Novel insights on interactions between folate and lipid metabolism

BioFactors - Tập 40 Số 3 - Trang 277-283 - 2014
Robin P. da Silva1, Karen Kelly1, Ala Al Rajabi1, René L. Jacobs1
1Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada

Tóm tắt

AbstractFolate is an essential B vitamin required for the maintenance of AdoMet‐dependent methylation. The liver is responsible for many methylation reactions that are used for post‐translational modification of proteins, methylation of DNA, and the synthesis of hormones, creatine, carnitine, and phosphatidylcholine. Conditions where methylation capacity is compromised, including folate deficiency, are associated with impaired phosphatidylcholine synthesis resulting in non‐alcoholic fatty liver disease and steatohepatitis. In addition, folate intake and folate status have been associated with changes in the expression of genes involved in lipid metabolism, obesity, and metabolic syndrome. In this review, we provide insight on the relationship between folate and lipid metabolism, and an outlook for the future of lipid‐related folate research. © 2013 BioFactors, 40(3):277–283, 2014

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BioFactors

Tập 40 Số 3

277-283

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