Obesity as a risk factor for developing functional limitation among older adults: A conditional inference tree analysis

Obesity - Tập 25 Số 7 - Trang 1263-1269 - 2017
Feon W. Cheng1, Xiang Gao1, Le Bao2, Diane C. Mitchell1, Craig Wood3, Martin J. Sliwinski4, Helen Smiciklas‐Wright1, Christopher D. Still4, David D.K. Rolston5, Gordon L. Jensen6
1Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
2Department of Statistics, Pennsylvania State University, University Park, Pennsylvania, USA
3Obesity Institute, Geisinger Health System, Danville, Pennsylvania, USA
4Department of Human Development and Family Studies Pennsylvania State University University Park Pennsylvania USA
5Department of Internal Medicine Geisinger Health System Danville Pennsylvania USA
6University of Vermont College of Medicine, Burlington, Vermont, USA

Tóm tắt

ObjectiveTo examine the risk factors of developing functional decline and make probabilistic predictions by using a tree‐based method that allows higher order polynomials and interactions of the risk factors.MethodsThe conditional inference tree analysis, a data mining approach, was used to construct a risk stratification algorithm for developing functional limitation based on BMI and other potential risk factors for disability in 1,951 older adults without functional limitations at baseline (baseline age 73.1 ± 4.2 y). We also analyzed the data with multivariate stepwise logistic regression and compared the two approaches (e.g., cross‐validation). Over a mean of 9.2 ± 1.7 years of follow‐up, 221 individuals developed functional limitation.ResultsHigher BMI, age, and comorbidity were consistently identified as significant risk factors for functional decline using both methods. Based on these factors, individuals were stratified into four risk groups via the conditional inference tree analysis. Compared to the low‐risk group, all other groups had a significantly higher risk of developing functional limitation. The odds ratio comparing two extreme categories was 9.09 (95% confidence interval: 4.68, 17.6).ConclusionsHigher BMI, age, and comorbid disease were consistently identified as significant risk factors for functional decline among older individuals across all approaches and analyses.

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Obesity

Tập 25 Số 7

1263-1269

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