Obesity and diabetes: the link between adipose tissue dysfunction and glucose homeostasis

Nutrition Research Reviews - Tập 28 Số 2 - Trang 121-132 - 2015
Monise Viana Abranches1, F. C. E. de Oliveira2, Lisiane Lopes da Conceição3, Maria do Carmo Gouveia Pelúzio3
1Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa Campus de Rio Paranaíba, Rodovia MG-230 – Km 7, Rio Paranaíba, MG, 38810-000, Brazil
2Departamento de Enfermagem, Faculdade de Ciências Sociais Aplicadas de Sinop, Sinop, MT, 78550-000, Brazil
3Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Campus Universitário, Edifício Centro de Ciências Biológicas II, s/n, Viçosa, MG, 36571-900, Brazil

Tóm tắt

AbstractObesity and type 2 diabetes mellitus (T2DM) epidemics, which have already spread, imply the possibility of both conditions being closely related. Thus, the goal of the present review was to draw a parallel between obesity, adipose tissue (AT) changes, and T2DM development. To this end, a search was conducted in PubMed, MEDLINE and SciELO databases, using the following key words and their combinations: obesity; diabetes; insulin resistance; diet; weight loss; adipocin; inflammation markers; and interleukins. Based on a literature review, AT dysfunction observed in obesity is characterised by adipocyte hypertrophy, macrophage infiltration, impaired insulin signalling and insulin resistance. In addition, there is release of inflammatory adipokines and an excessive amount of NEFA promoting ectopic fat deposition and lipotoxicity in muscle, liver and pancreas. Recent evidence supports the hypothesis that the conception of AT as a passive energy storage organ should be replaced by a dynamic endocrine organ, which regulates metabolism through a complex adipocyte communication with the surrounding microenvironment. The present review demonstrates how glucose homeostasis is changed by AT dysfunction. A better understanding of this relationship enables performing nutritional intervention strategies with the goal of preventing T2DM.

Từ khóa


Tài liệu tham khảo

10.1002/jcb.24852

10.1017/S095442241400002X

10.1152/ajpendo.2001.280.5.E745

10.1080/13813450903260864

Ramalho, 2008, Papel do TA e dos macrófagos no estado de inflamação crónica associada à obesidade – implicações clínicas (Role of adipose tissue and macrophages in the state of chronic inflammation associated with obesity – clinical implications), Acta Med Port, 21, 489

10.1590/S0004-27302008000600006

10.1172/JCI28510

10.1016/j.metabol.2007.06.005

10.1172/JCI26498

10.2337/db06-0911

10.2217/17460875.3.5.545

10.1016/S1097-2765(00)80210-5

10.1586/17446651.3.1.9

10.1210/endo.142.3.8037

10.1038/nrd4275

10.1016/j.yexcr.2005.04.029

10.1146/annurev-immunol-031210-101322

Sotorník, 2010, Adipose tissue blood flow and metabolic syndrome, Cas Lek Cesk, 149, 155

10.1210/jc.2006-1268

10.1007/s00125-009-1605-3

10.1146/annurev-physiol-021909-135846

10.12965/jer.140104

10.1007/s00125-007-0713-1

10.1152/ajpendo.00435.2007

10.1126/science.1156232

10.1096/fj.01-0147com

10.1590/S1517-86922009000600012

10.1111/j.1742-4658.2009.07303.x

10.1016/j.cell.2013.12.012

10.1016/S0014-2999(02)01431-0

Zulet, 2007, Biomarcadores del estado de inflamatorio: nexo de unión con la obesidad y complicaciones asociadas (Biomarkers of the inflammatory state: link with obesity and associated complications), Nutr Hosp, 22, 511

10.2337/db08-0457

10.1096/fj.09-133058

Potts, 1995, Impaired postprandial clearance of triacylglycerol-rich lipoproteins in adipose tissue in obese subjects, Am J Physiol, 268, E588

10.1183/09059180.00000109

10.1016/j.beem.2005.07.003

10.1017/S0007114508971282

10.1002/jcp.24680

10.1530/EJE-07-0206

10.1172/JCI111133

10.1038/oby.2009.370

10.1016/S0026-0495(00)80010-4

10.1016/j.physbeh.2007.10.010

10.1007/s00441-004-1012-5

White, 1992, Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue, J Biol Chem, 267, 9210, 10.1016/S0021-9258(19)50409-4

10.1017/S0954422408138732

10.1073/pnas.1003512107

10.1186/gb-2010-11-8-r80

10.1590/S0021-75572007000700011

10.1182/blood-2003-09-3070

10.1186/2045-3701-4-29

10.1016/j.cmet.2006.11.009

10.1177/153537020322801003

10.1111/j.1467-789X.2007.00316.x

10.1016/S0026-0495(96)90267-X

Zhou, 1995, Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans, J Clin Endocrinol Metab, 80, 1584

10.2337/diabetes.50.2.315

Tabidi I (2009) The effect of glucose on cardiac AMP-activated protein kinase. PhD Thesis, University College London.

10.2337/dc10-0284

10.1093/ajcn/87.2.295

10.1053/j.gastro.2007.04.068

10.1152/ajpendo.1996.271.5.E834

Costa, 2006, Tecido adiposo e adipocinas (Adipose tissue and adipokines), Acta Med Port, 19, 251

10.1210/jc.2008-2090

10.1152/ajpendo.00330.2010

10.1210/jc.2009-0517

10.1038/ijo.2010.216

10.1371/journal.pone.0009997

10.1128/MCB.00192-09

Chen, 2010, Chronic intermittent hypoxia from pedo-stage decreases glucose transporter 4 expression in adipose tissue and causes insulin resistance, Chin Med J, 123, 463

Chopra, 2014, Mechanism of leptin action, resistance and regulation of energy balance: a review, Asian J Multidiscip Stud, 2, 224

10.1038/ijo.2008.229

10.1146/annurev.pathol.2.010506.091859

10.3325/cmj.2014.55.228

10.1038/nm0106-41

10.1371/journal.pone.0099382

10.1172/JCI24335

10.1097/CRD.0000000000000004

10.1152/ajpendo.00506.2005

10.1172/JCI105705

Thông tin
Thông tin xuất bản

Nutrition Research Reviews

Tập 28 Số 2

121-132

Thông tin tác giả