Normal Development of the Corpus Callosum and Evolution of Corpus Callosum Sexual Dimorphism in Infancy

Journal of Ultrasound in Medicine - Tập 37 Số 4 - Trang 869-877 - 2018
Chaw‐Liang Chang1,2,3, Nan‐Chang Chiu4,5, Yichen Yang2, Che‐Sheng Ho4,5, Kun‐Long Hung6,3
1Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan
2Department of Center for Medical Education and Research, Cathay General Hospital, Hsinchu, Taiwan
3Department of Pediatrics, Cathay General Hospital, Hsinchu, Taiwan
4Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan
5Department of Pediatrics, Mackay Junior College of Medicine, Nursing, and Management, New Taipei City, Taiwan Department of Pediatrics (K.-L.H.), Cathay General Hospital, Taipei, Taiwan
6Department of Pediatrics School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

Tóm tắt

ObjectivesThe aim of this study was to establish reference ranges for the corpus callosum in infancy and to clarify how sexual dimorphism evolves between the fetal stage and infancy.MethodsNormal sonograms from cerebral ultrasonographic examinations of 1‐ to 6‐month‐old healthy full‐term infants were selected. The length and thickness of the corpus callosum were determined, and the effect of sex on these values was analyzed. Studies on corpus callosum sexual dimorphism were reviewed.ResultsIn total, sonograms from 236 1‐ to 6‐month‐old infants (120 male and 116 female) were collected, and the typical values (5th–95th percentiles) of the corpus callosum were determined for each group. During the first 2 months, with and without brain size adjustment, the corpus callosum in female infants was significantly thicker than that in male infants (mean thickness ± SD: 1 month, male infant, 1.8 ± 0.3 mm; female infant, 2.1 ± 0.3 mm; P = .005; 2 months, male infant, 1.8 ± 0.2 mm; female infant, 2.0 ± 0.3 mm; P = .002). The corpus callosum thickness of male and female infants had no significant differences after 2 months of age. Sexual dimorphism was not detected in corpus callosum length.ConclusionsOur study provides reference data on typical corpus callosum development in infants. In the fetal period and early infancy, the corpus callosum in female infants is thicker than that in male infants. From 3 months onward, the corpus callosum sexual dimorphism becomes insignificant throughout childhood. The evolvement of corpus callosum sexual dimorphism suggests that maternal factors may influence brain development.

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Thông tin xuất bản

Journal of Ultrasound in Medicine

Tập 37 Số 4

869-877

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