Nonsteroidal Anti-inflammatory Drugs

Aarons, 1983, The binding of ibuprofen to plasma proteins, Eur J Clin Pharmacol, 25, 815, 10.1007/BF00542526 Abas, 1987, Enantioselective disposition of 2-arylpropionic acid nonsteroidal antiinflammatory drugs. IV. Ketoprofen disposition, J Pharmacol Exp Ther, 240, 637 Abramson, 1989, The mechanisms of action of nonsteroidal anti-inflammatory drugs, Arthritis Rheum, 32, 1, 10.1002/anr.1780320102 Adams, 1976, Pharmacological differences between the optical isomers of ibuprofen: Evidence for the metabolic inversion of the (-) isomer, J Pharm Pharmacol, 28, 256, 10.1111/j.2042-7158.1976.tb04144.x Aggeler, 1967, Potentiation of anticoagulant effect of warfarin by phenylbutazone, N Engl J Med, 276, 496, 10.1056/NEJM196703022760904 Albert, 1984, Effects of age on the clinical pharmacokinetics of ibuprofen, Am J Med, 77, 47, 10.1016/S0002-9343(84)80018-2 Albert, 1984, Pharmacokinetics of ibuprofen, Am J Med, 77, 40, 10.1016/S0002-9343(84)80017-0 Andreasen, 1981, Hypoglycemia induced by azapropazone-tolbutamide interaction, J Clin Pharmacol, 12, 582 Ariens, 1983, Stereoselectivity of bioactive agents: General aspects, Stereochemistry and Biological Activity of Drugs, 11 Ariens, 1984, Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology, Eur J Clin Pharmacol, 26, 663, 10.1007/BF00541922 Ariens, 1987, Implications of the neglect of stereochemistry in pharmacokinetics and clinical pharmacology, Drug Intell Clin Pharm, 21, 827, 10.1177/106002808702101013 Ariens, 1988, Stereoselectivity of bioactive xenobiotics, Biochem Pharmacol, 37, 9, 10.1016/0006-2952(88)90749-6 Aronoff, 1982, Benoxaprofen kinetics in renal impairment, Clin Pharmacol Ther, 32, 190, 10.1038/clpt.1982.146 Baber, 1978, The interaction between indomethacin and probenecid, Clin Pharmacol Ther, 24, 298, 10.1002/cpt1978243298 Baum, 1985, Utilization of nonsteroidal antiinflammatory drugs, Arthritis Rheum, 28, 686, 10.1002/art.1780280613 Beard, 1987, Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly, Arch Intern Med, 147, 1621, 10.1001/archinte.1987.00370090097017 Blackshear, 1983, Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs, Arch Intern Med, 143, 1130, 10.1001/archinte.1983.00350060052007 Blackshear, 1985, Renal complications of nonsteroidal antiinflammatory drugs: Identification and monitoring of those at risk, Semin Arthritis Rheum, 14, 163, 10.1016/0049-0172(85)90035-6 Bonney, 1986, Renal safety of two analgesics used over the counter: Ibuprofen and aspirin, Clin Pharmacol Ther, 40, 373, 10.1038/clpt.1986.193 Bortnichak, 1986, Piroxicam in recent epidemiologic studies, Am J Med, 81, 44 Brater, 1985, Effects of ibuprofen, naproxen, and sulindac on prostaglandins in man, Kidney Int, 27, 66, 10.1038/ki.1985.11 Brater, 1986, Drug-drug and drug-disease interactions with nonsteroidal antiinflammatory drugs, Am J Med, 80, 62, 10.1016/0002-9343(86)90933-2 Burns, 1965, Enzyme stimulation and inhibition in the metabolism of drugs, Proc R Soc Med, 58, 955 Caldwell, 1983, Interrelationships between xenobiotic metabolism and lipid biosynthesis, Biochem Pharmacol, 32, 1667, 10.1016/0006-2952(83)90107-7 Caradoc-Davies, 1984, Nonsteroidal anti-inflammatory drugs, arthritis, and gastrointestinal bleeding in elderly in-patients, Age Aging, 13, 295, 10.1093/ageing/13.5.295 Carson, 1987, The association of nonsteroidal anti-inflammatory drugs with upper gastrointestinal tract bleeding, Arch Intern Med, 147, 85, 10.1001/archinte.1987.00370010087021 Castleden, 1977, The effect of ageing on drug absorption from the gut, Age Aging, 6, 138, 10.1093/ageing/6.3.138 Cayen, 1989, World Pharmaceutical Market Review, Bethesda, International Society for the Study of Xenobiotics Newsletter, 8, 12 Champion, 1987, Drug interactions with nonsteroidal antiinflammatory drugs, 245 Ciabattoni, 1984, Effects of sulindac and ibuprofen in patients with chronic glomerular disease: Evidence for the dependence of renal function on prostacyclin, N Engl J Med, 310, 279, 10.1056/NEJM198402023100502 Clive, 1984, Renal syndromes associated with nonsteroidal anti-inflammatory drugs, N Engl J Med, 310, 563, 10.1056/NEJM198403013100905 Collins, 1988, Prevalence of selected chronic conditions, United States, 1983-85 Cox, 1984, Ibuprofen stereoisomer hepatic clearance and distribution in normal and fatty in situ perfused rat liver, J Pharmacol Exp Ther, 232, 636 Cuny, 1979, Pharmacokinetics of salicylates in elderly, Gerontology, 25, 49, 10.1159/000212320 Darnell, 1986, Medication use by ambulatory elderly, J Am Geriatr Soc, 34, 1, 10.1111/j.1532-5415.1986.tb06332.x Darragh, 1985, Single-dose and steady-state pharmacokinetics of piroxicam in elderly vs. young adults, Eur J Clin Pharmacol, 28, 305, 10.1007/BF00543328 Davies, 1983, Review of the animal and clinical pharmacology of diflunisal, Pharmacotherapy, 3, 9S, 10.1002/phar.1983.3.2p2.9 Day, 1987, Variations in response to non-steroidal anti-inflammatory drugs, Br J Clin Pharmacol, 23, 655, 10.1111/j.1365-2125.1987.tb03098.x Day, 1987, Clinical pharmacology of non-steroidal anti inflammatory drugs, Pharmacol Ther, 33, 383, 10.1016/0163-7258(87)90072-6 Day, 1988, Variability in response to NSAIDs—fact or fiction?, Drugs, 36, 643, 10.2165/00003495-198836060-00001 Drayer, 1986, Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans: An overview, Clin Pharmacol Ther, 40, 125, 10.1038/clpt.1986.150 Duggan, 1977, Identification of the biologically active form of sulindac, J Pharmacol Exp Ther, 201, 8 Durao, 1977, Modification by indomethacin of the blood pressure lowering effect of pindolol and propranolol in conscious rabbits, Eur J Pharmacol, 43, 377, 10.1016/0014-2999(77)90044-9 Durao, 1977, Modification of antihypertensive effect of ݭ adrenoceptor-blocking agents by inhibition of endogenous prostaglandin synthesis, Lancet, 2, 1005, 10.1016/S0140-6736(77)92899-9 Durning, 1974, Body fat assessed from total body density and its estimation from skinfold thickness: Measurements in 481 men and women aged from 16 to 72 years, Br J Nutr, 32, 77, 10.1079/BJN19740060 Easton, 1980, Hypertensive reaction with sulindac, Can Med Assoc J, 122, 1273 Edwards, 1985, Factors affecting the kinetics of two benzothiazine non-steroidal anti-inflammatory medicines, piroxicam and isoxicam, Eur J Clin Pharmacol, 28, 689, 10.1007/BF00607917 Ekstrand, 1979, Concentration dependent plasma protein binding of salicylate in rheumatoid patients, Clin Pharmacokinet, 4, 137, 10.2165/00003088-197904020-00006 Elliot, 1962, Reduced adrenocortical steroid excretion rates in man following aspirin administration, Metabolism, 11, 1015 Eriksson, 1989, Influence of renal failure, rheumatoid arthritis and old age on the pharmacokinetics of diflunisal, Eur J Clin Pharmacol, 36, 165, 10.1007/BF00609190 Evans, 1988, Stereoselective drug disposition: Potential for misinterpretation of drug disposition data, Br J Clin Pharmacol, 26, 771, 10.1111/j.1365-2125.1988.tb05318.x Faed, 1984, Properties of acyl glucuronides: Implications for studies of the pharmacokinetics and metabolism of acidic drugs, Drug Metab Rev, 15, 1213, 10.3109/03602538409033562 Favre, 1982, Reversible acute renal failure from combined triamterene and indomethacin, Ann Intern Med, 96, 317, 10.7326/0003-4819-96-3-317 1989, FDA Drug Bulletin, Labeling Revisions for NSAIDs, 19, 3 Fournel, 1986, The metabolic inversion of 2-phenylpropionic acid in rat, mouse and rabbit, Biochem Pharmacol, 35, 4153, 10.1016/0006-2952(86)90689-1 Fox, 1984, Nonsteroidal anti-inflammatory drugs and renal disease, JAMA, 251, 1299, 10.1001/jama.1984.03340340039023 Fraser, 1980, Displacement of phenytoin from plasma binding sites by salicylate, Clin Pharmacol Ther, 27, 165, 10.1038/clpt.1980.25 Friedel, 1988, Nabumetone—A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases, Drugs, 35, 504, 10.2165/00003495-198835050-00002 Frolich, 1979, Indomethacin increases plasma lithium, Br Med J, 1, 1115, 10.1136/bmj.1.6171.1115 Furst, 1979, Salicylate clearance, the resultant of protein binding and metabolism, Clin Pharmacol Ther, 26, 380, 10.1002/cpt1979263380 Furst, 1988, Clinically important interactions of nonsteroidal antiinflammatory drugs with other medications, J Rheumatol, 15, 58 Gaut, 1975, Stereoisomeric relationships among antiinflammatory activity, inhibition of platelet aggregation and inhibition of prostaglandin synthetase, Prostaglandins, 10, 59, 10.1016/S0090-6980(75)80062-1 Gerhard, 1975, Decreased serum salicylate concentrations in children with rheumatic fever treated with antacid, N Engl J Med, 293, 323, 10.1056/NEJM197508142930703 Gibaldi, 1981, Pharmacokinetic concepts—Drug binding, apparent volume of distribution, and clearance, Eur J Clin Pharmacol, 20, 299, 10.1007/BF00618781 Gonzalez, 1987, Tenoxicam—A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, Drugs, 34, 289, 10.2165/00003495-198734030-00001 Graham, 1989, Prevention of gastroduodenal injury induced by chronic nonsteroidal antiinflammatory drug therapy, Gastroenterology, 96, 675, 10.1016/S0016-5085(89)80064-2 Graham, 1988, Prevention of NSAID-induced gastric ulcer with misoprostol: Multicentre, double-blind, placebo-controlled trial, Lancet, 2, 1277, 10.1016/S0140-6736(88)92892-9 Green, 1977, Potentiation of warfarin by azapropazone, Br Med J, 2, 1532, 10.1136/bmj.1.6075.1532-b Green, 1983, Effects of diflunisal on platelet function and fecal blood loss, Pharmacotherapy, 3, 65S, 10.1002/phar.1983.3.2p2.65 Greenblatt, 1982, Drug disposition in old age, N Engl J Med, 306, 1081, 10.1056/NEJM198205063061804 Greenblatt, 1984, Absorption and disposition of ibuprofen in the elderly, Arthritis Rheum, 27, 1066, 10.1002/art.1780270918 Greenblatt, 1985, Oxaprozin pharmacokinetics in the elderly, Br J Pharmacol, 19, 373, 10.1111/j.1365-2125.1985.tb02656.x Griffin, 1988, Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons, Ann Intern Med, 109, 359, 10.7326/0003-4819-109-5-359 Guentert, 1988, The influence of cholestyramine on the elimination of tenoxicam and piroxicam, Eur J Clin Pharmacol, 34, 283, 10.1007/BF00540957 Guralnik, 1989, Aging in the eighties: The prevalence of comorbidity and its association with disability Hamdy, 1982, The pharmacokinetics of benoxaprofen in elderly subjects, Eur J Rheumatol Inflamm, 5, 69 Hayball, 1987, Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. III. Fenoprofen disposition, J Pharmacol Exp Ther, 240, 631 Ho, 1985, The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites, Br J Clin Pharmacol, 19, 675, 10.1111/j.1365-2125.1985.tb02695.x Hobbs, 1986, Piroxicam pharmacokinetics: Recent clinical results relating kinetics and plasma levels to age, sex, and adverse effects, Am J Med, 81, 22 Homon, 1982, Protein binding and clearance of oxaprozin, a highly bound anti-inflammatory agent, Agents Actions, 12, 211, 10.1007/BF01965148 Husby, 1986, The norwegian multicenter study, Am J Med, 81, 6 Hutt, 1983, The metabolic chiral inversion of 2-arylpropionic acids—A novel route with pharmacological consequences, J Pharm Pharmacol, 35, 693, 10.1111/j.2042-7158.1983.tb02874.x Johnson, 1985, A followup study of ibuprofen users, J Rheumatol, 12, 549 Kamal, 1982, Pharmacokinetic studies of benoxaprofen in geriatric patients, Eur J Rheumatol Inflamm, 5, 76 Kaojarern, 1983, Nephron site of effect of nonsteroidal anti-inflammatory drugs on solute excretion in humans, Am J Physiol, 244, F134 Kent, 1981, The ability of vascular tissue to produce prostacyclin decreases with age, Prostaglandins, 21, 483, 10.1016/0090-6980(81)90093-9 Kirchner, 1985, Prostaglandin inhibitors alter loop segment chloride uptake during furosem-ide diuresis, Am J Physiol, 248, F698 Koch, 1986, The management of chronic pain in office-based ambulatory care. National Ambulatory Medical Care Survey, 1985 Koch, 1987, Highlights of drug utilization in office practice. National Ambulatory Medical Care Survey, 1985 Koch-Weser, 1971, Drug interactions with coumarin anti-coagulants, N Engl J Med, 285, 487, 10.1056/NEJM197108262850905 Koch-Weser, 1976, Binding of drugs to serum albumin, N Engl J Med, 294, 165, 10.1056/NEJM197603042941005 Koopmans, 1985, Effects of indomethacin and sulindac on hydrochlorothiazide kinetics, Clin Pharmacol Ther, 37, 625, 10.1038/clpt.1985.100 Kuzuna, 1974, Biological activities of optical isomers of 6-chloro-S-cyclohexyl-indan-L-carboxylic acid (TAI-284: anti-inflammatory agent), Jpn J Pharmacol, 24, 695, 10.1254/jjp.24.695 Lam, 1988, Stereoselectivity: An issue of significant importance in clinical pharmacology, Pharmacotherapy, 8, 147, 10.1002/j.1875-9114.1988.tb04069.x Lamy, 1986, Renal effects of nonsteroidal anti-inflammatory drugs: Heightened risk to the elderly?, J Am Geriatr Soc, 34, 361, 10.1111/j.1532-5415.1986.tb04319.x Lee, 1985, Stereoselective disposition of ibuprofen enantiomers in man, Br J Clin Pharmacol, 19, 669, 10.1111/j.1365-2125.1985.tb02694.x Levy, 1961, The effect of dosage form upon the gastrointestinal absorption of salicylate, Can Med Assoc J, 85, 414 Levy, 1965, Pharmacokinetics of salicylate elimination in man, J Pharm Sci, 54, 959, 10.1002/jps.2600540703 Levy, 1972, Limited capacity for salicyl phenolic glucuronide formation and its effect on the kinetics of salicylate elimination in man, Clin Pharmacol Ther, 13, 258, 10.1002/cpt1972132258 Levy, 1980, Clinical pharmacokinetics of salicylates: A re-assessment, Br J Clin Pharmacol, 10, 285S, 10.1111/j.1365-2125.1980.tb01811.x Lewis, 1974, Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone, J Clin Invest, 53, 1607, 10.1172/JCI107711 Liegler, 1969, The effect of organic acids on renal clearance of methotrexate in man, Clin Pharmacol Ther, 10, 849, 10.1002/cpt1969106849 Lin, 1987, Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs, Clin Pharmacokinet, 12, 402, 10.2165/00003088-198712060-00002 Lopez-Ovejero, 1978, Effects of indomethacin alone and during diuretic or ݭadreno-receptor-blockade therapy on blood pressure and the renin system in essential hypertension, Clin Sci Mol Med, 55, 203 MacKichan, 1989, Protein binding drug displacement interactions—Fact or fiction?, Clin Pharmacokinet, 16, 65, 10.2165/00003088-198916020-00001 MacLeod, 1976, Pharmacodynamic and pharmacokinetic drug interactions with coumarin anticoagulants, Drugs, 11, 461, 10.2165/00003495-197611060-00006 Meffin, 1986, Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. I.2-phenylpropionic acid disposition, J Pharmacol Exp Ther, 238, 280 Menconi, 1987, A review: Prostaglandins, aging, and blood vessels, J Am Geriatr Soc, 35, 239, 10.1111/j.1532-5415.1987.tb02316.x Miners, 1982, The effect of sulphinpyrazone on oxidative drug metabolism in man: Inhibition of tolbutamide elimination, Eur J Clin Pharmacol, 22, 321, 10.1007/BF00548400 Montgomery, 1981, Increased serum salicylate metabolites with age in patients receiving chronic acetylsalicylic acid therapy, Gerontology, 27, 329, 10.1159/000212493 Montgomery, 1986, Salicylate metabolism: Effects of age and sex in adults, Clin Pharmacol Ther, 39, 571, 10.1038/clpt.1986.98 Moore, 1981, Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension, Hypertension, 3, 168, 10.1161/01.HYP.3.2.168 Mroszczak, 1987, Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharmacokinetics in animals and humans, Drug Metab Dispos, 15, 618 Murray, 1989, Risk of ibuprofen-associated renal impairment, Clin Pharmacol Ther, 45, 158 Muther, 1981, Aspirin-induced depression of glomerular filtration rate in normal humans: Role of sodium balance, Ann Intern Med, 94, 317, 10.7326/0003-4819-94-3-317 Netter, 1985, Salicylate kinetics in old age, Clin Pharmacol Ther, 38, 6, 10.1038/clpt.1985.124 Neuvonen, 1979, Antipyrine analgesics in patients on antiepileptic drug therapy, Eur J Clin Pharmacol, 15, 263, 10.1007/BF00618515 Nierenberg, 1983, Competitive inhibition of methotrexate accumulation in rabbit kidney slices by nonsteroidal anti-inflammatory drugs, J Pharmacol Exp Ther, 226, 1 Nies, 1983, Indomethacin-furosemide interaction: The importance of renal blood flow, J Pharmacol Exp Ther, 226, 27 Nilsen, 1985, Steady-state pharmacokinetics and serum protein binding of tiaprofenic acid in the elderly, Tiaprofenic Acid, Pharmacology and Pharmacokinetics, 79 Oates, 1988, Clinical implications of prostaglandin and thromboxane A2 formation, N Engl J Med, 319, 689, 10.1056/NEJM198809153191106 o’Neill, 1982, Disposition of zomepirac sodium in man, J Clin Pharmacol, 22, 470, 10.1002/j.1552-4604.1982.tb02637.x Ouslander, 1981, Drug therapy in the elderly, Ann Intern Med, 95, 711, 10.7326/0003-4819-95-6-711 Patrono, 1985, Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus, J Clin Invest, 76, 1011, 10.1172/JCI112053 Pedersen, 1982, Clinical pharmacokinetics and potentially important drug interactions of sulphinpyrazone, Clin Pharmacokinet, 7, 42, 10.2165/00003088-198207010-00003 Pedersen, 1984, Dose-related kinetics of aspirin: Presystemic acetylation of platelet cyclooxygenase, N Engl J Med, 311, 1206, 10.1056/NEJM198411083111902 Perucca, 1982, Pharmacokinetic interactions with antiepileptic drugs, Clin Pharmacokinet, 7, 57, 10.2165/00003088-198207010-00004 Perucca, 1981, Drug interactions with phenytoin, Drugs, 21, 120, 10.2165/00003495-198121020-00003 Pond, 1979, Mechanisms of inhibition of tolbutamide metabolism: Phenylbutazone, oxyphenbutazone, sulfaphenazole, Clin Pharmacol Ther, 22, 573, 10.1002/cpt1977225part1573 Prescott, 1969, Pharmacokinetic drug interactions, Lancet, 2, 1239, 10.1016/S0140-6736(69)90766-1 Preston, 1988, Variability in response to nonsteroidal antiinflammatory analgesics: Evidence from controlled clinical therapeutic trial of flurbiprofen in rheumatoid arthritis, Br J Clin Pharmacol, 26, 759, 10.1111/j.1365-2125.1988.tb05316.x Reeves, 1985, Nephrotoxicity from nonsteroidal anti-inflammatory drugs, South Med J, 78, 318, 10.1097/00007611-198503000-00021 Reimann, 1981, Effects of diclofenac on lithium kinetics, Clin Pharmacol Ther, 30, 348, 10.1038/clpt.1981.171 Richardson, 1985, Effects of age and sex on piroxicam, Clin Pharmacol Ther, 37, 13, 10.1038/clpt.1985.4 Rider, 1983, Comparison of fecal blood loss after use of aspirin and diflunisal, Pharmacotherapy, 3, 61S, 10.1002/phar.1983.3.2p2.61 Ritch, 1982, Pharmacokinetics of azapropazone in the elderly, Br J Clin Pharmacol, 14, 116, 10.1111/j.1365-2125.1982.tb04947.x Roberts, 1983, Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease, Eur J Clin Pharmacol, 25, 253, 10.1007/BF00543800 Rooney, 1986, Comparison of toxicity in methotrexate (MTX) treated RA patients also taking aspirin or other NSAID, Arthritis Rheum, 29, S576 Rossi, 1987, Ulcerogenicity of piroxicam: An analysis of spontaneously reported data, Br Med J, 294, 147, 10.1136/bmj.294.6565.147 Roth, 1978, Acetylation of the NH2-terminal serine of prostaglandin synthetase by aspirin, J Biol Chem, 253, 3782, 10.1016/S0021-9258(17)34756-7 Roth, 1987, Nonsteroidal anti-inflammatory drug gastropathy: Recognition and response, Arch Intern Med, 247, 2093, 10.1001/archinte.1987.00370120029008 Roth, 1988, Nonsteroidal anti-inflammatory drugs: Gastropathy, deaths, and medical practice, Ann Intern Med, 109, 353, 10.7326/0003-4819-109-5-353 Roth, 1989, Misoprostol heals gastroduodenal injury in patients with rheumatoid arthritis receiving aspirin, Arch Intern Med, 149, 775, 10.1001/archinte.1989.00390040017004 Rowland, 1967, Kinetics of acetylsalicylic acid disposition in man, Nature, 215, 413, 10.1038/215413a0 Rowland, 1972, Absorption kinetics of aspirin in man following oral administration of an aqueous solution, J Pharm Sci, 61, 379, 10.1002/jps.2600610312 Rowland, 1980, Plasma protein binding and therapeutic drug monitoring, Ther Drug Monit, 2, 29, 10.1097/00007691-198001000-00005 Rubin, 1983, Concentration-dependence of salicylate distribution, J Pharm Pharmacol, 35, 115, 10.1111/j.2042-7158.1983.tb04282.x Rugstad, 1986, The Norway study: Plasma concentrations, efficacy, and adverse events, Am J Med, 81, 11 Runkel, 1978, Naproxen-probenecid interaction, Clin Pharmacol Ther, 24, 708, 10.1002/cpt1978246706 Scatina, 1986, Etodolac kinetics in the elderly, Clin Pharmacol Ther, 39, 550, 10.1038/clpt.1986.94 Schmucker, 1979, Age-related changes in drug disposition, Pharmacol Rev, 30, 445 Sellers, 1970, Displacement of warfarin from human albumin by diazoxide and ethacrynic, mefanamic, and nalidixic acids, Clin Pharmacol Ther, 11, 524, 10.1002/cpt1970114524 Sellers, 1979, Plasma protein displacement interactions are rarely of clinical significance, Pharmacology, 18, 225, 10.1159/000137256 Shen, 1977, Chemical and biological studies on indomethacin, sulindac, and their analogues, 2 Shen, 1983, Chemical and pharmacological properties of diflunisal, Pharmacotherapy, 3, 3S, 10.1002/phar.1983.3.2p2.3 Sitar, 1985, Effects of age and disease on the pharmacokinetics and pharmacodynamics of sulindac, Clin Pharmacol Ther, 38, 228, 10.1038/clpt.1985.163 Stenderup, 1985, Pharmacokinetics of tolfenamic acid in patients with cirrhosis of the liver, Eur J Clin Pharmacol, 28, 573, 10.1007/BF00544069 Taha, 1985, Non-oliguric renal failure during treatment with mefanamic acid in elderly patients: A continuing problem, Br Med J, 291, 661, 10.1136/bmj.291.6496.661 Thyss, 1986, Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen, Lancet, 1, 256, 10.1016/S0140-6736(86)90786-5 Tobert, 1981, Effect of antacids on the bioavailability of diflunisal in the fasting and postprandial states, Clin Pharmacol Ther, 30, 385, 10.1038/clpt.1981.177 Tocco, 1975, Physiological disposition and metabolism of 5-(2’,4’-difluorophenyl) salicylic acid, a new salicylate, Drug Metab Dispos, 3, 453 Todd, 1985, Suprofen—A review of its pharmacodynamic and pharmacokinetic properties, and analgesic efficacy, Drugs, 30, 514, 10.2165/00003495-198530060-00004 Todd, 1988, Diclofenac sodium—A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, Drugs, 35, 244, 10.2165/00003495-198835030-00004 Tweeddale, 1973, Antagonism of spironolactone-induced natriuresis by aspirin in man, N Engl J Med, 289, 198, 10.1056/NEJM197307262890408 Umbenhauer, 1983, Diflunisal in the treatment of the pain of osteoarthritis: Summary of clinical studies, Pharmacotherapy, 3, 55S, 10.1002/phar.1983.3.2p2.55 Unworth, 1987, Renal impairment associated with nonsteroidal anti-inflammatory drugs, Ann Rheum Dis, 46, 233, 10.1136/ard.46.3.233 Upton, 1984, Naproxen pharmacokinetics in the elderly, Br J Clin Pharmacol, 18, 207, 10.1111/j.1365-2125.1984.tb02454.x Van Den Ouweland, 1988, Pharmacokinetics of high-dosage naproxen in elderly patients, Int J Clin Pharmacol Ther Toxicol, 26, 143 Verbeeck, 1988, Pathophysiologic factors affecting the pharmacokinetics of nonsteroidal antiinflammatory drugs, J Rheumatol, 15, 44 Verbeeck, 1986, Clinical pharmacokinetics of piroxicam, J Rheumatol, 13, 789 Verbeeck, 1984, Effect of age and sex on the plasma binding of acidic and basic drugs, Eur J Clin Pharmacol, 27, 91, 10.1007/BF02395213 Verbeeck, 1984, Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation, Br J Clin Pharmacol, 17, 783, 10.1111/j.1365-2125.1984.tb02421.x Vestal, 1978, Drug use in the elderly: A review of problems and special considerations, Drugs, 16, 358, 10.2165/00003495-197816040-00004 Walbridge, 1985, An interaction between lithium carbonate and piroxicam presenting as lithium toxicity, Br J Psychiatry, 147, 206, 10.1192/bjp.147.2.206 Wallace, 1987, Plasma protein binding of drugs in the elderly, Clin Pharmacokinet, 12, 41, 10.2165/00003088-198712010-00004 Walshe, 1979, Acute oliguric renal failure induced by indomethacin: Possible mechanism, Ann Intern Med, 91, 47, 10.7326/0003-4819-91-1-47 Walt, 1986, Rising frequency of ulcer perforation in elderly people in the United Kingdom, Lancet, 1, 489, 10.1016/S0140-6736(86)92940-5 Webster, 1985, Interactions of NSAIDs with diuretics and β-blockers. Mechanisms and clinical implications, Drugs, 30, 32, 10.2165/00003495-198530010-00004 Weinberg, 1985, Anuric renal failure precipitated by indomethacin and triamterene, Nephron, 40, 216, 10.1159/000183461 Wilkinson, 1987, Clearance approaches in pharmacology, Pharmacol Rev, 39, 1 Williams, 1985, Clinical significance of esterases in man, Clin Pharmacokinet, 10, 392, 10.2165/00003088-198510050-00002 Williams, 1982, Hydrochlorothiazide pharmacokinetics and pharmacologic effect: The influence of indomethacin, J Clin Pharmacol, 22, 32, 10.1002/j.1552-4604.1982.tb05705.x Williams, 1984, Naproxen disposition in patients with alcoholic cirrhosis, Eur J Clin Pharmacol, 27, 291, 10.1007/BF00542162 Wing, 1985, Verapamil disposition-effects of sulphinpyrazone and cimetidine, Br J Clin Pharmacol, 19, 385, 10.1111/j.1365-2125.1985.tb02658.x Woodhouse, 1987, The pharmacokinetics of non-steroidal anti-inflammatory drugs in the elderly, Clin Pharmacokinet, 12, 111, 10.2165/00003088-198712020-00002 Woolf, 1983, Pharmacokinetic observations on piroxicam in young adult, middle-aged and elderly patients, Br J Clin Pharmacol, 16, 433, 10.1111/j.1365-2125.1983.tb02191.x Zipser, 1979, Prostaglandins: Modulators of renal function and pressor resistance in chronic liver disease, J Clin Endocrinol Metab, 48, 895, 10.1210/jcem-48-6-895