Nuclear PKM2 regulates the Warburg effect

Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809

Luo, 2012, Emerging roles of PKM2 in cell metabolism and cancer progression, Trends Endocrinol Metab, 23, 560, 10.1016/j.tem.2012.06.010

Bonuccelli, 2010, The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts, Cell Cycle, 9, 1960, 10.4161/cc.9.10.11601

Ghosh, 2008, New regulators of NFkappaB in inflammation, Nat Rev Immunol, 8, 837, 10.1038/nri2423

Hoffmann, 2006, Circuitry of nuclear factor kappaB signaling, Immunol Rev, 210, 171, 10.1111/j.0105-2896.2006.00375.x

Yang, 2012, EGFR-induced and PKCε monoubiquitylation-dependent NFκB activation upregulates PKM2 expression and promotes tumorigenesis, Mol Cell, 48, 771, 10.1016/j.molcel.2012.09.028

Yang, 2012, ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect, Nat Cell Biol, 14, 1295, 10.1038/ncb2629

Bluemlein, 2011, No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis, Oncotarget, 2, 393, 10.18632/oncotarget.278

Christofk, 2008, The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth, Nature, 452, 230, 10.1038/nature06734

Anastasiou, 2011, Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses, Science, 334, 1278, 10.1126/science.1211485

Chaneton, 2012, Serine is a natural ligand and allosteric activator of pyruvate kinase M2, Nature, 491, 458, 10.1038/nature11540

Hitosugi, 2009, Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth, Sci Signal, 2, ra73, 10.1126/scisignal.2000431

Bluemlein, 2012, Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis, Oncotarget, 3, 1356, 10.18632/oncotarget.730

Yang, 2011, Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation, Nature, 480, 118, 10.1038/nature10598

Mazurek, 2005, Pyruvate kinase type M2 and its role in tumor growth and spreading, Semin Cancer Biol, 15, 300, 10.1016/j.semcancer.2005.04.009

Gao, 2012, Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase, Mol Cell, 45, 598, 10.1016/j.molcel.2012.01.001

Luo, 2011, Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells, Oncotarget, 2, 551, 10.18632/oncotarget.299

Lu, 2012, Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis, Chin J Cancer, 31, 5

Yang, 2012, PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis, Cell, 150, 685, 10.1016/j.cell.2012.07.018

Marzluff, 2002, The human and mouse replication-dependent histone genes, Genomics, 80, 487, 10.1006/geno.2002.6850

Hake, 2006, Expression patterns and post-translational modifications associated with mammalian histone H3 variants, J Biol Chem, 281, 559, 10.1074/jbc.M509266200

Lu, 2012, PKM2 functions as a histone kinase, Cell Cycle, 11, 4101, 10.4161/cc.22325

Lu, 1998, Activation of protein kinase C triggers its ubiquitination and degradation, Mol Cell Biol, 18, 839, 10.1128/MCB.18.2.839

Xia, 2007, c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis, Mol Cell, 25, 219, 10.1016/j.molcel.2007.01.005