Obstructive Sleep Apnea and Cancer: Insights from Intermittent Hypoxia Experimental Models

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Intermittent hypoxia can modulate the number and content of circulating exosomes supporting cancer spreading. Almendros I, Campillo N, Torres M, et al. Role of COX-2 in intermittent hypoxia-induced tumor growth in a murine model of obstructive sleep apnea. Am J Respir Crit Care Med. 2016;193:A7738. Vilaseca A, Musquera M, Torres M, et al. Intermittent hypoxia increases tumor angiogenesis in a mouse model of kidney cancer. Eur Urol. 2016;15(3):E218. Gallego-Martin T, Farre R, Almendros I, Gonzalez-Obeso E, Obeso A. Chronic intermittent hypoxia mimicking sleep apnea increases spontaneous tumorigenesis in mice. Eur Respir J 2017; In press. First work showing increased cancer incidence in old mice exposed to chronic IH. Owens RL, Gold KA, Gozal D, et al. Sleep and breathing… cancer? Cancer Prev Res (Phila). 2016;9(11):821–7. doi:10.1158/1940-6207.CAPR-16-0092. Martinez-Garcia MA, Campos-Rodriguez F, Almendros I, Farre R. Relationship between sleep apnea and cancer. 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