Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice

Clifford MN (2000) Anthocyanins—nature, occurrence and dietary burden. J Sci Food Agric 80:1063–1072 Nyman NA, Kumpulainen JT (2001) Determination of anthocyanidins in berries and red wine by high-performance liquid chromatography. J Agric Food Chem 49:4183–4187 Ogawa K, Sakakibara H, Iwata R, Ishii T, Sato T, Goda T, Shimoi K, Kumazawa S (2008) Anthocyanin composition and antioxidant activity of the Crowberry (Empetrum nigrum) and other berries. J Agric Food Chem 56:4457–4462 Latti AK, Riihinen KR, Kainulainen PS (2008) Analysis of anthocyanin variation in wild populations of bilberry (Vaccinium myrtillus L.) in Finland. J Agric Food Chem 56:190–196 Galvano F, La Fauci L, Vitaglione P, Fogliano V, Vanella L, Felgines C (2007) Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann Ist Super Sanita 43:382–393 Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr (2007) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr 85:895–909 Xia X, Ling W, Ma J, Xia M, Hou M, Wang Q, Zhu H, Tang Z (2006) An anthocyanin-rich extract from black rice enhances atherosclerotic plaque stabilization in apolipoprotein E-deficient mice. J Nutr 136:2220–2225 Miyazaki K, Makino K, Iwadate E, Deguchi Y, Ishikawa F (2008) Anthocyanins from purple sweet potato ipomoea batatas cultivar ayamurasaki suppress the development of atherosclerotic lesions and both enhancements of oxidative stress and soluble vascular cell adhesion molecule-1 in apolipoprotein e-deficient mice. J Agric Food Chem 56:11485–11492 Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D (2007) Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51:675–683 Xia M, Hou M, Zhu H, Ma J, Tang Z, Wang Q, Li Y, Chi D, Yu X, Zhao T, Han P, Xia X, Ling W (2005) Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway. J Biol Chem 280:36792–36801 Hou DX, Yanagita T, Uto T, Masuzaki S, Fujii M (2005) Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Biochem Pharmacol 70:417–425 Kao ES, Tseng TH, Lee HJ, Chan KC, Wang CJ (2009) Anthocyanin extracted from Hibiscus attenuate oxidized LDL-mediated foam cell formation involving regulation of CD36 gene. Chem Biol Interact 179:212–218 Lazze MC, Pizzala R, Perucca P, Cazzalini O, Savio M, Forti L, Vannini V, Bianchi L (2006) Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. Mol Nutr Food Res 50:44–51 Chen J, Uto T, Tanigawa S, Kumamoto T, Fujii M, Hou DX (2008) Expression profiling of genes targeted by bilberry (Vaccinium myrtillus) in macrophages through DNA microarray. Nutr Cancer 60(Suppl 1):43–50 Lefevre M, Wiles JE, Zhang X, Howard LR, Gupta S, Smith AA, Ju ZY, DeLany JP (2008) Gene expression microarray analysis of the effects of grape anthocyanins in mice: a test of a hypothesis-generating paradigm. Metabolism 57:S52–S57 Ohashi R, Mu H, Wang X, Yao Q, Chen C (2005) Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Qjm 98:845–856 Choy PC, Siow YL, Mymin D, OK (2004) Lipids and atherosclerosis. Biochem Cell Biol 82:212–224 Talavera S, Felgines C, Texier O, Besson C, Mazur A, Lamaison JL, Remesy C (2006) Bioavailability of a bilberry anthocyanin extract and its impact on plasma antioxidant capacity in rats. J Sci Food Agric 86:90–97 Singleton VL, Rossi JA (1965) Colorimetry of total phenolics with phospomolybdic-phosphotungstic reagents. Am J Enol Vitic 16:144–158 Mazur A, Remesy C, Gueux E, Levrat MA, Demigne C (1990) Effects of diets rich in fermentable carbohydrates on plasma lipoprotein levels and on lipoprotein catabolism in rats. J Nutr 120:1037–1045 Huang D, Ou B, Hampsch-Woodill M, Flanagan JA, Prior RL (2002) High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem 50:4437–4444 Pandey R, Guru RK, Mount DW (2004) Pathway Miner: extracting gene association networks from molecular pathways for predicting the biological significance of gene expression microarray data. Bioinformatics 20:2156–2158 Auclair S, Milenkovic D, Besson C, Chauvet S, Gueux E, Morand C, Mazur A, Scalbert A (2008) Catechin reduces atherosclerotic lesion development in apo E-deficient mice: a transcriptomic study. Atherosclerosis Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408 Garcia-Alonso M, Minihane AM, Rimbach G, Rivas-Gonzalo JC, de Pascual-Teresa S (2009) Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma. J Nutr Biochem 20:521–529 Garcia-Alonso M, Rimbach G, Sasai M, Nakahara M, Matsugo S, Uchida Y, Rivas-Gonzalo JC, De Pascual-Teresa S (2005) Electron spin resonance spectroscopy studies on the free radical scavenging activity of wine anthocyanins and pyranoanthocyanins. Mol Nutr Food Res 49:1112–1119 Xia M, Ling WH, Ma J, Kitts DD, Zawistowski J (2003) Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice. J Nutr 133:744–751 Angelin B (1995) 1994 Mack-Forster award lecture. Review. Studies on the regulation of hepatic cholesterol metabolism in humans. Eur J Clin Invest 25:215–224 Shepherd J (2001) The role of exogenous pathway in hypercholesterolemia. Eur Heart J Suppl 3:E2–E5 Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis AJ, Davis RA (2002) Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6 J mice. Arterioscler Thromb Vasc Biol 22:121–126 Del Bas JM, Fernandez-Larrea J, Blay M, Ardevol A, Salvado MJ, Arola L, Blade C (2005) Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. Faseb J 19:479–481 Hofker MH, van Vlijmen BJ, Havekes LM (1998) Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis. Atherosclerosis 137:1–11 Meir KS, Leitersdorf E (2004) Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress. Arterioscler Thromb Vasc Biol 24:1006–1014 Jawien J, Nastalek P, Korbut R (2004) Mouse models of experimental atherosclerosis. J Physiol Pharmacol 55:503–517 Daniels TF, Killinger KM, Michal JJ, Wright RW Jr, Jiang Z (2009) Lipoproteins, cholesterol homeostasis and cardiac health. Int J Biol Sci 5:474–488 Zsigmond E, Fuke Y, Li L, Kobayashi K, Chan L (1998) Resistance of chylomicron and VLDL remnants to post-heparin lipolysis in ApoE-deficient mice: the role of apoE in lipoprotein lipase-mediated lipolysis in vivo and in vitro. J Lipid Res 39:1852–1861 Lambert G, Sakai N, Vaisman BL, Neufeld EB, Marteyn B, Chan CC, Paigen B, Lupia E, Thomas A, Striker LJ, Blanchette-Mackie J, Csako G, Brady JN, Costello R, Striker GE, Remaley AT, Brewer HB Jr, Santamarina-Fojo S (2001) Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice. J Biol Chem 276:15090–15098 Lambert G, Sinal CJ (2000) Nuclear receptors LXR and FXR control cholesterol and bile acid metabolism. Med Sci (Paris) 16:1456–1458 Hubbert ML, Zhang Y, Lee FY, Edwards PA (2007) Regulation of hepatic Insig-2 by the farnesoid X receptor. Mol Endocrinol 21:1359–1369 Modica S, Moschetta A (2006) Nuclear bile acid receptor FXR as pharmacological target: are we there yet? FEBS Lett 580:5492–5499 Matsumoto N, Okushio K, Hara Y (1998) Effect of black tea polyphenols on plasma lipids in cholesterol-fed rats. J Nutr Sci Vitaminol (Tokyo) 44:337–342 Jeon SM, Park YB, Choi MS (2004) Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. Clin Nutr 23:1025–1034 Gorinstein S, Leontowicz H, Leontowicz M, Drzewiecki J, Jastrzebski Z, Tapia MS, Katrich E, Trakhtenberg S (2005) Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets. Life Sci 77:2384–2397 Osada K, Suzuki T, Kawakami Y, Senda M, Kasai A, Sami M, Ohta Y, Kanda T, Ikeda M (2006) Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol. Lipids 41:133–139 Ferre N, Martinez-Clemente M, Lopez-Parra M, Gonzalez-Periz A, Horrillo R, Planaguma A, Camps J, Joven J, Tres A, Guardiola F, Bataller R, Arroyo V, Claria J (2009) Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol 296:G553–G562 Chait A, Han CY, Oram JF, Heinecke JW (2005) Thematic review series: the immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? J. Lipid Res 46:389–403 Kleemann R, Kooistra T (2005) HMG-CoA reductase inhibitors: effects on chronic subacute inflammation and onset of atherosclerosis induced by dietary cholesterol. Curr Drug Targets Cardiovasc Haematol Disord 5:441–453 Kleemann R, Verschuren L, van Erk MJ, Nikolsky Y, Cnubben NH, Verheij ER, Smilde AK, Hendriks HF, Zadelaar S, Smith GJ, Kaznacheev V, Nikolskaya T, Melnikov A, Hurt-Camejo E, van der Greef J, van Ommen B, Kooistra T (2007) Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol 8:R200 Titos E, Claria J, Planaguma A, Lopez-Parra M, Gonzalez-Periz A, Gaya J, Miquel R, Arroyo V, Rodes J (2005) Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells. J Leukoc Biol 78:871–878 Kmiec Z (2001) Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol 161:III–XIII (1–151) Friedrich EB, Tager AM, Liu E, Pettersson A, Owman C, Munn L, Luster AD, Gerszten RE (2003) Mechanisms of leukotriene B4-triggered monocyte adhesion. Arterioscler Thromb Vasc Biol 23:1761–1767 Bone-Larson CL, Simpson KJ, Colletti LM, Lukacs NW, Chen SC, Lira S, Kunkel SL, Hogaboam CM (2000) The role of chemokines in the immunopathology of the liver. Immunol Rev 177:8–20 Simpson KJ, Henderson NC, Bone-Larson CL, Lukacs NW, Hogaboam CM, Kunkel SL (2003) Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles. Clin Sci (Lond) 104:47–63 Ramadori G, Armbrust T (2001) Cytokines in the liver. Eur J Gastroenterol Hepatol 13:777–784 Lee WH, Kim SH, Lee Y, Lee BB, Kwon B, Song H, Kwon BS, Park JE (2001) Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Arterioscler Thromb Vasc Biol 21:2004–2010 Sampietro T, Bigazzi F, Rossi G, Dal Pino B, Puntoni MR, Sbrana F, Chella E, Bionda A (2005) Upregulation of the immune system in primary hypercholesterolemia: effect of atorvastatin therapy. J Intern Med 257:523–530 Wright MS, Sund NJ, Abrahamsen TG (2001) Modulation of C3 gene expression in HepG2 human hepatoma cells. Immunol Lett 76:119–123 Stapp JM, Sjoelund V, Lassiter HA, Feldhoff RC, Feldhoff PW (2005) Recombinant rat IL-1beta and IL-6 synergistically enhance C3 mRNA levels and complement component C3 secretion by H-35 rat hepatoma cells. Cytokine 30:78–85 Garcia-Alonso M, Rimbach G, Rivas-Gonzalo JC, De Pascual-Teresa S (2004) Antioxidant and cellular activities of anthocyanins and their corresponding vitisins A—studies in platelets, monocytes, and human endothelial cells. J Agric Food Chem 52:3378–3384