Novel ribozyme, RNA decoy, and siRNA approaches to inhibition of HIV in a gene therapy setting

Bossi, 2001, Current antiretroviral therapy, Rev Med Interne, 22, 42, 10.1016/S0248-8663(00)00284-8 Bridges, 1995, Gene therapy and immune restoration for HIV disease, Lancet, 345, 427, 10.1016/S0140-6736(95)90407-7 Rossi, 1991, The potential use of catalytic RNAs in therapy of HIV infection and other diseases, Pharmacol Ther, 50, 245, 10.1016/0163-7258(91)90016-F Zhou, 1994, Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes, Gene, 149, 33, 10.1016/0378-1119(94)90409-X Bauer, 1997, Inhibition of human immunodeficiency virus-1 (HIV-1) replication after transduction of granulocyte colony-stimulating factor-mobilized CD34+ cells from HIV-1-infected donors using retroviral vectors containing anti-HIV-1 genes, Blood, 89, 2259, 10.1182/blood.V89.7.2259 Miyoshi, 1999, Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors, Science, 283, 682, 10.1126/science.283.5402.682 Kingsman, 1996, The regulation of human immunodeficiency virus type-1 gene expression, Eur J Biochem, 240, 491, 10.1111/j.1432-1033.1996.0491h.x Dundr, 1996, Location of the HIV-1 Rev protein during mitosis, J Cell Sci, 109, 2239, 10.1242/jcs.109.9.2239 Dundr, 1995, The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein, J Cell Sci, 108, 2811, 10.1242/jcs.108.8.2811 Ruben, 1989, Structural and functional characterization of human immunodeficiency virus tat protein, J Virol, 63, 1, 10.1128/JVI.63.1.1-8.1989 Kubota, 2000, The nuclear function of the nuclear diffusion inhibitory signal of human immunodeficiency virus type 1, J Hum Virol, 3, 173 Michienzi, 2000, Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA, Proc Natl Acad Sci USA, 97, 8955, 10.1073/pnas.97.16.8955 Fragapane, 1993, A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA, EMBO J, 12, 2921, 10.1002/j.1460-2075.1993.tb05954.x Weinstein, 1999, Guided tours, Curr Opin Cell Biol, 11, 378, 10.1016/S0955-0674(99)80053-2 Buonomo, 1999, The Rev protein is able to transport to the cytoplasm small nucleolar RNAs containing a Rev binding element, RNA, 5, 993, 10.1017/S1355838299990064 Michienzi, 2002, A nucleolar TAR decoy inhibitor of HIV Replication, Proc Natl Acad Sci USA, 99C22, 14047, 10.1073/pnas.212229599 Foley, 1965, Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia, Cancer, 18, 522, 10.1002/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO;2-J Moss, 2001, RNA interference, Curr Biol, 11, R772, 10.1016/S0960-9822(01)00467-5 Bernstein, 2001, The rest is silence, RNA, 7, 1509 Elbashir, 2001, RNA interference is mediated by 21- and 22-nucleotide RNAs, Genes Dev, 15, 188, 10.1101/gad.862301 Elbashir, 2001, Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells, Nature, 411, 494, 10.1038/35078107 Bernstein, 2001, Role for a bidentate ribonuclease in the initiation step of RNA interference, Nature, 409, 363, 10.1038/35053110 Hammond, 2001, Argonaute2, a link between genetic and biochemical analyses of RNAi, Science, 293, 1146, 10.1126/science.1064023 Lee, 2002, Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells, Nat Biotechnol, 20, 500, 10.1038/nbt0502-500 Miyagishi, 2002, U6 promoter driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells, Nat Biotechnol, 20, 497, 10.1038/nbt0502-497 Paul, 2002, Effective expression of small interfering RNA in human cells, Nat Biotechnol, 20, 505, 10.1038/nbt0502-505 Brummelkamp, 2002, A system for stable expression of short interfering RNAs in mammalian cells, Science, 296, 550, 10.1126/science.1068999 Yang, 1999, Generation of retroviral vector for clinical studies using transient transfection, Hum Gene Ther, 10, 123, 10.1089/10430349950019255 Bahner, 1993, Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes, J Virol, 67, 3199, 10.1128/JVI.67.6.3199-3207.1993 Ragheb, 1995, Analysis of trans-dominant mutants of the HIV type 1 Rev protein for their ability to inhibit Rev function, HIV type 1 replication, and their use as anti-HIV gene therapeutics, AIDS Res Hum Retroviruses, 11, 1343, 10.1089/aid.1995.11.1343 Chinen, 1997, Protection of primary human T cells from HIV infection by Trev, Hum Gene Ther, 8, 861, 10.1089/hum.1997.8.7-861 Poznansky, 1998, Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat, Hum Gene Ther, 9, 487, 10.1089/hum.1998.9.4-487 Chen, 1994, Intracellular antibodies as a new class of therapeutic molecules for gene therapy, Hum Gene Ther, 5, 595, 10.1089/hum.1994.5.5-595 Novina, 2002, siRNA-directed inhibition of HIV-1 infection, Nat Med, 8, 681, 10.1038/nm725