Numerical investigation of unsteady particle deposition in a realistic human nasal cavity during inhalation

Experimental and Computational Multiphase Flow - Tập 1 Số 1 - Trang 39-50 - 2019
Xin Gu1, Jian Wen1, Mengmeng Wang2, Guanping Jian3, Guoxi Zheng4, Simin Wang3
1School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an, China
2School of Energy and Building Environment Engineering, Henan University of Urban Construction, Henan, China
3School of Chemical Engineering and Technology, Xi’an Jiaotong University, Xi’an, China
4Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), Xi’an Jiaotong University, Xi’an, China

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Abouali, O., Keshavarzian, E., Farhadi Ghalati, P., Faramarzi, A., Ahmadi, G., Bagheri, M. H. 2012. Micro and nanoparticle deposition in human nasal passage pre and post virtual maxillary sinus endoscopic surgery. Resp Physiol Neurobi, 181: 335–345.

Bahmanzadeh, H., Abouali, O., Faramarzi, M., Ahmadi, G. 2015. Numerical simulation of airflow and micro-particle deposition in human nasal airway pre- and post-virtual sphenoidotomy surgery. Comput Biol Med, 61: 8–18.

Cheng, K. H., Cheng, Y. S., Yeh, H. C., Guilmette, R. A., Simpson, S. Q., Yang, Y. H., Swift, D. L. 1996. In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways. J Aerosol Sci, 27: 785–801.

Cheng, Y. S. 2003. Aerosol deposition in the extrathoracic region. Aerosol Sci Tech, 37: 659–671.

Cheng, Y. S., Holmes, T. D., Gao, J., Guilmette, R. A., Li, S., Surakitbanharn, Y., Rowlings, C. 2001. Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway. J Aerosol Med, 14: 267–280.

Frank, D. O., Kimbell, J. S., Pawar, S., Rhee, J. S. 2012. Effects of anatomy and particle size on nasal sprays and nebulizers. Otolaryng Head Neck, 146: 313–319.

Golshahi, L., Noga, M. L., Thompson, R. B., Finlay, W. H. 2011. In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing. J Aerosol Sci, 42: 474–488.

Hahn, I., Scherer, P. W., Mozell, M. M. 1993. Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. J Appl Physiol, 75: 2273–2287.

Häußermann, S., Bailey, A. G., Bailey, M. R., Etherington, G., Youngman, M. 2002. The influence of breathing patterns on particle deposition in a nasal replicate cast. J Aerosol Sci, 33: 923–933.

Huang, J. H., Zhang, L. Z. 2011. Numerical simulation of micro-particle deposition in a realistic human upper respiratory tract model during transient breathing cycle. Particuology, 9: 424–431.

Inthavong, K., Choi, L. T., Tu, J. Y., Ding, S. L., Thien, F. 2010. Micron particle deposition in a tracheobronchial airway model under different breathing conditions. Med Eng Phys, 32: 1198–1212.

Inthavong, K., Tian, Z. F., Tu, J. Y., Yang, W., Xue, C. 2008. Optimising nasal spray parameters for efficient drug delivery using computational fluid dynamics. Comput Biol Med, 38: 713–726.

Inthavong, K., Tu, J. Y., Heschl, C. 2011. Micron particle deposition in the nasal cavity using the v2-f model. Comput Fluids, 51: 184–188.

Jin, H. H., Fan, J. R., Zeng, M. J., Cen, K. F. 2007. Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. J Aerosol Sci, 38: 257–268.

Kelly, J. T., Asgharian, B., Kimbell, J. S., Wong, B. A. 2004. Particle deposition in human nasal airway replicas manufactured by different methods. part I: Inertial regime particles. Aerosol Sci Tech, 38: 1063–1071.

Kelly, J. T., Prasad, A. K., Wexler, A. S. 2000. Detailed flow patterns in the nasal cavity. J Appl Physiol, 89: 323–337.

Kesavanathan, J., Swift, D. L. 1998. Human nasal passage particle deposition: the effect of particle size, flow rate, and anatomical factors. Aerosol Sci Tech, 28: 457–463.

Lee, J. H., Na, Y., Kim, S. K., Chung, S. K. 2010. Unsteady flow characteristics through a human nasal airway. Resp Physiol Neurobi, 172: 136–146.

Li, X. D., Inthavong, K., Tu, J. Y. 2012. Particle inhalation and deposition in a human nasal cavity from the external surrounding environment. Build Environ, 47: 32–39.

Liu, Y., Matida, E. A., Johnson, M. R. 2010. Experimental measurements and computational modeling of aerosol deposition in the Carleton–Civic standardized human nasal cavity. J Aerosol Sci, 41: 569–586.

Morsi, S. A., Alexander, A. J. 1972. An investigation of particle trajectories in two-phase flow systems. J Fluid Mech, 55: 193–208.

Rasmussen, T. R., Swift, D. L., Hilberg, O., Pedersen, O. F. 1990. Influence of nasal passage geometry on aerosol particle deposition in the nose. J Aerosol Med, 3: 15–25.

Saidi, M. S., Rismanian, M., Monjezi, M., Zendehbad, M., Fatehiboroujeni, S. 2014. Comparison between Lagrangian and Eulerian approaches in predicting motion of micron-sized particles in laminar flows. Atmos Environ, 89: 199–206.

Schroeter, J. D., Garcia, G. J. M., Kimbell, J. S. 2011. Effects of surface smoothness on inertial particle deposition in human nasal models. J Aerosol Sci, 42: 52–63.

Shi, H. W., Kleinstreuer, C., Zhang, Z. 2007. Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness. J Aerosol Sci, 38: 398–419.

Wang, S. M., Inthavong, K., Wen, J., Tu, J. Y., Xue, C. L. 2009a. Comparison of micron- and nanoparticle deposition patterns in a realistic human nasal cavity. Resp Physiol Neurobi, 166: 142–151.

Wang, Y., Liu, Y. X., Sun, X. Z., Yu, S., Gao, F. 2009b. Numerical analysis of respiratory flow patterns within human upper airway. Acta Mech Sinica, 25: 737–746.

Wen, J., Inthavong, K., Tu, J. Y., Wang, S. M. 2008. Numerical simulations for detailed airflow dynamics in a human nasal cavity. Resp Physiol Neurobi, 161: 125–135.

Zhang, Z., Kleinstreuer, C. 2004. Airflow structures and nano-particle deposition in a human upper airway model. J Comput Phys, 198: 178–210.