Novel Glucoalkaloids from Rauwolfia Cell Cultures – Acetylrauglucine and Related Glucosides

Carl Michael Ruyter1, Helmut Schübel1, Joachim Stöckigt1
1Institut für Pharmazeutische Biologie, Karlstraße 29, Universität München, D-8000 München 2, Bundesrepublik Deutschland

Tóm tắt

From cell suspension cultures of Rauwolfia serpentina grown in an optimized production medium for the glucoalkaloid raucaffricine, a novel glucoalkaloid was isolated and identified as 17-O-acetyl-21-O-β-ᴅ-glucopyranosyl-ajmaline (acetylrauglucine). This alkaloid is formed in very small amounts (< 5 × 10-4%). The biogenetically related Nα-demethylated base (acetyl-nor-rauglucine) and the deacetyl product rauglucine have also been detected in culture extracts. In addition 21(.R)-(β-D-glucopyranosyl)-hydroxy-sarpagan-17-al has been isolated and identified as an artifact which originates from raucaffricine.

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