Nonrecurring-items delayed nonmatching-to-sample in rats: A new paradigm for testing nonspatial working memory
Tóm tắt
Rats were trained on a nonrecurring-items delayed nonmatching-to-sample task, using a newly designed apparatus and a training protocol similar to that used in experiments on nonspatial working memory in humans and monkeys. On each trial, the rats were briefly presented with a sample object, which was presented again along with another object after a delay; the rats were rewarded with food if they chose the novel object. New stimuli were used on each trial. With delays of 4 sec between the sample and choice runs, the rats learned the task to 90% accuracy in less than 250 trials. When the delay was subsequently increased to 15, 60, 120, and 600 sec, the rats scored approximately 91%, 81%, 77%, and 57%, respectively. These results establish that rats are capable of excellent performance on a nonspatial working-memory task that is comparable to those commonly used in monkey models of amnesia, and they suggest that the nonrecurring-items delayed nonmatching-to-sample paradigm may prove valuable in modeling brain-damage-produced amnesia in rats.
Tài liệu tham khảo
Aggleton, J. P. (1985). One-trial object recognition by rats. Quarterly Journal of Experimental Psychology, 37B, 279–294.
Aggleton, J. P., & Mishkin, M. (1983). Memory impairments following restricted medial thalamic lesions in monkeys. Experimental Brain Research, 52, 199–209.
Alexinsky, T., & Chapouthier, G. (1978). A new behavioral model for studying delayed responses in rats. Behavioral Biology, 24, 442–456.
D’Amato, M. R. (1973). Delayed matching and short-term memory in monkeys. In G. H. Bower (Ed.), The psychology of learning and motivation: Advances in research and theory (Vol. 7, pp. 227–269). New York: Academic Press.
Gaffan, D. (1974). Recognition impaired and association intact in the memory of monkeys after transection of the fornix. Journal of Comparative & Physiological Psychology, 86, 1100–1109.
Iverson, S. D. (1976). Do hippocampal lesions produce amnesia in animals? International Review of Neurobiology, 19, 1–49.
Mishkin, M. (1978). Memory in monkeys severely impaired by combined but not separate removal of amygdala and hippocampus. Nature, 273, 297–298.
Mishkin, M., & Delacour, J. (1975). An analysis of short-term visual memory in the monkey. Journal of Experimental Psychology: Animal Behavior Processes, 1, 326–334.
Mumby, D. G., Pinel, J. P. J., & Wood, E. R. (1989). A rat model of medial temporal lobe amnesia: Nonrecurring-items delayed nonmatching-to-sample. Society for Neuroscience Abstracts, 15, 304.
Murray, E. A., & Mishkin, M. (1986). Visual recognition in monkeys following rhinal cortical ablations combined with either amygdalectomy or hippocampectomy. Journal of Neuroscience, 6, 1991–2003.
Nissen, H. W., Riesen, A. H., & Nowlis, V. (1938). Delayed response and discrimination learning by chimpanzees. Journal of Comparative Psychology, 26, 361–386.
Overman, W. H., McLain, C., Ormsby, G. E., & Brooks, V. (1983). Visual recognition memory in squirrel monkeys. Animal Learning & Behavior, 11, 483–488.
Rothblat, L. A., & Hayes, L. L. (1987). Short-term object recognition memory in the rat: Nonmatching with trial-unique stimuli. Behavioral Neuroscience, 101, 587–590.
Squire, L. R. (1987). Memory and brain. New York: Oxford University Press.
van Haaren, F., & van Hest, A. (1989). Spatial matching and non-matching in male and female Wistar rats: Effects of delay-interval duration. Animal Learning & Behavior, 17, 355–360.
Wood, E. R., Mumby, D. G., Pinel, J. P. J., & Phillips, A. G. (1989). Ischemia-induced damage to the rat hippocampus produces deficits in nonrecurring-items delayed nonmatching-to-sample. Society for Neuroscience Abstracts, 15, 305.
Zola-Morgan, S., & Squire, L. R. (1985). Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia. Behavioral Neuroscience, 100, 155–160.
Zola-Morgan, S., Squire, L. R., & Amaral, D. G. (1989). Lesions of the hippocampal formation but not lesions of the fornix or the mammillary nuclei produce long-lasting memory impairment in monkeys. Journal of Neuroscience, 9, 898–913.