Obesity and inflammation: the effects of weight loss

Nutrition Research Reviews - Tập 21 Số 2 - Trang 117-133 - 2008
L. Kirsty Pourshahidi1, Julie Wallace1, M. Barbara E. Livingstone1
1Northern Ireland Centre for Food and Health, Centre for Molecular Biosciences, University of Ulster, ColeraineBT52 1SA, UK

Tóm tắt

Following the discovery of TNF-α and leptin as secretory products of adipocytes in the early 1990s, subsequent obesity research focused on the new functional role of adipose tissue, as an active endocrine organ. Many more inflammatory peptides have been linked to adiposity, which ultimately characterised obesity as a state of low-grade systemic inflammation, or ‘metaflammation’ which may link obesity to its co-morbidities. The aim of the present review is to examine the effects of weight loss on inflammation in overweight and obese, but otherwise healthy, populations. Studies were broadly classified into four types (diet, physical activity, diet and physical activity combined, and surgical interventions) and discussed according to the method used to induce weight loss. All studies measured at least one obesity-related inflammatory marker (ORIM). The overall finding from the present review is that weight loss does improve inflammation in terms of both the inflammatory (C-reactive protein, TNF-α, IL-6 and leptin) and anti-inflammatory (adiponectin) ORIM. Within this, the greatest improvements in ORIM are observed in studies achieving a weight loss of at least 10 %. However, a number of methodological issues have been identified as potential limitations within the literature including the sex and age of subjects, sample size, study duration and the assessment of body composition. In conclusion, although a period of weight lossper seis capable of reversing the unfavourable inflammatory profile evident in the obese state, further studies are required to determine the time needed, in which a reduced weight is maintained, in order to benefit from improved inflammatory status long term.

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Tài liệu tham khảo

10.1038/sj.ijo.0801970

10.1038/sj.ijo.0802983

10.1038/372425a0

10.1161/hc0702.104279

10.1210/jc.2002-021309

10.1038/nature06902

10.1210/jc.2006-0960

10.2337/diabetes.54.8.2277

Ronti, 2006, The endocrine function of adipose tissue: an update, Clin Endocrinol (Oxf), 64, 355, 10.1111/j.1365-2265.2006.02474.x

10.1007/s00125-004-1618-x

10.1210/en.2003-1336

10.1016/S0261-5614(03)00092-X

10.1161/01.ATV.21.6.961

10.1038/sj.ijo.0801792

10.1038/sj.ijo.0802240

10.1007/s11883-003-0032-z

10.1016/j.diabres.2004.07.023

10.1530/eje.0.1450273

10.1210/en.2003-0285

10.1161/01.ATV.21.6.968

10.1038/sj.ijo.0803740

10.1038/oby.2006.40

10.1038/oby.2008.38

10.1079/PNS2004406

10.1001/jama.280.21.1843

10.1001/jama.289.14.1799

10.1152/ajpendo.00150.2002

10.1079/PNS2005428

10.1291/hypres.25.881

10.2337/diabetes.53.4.939

10.1016/j.jaci.2005.02.023

10.1016/S1043-2760(00)00301-5

10.1074/jbc.270.45.26746

10.1007/BF03345154

10.1161/01.ATV.0000140060.13203.22

10.1016/j.bjps.2003.12.010

10.1038/nature05485

10.1530/EJE-07-0721

10.1056/NEJM199602013340503

10.1056/NEJMoa033179

10.1096/fj.04-2204com

10.1093/ajcn/86.5.1293

10.1017/S0007114507815789

10.1093/ajcn/52.6.953

Moreno-Aliaga, 2005, Adiposity and proinflammatory state: the chicken or the egg, Adipocytes, 1, 1

Ballor, 1994, Exercise-training enhances fat-free mass preservation during diet-induced weight loss: a meta-analytical finding, Int J Obes Relat Metab Disord, 18, 35

10.1161/hc0502.103331

10.1038/sj.ijo.0802037

10.2337/diab.34.10.1055

10.14310/horm.2002.11190

10.1001/jama.288.8.980

Bassuk, 2004, High-sensitivity C-reactive protein: clinical importance, Curr Probl Cardiol, 29, 439

10.1161/01.CIR.0000080289.72166.CF

10.1172/JCI200319246

10.1373/clinchem.2007.100156

10.1093/ajcn/81.6.1298

10.1172/JCI200319451

10.2337/diacare.27.7.1699

10.1210/jc.2004-0672

10.1530/EJE-07-0797

10.1038/oby.2004.118

10.1001/jama.291.24.2978

10.1172/JCI25102

10.2337/diabetes.53.8.1966

10.1007/s11695-007-9202-3

10.1038/447525a

10.1038/oby.2004.61

10.1038/sj.ijo.0800770

10.1093/ajcn/83.2.461S

2000, Obesity: Preventing and Managing the Global Epidemic, no. 894

Craig, 2008, Health Survey for England 2006 Latest Trends

4 McPherson K , Marsh T & Brown M (2007) Modelling future trends in obesity and the impact on health. http://www.foresight.gov.uk.

10.1161/01.CIR.100.7.713

10.1161/01.ATV.19.4.972

10.1079/BJN20041213

10.1079/BJN20041262

10.1016/S0899-9007(01)00672-4

10.1126/science.7678183

10.2337/diabetes.52.8.2097

10.1381/096089204323093345

10.1093/oxfordjournals.aje.a113727

10.1093/oxfordjournals.aje.a117385

10.1001/archinte.162.18.2074

10.1038/sj.ijo.0802309

10.1093/ije/dyi253

10.1016/S0083-6729(06)74018-3

10.1079/PNS2004403

10.1016/j.coph.2004.03.003

10.1111/j.1753-4887.2005.tb00107.x

10.1007/s11883-006-0023-y

10.1001/archinte.167.1.31

10.1210/jc.2003-031310

10.1093/ajcn/83.4.774

10.1017/S0007114507747815

10.1001/jama.288.16.2008

10.1161/01.CIR.0000041046.32962.86

10.1530/eje.0.1480535

Bastard, 2000, Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss, J Clin Endocrinol Metab, 85, 3338

10.1210/jc.2004-1011

10.1186/1743-7075-3-19

10.1001/jama.292.20.2482

10.1038/sj.ijo.0803534

10.1038/sj.ijo.0801373

10.1161/01.ATV.0000140199.14930.32

10.1038/oby.2008.37

10.1016/j.metabol.2005.09.010

10.1038/sj.ijo.0803348

10.1161/01.ATV.0000109749.11042.7c

10.1038/sj.ijo.0802942

10.1210/jc.2003-032059

10.1016/j.metabol.2007.12.001

10.1038/sj.ijo.0801398

10.1016/j.numecd.2006.09.009

10.1016/S0300-595X(76)80023-0

10.1210/jc.2005-2248

10.1210/jcem.86.8.7741

10.1038/sj.ijo.0802897

Webster, 1984, The composition of excess weight in obese women estimated by body density, total body water and total body potassium, Hum Nutr Clin Nutr, 38, 299

10.1038/oby.2004.36

10.1161/01.ATV.0000073313.16135.21

10.1038/oby.2003.131

10.1007/s11695-007-9305-x

10.1210/jc.2003-032125

10.1007/s11695-007-9265-1

10.1136/bmj.311.6998.158

10.1136/bmj.311.7017.1401

1998, Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults – The Evidence Report. National Institutes of Health, Obes Res, 6, 51S

10.1038/sj.ijo.0803761

10.1016/j.atherosclerosis.2005.04.011

10.1093/ajcn/87.6.1959

10.1016/S0899-9007(03)00061-3

Dandona, 1998, Tumor necrosis factor-α in sera of obese patients: fall with weight loss, J Clin Endocrinol Metab, 83, 2907

10.1017/S0029665108009300

10.2337/diacare.27.1.47

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Nutrition Research Reviews

Tập 21 Số 2

117-133

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