Norlignan derivatives from Curculigo crassifolia and their DPPH radical scavenging activity
Tóm tắt
A novel norlignan derivative, crassifogenin C (1), and a known compound, curcapital (2), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data. Curcapital (2) was isolated from this plant for the first time. The free radical scavenging activity of the isolated compounds along with crassifoside E (3) and crassifoside F (4), which were reported previously, was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All compounds showed strong radical scavenging activity. The primary structure-activity relationship is also discussed.
Tài liệu tham khảo
Blois, M. S., Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199–1200 (1958).
Chang, W. L., Chen, C. H., and Lee, S. S., Three novel constituents from Curculigo capitulata and revision of C-2 stereochemistry in nyasicoside. J. Nat. Prod., 62, 734–739 (1999).
Institutum Botanicum Kunmingense, Academiae Sinicae. Flora Yunnanica. Beijing: Science Press, Vol. 6, pp. 819–828 (1995).
Li, N., Chen, J. J., and Zhou, J., Four new phenolic compounds from Curculigo crassifolia (Hypoxidaceae). Helv. Chim. Acta, 87, 845–850 (2004).
Li, N., Chen, J. J., and Zhou, J., Two new phenolic glycosides from rhizomes of Curculigo crassifolia. Z. Naturforsch. B., 61b, 611–614 (2006).
Li, N., Wang, K. J., Chen, J. J., and Zhou, J., Two novel glucosylfused compounds from Curculigo crassifolia (Hypoxidaceae). Tetrahedron Lett., 46, 6445–6447 (2005).
Wang, K. J. and Li, N., Antioxidant Phenolic Compounds from Rhizomes of Curculigo crassifolia. Arch. Pharm. Res., 30, 8–12 (2007).
Yoshida, T., Mori, K., Hatano, T., Okumura, T., Uehara, I., Komagoe, K., Fujita, Y., and Okuda, T., Studies on inhibition mechanism of autoxidation by tannins and flavonoids. V Radical-scavenging effects of tannins and related polyphenols on 1, 1-diphenyl-2-picrylhydrzyl radical. Chem. Pharm. Bull., 37, 1919–1921 (1989).