Notch as a Driver of Gastric Epithelial Cell Proliferation

Torre, 2015, Global cancer statistics, 2012, CA Cancer J Clin, 65, 87, 10.3322/caac.21262 2014, Comprehensive molecular characterization of gastric adenocarcinoma, Nature, 513, 202, 10.1038/nature13480 Huels, 2015, Stem vs non-stem cell origin of colorectal cancer, Br J Cancer, 113, 1, 10.1038/bjc.2015.214 Vries, 2010, Stem cells and cancer of the stomach and intestine, Mol Oncol, 4, 373, 10.1016/j.molonc.2010.05.001 Demitrack, 2015, Notch signaling regulates gastric antral LGR5 stem cell function, EMBO J, 34, 2522, 10.15252/embj.201490583 Kim, 2011, Notch signaling in stomach epithelial stem cell homeostasis, J Exp Med, 208, 677, 10.1084/jem.20101737 Bauer, 2015, Clinical significance of NOTCH1 and NOTCH2 expression in gastric carcinomas: an immunohistochemical study, Front Oncol, 5, 94, 10.3389/fonc.2015.00094 Hsu, 2012, Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression, Carcinogenesis, 33, 1459, 10.1093/carcin/bgs165 Kim, 2016, Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer, Oncogene, 35, 251, 10.1038/onc.2015.80 Li, 2014, Gastric cancer cell growth and epithelial-mesenchymal transition are inhibited by gamma-secretase inhibitor DAPT, Oncol Lett, 7, 2160, 10.3892/ol.2014.1980 Piazzi, 2011, Epigenetic regulation of delta-like1 controls Notch1 activation in gastric cancer, Oncotarget, 2, 1291, 10.18632/oncotarget.414 Yeh, 2009, The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2, Cancer Res, 69, 5039, 10.1158/0008-5472.CAN-08-4021 Bray, 2016, Notch signalling in context, Nat Rev Mol Cell Biol, 17, 722, 10.1038/nrm.2016.94 Demitrack, 2016, Notch regulation of gastrointestinal stem cells, J Physiol, 594, 4791, 10.1113/JP271667 Kopan, 2009, The canonical Notch signaling pathway: unfolding the activation mechanism, Cell, 137, 216, 10.1016/j.cell.2009.03.045 Tsai, 2014, ADAM10 regulates Notch function in intestinal stem cells of mice, Gastroenterology, 147, 822, 10.1053/j.gastro.2014.07.003 VanDussen, 2012, Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells, Development, 139, 488, 10.1242/dev.070763 Mills, 2011, Gastric epithelial stem cells, Gastroenterology, 140, 412, 10.1053/j.gastro.2010.12.001 Barker, 2007, Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, 449, 1003, 10.1038/nature06196 Barker, 2010, Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro, Cell Stem Cell, 6, 25, 10.1016/j.stem.2009.11.013 Sato, 2009, Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, 459, 262, 10.1038/nature07935 McCracken, 2017, Wnt/beta-catenin promotes gastric fundus specification in mice and humans, Nature, 541, 182, 10.1038/nature21021 Arnold, 2011, Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice, Cell Stem Cell, 9, 317, 10.1016/j.stem.2011.09.001 Powell, 2012, The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor, Cell, 149, 146, 10.1016/j.cell.2012.02.042 Hayakawa, 2015, CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis, Gut, 64, 544, 10.1136/gutjnl-2014-307190 Matsuo, 2017, Identification of stem cells in the epithelium of the stomach corpus and antrum of mice, Gastroenterology, 152, 218, 10.1053/j.gastro.2016.09.018 Mills, 2015, Reserve stem cells: differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract, Sci Signal, 8, re8, 10.1126/scisignal.aaa7540 Qiao, 2007, Prospective identification of a multilineage progenitor in murine stomach epithelium, Gastroenterology, 133, 1989, 10.1053/j.gastro.2007.09.031 Stange, 2013, Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium, Cell, 155, 357, 10.1016/j.cell.2013.09.008 Hayakawa, 2015, Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche, Cancer Cell, 28, 800, 10.1016/j.ccell.2015.10.003 Sigal, 2015, Helicobacter pylori activates and expands Lgr5(+) stem cells through direct colonization of the gastric glands, Gastroenterology, 148, 1392, 10.1053/j.gastro.2015.02.049 Huh, 2012, Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach, Gastroenterology, 142, 21, 10.1053/j.gastro.2011.09.050 Jensen, 2000, Control of endodermal endocrine development by Hes-1, Nat Genet, 24, 36, 10.1038/71657 Demitrack, 2017, NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus, Am J Physiol Gastrointest Liver Physiol, 312, G133, 10.1152/ajpgi.00325.2016 Gifford, 2016, Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis, Gut Verzi, 2008, Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells, Gastroenterology, 135, 591, 10.1053/j.gastro.2008.04.019 Horst, 2010, Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum, J Biol Chem, 285, 35047, 10.1074/jbc.M110.164541 Lee, 2002, Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity, Genes Dev, 16, 1488, 10.1101/gad.985002 Shroyer, 2007, Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis, Gastroenterology, 132, 2478, 10.1053/j.gastro.2007.03.047 VanDussen, 2010, Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate, Dev Biol, 346, 215, 10.1016/j.ydbio.2010.07.026 Yang, 2001, Requirement of Math1 for secretory cell lineage commitment in the mouse intestine, Science, 294, 2155, 10.1126/science.1065718 Nomura, 1998, Clonal analysis of isolated intestinal metaplastic glands of stomach using X linked polymorphism, Gut, 42, 663, 10.1136/gut.42.5.663 Loeffler, 1997, Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization, J Theor Biol, 186, 41, 10.1006/jtbi.1996.0340 Gutierrez-Gonzalez, 2011, The clonal origins of dysplasia from intestinal metaplasia in the human stomach, Gastroenterology, 140, 1251, 10.1053/j.gastro.2010.12.051 McDonald, 2008, Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells, Gastroenterology, 134, 500, 10.1053/j.gastro.2007.11.035 Fujita, 2015, Identification and characterization of CXCR4-positive gastric cancer stem cells, PLoS One, 10, e0130808, 10.1371/journal.pone.0130808 Hashimoto, 2014, Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer, Gastric Cancer, 17, 97, 10.1007/s10120-013-0255-9 Wen, 2013, Prognostic value of cancer stem cell marker CD133 expression in gastric cancer: a systematic review, PLoS One, 8, e59154, 10.1371/journal.pone.0059154 Zhao, 2010, Aberrant expression of CD133 protein correlates with Ki-67 expression and is a prognostic marker in gastric adenocarcinoma, BMC Cancer, 10, 218, 10.1186/1471-2407-10-218 Ghaffarzadehgan, 2008, Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance, World J Gastroenterol, 14, 6376, 10.3748/wjg.14.6376 da Cunha, 2010, De novo expression of CD44 variants in sporadic and hereditary gastric cancer, Lab Invest, 90, 1604, 10.1038/labinvest.2010.155 Hirata, 2013, CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence, Br J Cancer, 109, 379, 10.1038/bjc.2013.314 Hutz, 2014, The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells, Carcinogenesis, 35, 942, 10.1093/carcin/bgt410 Matsuoka, 2012, Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma, J Surg Res, 174, 130, 10.1016/j.jss.2010.11.903 Otsubo, 2008, SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis, Br J Cancer, 98, 824, 10.1038/sj.bjc.6604193 Sarkar, 2016, Sox2 suppresses gastric tumorigenesis in mice, Cell Rep, 16, 1929, 10.1016/j.celrep.2016.07.034 Wang, 2015, SOX2, a predictor of survival in gastric cancer, inhibits cell proliferation and metastasis by regulating PTEN, Cancer Lett, 358, 210, 10.1016/j.canlet.2014.12.045 Li, 2015, Gastric tumor-initiating CD44+ cells and epithelial-mesenchymal transition are inhibited by gamma-secretase inhibitor DAPT, Oncol Lett, 10, 3293, 10.3892/ol.2015.3727 Konishi, 2016, Notch1 directly induced CD133 expression in human diffuse type gastric cancers, Oncotarget, 7, 56598, 10.18632/oncotarget.10967 Carulli, 2015, Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration, Dev Biol, 402, 98, 10.1016/j.ydbio.2015.03.012 Fre, 2011, Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice, PLoS One, 6, e25785, 10.1371/journal.pone.0025785 Riccio, 2008, Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2, EMBO Rep, 9, 377, 10.1038/embor.2008.7 Tran, 2013, Blockade of individual Notch ligands and receptors controls graft-versus-host disease, J Clin Invest, 123, 1590, 10.1172/JCI65477 Wu, 2010, Therapeutic antibody targeting of individual Notch receptors, Nature, 464, 1052, 10.1038/nature08878 Barker, 2009, Crypt stem cells as the cells-of-origin of intestinal cancer, Nature, 457, 608, 10.1038/nature07602 Powell, 2014, Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis, Am J Physiol Gastrointest Liver Physiol, 307, G16, 10.1152/ajpgi.00358.2013 Fearon, 2011, Molecular genetics of colorectal cancer, Annu Rev Pathol, 6, 479, 10.1146/annurev-pathol-011110-130235 Arnason, 2014, Morphology and natural history of familial adenomatous polyposis-associated dysplastic fundic gland polyps, Histopathology, 65, 353, 10.1111/his.12393