Obesity phenotypes are, in part, associated with physical activity in diabetic hemodialysis patients

Springer Science and Business Media LLC - Tập 54 - Trang 1751-1759 - 2021
Beatriz de Oliveira Matos1, Clara Suemi da Costa Rosa2,3, Heitor Siqueira Ribeiro4,5, Natasha Maggi Marcos1, Milene Peron Rodrigues Losilla1, Henrique Luiz Monteiro2, Camila Gimenes1
1Centro Universitário do Sagrado Coração (UNISAGRADO), Bauru, Brazil
2Universidade Estadual Paulista (UNESP), Faculdade de Ciências, Bauru, Brazil
3UNESP-Instituto de Biociências, Rio Claro, Brazil
4Faculty of Physical Education, University of Brasília, Brasília, Brazil
5Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia, Porto, Portugal

Tóm tắt

To investigate the prevalence of obesity phenotypes and their association with physical activity levels among diabetic hemodialysis patients. This is a cross-sectional study with 84 diabetic hemodialysis patients (63.5 ± 9.4 years, 54.8% of men). Obesity was diagnosed as high body fat (≥ 40% for male and ≥ 30% for female). Sarcopenic obesity was considered if low skeletal muscle mass (< 20.0 kg for males and < 15.0 kg for females) and obesity were combined. Dynapenic obesity was defined in the presence of low handgrip strength (< 27 kg for males and < 16 kg for females) and obesity. Muscle failure obesity was confirmed in the concomitant presence of obesity, sarcopenia, and dynapenia. Physical activity level was assessed by the Baecke questionnaire and patients were classified as low physical activity according to the first tertile for each of and total domains. Fifty-four patients (64%) presented obesity. From these, 5 (6%), 19 (23%) and 8 (10%) were classified as sarcopenic obese, dynapenic obese, and muscle failure obese, respectively, and 22 (26%) were only obese. Patients with sarcopenic obesity and muscle failure obesity had lower leisure and locomotion physical activity scores than non-obese, whereas the total domain score did not differ across the groups. Muscle failure obesity was independently associated with low leisure physical activity (OR 10.8, 95% CI 1.3–88.1). Only sarcopenic obesity was independently associated with the locomotion and total physical activity domains (OR 15.4, 95% CI 1.4–90.2 and OR 17.0, 95% CI 1.5–95.4, respectively). Our study found a lower prevalence of sarcopenic obesity compared to dynapenic obesity and muscle failure obesity among diabetic hemodialysis patients. Moreover, sarcopenic obesity and muscle failure obesity, but not dynapenic obesity, were associated with low physical activity levels.

Tài liệu tham khảo

Carrero JJ, Stenvinkel P, Cuppari L, Ikizler TA, Kalantar-Zadeh K, Kaysen G et al (2013) Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr 23:77–90. https://doi.org/10.1053/j.jrn.2013.01.001 Ghaderian SB, Hayati F, Shayanpour S, Mousavi SSB (2015) Diabetes and end-stage renal disease; a review article on new concepts. J Ren Inj Prev 4:28–33. https://doi.org/10.12861/jrip.2015.07 Karamé A, Labeeuw M, Trolliet P, Caillette-Beaudoin A, Cahen R, Ecochard R et al (2009) The impact of type 2 diabetes on mortality in end-stage renal disease patients differs between genders. Nephron Clin Pract 112:268–275. https://doi.org/10.1159/000224794 Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME (2019) Obesity, kidney dysfunction and hypertension: mechanistic links. Nat Rev Nephrol 15:367–385. https://doi.org/10.1038/s41581-019-0145-4 Saitoh M, Ogawa M, Kondo H, Suga K, Takahashi T, Itoh H et al (2019) Sarcopenic obesity and its association with frailty and protein-energy wasting in hemodialysis patients: preliminary data from a single center in Japan. Ren Replace Ther 5:46. https://doi.org/10.1186/s41100-019-0240-9 Khadra D, Itani L, Tannir H, Kreidieh D, El MD, El GM (2019) Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: a systematic review and meta-analysis. World J Diabetes 10:311–323. https://doi.org/10.4239/wjd.v10.i5.311 Wannamethee SG, Atkins JL (2015) Muscle loss and obesity: The health implications of sarcopenia and sarcopenic obesity. Proc Nutr Soc 74:405–412. https://doi.org/10.1017/S002966511500169X Malhotra R, Deger SM, Salat H, Bian A, Stewart TG, Booker C et al (2017) Sarcopenic obesity definitions by body composition and mortality in the hemodialysis patients. J Ren Nutr 27:84–90. https://doi.org/10.1053/j.jrn.2016.09.010 Isoyama N, Qureshi AR, Avesani CM, Lindholm B, Bárány P, Heimbürger O et al (2014) Comparative associations of muscle mass and muscle strength with mortality in dialysis patients. Clin J Am Soc Nephrol 9:1720–1728. https://doi.org/10.2215/CJN.10261013 Souweine J-S, Pasquier G, Kuster N, Rodriguez A, Patrier L, Morena M et al (2020) Dynapenia and sarcopenia in chronic haemodialysis patients: do muscle weakness and atrophy similarly influence poor outcome? Nephrol Dial Transplant. https://doi.org/10.1093/ndt/gfaa353 Cuthbertson DJ, Bell JA, Ng SY, Kemp GJ, Kivimaki M, Hamer M (2016) Dynapenic obesity and the risk of incident type 2 diabetes: the English Longitudinal Study of Ageing. Diabet Med 33:1052–1059. https://doi.org/10.1111/dme.12991 Corrêa LH, Rosa ST, Dutra MT, Sales MM, Noll M, Deus LA et al (2021) Association between dynapenic abdominal obesity and inflammatory profile in diabetic older community-dwelling patients with end-stage renal disease. Exp Gerontol. https://doi.org/10.1016/j.exger.2021.111243 Zelle DM, Klaassen G, Van Adrichem E, Bakker SJL, Corpeleijn E, Navis G (2017) Physical inactivity: a risk factor and target for intervention in renal care. Nat Rev Nephrol 13:152–168. https://doi.org/10.1038/nrneph.2016.187 Rosa CSC, Nishimoto DY, Júnior IFF, Ciolac EG, Monteiro HL (2017) Factors associated with levels of physical activity in chronic kidney disease patients undergoing hemodialysis: the role of dialysis versus non-dialysis day. J Phys Act Heal 14:1–17. https://doi.org/10.1123/jpah.2016-0715 Santos CP, Silva LF, Lopes MB, Martins MTS, Kraychete AC, Silva FA et al (2017) Associations of physical activity energy expenditure with nutritional-inflammatory markers in hemodialysis patients. Int J Artif Organs 40:670–675. https://doi.org/10.5301/ijao.5000632 Turoń-Skrzypińska A, Dutkiewicz G, Marchelek-Myśliwiec M, Rył A, Dziedziejko V, Safranow K et al (2020) Physical activity versus sclerostin and interleukin 6 concentration in patients receiving renal replacement therapy by hemodialysis. Risk Manag Healthc Policy 13:1467–1475. https://doi.org/10.2147/RMHP.S255780 Lee DR, Kawas CH, Gibbs L, Corrada MM (2016) Prevalence of frailty and factors associated with frailty in individuals aged 90 and older: the 90+ study. J Am Geriatr Soc 64:2257–2262. https://doi.org/10.1111/jgs.14317 Janssen I, Heymsfield SB, Baumgartner RN, Ross R (2000) Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol 89:465–471. https://doi.org/10.3945/ajcn.115.119925 Schlüssel MM, dos Anjos LA, de Vasconcellos MTL, Kac G (2008) Reference values of handgrip dynamometry of healthy adults: a population-based study. Clin Nutr 27:601–607. https://doi.org/10.1016/j.clnu.2008.04.004 Dufour AB, Hannan MT, Murabito JM, Kiel DP, McLean RR (2013) Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: the Framingham study. J Gerontol Ser A Biol Sci Med Sci 68:168–174. https://doi.org/10.1093/gerona/gls109 Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48:16–31. https://doi.org/10.1093/ageing/afy169 Suetta C, Maier AB (2019) Is muscle failure a better term than sarcopenia? J Cachexia Sarcopenia Muscle 10:1146–1147. https://doi.org/10.1002/jcsm.12447 Florindo AA, Latorre MRDO (2003) Validation and reliability of the Baecke questionnaire for the evaluation of habitual physical activity in adult men. Rev Bras Med Do Esporte 9:129–135. https://doi.org/10.1590/S1517-86922003000300002 Honda H, Qureshi AR, Axelsson J, Heimburger O, Suliman ME, Barany P et al (2007) Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr 86:633–638. https://doi.org/10.1093/ajcn/86.3.633 dos Santos VR, Araujo MYC, Cardoso MR, Batista VC, Christofaro DGD, Gobbo LA (2017) Association of insufficient physical activity with sarcopenia and sarcopenic obesity in individuals aged 50 years or more. Rev Nutr 30:175–184. https://doi.org/10.1590/1678-98652017000200003 Tabibi H, Ashabi A, Najafi I, Hedayati M (2018) Prevalence of dynapenic obesity and sarcopenic obesity and their associations with cardiovascular disease risk factors in peritoneal dialysis patients. Kidney Res Clin Pract 37:404–413. https://doi.org/10.23876/j.krcp.18.0064 Kooman JP, Kotanko P, Schols AMWJ, Shiels PG, Stenvinkel P (2014) Chronic kidney disease and premature ageing. Nat Rev Nephrol 10:732–742. https://doi.org/10.1038/nrneph.2014.185 Mogi M, Kohara K, Nakaoka H, Kan-no H, Tsukuda K, Wang X et al (2016) Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation. J Cachexia Sarcopenia Muscle 7:213–224. https://doi.org/10.1002/jcsm.12044 Deger SM, Ellis CD, Bian A, Shintani A, Ikizler TA, Hung AM (2014) Obesity, diabetes and survival in maintenance hemodialysis patients. Ren Fail 36:546–551. https://doi.org/10.3109/0886022X.2013.876351 Garneau L, Aguer C (2019) Role of myokines in the development of skeletal muscle insulin resistance and related metabolic defects in type 2 diabetes. Diabetes Metab 45:505–516. https://doi.org/10.1016/j.diabet.2019.02.006 Cheema B, Abas H, Smith B, O’Sullivan AJ, Chan M, Patwardhan A et al (2010) Investigation of skeletal muscle quantity and quality in end-stage renal disease: original article. Nephrology 15:454–463. https://doi.org/10.1111/j.1440-1797.2009.01261.x Rosa CSC, Bueno DR, Souza GD, Gobbo LA, Freitas IF, Sakkas GK et al (2015) Factors associated with leisure-time physical activity among patients undergoing hemodialysis. BMC Nephrol 16:192. https://doi.org/10.1186/s12882-015-0183-5 de Souza VA, de Oliveira D, Mansur HN, Fernandes NMS, Bastos MG (2015) Sarcopenia in chronic kidney disease. J Bras Nefrol 37:98–105. https://doi.org/10.5935/0101-2800.20150014 Watanabe H, Enoki Y, Maruyama T (2019) Sarcopenia in chronic kidney disease: factors, mechanisms, and therapeutic interventions. Biol Pharm Bull 42:1437–1445. https://doi.org/10.1248/bpb.b19-00513 Lopes LCC, Gonzalez MC, Avesani CM, Prado CM, Peixoto MRG, Mota JF (2021) Low handgrip strength is associated with worse functional capacity and inflammation in maintenance hemodialysis patients. Nutrition. https://doi.org/10.1016/j.nut.2021.111469 Coelho-Junior HJ, Picca A, Calvani R, Uchida MC, Marzetti E (2019) If my muscle could talk: myokines as a biomarker of frailty. Exp Gerontol 127:110715. https://doi.org/10.1016/j.exger.2019.110715 Lee JH, Jun H-S (2019) Role of myokines in regulating skeletal muscle mass and function. Front Physiol 10:1–9. https://doi.org/10.3389/fphys.2019.00042 Bouchard DR, Janssen I (2010) Dynapenic-obesity and physical function in older adults. J Gerontol Ser A Biol Sci Med Sci 65:71–77. https://doi.org/10.1093/gerona/glp159 Kirk B, Feehan J, Lombardi G, Duque G (2020) Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines. Curr Osteoporos Rep 18:388–400. https://doi.org/10.1007/s11914-020-00599-y Marcus RL, Addison O, Kidde JP, Dibble LE, Lastayo PC (2010) Skeletal muscle fat infiltration: impact of age, inactivity, and exercise. J Nutr Health Aging 14:362–366. https://doi.org/10.1007/s12603-009-0230-7 Wilkinson TJ, Gould DW, Nixon DGD, Watson EL, Smith AC (2019) Quality over quantity? Association of skeletal muscle myosteatosis and myofibrosis on physical function in chronic kidney disease. Nephrol Dial Transplant 34:1344–1353. https://doi.org/10.1093/ndt/gfy139 Andrade FP, Ribeiro HS, Eidit Rovedder PM (2020) Comments on “Supervised Exercise Intervention and Overall Activity in CKD” by Pike et al. Kidney Int Rep 5:2404–2405. https://doi.org/10.1016/j.ekir.2020.09.026