Novel methods for preparing phospholipid coated microbubbles
Tóm tắt
Two new methods for preparing phospholipid coated microbubble suspensions are elucidated. Firstly, co-axial electrohydrodynamic atomisation was utilized to generate 3–7 µm diameter microbubbles. Secondly, a specially designed and constructed T-junction device was used to prepare monodisperse microbubbles. Characteristics of microbubbles prepared by these two methods are compared with those obtained by sonication of the phospholipid suspension.
Tài liệu tham khảo
Dayton PA, Ferrara KW (2002) Targetted imaging using ultrasound. J Mag Resonance Imaging 16:372–377
Farook U, Zhang HB, Edirisinghe MJ, Stride E, Saffari N (2007a) Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. Med Eng Phys 29:749–754
Farook U, Stride E, Edirisinghe M, Moaleji R (2007b) Microbubbling by co-axial electrohydrodynamic atomization. Med Biol Eng Comp (in press)
Hallowell CP, Hirt DE (1994) Unusual characteristics of the maximum bubble pressure method using a Teflon capillary. J Coll Interf Sci 168:281–288
Hettiarachchi K, Talu E, Longo ML, Dayton PA, Lee AP (2007) On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging. Lab Chip 7:463–468
Jayasinghe SN, Edirisinghe MJ (2002) Effect of viscosity on the size of relics produced by electrostatic atomization. J Aerosol Sci 33:1379–1388
Klibanov AL (1999) Targeted delivery of gas-filled microspheres, contrast agent for ultrasound imaging. Adv Drug Delivery Rev 37:139–157
Stride E, Saffari N (2003) Microbubble ultrasound contrast agent: a review. Proc Inst Mech Eng Part H 217(H6):429–447
Talu E, Lozano MM, Powell RL, Dayton PA, Longo ML (2006) Long-term stability by lipid coating monodisperse microbubbles formed by a flow-focusing device. Langmuir 22:9487–9490
Unger EC, Hersh E, Vannan M, Matsunaga TO, McCreery T (2001) Local drug and gene delivery through microbubbles. Progress Cardiovascular Diseases 44:45–54
Unger EC, Porter T, Culp W, Labell R, Matsunaga T, Zutshi R (2004) Therapeutic applications of lipid-coated microbubbles. Adv Drug Delivery Rev 56:1291–1314