Novel Molecular Imaging Approach for Subclinical Detection of Iritis and Evaluation of Therapeutic Success

Rothova, 1996, Causes and frequency of blindness in patients with intraocular inflammatory disease, Br J Ophthalmol, 80, 332, 10.1136/bjo.80.4.332 Hafezi-Moghadam, 2007, VLA-4 blockade suppresses endotoxin-induced uveitis: in vivo evidence for functional integrin up-regulation, FASEB J, 21, 464, 10.1096/fj.06-6390com Maruyama, 1995, Infrared angiography of the anterior ocular segment, Surv Ophthalmol, 39, S40, 10.1016/S0039-6257(05)80072-4 Rosenbaum, 1980, Endotoxin-induced uveitis in rats as a model for human disease, Nature, 286, 611, 10.1038/286611a0 Dullforce, 2004, APCs in the anterior uveal tract do not migrate to draining lymph nodes, J Immunol, 172, 6701, 10.4049/jimmunol.172.11.6701 Becker, 2002, Immune mechanisms in uveitis. What can be learned from in vivo imaging?, Ophthalmol Clin North Am, 15, 259, 10.1016/S0896-1549(02)00022-6 Becker, 2000, Digital video-imaging of leukocyte migration in the iris: intravital microscopy in a physiological model during the onset of endotoxin-induced uveitis, J Immunol Methods, 240, 23, 10.1016/S0022-1759(00)00165-4 Planck, 2008, Characterizing extravascular neutrophil migration in vivo in the iris, Inflammation, 31, 105, 10.1007/s10753-007-9055-x Miyahara, 2008, In vivo imaging of endothelial injury in choriocapillaris during endotoxin-induced uveitis, FASEB J, 22, 1973, 10.1096/fj.07-096891 Sun, 2010, Superior sensitivity of novel molecular imaging probe: simultaneously targeting two types of endothelial injury markers, FASEB J, 24, 1532, 10.1096/fj.09-148981 Parnaby-Price, 1998, Leukocyte trafficking in experimental autoimmune uveitis in vivo, J Leukoc Biol, 64, 434, 10.1002/jlb.64.4.434 Hafezi-Moghadam, 1999, Relevance of L-selectin shedding for leukocyte rolling in vivo, J Exp Med, 189, 939, 10.1084/jem.189.6.939 Hafezi-Moghadam, 2001, L-selectin shedding regulates leukocyte recruitment, J Exp Med, 193, 863, 10.1084/jem.193.7.863 Laszik, 1996, P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells, Blood, 88, 3010, 10.1182/blood.V88.8.3010.bloodjournal8883010 Spertini, 1996, P-selectin glycoprotein ligand 1 is a ligand for L-selectin on neutrophils, monocytes, and CD34+ hematopoietic progenitor cells, J Cell Biol, 135, 523, 10.1083/jcb.135.2.523 Moore, 1998, Structure and function of P-selectin glycoprotein ligand-1, Leukemia Lymphoma, 29, 1, 10.3109/10428199809058377 Norman, 1995, Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand-1, Blood, 86, 4417, 10.1182/blood.V86.12.4417.bloodjournal86124417 Geng, 1990, Rapid neutrophil adhesion to activated endothelium mediated by GMP-140, Nature, 343, 757, 10.1038/343757a0 Abramoff, 2004, Image processing with ImageJ, Biophotonics Int, 11, 36 Hoekzema, 1992, Endotoxin-induced uveitis in the rat. The significance of intraocular interleukin-6, Invest Ophthalmol Vis Sci, 33, 532 Cronstein, 1992, A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1, Proc Natl Acad Sci USA, 89, 9991, 10.1073/pnas.89.21.9991