Obesity, adipocytokines, and insulin resistance in breast cancer

Obesity Reviews - Tập 5 Số 3 - Trang 153-165 - 2004
David P. Rose1, Despina Komninou1, Gina Day Stephenson1
1Institute for Cancer Prevention, Valhalla, NY, USA

Tóm tắt

SummaryThe adipocytokines are biologically active polypeptides that are produced either exclusively or substantially by the adipocytes, and act by endocrine, paracrine, and autocrine mechanisms. Most have been associated with obesity, hyperinsulinaemia, type 2 diabetes, and chronic vascular disease; in addition, six adipocytokines – vascular endothelial growth factor, hepatocyte growth factor, leptin, tumour necrosis factor‐alpha, heparin‐binding epidermal growth factor‐like growth factor, and interleukin‐6 – promote angiogenesis while one, adiponectin, is inhibitory. Obesity and insulin resistance have both been identified as risk factors for breast cancer and are associated with late‐stage disease and poor prognosis. Angiogenesis is essential for breast cancer development and progression, and so it is plausible that obesity‐related increases in adipocytokine production and a reduction in adiponectin may adversely affect breast cancer outcome by their angiogenesis‐related activities. There is also experimental evidence that some adipocytokines can act directly on breast cancer cells to stimulate their proliferation and invasive capacity. Thus, adipocytokines may provide a biological mechanism by which obesity and insulin resistance are causally associated with breast cancer risk and poor prognosis. Both experimental and clinical studies are needed to develop this concept, and particularly in oestrogen‐independent breast cancers where preventive and therapeutic options are limited.

Từ khóa


Tài liệu tham khảo

10.1056/NEJMoa021423

10.3181/00379727-216-44153B

10.1207/S15327914NC4501_1

10.1046/j.1467-789X.2003.00108.x

10.1093/ije/26.3.484

10.1200/JCO.2002.20.4.1128

10.1093/jnci/94.8.606

10.1016/S1521-690X(03)00044-7

10.1016/S1040-8428(03)00157-4

10.1146/annurev.pu.14.050193.000245

10.1016/0960-0760(94)90274-7

Mauri FA, 1999, Prognostic value of estrogen receptor status can be improved by combined evaluation of p53, Bcl 2 and PgR expression: an immunohistochemical study on breast carcinoma with long‐term follow‐up, Int J Oncol, 15, 1137

10.1007/BF01807157

10.1023/A:1011977118921

10.1002/1097-0142(20010815)92:4<720::AID-CNCR1375>3.0.CO;2-T

10.1200/JCO.2002.20.1.42

10.1111/j.1749-6632.1999.tb07793.x

10.1093/jnci/82.1.4

10.1016/S0303-7207(00)00387-7

10.1007/BF02967545

10.1006/bbrc.1999.0255

10.1126/science.7624777

MacDougaldOA HwangCS FanH LaneMD.Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3‐L1 adipocytes.Proc Natl Acad Sci USA 1995:9034–9037.

10.1038/sj.cr.7290038

10.1126/science.281.5383.1683

10.1161/01.RES.83.10.1059

10.1074/jbc.M301695200

Smith‐Kerwin SM, 1998, Leptin expression in human mammary epithelial cells and breast milk, J Clin Endocrinol Metab, 83, 1810, 10.1210/jcem.83.5.4952

Rose DP, 2002, Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review), Int J Oncol, 21, 1285

10.1007/BF02592977

Rozen F, 1998, Antiproliferative action of tumor necrosis factor‐α on MCF‐7 breast cancer cells is associated with increased insulin‐like growth factor binding protein‐3 accumulation, Int J Oncol, 13, 865

10.1038/sj.cdd.4401228

10.1016/S0039-128X(02)00046-6

Fajardo LF, 1992, Dual role of tumor necrosis factor‐α in angiogenesis, Am J Pathol, 140, 539

10.1172/JCI200319246

10.1152/ajpendo.2001.280.5.E745

10.1016/S0304-419X(97)00024-3

10.1016/S0014-5793(98)00283-X

10.1002/1097-4652(200002)186:2<233::AID-JCP1017>3.0.CO;2-L

10.1006/bbrc.2002.6720

10.1074/jbc.271.2.603

Hausman GJ, 2004, Adipose  tissue  angiogenesis, J Anim, 82, 925

Rosen EM, 1993, Scatter factor (hepatocyte growth factor) is a potent angiogenesis factor in vivo, Symp Soc Exp Biol, 47, 227

10.1016/S0735-1097(03)00231-6

10.1074/jbc.270.45.26746

10.1074/jbc.C200251200

10.1073/pnas.0308671100

10.2337/diab.45.7.984

10.1056/NEJM199602013340503

10.1038/sj.ijo.0800792

10.1053/meta.2000.9519

10.1038/oby.2002.68

10.1210/jc.85.9.3338

10.1007/s00125-003-1221-6

10.1210/jcem.86.8.7741

10.1530/eje.0.1470173

10.1161/01.ATV.20.6.1595

10.1093/aje/kwg236

10.1016/0021-9150(89)90029-4

10.2337/diacare.19.4.333

10.1038/oby.2002.126

10.1016/0026-0495(95)90084-5

10.1038/sj.ijo.0800917

10.1210/jc.83.4.1306

10.1055/s-2002-38256

Okosun IS, 1999, The relation of central adiposity to components of the insulin resistance syndrome in a biracial US population sample, Ethn Dis, 9, 218

10.1016/S1047-2797(00)00045-4

10.1007/BF03339999

10.1016/S0026-0495(99)90277-9

10.1038/sj.ijo.0801220

10.1038/sj.ijo.0801480

10.2337/diabetes.51.4.1005

10.1038/oby.2003.48

10.1677/joe.0.1630055

Bertin E, 2000, Plasma levels of tumor necrosis factor‐α (TNF‐α) are essentially dependent on visceral fat amount in type 2 diabetic patients, Diabetes Metab, 26, 178

10.1007/s005920200027

10.1055/s-2003-39054

10.1161/01.ATV.18.6.928

10.1172/JCI117936

10.1038/sj.ijo.0802187

10.1006/bbrc.2001.6307

10.2337/diabetes.51.6.1884

10.1093/aje/kwf050

10.2337/diacare.26.6.1752

10.1023/B:CACO.0000024225.14618.a8

10.1002/ijc.2910520402

Yang G, 2001, Population‐based, case–control study of blood C‐peptide level and breast cancer, Cancer Epidemiol Biomarkers Prev, 10, 1207

10.1002/ijc.11624

10.1002/cncr.20023

10.1089/jwh.1.1999.8.1265

10.1002/ijc.11193

10.1007/978-1-4615-2926-2_1

Godden J, 1992, The response of breast cancer cells to steroid and peptide growth factors, Anticancer Res, 12, 1683

10.1074/jbc.M104416200

Sepp‐Lorenzino L, 1994, Insulin and insulin‐like growth factor signaling are defective in the MDA‐MB‐468 human breast cancer cell line, Cell Growth Differ, 5, 1077

Tessitore L, 2000, Leptin expression in colorectal and breast cancer patients, Int J Mol Med, 5, 421

10.1023/A:1008903727238

Miyoshi Y, 2003, Association of serum adiponectin levels with breast cancer risk, Clin Cancer Res, 9, 5699

10.1210/jc.2003-031804

10.1093/jnci/94.22.1704

10.1016/S0303-7207(01)00678-5

10.1016/S0006-291X(02)00205-X

10.1074/jbc.M313191200

Tuck AB, 1996, Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma, Am J Pathol, 148, 225

10.1002/(SICI)1097-0142(19970215)79:4<749::AID-CNCR12>3.0.CO;2-#

Parr C, 2001, Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c‐Met receptor in human cancer cells, Int J Oncol, 19, 857

10.1089/dna.1994.13.1189

10.1074/jbc.271.11.6071

Vuk‐Pavlovic S, 1989, Recycling of tumor necrosis factor‐α receptor in MCF‐7 cells, FASEB J, 3, 2633, 10.1096/fasebj.3.14.2556313

Chiu JJ, 1996, Interleukin 6 acts as a paracrine growth factor in human mammary carcinoma cell lines, Clin Cancer Res, 2, 215

10.1002/ijc.11202

10.1182/blood.V96.5.1723

10.1091/mbc.01-10-0477

10.1093/carcin/22.7.1035

Fujiuchi Y, 2003, Effect of hepatocyte growth factor on invasion of prostate cancer cell lines, Oncol Rep, 10, 1001

10.1046/j.1525-1438.2003.13033.x

Lamszus K, 1997, Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice, Laboratory Invest, 76, 339

10.1210/jc.84.11.4092

Bischof P, 2001, Endocrine, paracrine and autocrine regulation of trophoblastic metalloproteinases, Early Pregnancy, 5, 30

10.1016/S0140-6736(02)11283-9

10.1093/molehr/6.10.951

10.1093/molehr/5.11.1055

10.1210/endo.141.10.7697

10.1038/bjc.1998.373

10.1007/BF02967464

10.1002/ijc.10833

Heffelfinger SC, 1996, Vascularity of proliferative breast disease and carcinoma in situ correlates with histological features, Clin Cancer Res, 2, 1873

Engels K, 1997, Angiogenesis as a biologic and prognostic indicator in human breast carcinoma, EXS, 79, 113

10.1038/emm.2001.17

10.1161/01.ATV.0000048701.86621.D0

10.1006/bbrc.1999.1589

10.1038/sj.ijo.0801947

10.1074/jbc.270.21.12607

10.1177/002215540205000204

10.1152/ajpcell.00064.2002

10.1073/pnas.84.15.5277

10.1161/01.ATV.19.8.1835

10.1002/path.1430

Magoffin DA, 1999, Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women, Ginekol Pol, 70, 1

Simpson ER, 1997, Aromatase expression in health and disease, Rec Prog Horm Res, 52, 185

10.3109/10739689709146786