Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites

Dina le Roux1, Pieter B. Burger1, Jandeli Niemand1, Anne Grobler2, Patricia Urbán3,4,5, Xavier Fernàndez-Busquets3,4,5, Robert H. Barker6, Adelfa E. Serrano7, Abraham I. Louw1, Lyn-Marie Birkholtz1
1Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa
2DST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom 2531, South Africa
3Nanobioengineering Group, Institute for Bioengineering of Catalonia, Baldiri Reixac 10-12, Barcelona E08028, Spain
4Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Rosselló 149-153, Barcelona E08036, Spain
5Biomolecular Interactions Team, Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès 1, Barcelona E08028, Spain
6Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA
7University of Puerto Rico-School of Medicine, Department of Microbiology and Medical Zoology, P.O. Box 365067, San Juan PR 00936-5067, Puerto Rico

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