Obesity’s role in secondary male hypogonadism: a review of pathophysiology and management issues

SN Comprehensive Clinical Medicine - Tập 1 - Trang 408-418 - 2019
Omar Seyam1, Jason Gandhi1,2, Gunjan Joshi3, Noel L. Smith4, Sardar Ali Khan1,5
1Department of Physiology and Biophysics, Renaissance School of Medicine, Stony Brook University, Stony Brook, USA
2Medical Student Research Institute, St. George’s University School of Medicine, West Indies, Grenada
3Department of Internal Medicine, Stony Brook Southampton Hospital, Southampton, USA
4Foley Plaza Medical, New York, USA
5Department of Urology, Renaissance School of Medicine, Stony Brook University, Stony Brook, USA

Tóm tắt

Obesity and male hypogonadism are both associated with one another. Moreover, male hypogonadism can serve as a risk factor for obesity while obesity can serve as a risk factor for male hypogonadism. There has been little research regarding obesity and its reduction on that of gonadal function. Lifestyle factors as well as other factors have been attributed to the development of obesity which can induce gonadal dysfunction. Therefore, the treatment of male hypogonadism is of great interest for both providers and patients. The future of hypogonadism therapy may exist with the development of aromatase inhibitors that can minimize undesired effects and allow the benefits of androgens. Testosterone treatment can lead to compromised fertility and addiction. Aromatase allows for the peripheral conversion of androgens into estrogens resulting in the inhibition of gonadotropin production. Therefore, aromatase inhibitors can be used instead to increase gonadotropin secretion. There is growing evidence that aromatase inhibitors can improve the fertility and raise testosterone levels.

Tài liệu tham khảo

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