Nuclear deformation mediates liver cell mechanosensing in cirrhosis

JHEP Reports - Tập 2 - Trang 100145 - 2020
Sergi Guixé-Muntet1, Martí Ortega-Ribera2, Cong Wang1, Sonia Selicean1, Ion Andreu3, Jenny Z. Kechagia3, Constantino Fondevila4, Pere Roca-Cusachs3, Jean-François Dufour1,5, Jaime Bosch1,2,5, Annalisa Berzigotti1,5, Jordi Gracia-Sancho1,2,5
1Department of BioMedical Research, University of Bern, Bern, Switzerland
2Liver Vascular Biology Research Group, Hepatic Hemodynamic Laboratory, IDIBAPS Biomedical Research Institute, CIBEREHD, Barcelona, Spain
3Institute for Bioengineering of Catalonia, Barcelona Institute of Technology, University of Barcelona, Barcelona, Spain
4Liver Surgery, Hospital Clinic de Barcelona, CIBEREHD, Barcelona, Spain
5Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital, Bern, Switzerland

Tài liệu tham khảo

Gracia-Sancho, 2019, Hepatic microcirculation and mechanisms of portal hypertension, Nat Rev Gastroenterol Hepatol, 16, 221, 10.1038/s41575-018-0097-3 Schrader, 2011, Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells, Hepatology, 53, 1192, 10.1002/hep.24108 You, 2016, Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells, Oncotarget, 7, 32221, 10.18632/oncotarget.8515 Elosegui-Artola, 2017, Force triggers YAP nuclear entry by regulating transport across nuclear pores, Cell, 171, 1397, 10.1016/j.cell.2017.10.008 Chen, 2009, Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers, Biomaterials, 30, 1113, 10.1016/j.biomaterials.2008.10.055 Olsen, 2011, Hepatic stellate cells require a stiff environment for myofibroblastic differentiation, Am J Physiol Gastrointest Liver Physiol, 301, G110, 10.1152/ajpgi.00412.2010 Desai, 2016, Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha, Hepatology, 64, 261, 10.1002/hep.28450 Dou, 2018, P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts, Gastroenterology, 154, 2209, 10.1053/j.gastro.2018.02.015 Guvendiren, 2014, Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells, J Mech Behav Biomed Mater, 38, 198, 10.1016/j.jmbbm.2013.11.008 Caliari, 2016, Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression, Integr Biol (Camb), 8, 720, 10.1039/C6IB00027D Vergniol, 2011, Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C, Gastroenterology, 140, 1970, 10.1053/j.gastro.2011.02.058 Singh, 2013, Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases: a systematic review and meta-analysis, Clin Gastroenterol Hepatol, 11, 1573, 10.1016/j.cgh.2013.07.034 Thiele Maja, 2016, 2-Dimensional shear wave elastography rather than HVPG significantly improves MELD-Na to predict survival in decompensated cirrhosis patients, Hepatology, 64, 704A Fernández-Iglesias, 2018, 4 in 1: Antibody-free protocol for isolating the main hepatic cells from healthy and cirrhotic single rat livers, J Cell Mol Med, 23, 877, 10.1111/jcmm.13988 Elosegui-Artola, 2016, Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity, Nat Cell Biol, 18, 540, 10.1038/ncb3336 Levental, 2007, Soft biological materials and their impact on cell function, Soft Matter, 3, 299, 10.1039/B610522J Berzigotti, 2017, Non-invasive evaluation of portal hypertension using ultrasound elastography, J Hepatol, 67, 399, 10.1016/j.jhep.2017.02.003 Zhang, 2001, Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues, J Cell Sci, 114, 4485, 10.1242/jcs.114.24.4485 Gracia-Sancho, 2008, Increased oxidative stress in cirrhotic rat livers: a potential mechanism contributing to reduced nitric oxide bioavailability, Hepatology, 47, 1248, 10.1002/hep.22166 Gracia-Sancho, 2011, Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver, Gut, 60, 517, 10.1136/gut.2010.220913 De Mesquita, 2017, Liraglutide improves liver microvascular dysfunction in cirrhosis: evidence from translational studies, Sci Rep, 7, 3255, 10.1038/s41598-017-02866-y Marcellin, 2018, Liver diseases: a major, neglected global public health problem requiring urgent actions and large-scale screening, Liver Int, 38, 2, 10.1111/liv.13682 Sepanlou, 2020, The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet Gastroenterol Hepatol, 5, 245, 10.1016/S2468-1253(19)30349-8 Vilaseca, 2018, Advances in therapeutic options for portal hypertension, Therap Adv Gastroenterol, 11, 10.1177/1756284818811294 Discher, 2005, Tissue cells feel and respond to the stiffness of their substrate, Science, 310, 1139, 10.1126/science.1116995 Hilscher, 2019, Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal hypertension, Gastroenterology, 157, 193, 10.1053/j.gastro.2019.03.013 Yeh, 2012, Matrix stiffness regulates endothelial cell proliferation through septin 9, PLoS One, 7, e46889, 10.1371/journal.pone.0046889 Ataollahi, 2015, Endothelial cell responses in terms of adhesion, proliferation, and morphology to stiffness of polydimethylsiloxane elastomer substrates, J Biomed Mater Res A, 103, 2203, 10.1002/jbm.a.35186 Swift, 2013, Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation, Science, 341, 1240104, 10.1126/science.1240104 Marrone, 2013, The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins, J Hepatol, 58, 98, 10.1016/j.jhep.2012.08.026 Marrone, 2015, KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins, Gut, 64, 1434, 10.1136/gutjnl-2014-308338 Ortega-Ribera, 2018, Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications, Biotechnol Bioeng, 115, 2585, 10.1002/bit.26776 Gracia-Sancho, 2019, Emricasan ameliorates portal hypertension and liver fibrosis in cirrhotic rats through a hepatocyte-mediated paracrine mechanism, Hepatol Commun, 3, 987, 10.1002/hep4.1360 Ivanovska, 2017, Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation, Mol Biol Cell, 28, 2010, 10.1091/mbc.e17-01-0010 Discher, 2017, Matrix mechanosensing: from scaling concepts in 'omics data to mechanisms in the nucleus, regeneration, and cancer, Annu Rev Biophys, 46, 295, 10.1146/annurev-biophys-062215-011206 Cho, 2017, Mechanosensing by the nucleus: from pathways to scaling relationships, J Cell Biol, 216, 305, 10.1083/jcb.201610042 Lammerding, 2016, Nuclear envelope rupture: actin fibers are putting the squeeze on the nucleus, J Cell Biol, 215, 5, 10.1083/jcb.201609102 Trappmann, 2013, How cells sense extracellular matrix stiffness: a material's perspective, Curr Opin Biotechnol, 24, 948, 10.1016/j.copbio.2013.03.020 Lombardi, 2011, The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton, J Biol Chem, 286, 26743, 10.1074/jbc.M111.233700