Novel Inhibitors of DNA Gyrase: 3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening

Journal of Medicinal Chemistry - Tập 43 Số 14 - Trang 2664-2674 - 2000
Hans-Joachim Boehm1, Markus Boehringer1, Daniel Bur1, Hans Gmuender1, Walter Huber1, Werner Klaus1, Dirk Kostrewa1, Holger Kuehne1, Thomas Luebbers1, Nathalie Meunier-Keller1, Francis Mueller1
1Preclinical Research, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland

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