Noncanonical Activin A Signaling in PC12 Cells: A Self-Limiting Feedback Loop

Wu H, Mezghenna K, Marmol P, Guo T, Moliner A, Yang SN, Berggren PO, Ibáñez CF (2014) Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands. Diabetologia 57(1):148–156

Pauklin S, Vallier L (2015) Activin/Nodal signalling in stem cells. Development 142(4):607–619

Rodríguez-Martínez G, Molina-Hernández A, Velasco I (2012) Activin A promotes neural differentiation of cerebrocortical neural progenitor cells. PLoS One 7(8):e43797

Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, Dani C (2010) Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes 59(10):2513–2521

Hughes PE, Alexi T, Williams CE, Clark RG, Gluckman PD (1999) Administration of recombinant human Activin-A has powerful neurotrophic effects on select striatal phenotypes in the quinolinic acid lesion model of Huntington’s disease. Neuroscience 92(1):197–209

Wu DD, Lai M, Hughes PE, Sirimanne E, Gluckman PD, Williams CE (1999) Expression of the activin axis and neural rescue effects of recombinant activin A following hypoxic–ischemic brain injury in the infant rat. Brain Res 835(2):369–378

Krieglstein K, Zheng F, Unsicker K, Alzheimer C (2011) More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses. Trends Neurosci 34(8):421–429

Hasegawa Y, Mukai H, Asashima M, Hojo Y, Ikeda M, Komatsuzaki Y, Ooishi Y, Kawato S (2014) Acute modulation of synaptic plasticity of pyramidal neurons by activin in adult hippocampus. Front Neural Circuits 8:56

Mukerji SS, Katsman EA, Wilber C, Haner NA, Selman WR, Hall AK (2007) Activin is a neural survival factor that is rapidly increased after transient cerebral ischemia and hypoxia in mice. J Cereb Blood Flow Metab 27(6):1161–1172

Lai M, Gluckman P, Dragunow M, Hughes PE (1997) Focal brain injury increases activin betaA mRNA expression in hippocampal neurons. NeuroReport 8(12):2691–2694

Gressner OA (2011) Intracrine signaling mechanisms of activin A and TGF-β. Vitam Horm 85:59–77

Kretzschmar M, Massagué J (1998) SMADs: mediators and regulators of TGF-beta signaling. Curr Opin Genet Dev 8(1):103–111

Wang JQ, He JT, Du ZW, Li ZS, Liu YF, Mang J, Xu ZX (2013) Effects of SARA on oxygen–glucose deprivation in PC12 cell line. Neurochem Res 38(5):961–971

Marino FE, Risbridger G, Gold E (2014) The inhibin/activin signalling pathway in human gonadal and adrenal cancers. Mol Hum Reprod 20(12):1223–1237

Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massagué J, Shi Y (2000) Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science 287(5450):92–97

Runyan CE, Schnaper HW, Poncelet AC (2005) The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells. J Biol Chem 280(9):8300–8308

Runyan CE, Poncelet AC, Schnaper HW (2006) TGF-beta receptor-binding proteins: complex interactions. Cell Signal 18(12):2077–2088

Heldin CH, Miyazono K, ten Dijke P (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390(6659):465–471

Liu F, Pouponnot C, Massagué J (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev 11(23):3157–3167

Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell 2(1):109–120

Mang J, Mei CL, Wang JQ, Li ZS, Chu TT, He JT, Xu ZX (2013) Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic injury in PC12 cells. Molecules 18(10):12977–12986

Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73(7):2424–2428

Ardekani AM, Romanelli JC, Mayo KE (1998) Structure of the rat inhibin and activin betaA-subunit gene and regulation in an ovarian granulosa cell line. Endocrinology 139(7):3271–3279

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25(4):402–408

Li CT, Zhang WP, Lu YB, Fang SH, Yuan YM, Qi LL, Zhang LH, Huang XJ, Zhang L, Chen Z, Wei EQ (2009) Oxygen–glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells. J Neurosci Res 87(4):991–1001

Schubert D, Kimura H, LaCorbiere M, Vaughan J, Karr D, Fischer WH (1990) Activin is a nerve cell survival molecule. Nature 344(6269):868–870

Brackmann FA, Link AS, Jung S, Richter M, Zoglauer D, Walkinshaw G, Alzheimer C, Trollmann R (2013) Activin A regulation under global hypoxia in developing mouse brain. Brain Res 1531:65–74

Phillips DJ, Nguyen P, Adamides AA, Bye N, Rosenfeld JV, Kossmann T, Vallance S, Murray L, Morganti-Kossmann MC (2006) Activin a release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury. J Neurotrauma 23(9):1283–1294

He JT, Mang J, Mei CL, Yang L, Wang JQ, Xing Y, Yang H, Xu ZX (2011) Neuroprotective effects of exogenous activin A on oxygen–glucose deprivation in PC12 cells. Molecules 17(1):315–327

Chng WB, Bou Sleiman MS, Schüpfer F, Lemaitre B (2014) Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression. Cell Rep 9(1):336–348

Wolchinsky Z, Shivtiel S, Kouwenhoven EN, Putin D, Sprecher E, Zhou H, Rouleau M, Aberdam D (2014) Angiomodulin is required for cardiogenesis of embryonic stem cells and is maintained by a feedback loop network of p63 and Activin-A. Stem Cell Res 12(1):49–59

Huang C, Lin Y, Su H, Ye D (2015) Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell. Neurochem Res 40(1):27–35

Li ZY, Guo Z, Liu YM, Liu XM, Chang Q, Liao YH, Pan RL (2013) Neuroprotective effects of total saikosaponins of Bupleurum yinchowense on corticosterone-induced apoptosis in PC12 cells. J Ethnopharmacol 148(3):794–803

Mabuchi Y, Yamoto M, Minami S, Umesaki N (2006) The autocrine effect of activin A on human ovarian clear cell adenocarcinoma cells. Oncol Rep 16(2):373–379

Nicholls PK, Harrison CA, Rainczuk KE, Wayne Vogl A, Stanton PG (2013) Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation. Mol Cell Endocrinol 377(1–2):33–43