Nonsteroidal Anti-inflammatory Drugs as Emerging Contaminants

Springer Science and Business Media LLC - Tập 89 Số 2 - Trang 148-163 - 2020
Elena A. Tyumina1, Grigory A. Bazhutin2, Antonio Gómez2, И. Б. Ившина2
1Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia
2Perm State University, 614990 Perm, Russia

Tóm tắt

Từ khóa


Tài liệu tham khảo

Agunbiade, F.O. and Moodley, B., Occurrence and distribution pattern of acidic pharmaceuticals in surface water, wastewater, and sediment of the Msunduzi River, Kwazulu-Natal, South Africa, Environ. Toxicol. Chem., 2016, vol. 35, pp. 36–46.

Aissaoui, S., Ouled-Haddar, H., Sifour, M., Harrouche, K., and Sghaier, H., Metabolic and co-metabolic transformation of diclofenac by Enterobacter hormaechei D15 isolated from activated sludge, Curr. Microbiol., 2017, vol. 74, pp. 381–388.

Alkimin, G.D., Daniel, D., Frankenbach, S., Serôdio, J., Soares, A.M.V.M., Barata, C., and Nunes, B., Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba,Sci. Total Environ., 2019, vol. 657, pp. 926–937.

Almeida, B., Oehmen, A., Marques, R., Brito, D., Carvalho, G., and Barreto Crespo, M.T., Modelling the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) by activated sludge and a pure culture, Bioresour. Technol., 2013, vol. 133, pp. 31–37.

Alsop, D. and Wilson, J.Y., Waterborne pharmaceutical uptake and toxicity is modified by pH and dissolved organic carbon in zebrafish, Aquat. Toxicol., 2019, vol. 210, pp. 11–18.

Anteneh, Y.S. and Franco, C.M.M., Whole cell Actinobacteria as biocatalysts, Front. Microbiol., 2019, vol. 10, article 77. https://doi.org/10.3389/fmicb.2019.00077

Aracagök, Y.D., Göker, H., and Cihangir, N., Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites, Z. Naturforsch. C, 2017, vol. 72, pp. 173–179.

aus der Beek, T., Weber, F.A., Bergmann, A., Hickmann, S., Ebert, I., Hein, A., and Küster, A., Pharmaceuticals in the environment–global occurrences and perspectives, Environ. Toxicol. Chem., 2016, vol. 35, pp. 823–835.

Baena-Nogueras, R.M., González-Mazo, E., and Lara-Martín, P.A., Degradation kinetics of pharmaceuticals and personal care products in surface waters: photolysis vs biodegradation, Sci. Total Environ., 2017, vols. 590–591, pp. 643–654.

Barenboim, G.M. and Chiganova, M.A., Wastewater and surface water contamination with pharmaceutical preparations, Voda: Khim. Ekol., 2012, no. 10, pp. 40–46.

Barenboim, G.M., Chiganova, M.A., and Berezovskaya, I.V., Contamination of surface water bodies by components of pharmaceuticals, Vodn. Khoz. Rossii: Problemy, Tekhnologii, Upravlenie, 2014, no. 3, pp. 131–141.

Barroso, P.J., Santos, J.L., Martín, J., Aparicio, I., and Alonso, E., Emerging contaminants in the atmosphere: Analysis, occurrence and future challenges, Crit. Rev. Environ. Sci. Technol., 2019, vol. 49, pp. 104–171.

Bashaar, M., Thawani, V., Hassali, M.A., and Saleem, F., Disposal practices of unused and expired pharmaceuticals among general public in Kabul, BMC Public Health, 2017, vol. 17, article 45. https://doi.org/10.1186/s12889-016-3975-z

Bessa, V.S., Moreira, I.S., Tiritan, M.E., and Castro, P.M.L., Enrichment of bacterial strains for the biodegradation of diclofenac and carbamazepine from activated sludge, Int. Biodeterior. Biodegrad., 2017, vol. 120, pp. 135–142.

Botero-Coy, A.M., Martínez-Pachón, D., Boix, C., Rincón, R.J., Castillo, N., Arias-Marín, L.P., Manrique-Losada, L., Torres-Palma, R., Moncayo-Lasso, A., and Hernández, F., An investigation into the occurrence and removal of pharmaceuticals in Colombian wastewater, Sci. Total Environ., 2018, vol. 642, pp. 842–853.

Bragança, I., Danko, A.S., Pacheco, J., Frascari, D., Delerue-Matos, C., and Domingues, V.F., Cometabolic degradation of anti-inflammatory and analgesic pharmaceuticals by a pentane enrichment culture, Water Air Soil Pollut., 2016, vol. 227, article 227. https://doi.org/10.1007/s11270-016-2933-9

Chen, G., Den Braver, M.W., Van Gestel, C.A.M., Van Straalen, N.M., and Roelofs, D., Ecotoxicogenomic assessment of diclofenac toxicity in soil, Environ. Pollut., 2015, vol. 199, pp. 253–260.

Chinnaiyan, P., Thampi, S.G., Kumar, M., and Mini, K.M., Pharmaceutical products as emerging contaminant in water: relevance for developing nations and identification of critical compounds for Indian environment, Environ. Monit. Assess., 2018, vol. 190, article 288. https://doi.org/10.1007/s10661-018-6672-9

Collard, H.J., Ji, K., Lee, S., Liu, X., Kang, S., Kho, Y., Ahn, B., Ryu, J., Lee, J., and Choi, K., Toxicity and endocrine disruption in zebrafish (Danio rerio) and two freshwater invertebrates (Daphnia magna and Moina macrocopa) after chronic exposure to mefenamic acid, Ecotoxicol. Environ. Saf., 2013, vol. 94, pp. 80–86.

Corcoll, N., Acuña, V., Barceló, D., Casellas, M., Guasch, H., Huerta, B., Petrovic, M., Ponsatí, L., Rodríguez-Mozaz, S., and Sabater, S., Pollution-induced community tolerance to non-steroidal anti-inflammatory drugs (NSAIDs) in fluvial biofilm communities affected by WWTP effluents, Chemosphere, 2014, vol. 112, pp. 185–193.

Cycoń, M., Borymski, S., Żołnierczyk, B., and Piotrowska-Seget, Z., Variable effects of non-steroidal anti-inflammatory drugs (NSAIDs) on selected biochemical processes mediated by soil microorganisms, Front. Microbiol., 2016, vol. 7, article 1969. https://doi.org/10.3389/fmicb.2016.01969

Czech, B., Jośko, I., and Oleszczuk, P., Ecotoxicological evaluation of selected pharmaceuticals to Vibrio fischeri and Daphnia magna before and after photooxidation process, Ecotoxicol. Environ. Saf., 2014, vol. 104, pp. 247–253.

De García, S.O., García-Encina, P.A., and Irusta-Mata, R., Dose-response behavior of the bacterium Vibrio fischeri exposed to pharmaceuticals and personal care products, Ecotoxicology, 2016, vol. 25, pp. 141–162.

Di Nica, V., Villa, S., and Finizio, A., Toxicity of individual pharmaceuticals and their mixtures to Aliivibrio fischeri: experimental results for single compounds and considerations of their mechanisms of action and potential acute effects on aquatic organisms, Environ. Toxicol. Chem., 2017, vol. 36, pp. 807–814.

Domaradzka, D., Guzik, U., Hupert-Kocurek, K., and Wojcieszyńska, D., Cometabolic degradation of naproxen by Planococcus sp. strain S5, Water Air Soil Pollut., 2015, vol. 226, article 297. https://doi.org/10.1007/s11270-015-2564-6

Domaradzka, D., Guzik, U., Hupert-Kocurek, K., and Wojcieszyńska, D., Toxicity of diclofenac and its biotransformation by Raoultella sp. DD4, Polish J. Environ. Stud., 2016, vol. 25, pp. 2211–2216.

Facey, S.J., Nebel, B.A., Kontny, L., Allgaier, M., and Hauer, B., Rapid and complete degradation of diclofenac by native soil microorganisms, Environ. Technol. Innov., 2018, vol. 10, pp. 55–61.

Geiger, E., Hornek-Gausterer, R., and Saçan, M.T., Single and mixture toxicity of pharmaceuticals and chlorophenols to freshwater algae Chlorella vulgaris,Ecotoxicol. Environ. Saf., 2016, vol. 129, pp. 189–198.

Gómez-Oliván, L.M., Neri-Cruz, N., Galar-Martínez, M., Islas-Flores, H., and García-Medina, S., Binary mixtures of diclofenac with paracetamol, ibuprofen, naproxen, and acetylsalicylic acid and these pharmaceuticals in isolated form induce oxidative stress on Hyalella azteca,Environ. Monit. Assess., 2014, vol. 186, pp. 7259–7271.

Gonda, S., Kiss-Szikszai, A., Szucs, Z., Balla, B., and Vasas, G., Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L., Int. Biodeterior. Biodegrad., 2016, vol. 108, pp. 115–121.

González-Alonso, S., Merino, L.M., Esteban, S., López de Alda, M., Barceló, D., Durán, J.J., López-Martínez, J., Aceña, J., Pérez, S., Mastroianni, N., Silva, A., Catalá, M., and Valcárcel, Y., Occurrence of pharmaceutical, recreational and psychotropic drug residues in surface water on the northern Antarctic Peninsula region, Environ. Pollut., 2017, vol. 229, pp. 241–254.

Górny, D., Guzik, U., Hupert-Kocurek, K., and Wojcieszyńska, D., Naproxen ecotoxicity and biodegradation by Bacillus thuringiensis B1(2015b) strain, Ecotoxicol. Environ. Saf., 2019, vol. 167, pp. 505–512.

Grenni, P., Patrolecco, L., Ademollo, N., Di Lenola, M., and Barra Caracciolo, A., Capability of the natural microbial community in a river water ecosystem to degrade the drug naproxen, Environ. Sci. Pollut. Res., 2014, vol. 21, pp. 13470–13479.

Gumbi, B.P., Moodley, B., Birungi, G., and Ndungu, P.G., Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry, Chemosphere, 2017, vol. 168, pp. 1042–1050.

Hata, T., Kawai, S., Okamura, H., and Nishida, T., Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation, Biodegradation, 2010, vol. 21, pp. 681–689.

HELCOM, BASE project 2012−2014: PilotActivity to Identify Sources and Flow Patterns of Pharmaceuticals in St. Petersburg to the Baltic Sea, 2014.

He, Y., Langenhoff, A.A.M., Comans, R.N.J., Sutton, N.B., and Rijnaarts, H.H.M., Effects of dissolved organic matter and nitrification on biodegradation of pharmaceuticals in aerobic enrichment cultures, Sci. Total Environ., 2018, vol. 630, pp. 1335–1342.

Hignite, C. and Azarnoff, D.L., Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicylic acid in sewage water effluent, Life Sci., 1977, vol. 20, pp. 337–341.

Ikkere, L.E., Perkons, I., Sire, J., Pugajeva, I., and Bartkevics, V., Occurrence of polybrominated diphenyl ethers, perfluorinated compounds, and nonsteroidal anti-inflammatory drugs in freshwater mussels from Latvia, Chemosphere, 2018, vol. 213, pp. 507–516.

Ismail, M.M., Essam, T.M., Ragab, Y.M., and Mourad, F.E., Biodegradation of ketoprofen using a microalgal–bacterial consortium, Biotechnol. Lett., 2016, vol. 38, pp. 1493–1502.

Ivshina, I.B., Mukhutdinova, A.N., Tyumina, H.A., Vikhareva, H.V., Suzina, N.E., El’-Registan, G.I., and Mulyukin, A.L., Drotaverine hydrochloride degradation using cyst-like dormant cells of Rhodococcus ruber,Curr. Microbiol., 2015, vol. 70, pp. 307–314.

Ivshina, I.B., Tyumina, E.A., and Vikhareva, E.V., Biodegradation of emerging pollutants: focus on pharmaceuticals, Microbiol. Australia, 2018, vol. 39, pp. 117–122.

Ivshina, I.B., Tyumina, E.A., Kuzmina, M.V., and Vikhareva, E.V., Features of diclofenac biodegradation by Rhodococcus ruber IEGM 346, Sci. Rep., 2019, vol. 9, article 9159. https://doi.org/10.1038/s41598-019-45732-9

Ivshina, I.B., Vikhareva, E.V, Richkova, M.I., Mukhutdinova, A.N., and Karpenko, J.N., Biodegradation of drotaverine hydrochloride by free and immobilized cells of Rhodococcus rhodochrous IEGM 608, World J. Microbiol. Biotechnol., 2012, vol. 28, pp. 2997–3006.

Jewell, K.S., Falås, P., Wick, A., Joss, A., and Ternes, T.A., Transformation of diclofenac in hybrid biofilm–activated sludge processes, Water Res., 2016, vol. 105, pp. 559–567.

Jiang, C., Geng, J., Hu, H., Ma, H., Gao, X., and Ren, H. Impact of selected non-steroidal anti-inflammatory pharmaceuticals on microbial community assembly and activity in sequencing batch reactors, PLoS One, 2017, vol. 12, article e0179236. https://doi.org/10.1371/journal.pone.0179236

Kot-Wasik, A., Jakimska, A., and Śliwka-Kaszyńska, M., Occurrence and seasonal variations of 25 pharmaceutical residues in wastewater and drinking water treatment plants, Environ. Monit. Assess., 2016, vol. 188, article 661. https://doi.org/10.1007/s10661-016-5637-0

Koumaki, E., Mamais, D., and Noutsopoulos, C., Environmental fate of non-steroidal anti-inflammatory drugs in river water/sediment systems, J. Hazard. Mater., 2017, vol. 323, pp. 233–241.

Kwak, K., Ji, K., Kho, Y., Kim, P., Lee, J., Ryu, J., and Choi, K., Chronic toxicity and endocrine disruption of naproxen in freshwater waterfleas and fish, and steroidogenic alteration using H295R cell assay, Chemosphere, 2018, vol. 204, pp. 156–162.

Langenhoff, A., Inderfurth, N., Veuskens, T., Schraa, G., Blokland, M., Kujawa-Roeleveld, K., and Rijnaarts, H., Microbial removal of the pharmaceutical compounds ibuprofen and diclofenac from wastewater, Biomed. Res. Int., 2013, vol. 2013. article 325806.https://doi.org/10.1155/2013/325806

Lazarenko, L.V., Liver and Pancreas Drug Diseases in Animals Treated with Nonsteroid Antiinflammatory Drugs, Perm: Perm Inst. FSIN RF, 2016

Liu, W., Sutton, N.B., Rijnaarts, H.H.M., and Langenhoff, A.A.M., Anaerobic biodegradation of pharmaceutical compounds coupled to dissimilatory manganese (IV) or iron (III) reduction, J. Hazard. Mater., 2018. https://doi.org/10.1016/j.jhazmat.2018.04.078

Liu, Y., Wang, L., Pan, B., Wang, C., Bao, S., and Nie, X., Toxic effects of diclofenac on life history parameters and the expression of detoxification-related genes in Daphnia magna,Aquat. Toxicol., 2017, vol. 183, pp. 104–113.

Marchlewicz, A., Domaradzka, D., Guzik, U., and Wojcieszyńska, D., Bacillus thuringiensis B1(2015b) is a Gram-positive bacteria able to degrade naproxen and ibuprofen, Water. Air. Soil Pollut., 2016, vol. 227, article 197. https://doi.org/10.1007/s11270-016-2893-0

Marchlewicz, A., Guzik, U., Hupert-Kocurek, K., Nowak, A., Wilczyńska, S., and Wojcieszyńska, D. Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1 (2015b), Environ. Sci. Pollut. Res., 2017a, vol. 24, pp. 7572–7584.

Marchlewicz, A., Guzik, U., Smułek, W., and Wojcieszyńska, D., Exploring the degradation of ibuprofen by Bacillus thuringiensis B1(2015b): the new pathway and factors affecting degradation, Molecules, 2017b, vol. 22, article E1676. https://doi.org/10.3390/molecules22101676

Marco-Urrea, E., Pérez-Trujillo, M., Blánquez, P., Vicent, T., and Caminal, G., Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR, Bioresour. Technol., 2010a, vol. 101, pp. 2159–2166.

Marco-Urrea, E., Pérez-Trujillo, M., Cruz-Morató, C., Caminal, G., and Vicent, T., Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR, J. Hazard. Mater., 2010b, vol. 176, pp. 836–842.

Marco-Urrea, E., Pérez-Trujillo, M., Cruz-Morató, C., Caminal, G., and Vicent, T., White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR, Chemosphere, 2010c, vol. 78, pp. 474–481.

Mezzelani, M., Gorbi, S., Fattorini, D., D’Errico, G., Consolandi, G., Milan, M., Bargelloni, L., and Regoli, F., Long-term exposure of Mytilus galloprovincialis to diclofenac, ibuprofen and ketoprofen: insights into bioavailability, biomarkers and transcriptomic changes, Chemosphere, 2018, vol. 198, pp. 238–248.

Moreira, I.S., Bessa, V.S., Murgolo, S., Piccirillo, C., Mascolo, G., and Castro, P.M.L., Biodegradation of diclofenac by the bacterial strain Labrys portucalensis F11, Ecotoxicol. Environ. Saf., 2018, vol. 152, pp. 104–113.

Murdoch, R.W. and Hay, A.G., The biotransformation of ibuprofen to trihydroxyibuprofen in activated sludge and by Variovorax Ibu-1, Biodegradation, 2015, vol. 26, pp. 105–113.

Nguyen, L.N., Nghiem, L.D., Kumar Pramanik, B., and Oh, S., Cometabolic biotransformation and impacts of the anti-inflammatory drug diclofenac on activated sludge microbial communities, Sci. Total Environ., 2019, vol. 657, pp. 739–745.

Nieto, E., Hampel, M., González-Ortegón, E., Drake, P., and Blasco, J., Influence of temperature on toxicity of single pharmaceuticals and mixtures, in the crustacean A. desmarestii,J. Hazard. Mater., 2016, vol. 313, pp. 159–169.

Novoa-Luna, K.A., Romero-Romero, R., Natividad-Rangel, R., Galar-Martínez, M., SanJuan-Reyes, N., García-Medina, S., Martínez-Vieyra, C., Neri-Cruz, N., and Gómez-Oliván, L.M., Oxidative stress induced in Hyalella azteca by an effluent from a NSAID-manufacturing plant in Mexico, Ecotoxicology, 2016, vol. 25, pp. 1288–1304.

Olicón-Hernández, D.R., Camacho-Morales, R.L., Pozo, C., González-López, J., and Aranda, E., Evaluation of diclofenac biodegradation by the ascomycete fungus Penicillium oxalicum at flask and bench bioreactor scales, Sci. Total Environ., 2019, vol. 662, pp. 607–614.

Palli, L., Castellet-Rovira, F., Pérez-Trujillo, M., Caniani, D., Sarrà-Adroguer, M., and Gori, R., Preliminary evaluation of Pleurotus ostreatus for the removal of selected pharmaceuticals from hospital wastewater, Biotechnol. Prog., 2017, vol. 33, pp. 1529–1537.

Palyzová, A., Zahradník, J., Marešová, H., and Řezanka, T., Characterization of the catabolic pathway of diclofenac in Raoultella sp. KDF8, Int. Biodeterior. Biodegrad., 2019, vol. 137, pp. 88–94.

Park, J., Yamashita, N., Wu, G., and Tanaka, H., Removal of pharmaceuticals and personal care products by ammonia oxidizing bacteria acclimated in a membrane bioreactor: contributions of cometabolism and endogenous respiration, Sci. Total Environ., 2017, vol. 605–606, pp. 18–25.

Parolini, M., Binelli, A., and Provini, A., Chronic effects induced by ibuprofen on the freshwater bivalve Dreissena polymorpha,Ecotoxicol. Environ. Saf., 2011, vol. 74, pp. 1586–1594.

Passananti, M., Lavorgna, M., Iesce, M.R., DellaGreca, M., Brigante, M., Criscuolo, E., Cermola, F., and Isidori, M., Photochemical fate and eco-genotoxicity assessment of the drug etodolac, Sci. Total Environ., 2015, vol. 518–519, pp. 258–265.

Pi, N., Ng, J.Z., and Kelly, B.C., Bioaccumulation of pharmaceutically active compounds and endocrine disrupting chemicals in aquatic macrophytes: results of hydroponic experiments with Echinodorus horemanii and Eichhornia crassipes,Sci. Total Environ., 2017, vol. 601–602, pp. 812–820.

Pino, M.R., Val, J., Mainar, A.M., Zuriaga, E., Español, C., and Langa, E., Acute toxicological effects on the earthworm Eisenia fetida of 18 common pharmaceuticals in artificial soil, Sci. Total Environ., 2015, vols. 518–519, pp. 225–237.

Pino-Otín, M.R., Muñiz, S., Val, J., and Navarro, E., Effects of 18 pharmaceuticals on the physiological diversity of edaphic microorganisms, Sci. Total Environ., 2017, vol. 595, pp. 441–450.

Richards, N.L., Cook, G., Simpson, V., Hall, S., Harrison, N., and Scott, K.S., Qualitative detection of the NSAIDs diclofenac and ibuprofen in the hair of Eurasian otters (Lutra lutra) occupying UK waterways with GC-MS, Eur. J. Wildl. Res., 2011, vol. 57, pp. 1107–1114.

Richmond, E.K., Rosi, E.J., Walters, D.M., Fick, J., Hamilton, S.K., Brodin, T., Sundelin, A., and Grace, M.R., A diverse suite of pharmaceuticals contaminates stream and riparian food webs, Nat. Commun., 2018, vol. 9, article 4491. https://doi.org/10.1038/s41467-018-06822-w

Rodarte-Morales, A.I., Moreira, M.T., Feijoo, G., and Lema, J.M., Evaluation of two fungal strains for the degradation of pharmaceutical and personal care products (PPCPs), Chem. Eng. Trans., 2010, vol. 20, pp. 31–36.

Russkikh, Ya.V., Chernova, E.N. Nikiforov, V.A., and Zhakovskaya, Z.A., Pharmaceutical compounds in water bodies of Northwestern Russia, Region. Ekol., 2014, nos. 1–2, pp. 77–83.

Salgado, R., Brito, D., Noronha, J.P., Almeida, B., Bronze, M.R., Oehmen, A., Carvalho, G., and Barreto Crespo, M.T., Metabolite identification of ibuprofen biodegradation by Patulibacter medicamentivorans under aerobic conditions, Environ. Technol., 2018, pp. 1–16.

Schwarz, S., Schmieg, H., Scheurer, M., Köhler, H.R., and Triebskorn, R., Impact of the NSAID diclofenac on survival, development, behaviour and health of embryonic and juvenile stages of brown trout, Salmo trutta f. fario,Sci. Total Environ., 2017, vols. 607–608, pp. 1026–1036.

Selderslaghs, I.W.T., Blust, R., and Witters, H.E., Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds, Reprod. Toxicol., 2012, vol. 33, pp. 142–154.

Sim, W.-J., Lee, J.-W., Lee, E.-S., Shin, S.-K., Hwang, S.-R., and Oh, J.-E., Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures, Chemosphere, 2011, vol. 82, pp. 179–186.

Spongberg, A.L., Witter, J.D., Acuña, J., Vargas, J., Murillo, M., Umaña, G., Gómez, E., and Perez, G., Reconnaissance of selected PPCP compounds in Costa Rican surface waters, Water Res., 2011, vol. 45, pp. 6709–6717.

Stenholm, Å., Hedeland, M., Arvidsson, T., and Pettersson, C.E., Removal of diclofenac from a non-sterile aqueous system using Trametes versicolor with an emphasis on adsorption and biodegradation mechanisms, Environ. Technol., 2019, vol. 40, pp. 2460–2472.

Stylianou, K., Hapeshi, E., Vasquez, M.I., Fatta-Kassinos, D., and Vyrides, I., Diclofenac biodegradation by newly isolated Klebsiella sp. KSC: microbial intermediates and ecotoxicological assessment, J. Environ. Chem. Eng., 2018, vol. 6, pp. 3242–3248.

Swan, G.E., Cuthbert, R., Quevedo, M., Green, R.E., Pain, D.J., Bartels, P., Cunningham, A.A., Duncan, N., Meharg, A.A., Oaks, J.L., Parry-Jones, J., Shultz, S., Taggart, M.A., Verdoorn, G., and Wolter, K., Toxicity of diclofenac to Gyps vultures, Biol. Lett., 2006, vol. 2, pp. 279–282.

Thelusmond, J.R., Kawka, E., Strathmann, T.J., and Cupples, A.M., Diclofenac, carbamazepine and triclocarban biodegradation in agricultural soils and the microorganisms and metabolic pathways affected, Sci. Total Environ., 2018, vol. 640–641, pp. 1393–1410.

Tong, A.Z., Ghoshdastidar, A.J., and Fox, S., The presence of the top prescribed pharmaceuticals in treated sewage effluents and receiving waters in southwest Nova Scotia, Canada, Environ. Sci. Pollut. Res., 2015, vol. 22, pp. 689–700.

Torán, J., Blánquez, P., and Caminal, G., Comparison between several reactors with Trametes versicolor immobilized on lignocellulosic support for the continuous treatments of hospital wastewater, Bioresour. Technol., 2017, vol. 243, pp. 966–974.

Toušová, Z., Vrana, B., Smutná, M., Novák, J., Klučárová, V., Grabic, R., Slobodník, J., Giesy, J.P., and Hilscherová, K., Analytical and bioanalytical assessments of organic micropollutants in the Bosna River using a combination of passive sampling, bioassays and multi-residue analysis, Sci. Total Environ., 2019, vol. 650, pp. 1599–1612.

Tyumina, E.A., Bazhutin, G.A., Vikhareva, E.V., Selyaninov, A.A., and Ivshina, I.B., Diclofenac as a factor in the change of Rhodococcus metabolism, IOP Conf. Ser. Mat. Sci., 2019, vol. 487, article 012027. https://doi.org/10.1088/1757-899X/487/1/012027

UNESCO, HELCOM, Pharmaceuticals in the aquatic environment of the Baltic Sea region–a status report, UNESCO Emerging Pollutants in Water Series, Paris: UNESCO Publishing, 2017.

United Nations, Globally Harmonized System of Classification and Labelling of Chemicals (GHS), 4th ed, United Nations, New York and Geneva, 2011.Velázquez, Y.F. and Nacheva, P.M., Biodegradability of fluoxetine, mefenamic acid, and metoprolol using different microbial consortiums, Environ. Sci. Pollut. Res., 2017, vol. 24, pp. 6779–6793.

Vieno, N. and Sillanpää, M., Fate of diclofenac in municipal wastewater treatment plant–a review, Environ. Int., 2014, vol. 69, pp. 28–39.

Węgrzyn, A. and Felis, E., Isolation of bacterial endophytes from Phalaris arundinacea and their potential in diclofenac and sulfamethoxazole degradation, Polish J. Microbiol., 2018, vol. 67, pp. 321–331.

Wojcieszyńska, D., Domaradzka, D., Hupert-Kocurek, K., and Guzik, U., Bacterial degradation of naproxen – Undisclosed pollutant in the environment, J. Environ. Manage., 2014, vol. 145, pp. 157–161.

Wojcieszyńska, D., Domaradzka, D., Hupert-Kocurek, K., and Guzik, U., Enzymes involved in naproxen degradation by Planococcus sp. S5, Polish J. Microbiol., 2016, vol. 65, pp. 177–182.

Wolfson, S.J., Porter, A.W., Campbell, J.K., and Young, L.Y., Naproxen is transformed via acetogenesis and syntrophic acetate oxidation by a methanogenic wastewater consortium, Microb. Ecol., 2018, vol. 76, pp. 362–371.

Yang, L., He, J.T., Su, S.H., Cui, Y.F., Huang, D.L., and Wang, G.C., Occurrence, distribution, and attenuation of pharmaceuticals and personal care products in the riverside groundwater of the Beiyun River of Beijing, China, Environ. Sci. Pollut. Res., 2017, vol. 24, pp. 15838–15851.