Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis
Tóm tắt
Từ khóa
Tài liệu tham khảo
Xu R, Zhang Z, Wang FS . Liver fibrosis: mechanisms of immune-mediated liver injury. Cell Mol Immunol 2012; 9: 296–301.
Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW . Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 2010; 138: 513–21, 21 e1–6.
Mitchell AE, Colvin HM, Palmer Beasley R . Institute of medicine recommendations for the prevention and control of hepatitis B and C. Hepatology 2010; 51: 729–33.
Lim YS, Kim WR . The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis 2008; 12: 733–46.
Friedman SL . Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 2004; 1: 98–105.
Zhu W, Fung PC . The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice. Free Radic Biol Med 2000; 29: 870–80.
Yang YS1, Ahn TH, Lee JC, Moon CJ, Kim SH, Jun W, et al. Protective effects of pycnogenol on carbon tetrachloride-induced hepatotoxicity in sprague-dawley rats. Food Chem Toxicol 2008; 46: 380–7.
Weber LW, Boll M, Stampfl A . Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33: 105–36.
Wu S, Yue Y, Tian H, Li Z, Li X, He W, et al. Carthamus red from Carthamus tinctorius L exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway. J Ethnopharmacol 2013; 148: 570–8.
Jiang T, Huang Z, Chan JY, Zhang DD . Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol 2009; 240: 8–14.
Xu W, Hellerbrand C, Kohler UA, Bugnon P, Kan YW, Werner S, et al. The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest 2008; 88: 1068–78.
Du J, Cheng B, Zhu X, Ling C . Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects. J Immunol 2011; 187: 942–50.
Im DS, Nah SY . Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin. Acta Pharmacol Sin 2013; 34: 1367–73.
Radad K, Gille G, Moldzio R, Saito H, Rausch WD . Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res 2004; 1021: 41–53.
Ki SH, Yang JH, Ku SK, Kim SC, Kim YW, Cho IJ . Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis. J Ginseng Res 2013; 37: 45–53.
Korivi M, Hou CW, Huang CY, Lee SD, Hsu MF, Yu SH, et al. Ginsenoside-Rg1 protects the liver against exhaustive exercise-induced oxidative stress in rats. Evid Based Complement Alternat Med 2012; 2012: 932165.
Nguyen HT, Uto T, Morinaga O, Kim YH, Shoyama Y . Pharmacological effects of ginseng on liver functions and diseases: a minireview. Evid Based Complement Alternat Med 2012; 2012: 173297.
Tsai KD1, Yang SM, Lee JC, Wong HY, Shih CM, Lin TH, et al. Panax notoginseng attenuates bleomycin-induced pulmonary fibrosis in mice. Evid Based Complement Alternat Med 2011; 2011: 404761.
Geng J, Peng W, Huang Y, Fan H, Li S . Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats. Eur J Pharmacol 2010; 634: 162–9.
Park WH, Lee SK, Kim CH . A Korean herbal medicine, Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats. Life Sci 2005; 76: 1675–90.
Thompson K, Maltby J, Fallowfield J, Mcaulay M, Millward-Sadler H, Shero N . Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis. Hepatology 1998; 28: 1597–606.
Chen S, Zou L, Li L, Tie W . The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2. PloS One 2013; 8: e53662.
Rej R . Aspartate aminotransferase activity and isoenzyme proportions in human liver tissues. Clin Chem 1978; 24: 1971–9.
Friedman SL . Stellate cell activation in alcoholic fibrosi — an overview. Alcohol CIin Exp Res 1999; 23: 904–10.
Novo E, Parola M . Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogen Tissue Repair 2008; 1: 1–58.
Zhang F, Ni C, Kong D, Zhang X, Zhu X, Chen L, et al. Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-beta receptor-mediated ERK and p38 pathways. Toxicol Appl Pharmacol 2012; 265: 51–60.
Tsai MK, Lin YL, Huang YT . Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats. Toxicol Appl Pharmacol 2010; 242: 155–64.
Shaker ME, Zalata KR, Mehal WZ, Shiha GE, Ibrahim TM . Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis. Toxicol Appl Pharmacol 2011; 252: 165–75.
Pirinccioglu M, Kizil G, Kizil M, Kanay Z, Ketani A . The protective role of pomegranate juice against carbon tetrachloride-induced oxidative stress in rats. Toxicol Indust Health 2012.
Domitrovic R, Jakovac H, Marchesi VV, Blazekovic B . Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl4-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression. J Med Food 2013; 16: 518–28.
Nurrochmad A1, Margono SA, Sardjiman, Hakim AR, Ernawati, Kurniawati E, Fatmawati E . Hepatoprotective and antioxidant activity of pentagamavunon-0 against carbon tetrachloride-induced hepatic injury in rats. Asian Pacific J Trop Med 2013; 6: 438–42.
Ottu OJ, Atawodi SE, Onyike E . Antioxidant, hepatoprotective and hypolipidemic effects of methanolic root extract of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication. Asian Pacific J Trop Med 2013; 6: 609–15.
Bak MJ, Jun M, Jeong WS . Antioxidant and hepatoprotective effects of the red ginseng essential oil in H2O2-treated HepG2 cells and CCl4-treated mice. Int J Mol Sci 2012; 13: 2314–30.
Altamirano J, Bataller R . Alcoholic liver disease: pathogenesis and new targets for therapy. Nat Rev Gastroenterol Hepatol 2011; 8: 491–501.
Tuñón MJ . An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World J Gastroenterol 2009; 15: 3086.
Arthur MJP, Iredale JP, Mann DA . Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease. Alcohol Clin Exp Res 1999; 23: 940–3.
Meagher EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, et al. Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest 1999; 104: 805–13.
Houstis N, Rosen ED, Lander ES . Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440: 944–8.
Lieber CS, Weiss DG, Paronetto F . Value of fibrosis markers for staging liver fibrosis in patients with precirrhotic alcoholic liver disease. Alcohol Clin Exp Res 2008; 32: 1031–9.
Kluwe J, Pradere JP, Gwak GY, Mencin A, De Minicis S, Osterreicher CH, et al. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology 2010; 138: 347–59.
Wang JH, Choi MK, Shin JW, Hwang SY, Son CG . Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model. J Ethnopharmacol 2012; 140: 179–85.
El Denshary ES, Al-Gahazali MA, Mannaa FA, Salem HA, Hassan NS, Abdel-Wahhab MA . Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats. Exp Toxicol Pathol 2012; 64: 753–60.
Gouillon ZQ, Miyamoto K, Donohue TM, Wan YJ, French BA, Nagao Y, et al. Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway. Front Biosci 1999; 4: 16–25.
Chiang DJ, Roychowdhury S, Bush K, McMullen MR, Pisano S, Niese K, et al. Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis. PloS One 2013; 8: e69114.
Roychowdhury S, Chiang DJ, Mandal P, McMullen MR, Liu X, Cohen JI, et al. Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4-induced fibrosis but not steatosis or inflammation. Alcohol Clin Exp Res 2012; 36: 1139–47.
Gressner AM, Weiskirchen R . Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med 2006; 10: 76–99.
Cho IJ, Kim YW, Han CY, Kim EH, Anderson RA, Lee YS, et al. E-cadherin antagonizes transforming growth factor beta1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation. Hepatology 2010; 52: 2053–64.
Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, Gabbiani G . The myofibroblast: one function, multiple origins. Am J Pathol 2007; 170: 1807–16.
Kang KW, Kim YG, Cho MK, Bae SK, Kim CW, Lee MG, et al. Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation. FASEB J 2002; 16: 1988–90.
Xia D, Fan Y, Zhang P, Fu Y, Ju M, Zhang X . Protective effects of the flavonoid-rich fraction from Rhizomes of Smilax glabra Roxb on carbon tetrachloride-induced hepatotoxicity in rats. J Membr Biol 2013; 246: 479–85.
Saravanan KS, Sindhu KM, Mohanakumar KP . Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model. J Pineal Res 2007; 42: 247–53.
Itoh K, Tong KI, Yamamoto M . Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radical Biol Med 2004; 36: 1208–13.
Kobayashi M, Yamamoto M . Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 2005; 7: 385–94.
Bardag-Gorce F, Oliva J, Lin A, Li J, French BA, French SW . Proteasome inhibitor up-regulates liver antioxidative enzymes in rat model of alcoholic liver disease. Exp Mol Pathol 2011; 90: 123–30.
Farombi EO, Shrotriya S, Na HK, Kim SH, Surh YJ . Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem Toxicol 2008; 46: 1279–87.
Wartman MA . Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J Biol Chem 1997; 272: 7445–54.
Jeong WS, Jun M, Kong AN . Nrf2: A potential molecular target for cancer chemoprevention by natural compounds. Antioxid Redox Signal 2006; 8: 99–106.
Mann GE, Niehueser-Saran J, Watson A, Gao L, Ishii T, de Winter P, et al. Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Acta Physiol Sin 2007; 59: 117–27.
Bataille AM, Manautou JE . Nrf2: a potential target for new therapeutics in liver disease. Clin Pharmacol Ther 2012; 92: 340–8.
Lamlé J1, Marhenke S, Borlak J, von Wasielewski R, Eriksson CJ, Geffers R, et al. Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury. Gastroenterology 2008; 134: 1159–68.e2.
Wu KC, Cui JY, Klaassen CD . Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol Sci 2011; 123: 590–600.
Collins AR1, Gupte AA, Ji R, Ramirez MR, Minze LJ, Liu JZ, et al. Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury. Arterioscler Thromb Vasc Biol 2012: 2839–46.
Shin SM, Yang JH, Ki SH . Role of the Nrf2-ARE pathway in liver diseases. Oxidat Med Cell Longevity 2013; 2013: 763257.
Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, et al. Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J 2008; 27: 212–23.