Nonalcoholic Fatty Liver Disease

Gastroenterology Clinics of North America - Tập 45 Số 4 - Trang 639-652 - 2016
Rotonya M. Carr1, Amanke Oranu1, Vandana Khungar1
1Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Chalasani, 2012, The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association, Hepatology, 55, 2005, 10.1002/hep.25762

Younossi, 2015, Global epidemiology of nonalcoholic fatty liver disease–Meta-analytic assessment of prevalence, incidence and outcomes, Hepatology, 64, 73, 10.1002/hep.28431

Vernon, 2011, Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults, Aliment Pharmacol Ther, 34, 274, 10.1111/j.1365-2036.2011.04724.x

Petersen, 2006, Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men, Proc Natl Acad Sci U S A, 103, 18273, 10.1073/pnas.0608537103

Pan, 2014, Gender and racial differences in nonalcoholic fatty liver disease, World J Hepatol, 6, 274, 10.4254/wjh.v6.i5.274

Browning, 2004, Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity, Hepatology, 40, 1387, 10.1002/hep.20466

Fleischman, 2014, NAFLD prevalence differs among Hispanic subgroups: the multi-ethnic study of atherosclerosis, World J Gastroenterol, 20, 4987, 10.3748/wjg.v20.i17.4987

Kallwitz, 2015, Prevalence of suspected nonalcoholic fatty liver disease in Hispanic/Latino individuals differs by heritage, Clin Gastroenterol Hepatol, 13, 569, 10.1016/j.cgh.2014.08.037

Saab, 2016, Nonalcoholic fatty liver disease in Latinos, Clin Gastroenterol Hepatol, 14, 5, 10.1016/j.cgh.2015.05.001

Charlton, 2011, Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the united states, Gastroenterology, 141, 1249, 10.1053/j.gastro.2011.06.061

Rafiq, 2009, Long-term follow-up of patients with nonalcoholic fatty liver, Clin Gastroenterol Hepatol, 7, 234, 10.1016/j.cgh.2008.11.005

Grundy, 2005, Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement, Circulation, 112, 2735, 10.1161/CIRCULATIONAHA.105.169404

Liu, 2006, Ethnic-specific criteria for the metabolic syndrome: evidence from china, Diabetes Care, 29, 1414, 10.2337/dc06-0481

Marchesini, 2003, Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome, Hepatology, 37, 917, 10.1053/jhep.2003.50161

Lonardo, 2015, Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome, Dig Liver Dis, 47, 181, 10.1016/j.dld.2014.09.020

Pelchat, 2004, Images of desire: food-craving activation during fMRI, Neuroimage, 23, 1486, 10.1016/j.neuroimage.2004.08.023

Kelley, 2002, Opioid modulation of taste hedonics within the ventral striatum, Physiol Behav, 76, 365, 10.1016/S0031-9384(02)00751-5

Page, 2013, Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways, JAMA, 309, 63, 10.1001/jama.2012.116975

Teff, 2004, Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women, J Clin Endocrinol Metab, 89, 2963, 10.1210/jc.2003-031855

Ahima, 2000, Leptin, Annu Rev Physiol, 62, 413, 10.1146/annurev.physiol.62.1.413

Buechler, 2011, Adiponectin, a key adipokine in obesity related liver diseases, World J Gastroenterol, 17, 2801

Chitturi, 2002, Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?, Hepatology, 36, 403, 10.1053/jhep.2002.34738

Targher, 2006, Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease, Clin Endocrinol (Oxf), 64, 679, 10.1111/j.1365-2265.2006.02527.x

Armstrong, 2016, Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study, Lancet, 387, 679, 10.1016/S0140-6736(15)00803-X

Kang, 2006, Metabolic syndrome is associated with greater histologic severity, higher carbohydrate, and lower fat diet in patients with NAFLD, Am J Gastroenterol, 101, 2247, 10.1111/j.1572-0241.2006.00719.x

Musso, 2003, Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis, Hepatology, 37, 909, 10.1053/jhep.2003.50132

Lai, 2005, Effects of a high-fiber diet on hepatocyte apoptosis and liver regeneration after partial hepatectomy in rats with fatty liver, JPEN J Parenter Enteral Nutr, 29, 401, 10.1177/0148607105029006401

Sullivan, 2010, Implications of diet on nonalcoholic fatty liver disease, Curr Opin Gastroenterol, 26, 160, 10.1097/MOG.0b013e3283358a58

Festi, 2014, Gut microbiota and metabolic syndrome, World J Gastroenterol, 20, 16079, 10.3748/wjg.v20.i43.16079

Ouyang, 2008, Fructose consumption as a risk factor for non-alcoholic fatty liver disease, J Hepatol, 48, 993, 10.1016/j.jhep.2008.02.011

Abid, 2009, Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome, J Hepatol, 51, 918, 10.1016/j.jhep.2009.05.033

Mouzaki, 2013, Intestinal microbiota in patients with nonalcoholic fatty liver disease, Hepatology, 58, 120, 10.1002/hep.26319

Miele, 2009, Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease, Hepatology, 49, 1877, 10.1002/hep.22848

Giorgio, 2014, Intestinal permeability is increased in children with non-alcoholic fatty liver disease, and correlates with liver disease severity, Dig Liver Dis, 46, 556, 10.1016/j.dld.2014.02.010

Fu, 2013, Regulation of insulin synthesis and secretion and pancreatic beta-cell dysfunction in diabetes, Curr Diabetes Rev, 9, 25, 10.2174/157339913804143225

McGarry, 1992, What if Minkowski had been ageusic? An alternative angle on diabetes, Science, 258, 766, 10.1126/science.1439783

Gao, 2016, Inflammation in alcoholic and nonalcoholic fatty liver disease: friend or foe?, Gastroenterology, 150, 1704, 10.1053/j.gastro.2016.01.025

Makkonen, 2009, Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins, J Hepatol, 50, 1035, 10.1016/j.jhep.2008.12.025

Jenkins, 2004, Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase a2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities, J Biol Chem, 279, 48968, 10.1074/jbc.M407841200

He, 2010, A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis, J Biol Chem, 285, 6706, 10.1074/jbc.M109.064501

Speliotes, 2010, PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease, Hepatology, 52, 904, 10.1002/hep.23768

Romeo, 2008, Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease, Nat Genet, 40, 1461, 10.1038/ng.257

Sookoian, 2011, Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease, Hepatology, 53, 1883, 10.1002/hep.24283

Santoro, 2010, A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents, Hepatology, 52, 1281, 10.1002/hep.23832

Hernaez, 2013, Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third National Health and Nutrition Examination Survey, Clin Gastroenterol Hepatol, 11, 1183, 10.1016/j.cgh.2013.02.011

Basantani, 2011, PNPLA3/adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome, J Lipid Res, 52, 318, 10.1194/jlr.M011205

Li, 2012, Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis, J Clin Invest, 122, 4130, 10.1172/JCI65179

Smagris, 2015, PNPLA3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis, Hepatology, 61, 108, 10.1002/hep.27242

Speliotes, 2011, Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits, PLoS Genet, 7, e1001324, 10.1371/journal.pgen.1001324

Palmer, 2013, Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent, Hepatology, 58, 966, 10.1002/hep.26440

Fracanzani, 2008, Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes, Hepatology, 48, 792, 10.1002/hep.22429

Verma, 2013, Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD), Liver Int, 33, 1398, 10.1111/liv.12226

Adams, 2004, The prevalence of autoantibodies and autoimmune hepatitis in patients with nonalcoholic fatty liver disease, Am J Gastroenterol, 99, 1316, 10.1111/j.1572-0241.2004.30444.x

Cotler, 2004, Prevalence and significance of autoantibodies in patients with non-alcoholic steatohepatitis, J Clin Gastroenterol, 38, 801, 10.1097/01.mcg.0000139072.38580.a0

Loria, 2003, Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates, Dig Dis Sci, 48, 2173, 10.1023/B:DDAS.0000004522.36120.08

Lee, 2010, Non-invasive assessment of hepatic steatosis: prospective comparison of the accuracy of imaging examinations, J Hepatol, 52, 579, 10.1016/j.jhep.2010.01.008

Saadeh, 2002, The utility of radiological imaging in nonalcoholic fatty liver disease, Gastroenterology, 123, 745, 10.1053/gast.2002.35354

Feldstein, 2009, Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study, Hepatology, 50, 1072, 10.1002/hep.23050

Angulo, 2007, The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD, Hepatology, 45, 846, 10.1002/hep.21496

Castera, 2010, Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations, Hepatology, 51, 828

Rinaldi, 2014, Hepatic steatosis and necro-inflammatory activity overestimate liver stiffness by transient elastography in staging liver fibrosis in chronic hepatitis c, J Hepat Res, 1, 1012

Myers, 2012, Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients, Hepatology, 55, 199, 10.1002/hep.24624

Imajo, 2016, Magnetic resonance imaging more accurately classifies steatosis and fibrosis in patients with nonalcoholic fatty liver disease than transient elastography, Gastroenterology, 150, 626, 10.1053/j.gastro.2015.11.048

Rockey, 2009, Liver biopsy, Hepatology, 49, 1017, 10.1002/hep.22742

Booth, 2004, Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status, Am J Clin Nutr, 80, 143, 10.1093/ajcn/80.1.143

Angulo, 2015, Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease, Gastroenterology, 149, 389, 10.1053/j.gastro.2015.04.043

Carr, 2016, Pathophysiology of lipid droplet proteins in liver diseases, Exp Cell Res, 340, 187, 10.1016/j.yexcr.2015.10.021

Straub, 2013, Adipophilin/perilipin-2 as a lipid droplet-specific marker for metabolically active cells and diseases associated with metabolic dysregulation, Histopathology, 62, 617, 10.1111/his.12038

Straub, 2008, Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis, Hepatology, 47, 1936, 10.1002/hep.22268

Carr, 2012, Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice, Am J Physiol Regul Integr Comp Physiol, 302, R996, 10.1152/ajpregu.00177.2011

Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology, 41, 1313, 10.1002/hep.20701

Ratziu, 2005, Sampling variability of liver biopsy in nonalcoholic fatty liver disease, Gastroenterology, 128, 1898, 10.1053/j.gastro.2005.03.084

Promrat, 2010, Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis, Hepatology, 51, 121, 10.1002/hep.23276

Vilar-Gomez, 2015, Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis, Gastroenterology, 149, 367, 10.1053/j.gastro.2015.04.005

Paradis, 2009, Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis, Hepatology, 49, 851, 10.1002/hep.22734

Belfort, 2006, A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis, N Engl J Med, 355, 2297, 10.1056/NEJMoa060326

Chalasani, 2009, Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design, Contemp Clin Trials, 30, 88, 10.1016/j.cct.2008.09.003

Carr, 2015, FXR agonists as therapeutic agents for non-alcoholic fatty liver disease, Curr Atheroscler Rep, 17, 500, 10.1007/s11883-015-0500-2

Neuschwander-Tetri, 2015, Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial, Lancet, 385, 956, 10.1016/S0140-6736(14)61933-4

Clinical trials.Gov. 2016. Available at: https://clinicaltrials.gov/ct2/show/NCT02548351.

Ratziu, 2016, Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening, Gastroenterology, 150, 1147, 10.1053/j.gastro.2016.01.038

Lassailly, 2015, Bariatric surgery reduces features of nonalcoholic steatohepatitis in morbidly obese patients, Gastroenterology, 149, 379, 10.1053/j.gastro.2015.04.014

Abu Dayyeh, 2015, Endoscopic bariatric therapies, Gastrointest Endosc, 81, 1073, 10.1016/j.gie.2015.02.023

Gorden, 2013, Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity, Hum Hered, 75, 34, 10.1159/000346195

Sookoian, 2016, Meta-analysis of the influence of TM6SF2 E167K variant on plasma concentration of aminotransferases across different populations and diverse liver phenotypes, Sci Rep, 6, 27718, 10.1038/srep27718