Normotensive renal failure in systemic sclerosis
Tóm tắt
Of 140 patients with “scleroderma renal crisis” encountered during a 33‐year period, 15 of 131 (11%) whose blood pressures were recorded were normotensive during this complication. In comparison with 116 patients with hypertension, the normotensive patients significantly more often had microangiopathic hemolytic anemia (90% versus 38%) and thrombocytopenia (83% versus 21%). Pulmonary hemorrhage occurred in 6 normotensive patients. More normotensive patients had received high doses of corticosteroids (prednisone gE;30 mg/day) during the 2 months immediately preceding renal crisis (64% versus 16%). A role for corticosteroids in precipitating renal crisis is suggested. The 12‐month survival was significantly reduced in the normotensive patients (13% versus 35%).
Từ khóa
Tài liệu tham khảo
Auspitz H, Ein Beitrag zur Lehre vom Haut‐Sklerem der Erwachsenen, Wien Med Wochenschr, 13, 739
Johnson SJ, 1980, Development of scleroderma renal failure without severe hypertension: five cases (abstract), Arthritis Rheum, 23, 698
Medsger TA, 1980, The natural history of skin involvement in progressive systemic sclerosis (abstract), Arthritis Rheum, 23, 720
Bagnall AW, 1954, The development of fatal “malignant” hypertension in a case of diffuse systemic sclerosis (scleroderma) in the course of treatment with adrenocorticotropin (abstract), Clin Res, 2, 145
Bartels ED, 1955, Renal affection complicating scleroderma, Acta Pathol Microbiol Scand, 150, 174
Selye H, 1942, Production of nephrosclerosis by overdosage with desoxycorticosterone acetate, Can Med Assoc J, 47, 515
Hay EC, 1946, The assay of nephrosclerosis producing anterior pituitary preparations, Am J Physiol, 147, 299, 10.1152/ajplegacy.1946.147.2.299
Baylis C, 1978, Mechanism of the glucocorticoid‐induced increase in glomerular filtration rate, Am J Physiol, 234, F166
Crutchley DJ, 1985, Glucocorticoid modulation of prostacyclin production in cultured bovine pulmonary endothelial cells, J Pharmacol Exp Ther, 233, 650
DeCaterina R, 1986, Modulation of arachidonic acid metabolism in human endothelial cells by glucocorticoids, Thromb Haemost, 55, 369, 10.1055/s-0038-1661566