OPCML: A Promising Biomarker and Therapeutic Avenue

Trends in Cancer - Tập 5 - Trang 463-466 - 2019
Isidora Simovic1, Natalia Castaño-Rodríguez1, Nadeem O. Kaakoush2
1School of Biotechnology and Biomolecular Sciences, UNSW Sydney, NSW 2052, Australia
2School of Medical Sciences, UNSW Sydney, NSW, 2052, Australia

Tài liệu tham khảo

Cui, 2008, OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation, PLoS One, 3, 10.1371/annotation/f394b95b-c731-41a3-b0dc-be25fb6a227c Xing, 2017, Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer, BMC Cancer, 17, 268, 10.1186/s12885-017-3203-y Roy, 1988, A monoclonal antibody that inhibits opioid binding to rat brain membranes, Biochem. Biophys. Res. Commun., 154, 688, 10.1016/0006-291X(88)90194-5 Yamada, 2007, Synaptic adhesion molecule OBCAM; synaptogenesis and dynamic internalization, Brain Res., 1165, 5, 10.1016/j.brainres.2007.04.062 Sugimoto, 2012, Overexpression of IgLON cell adhesion molecules changes proliferation and cell size of cortical astrocytes, Cell Biochem. Funct., 30, 400, 10.1002/cbf.2813 Sellar, 2003, OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer, Nat. Genet., 34, 337, 10.1038/ng1183 McKie, 2012, The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer, Cancer Discov., 2, 156, 10.1158/2159-8290.CD-11-0256 Zanini, 2017, The tumor-suppressor protein OPCML potentiates anti-EGFR- and anti-HER2-targeted therapy in HER2-positive ovarian and breast cancer, Mol. Cancer Ther., 16, 2246, 10.1158/1535-7163.MCT-17-0081 Antony, 2018, The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer, EMBO Rep., 19, 10.15252/embr.201745670 Zhou, 2014, Detection of circulating methylated opioid binding protein/cell adhesion molecule-like gene as a biomarker for ovarian carcinoma, Clin. Lab., 60, 759, 10.7754/Clin.Lab.2013.130446 Duarte-Pereira, 2011, Prognostic value of opioid binding protein/cell adhesion molecule-like promoter methylation in bladder carcinoma, Eur. J. Cancer, 47, 1106, 10.1016/j.ejca.2010.12.025 Zhou, 2014, Methylation of OPCML promoter in ovarian cancer tissues predicts poor patient survival, Clin. Chem. Lab. Med., 52, 735, 10.1515/cclm-2013-0736 Castano-Rodriguez, 2018, OPCML is hypermethylated in a subset of patients with metaplastic changes in their esophagus, Biomark. Res., 6, 35, 10.1186/s40364-018-0150-y Li, 2015, OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT via downregulation of smad signaling, Am. J. Cancer Res., 5, 1635 Margetts, 2008, Evaluation of a functional epigenetic approach to identify promoter region methylation in phaeochromocytoma and neuroblastoma, Endocr. Relat. Cancer, 15, 777, 10.1677/ERC-08-0072