of urine from nurses handling cytotoxic drugs, Lancet, i, 100, 10.1016/S0140-6736(84)90024-2 Gombar, 1980, Mechanism of action of the nitrosoureas, IV. Reactions of BCNU and CCNU with DNA, Biochem. Pharmacol., 29, 2639, 10.1016/0006-2952(80)90079-9 Hemminki, 1984, Covalent modification of DNA by antineoplastic agents, J. Natl. Cancer Inst., 73, 1021 Hemminki, 1983, Assessment of methods and results of reproductive occupational epidemiology: spontaneous abortions and malformations in the offspring of working women, Am. J. Ind. Med., 4, 293, 10.1002/ajim.4700040122 Hemminki, 1985, Spontaneous abortions and malformations in the offspring of nurses exposed to anesthetic gases, cytostatic drugs and other potential hazards in hospitals based on registered information of outcome, J. Epidemiol. Commun. Health, 39 Hemminki, 1985 Hirst, 1984, Occupational exposure to cyclophosphamide, Lancet, i, 186, 10.1016/S0140-6736(84)92111-1 IARC, 1975, 268 IARC, 1976, 353 IARC, 1981, 441 IARC, 1982, Chemicals, Industrial Processes and Industries Associated with Cancer in Humans, Vols. 1–29, IARC Monographs, 292 Ikegami, 1968, Subcutaneous sarcomas induced by mitomycin C in mice: Comparisons of occurrence, transplantability and histology between sarcomas induced by actinomycin D and methylcholanthrene, Acta Pathol. Japan, 17, 495 Jagun, 1982, Urinary thioether excretion in nurses handling cytotoxic drugs, Lancet, i, 443, 10.1016/S0140-6736(82)90474-3 Kaldor, 1985, The use of epidemiological data for the assessments of human cancer risk, Cold Spr. Harbor, Banbury Report No. 19 Kleinberg, 1981, Airborne drug levels in a laminar flow hood, Am. J. Hosp. Pharm., 38, 1301 Kolmodin-Hedman, 1983, Occupational handling of cytostatic drugs, Arch. Toxicol., 54, 25, 10.1007/BF00277812 Krogh Jensen, 1979, Cytogenetic effect of methotrexate on human cells in vivo, Mutation Res., 64, 339, 10.1016/0165-1161(79)90126-2 Ladik, 1980, Precautionary methods in the preparation of antineoplastics, Am. J. Hosp. Pharm., 37, 1184 Lambert, 1978, Sister chromatid exchanges in lymphocyte cultures of patients receiving chemotherapy for malignant disorders, Cancer Treat. Rep., 62, 1413 Lambert, 1984, Persistance of chromosome rearrangements in peripheral lymphocytes from patients treated with melphalan for ovarian carcinoma, Hum. Genet., 67, 94, 10.1007/BF00270564 Lawley, 1967, Interstrand cross-linking of DNA by bifunctional alkylating agents, J. Mol. Biol., 25, 143, 10.1016/0022-2836(67)90285-9 Lippard, 1982, New chemistry of an old molecule: cis-diamminedichloroplatinum (II), Science, 218, 1075, 10.1126/science.6890712 Mohtashamipur, 1985, Isolation of frameshift mutagens from smokers' urine: experiences with 3 methods, Carcinogenesis, 10.1093/carcin/6.5.783 Musilova, 1979, Sister-chromatid exchanges and chromosomal breakage in patients treated with cytostatics, Mutation Res., 67, 289, 10.1016/0165-1218(79)90023-5 Nguyen, 1982, Exposure of pharmacy personnel to mutagenic antineoplastic drugs, Cancer Res., 42, 4792 Nikula, 1984, Chromosome aberrations in lymphocytes of nurses handling cytostatic agents, Scand. J. Work Environ. Health, 10, 71, 10.5271/sjweh.2355 Norppa, 1980, Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs, Scand. J. Work Environ. Health, 67, 229 Palmer, 1984, Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative, Lancet, i, 246, 10.1016/S0140-6736(84)90125-9 Plooy, 1980, Platinum compounds with anti-tumour activity, Toxicology, 17, 169, 10.1016/0300-483X(80)90090-6 Poirier, 1982, Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro, 79, 6443 Prejean, 1984, Structure-activity relationships in the carcinogenicity of anticancer agents, Drug. Metab. Rev., 15, 619, 10.3109/03602538409029975 Salmon, 1976, Nitrosoureas in multiple myeloma, Cancer Treat. Rep., 60, 789 Schinzel, 1976, Lymphocyte chromosome studies in humans exposed to chemical mutagens, Mutation Res., 40, 139, 10.1016/0165-1218(76)90009-4 Selevan, 1985, A case-referent study of occupational exposure to antineoplastic drugs and fetal loss in nurses, N. Engl. J. Med., 10.1056/NEJM198511073131901 Sieber, 1975, Toxicity of antineoplastic agents in man: Chromosomal aberrations, antifertility effects, congenital malformations, and carcinogenic potential, Adv. Cancer Res., 22, 57, 10.1016/S0065-230X(08)60176-1 Siebert, 1973, Cyclophosphamide: Pilot study of genetically active metabolites in urine of a treated human patient, Mutation Res., 19, 65, 10.1016/0027-5107(73)90114-0 Skibba, 1971, Methylation of nucleic acids and urinary excretion of 14C-labeled 7-methylguanine by rats and man after administration of 4(5)-(3,3-dimethyl-1-triazeno)imidazole 5(4)-carboxamide, Toxicol. Appl. Pharmacol., 18, 707, 10.1016/S0041-008X(71)80026-1 Skibba, 1970, Induction of thymic lymphosarcoma and mammary adenocarcinomas in rats by oral administration of the antitumour agent 4(5)-3,3-dimethyl-1-triazeno-imidazole-5(4)carboxamide, Cancer, 26, 1000, 10.1002/1097-0142(197011)26:5<1000::AID-CNCR2820260506>3.0.CO;2-2 Sokal, 1960, Effects of cancer chemotherapeutic agents on the human fetus, J. Am. Med. Ass., 172, 1765, 10.1001/jama.1960.63020160002008 Sorsa, 1981, Monitoring genotoxicity in the occupational environment, Scand. J. Work Environ. Health, 7, 61 Sorsa, 1982, Induction of sister chromatid exchanges among nurses handling cytostatic drugs, 341 Sorsa, 1985, Monitoring of sister chromatid exchange and micronuclei as biological endpoints Sotaniemi, 1983, Liver damage in nurses handling cytostatic agents, Acta Med. Scand., 214, 181, 10.1111/j.0954-6820.1983.tb08593.x Staiano, 1981, Lack of mutagenic activity in urine from hospital pharmacists admixing antitumor drugs, Lancet, i, 615, 10.1016/S0140-6736(81)92064-X Stellman, 1984, Assessment of potential exposure to antineoplastic agents in the health care setting, Prev. Med., 13, 245, 10.1016/0091-7435(84)90082-3 Sternberg, 1972, Renal tumours and other lesions in rats following a single intravenous injection of daunomycin, Cancer Res., 32, 1029 Stevens, 1980, Cytogenetic effects of antitumour drugs in man in vivo, Mutation Res., 74, 242, 10.1016/0165-1161(80)90146-6 Tong, 1980, Crosslinking of DNA by busulfan, Biochim. Biophys. Acta, 608, 174, 10.1016/0005-2787(80)90145-8 Tong, 1982, Formation of the cross-link, 1-(N3-deoxycytidyl)-2-(N1-deoxyguanosinyl)-ethane, in DNA treated with N,N′-bis(2-chloroethyl)-N-nitrosourea (BCNU), Cancer Res., 42, 3102 Tortorici, 1980, Precautions followed by personnel involved with the preparation of parenteral antineoplastic medications, Hosp. Pharm., 15, 293 Turakka, 1984, Consumption of antineoplastic drugs in Finnish hospitals in 1972–1982 UKEMS (United Kingdom Environmental Mutagen Society), 1984, Report of the UKEMS subcommittee on guidelines for mutagenicity testing, 260 Vainio, 1985, Bacterial mutagenicity assay in monitoring exposure to mutagens and carcinogens, 59 Venitt, 1984, Monitoring of exposure of nursing and pharmacy personnel to cytotoxic drugs: urinary mutation assays and urinary platinum as markers of absorption, Lancet, i, 74, 10.1016/S0140-6736(84)90005-9 Waksvik, 1981, Chromosome analyses of nurses handling cytostatic agents, Cancer Treat. Rep., 65, 607 Weisburger, 1975, The carcinogenic properties of some principal drugs used in clinical cancer chemotherapy, Recent Results Cancer Res., 52, 1, 10.1007/978-3-642-80940-8_1 de Werk, 1983, Exposure of hospital workers to airborne antineoplastic agents, Am. J. Hosp. Pharm., 40, 597