OVARIAN CANCER GENE THERAPY

Arteaga, 1996, Tissue-targeted antisense anti-fos retroviral vector inhibits established breast cancer in nude mice xenografts, Cancer Res, 56, 1098 Ayesh, 1995, Purification and characterization of a C5a-inactivating enzyme from human peritoneal fluid, Blood, 85, 3503, 10.1182/blood.V85.12.3503.bloodjournal85123503 Chapman, 1996, Transcriptional activation by BRCA1 [letter], Nature, 382, 678, 10.1038/382678a0 Chen, 1995, Aberrant subcellular localization of BRCA1 in breast cancer, Science, 270, 789, 10.1126/science.270.5237.789 Friedman, 1994, Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families, Nat Genet, 8, 399, 10.1038/ng1294-399 Futreal, 1994, BRCA1 mutations in primary breast and ovarian carcinomas, Science, 266, 120, 10.1126/science.7939630 Gayther, 1995, Germline mutations of the BRCA1 gene in breast/ovarian cancer families: Evidence for a genotype/phenotype correlation, Nat Genet, 11, 428, 10.1038/ng1295-428 Hakem, 1996, The tumor suppressor gene Brca1 is required for embryonic proliferation in the mouse, Cell, 85, 1009, 10.1016/S0092-8674(00)81302-1 Hall, 1990, Linkage of early-onset breast cancer to chromosome 17q21, Science, 250, 1684, 10.1126/science.2270482 Holt, 1996, Growth retardation and tumor inhibition by BRCA1, Nat Genet, 12, 298, 10.1038/ng0396-298 Hosking, 1995, A somatic BRCA1 mutation in an ovarian tumor, Nat Genet, 9, 343, 10.1038/ng0495-343 Jensen, 1996, BRCA1 is secreted and exhibits properties of a granin, Nat Genet, 12, 303, 10.1038/ng0396-303 Kinzler, 1997, Gatekeepers and caretakers, Nature, 386, 761, 10.1038/386761a0 Lane, 1995, Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice, Genes Dev, 9, 2712, 10.1101/gad.9.21.2712 Marquis, 1995, The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues, Nat Genet, 11, 17, 10.1038/ng0995-17 Merajver, 1995, Somatic mutations in the BRCA1 gene in sporadic ovarian tumors, Nat Genet, 9, 439, 10.1038/ng0495-439 Miki, 1994, A strong candidate gene for the breast and ovarian cancer susceptibility gene BRCA1, Science, 266, 66, 10.1126/science.7545954 Monteiro, 1996, Evidence for a transcriptional activation function of BRCA1 C-terminal region, Proc Natl Acad Sci USA, 93, 13595, 10.1073/pnas.93.24.13595 Pensiero, 1996, Development of amphotropic murine retrovirus vectors resistant to inactivation by human serum, Hum Gene Ther, 7, 1095, 10.1089/hum.1996.7.9-1095 Rao, 1996, Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts, Oncogene, 12, 523 Rollins, 1996, Retroviral vector producer cell killing in human serum by natural antibody and complement: Strategies for evading the humoral immune response, Hum Gene Ther, 7, 619, 10.1089/hum.1996.7.5-619 Roth, 1997, Gene therapy for cancer: What have we done and where are we going?, J Natl Cancer Inst, 89, 21, 10.1093/jnci/89.1.21 Roth, 1996, Retroviral mediated wildtype p53 gene transfer to tumors of patients with lung cancer, Nature Medicine, 2, 985, 10.1038/nm0996-985 Rother, 1995, Protection of retroviral vector particles in human blood through complement inhibition, Hum Gene Ther, 6, 429, 10.1089/hum.1995.6.4-429 Rother, 1995, A novel mechanism of retrovirus inactivation in human serum mediated by anti–alpha-galactosyl natural antibody, J Exp Med, 182, 1345, 10.1084/jem.182.5.1345 Scully, 1996, Location of BRCA1 in human breast and ovarian cancer cells [letter], Science, 272, 123, 10.1126/science.272.5258.123 Scully, 1997, Association of BRCA1 with Rad51 in mitotic and meiotic cells, Cell, 88, 265, 10.1016/S0092-8674(00)81847-4 Shao, 1996, Induction of apoptosis by the tumor suppressor protein BRCA1, Oncogene, 13, 1 Tait, 1997, A phase I trial of retroviral BRCA1sv gene therapy in ovarian cancer, Clin Cancer Res, 3, 1959 Takahashi, 1995, Mutation analysis of the BRCA1 gene in ovarian cancers, Cancer Res, 55, 2998 Thompson, 1995, Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression, Nat Genet, 9, 444, 10.1038/ng0495-444 Welsh, 1975, Human serum lysis RNA tumor viruses, Nature, 257, 612, 10.1038/257612a0 Wilson, 1996, BRCA1 protein products: Antibody specificity [letter], Nat Genet, 13, 264, 10.1038/ng0796-264 Wilson, 1997, Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta1 1b, Oncogene, 14, 1, 10.1038/sj.onc.1200924