Nuovi farmaci a bersaglio molecolare nei tumori neuroendocrini gastroenteropancreatici

Biagio Cangiano1,2, Letizia Maria Fatti1, Luca Persani2,1, Giovanni Vitale1,2,3
1Divisione di Endocrinologia e Malattie Metaboliche, IRCCS Istituto Auxologico Italiano, Milano, Italia
2Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milano, Italia
3Laboratorio Sperimentale di Ricerche di Neuroendocrinologia Geriatrica ed Oncologica, Cusano Milanino, Italia

Tóm tắt

Từ khóa


Tài liệu tham khảo

Ito T, Lee L, Jensen RT (2016) Treatment of symptomatic neuroendocrine tumor syndromes: recent advances and controversies. Expert Opin Pharmacother 17(16):2191–2205

Öberg K, Lamberts SW (2016) Somatostatin analogues in acromegaly and gastroenteropancreatic neuroendocrine tumours: past, present and future. Endocr Relat Cancer 23(12):R551–566

Lee MS, O’Neil BH (2016) Summary of emerging personalized medicine in neuroendocrine tumors: are we on track? J Gastrointest Oncol 7(5):804–818

Broder MS, Beenhouwer D, Strosberg JR et al. (2015) Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR: a systematic literature review. World J Gastroenterol 21(6):1945

Veenstra MJ, van Koetsveld PM, Dogan F et al (2016) Epidrug-induced upregulation of functional somatostatin type 2 receptors in human pancreatic neuroendocrine tumor cells. Oncotarget. Available from http://www.oncotarget.com/abstract/9462

Alonso-Gordoa T, Capdevila J, Grande E (2015) GEP-NETs update: biotherapy for neuroendocrine tumours. Eur J Endocrinol 172(1):R31–46

Pópulo H, Lopes JM, Soares P (2012) The mTOR signalling pathway in human cancer. Int J Mol Sci 13(2):1886–1918

Fazio N (2015) Neuroendocrine tumors resistant to mammalian target of rapamycin inhibitors: a difficult conversion from biology to the clinic. World J Clin Oncol 6(6):194–197

Manfredi GI, Dicitore A, Gaudenzi G et al. (2015) PI3K/Akt/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy. Endocrine 48(2):363–370

Hobday TJ, Qin R, Reidy-Lagunes D et al. (2015) Multicenter phase II trial of temsirolimus and bevacizumab in pancreatic neuroendocrine tumors. J Clin Oncol 33(14):1551–1556

Raymond E, Hobday T, Castellano D et al. (2011) Therapy innovations: tyrosine kinase inhibitors for the treatment of pancreatic neuroendocrine tumors. Cancer Metastasis Rev 30(S1):19–26

Abdel-Rahman O (2014) Vascular endothelial growth factor (VEGF) pathway and neuroendocrine neoplasms (NENs): prognostic and therapeutic considerations. Tumor Biol 35(11):10615–10625