Normal Structure, Function, and Histology of the Spleen

Toxicologic Pathology - Tập 34 Số 5 - Trang 455-465 - 2006
Mark F. Cesta1
1Integrated Laboratory Systems, Inc., Durham, North Carolina 27713, USA

Tóm tắt

The spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to blood-borne antigens and for filtering the blood of foreign material and old or damaged red blood cells. These functions are carried out by the 2 main compartments of the spleen, the white pulp (including the marginal zone) and the red pulp, which are vastly different in their architecture, vascular organization, and cellular composition. The morphology of these compartments is described and, to a lesser extent, their functions are discussed. The variation between species and effects of aging and genetics on splenic morphology are also discussed.

Từ khóa


Tài liệu tham khảo

10.1177/002215540405201005

Bell EB, 1987, J Immunol, 139, 1379, 10.4049/jimmunol.139.5.1379

10.1002/aja.1001610205

10.1016/0047-6374(83)90004-0

Custer RP, 1985, Am J Pathol, 120, 464

10.1007/978-3-642-84110-1_28

Hanes MA, 2005, The Laboratory Rat, 733

HoganEsch H, 2001, Pathobiology of the Aging Dog, 1, 127

Kuper DF, 2002, Handbook of Toxicologic Pathology, 2, 585, 10.1016/B978-012330215-1/50040-5

Losco P, 1992, Pathobiology of the Aging Rat, 1, 75

10.1007/BF00221456

10.1038/nri1669

Nicander L, 1993, Textbook of Veterinary Histology, 120

10.1046/j.1365-2567.2002.01443.x

10.1354/vp.41-2-95

10.1002/aja.1001810303

10.1002/ar.1092150304

10.1007/BF00214803

10.1002/jmor.1051780204

10.1002/jmor.1051860103

10.1002/jmor.1051860102

Schmidt EE, 1993, Scanning Microsc, 7, 613

10.1354/vp.43-4-401

10.1002/aja.1000870103

Stefanski SA, 1990, Pathology of the Fisher Rat, 369

10.1016/B978-012330215-1/50041-7

Van Rees EP, 1996, Pathobiology of the Aging Mouse, 1, 173

Ward JM, 1999, Pathology of the Mouse, 333

Thông tin
Thông tin xuất bản

Toxicologic Pathology

Tập 34 Số 5

455-465

Thông tin tác giả