Nrf2 Activator RTA-408 Protects Against Ozone-Induced Acute Asthma Exacerbation by Suppressing ROS and γδT17 Cells

Sarhan, H.A., O.H. El-Garhy, M.A. Ali, and N.A. Youssef. 2016. The efficacy of nebulized magnesium sulfate alone and in combination with salbutamol in acute asthma. Drug Design, Development and Therapy 10: 1927–1933.

Bao, A., L. Liang, F. Li, M. Zhang, and X. Zhou. 2013. Effects of acute ozone exposure on lung peak allergic inflammation of mice. Front Biosci (Landmark Ed) 18: 838–851.

Duran, C.G., A.J. Burbank, K.H. Mills, H.R. Duckworth, M.M. Aleman, M.J. Kesic, D.B. Peden, Y. Pan, H. Zhou, and M.L. Hernandez. 2016. A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation. Respiratory Research 17 (1): 89.

Che, L., Y. Jin, C. Zhang, T. Lai, H. Zhou, L. Xia, B. Tian, Y. Zhao, J. Liu, Y. Wu, Y. Wu, J. du, W. Li, S. Ying, Z. Chen, and H. Shen. 2016. Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade. Scientific Reports 6: 18680.

Zhao, Q., L.G. Simpson, K.E. Driscoll, and G.D. Leikauf. 1998. Chemokine regulation of ozone-induced neutrophil and monocyte inflammation. The American Journal of Physiology 274 (1 Pt 1): L39–L46.

Baird, L., and A.T. Dinkova-Kostova. 2011. The cytoprotective role of the Keap1-Nrf2 pathway. Archives of Toxicology 85 (4): 241–272.

Jeong, W.S., M. Jun, and A.N. Kong. 2006. Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxidants & Redox Signaling 8 (1–2): 99–106.

Castellano, J.M., A. Guinda, T. Delgado, M. Rada, and J.A. Cayuela. 2013. Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 (6): 1791–1799.

Gupte, A.A., C.J. Lyon, and W.A. Hsueh. 2013. Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitis. Current Diabetes Reports 13 (3): 362–371.

Laan, M., Z.H. Cui, H. Hoshino, J. Lotvall, M. Sjostrand, D.C. Gruenert, B.E. Skoogh, and A. Linden. 1999. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. Journal of Immunology 162 (4): 2347–2352.

Chen, Y.P., J.H. Zhang, C.Q. Li, Q.X. Sun, and X.H. Jiang. 2015. Obesity enhances Th2 inflammatory response via natural killer T cells in a murine model of allergic asthma. International Journal of Clinical and Experimental Medicine 8 (9): 15403–15412.

Zhang, J., C. Li, and S. Guo. 2012. Effects of inhaled inactivated Mycobacterium phlei on airway inflammation in mouse asthmatic models. Journal of Aerosol Medicine and Pulmonary Drug Delivery 25 (2): 96–103.

Ito, K., C. Herbert, J.S. Siegle, C. Vuppusetty, N. Hansbro, P.S. Thomas, P.S. Foster, P.J. Barnes, and R.K. Kumar. 2008. Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. American Journal of Respiratory Cell and Molecular Biology 39 (5): 543–550.

Kim, W., H.U. Kim, H.N. Lee, S.H. Kim, C. Kim, Y.N. Cha, Y. Joe, H.T. Chung, J. Jang, K. Kim, Y.G. Suh, H.O. Jin, J.K. Lee, and Y.J. Surh. 2015. Taurine chloramine stimulates efferocytosis through upregulation of Nrf2-mediated heme oxygenase-1 expression in murine macrophages: possible involvement of carbon monoxide. Antioxidants & Redox Signaling 23 (2): 163–177.

Ruiz, S., P.E. Pergola, R.A. Zager, and N.D. Vaziri. 2013. Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney International 83 (6): 1029–1041.

Johnson, D.A., S. Amirahmadi, C. Ward, Z. Fabry, and J.A. Johnson. 2010. The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicological Sciences 114 (2): 237–246.

Turley, A.E., J.W. Zagorski, and C.E. Rockwell. 2015. The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells. Cytokine 71 (2): 289–295.

Rockwell, C.E., M. Zhang, P.E. Fields, and C.D. Klaassen. 2012. Th2 skewing by activation of Nrf2 in CD4(+) T cells. Journal of Immunology 188 (4): 1630–1637.

Manzo, N.D., A.J. LaGier, R. Slade, A.D. Ledbetter, J.H. Richards, and J.A. Dye. 2012. Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells--implications for susceptibility to traffic-related air pollution. Particle and Fibre Toxicology 9: 43.

Silva, F.M.C., E.E. Oliveira, A.C.C. Gouveia, A.S.S. Brugiolo, C.C. Alves, J.O.A. Correa, J. Gameiro, J. Mattes, H.C. Teixeira, and A.P. Ferreira. 2017. Obesity promotes prolonged ovalbumin-induced airway inflammation modulating T helper type 1 (Th1), Th2 and Th17 immune responses in BALB/c mice. Clinical and Experimental Immunology 189 (1): 47–59.

Cheng, G., S. Swaidani, M. Sharma, M.E. Lauer, V.C. Hascall, and M.A. Aronica. 2011. Hyaluronan deposition and correlation with inflammation in a murine ovalbumin model of asthma. Matrix Biology 30 (2): 126–134.

Mathews, J. A., A. S. Williams, J. D. Brand, A. P. Wurmbrand, L. Chen, F. M. Ninin, H. Si, D. I. Kasahara, and S. A. Shore. 2014. Gammadelta T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFalpha. PLoS One 9 (5):e97707.