Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years

Prakash, 2020, Cell-bound Nanoparticles for Tissue Targeting and Immunotherapy: Engineering of the Particle-Membrane Interface, Curr. Opin. Colloid Interface Sci. Zhao, 2019, Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers, Adv. Drug Deliv. Rev., 143, 3, 10.1016/j.addr.2019.01.002 Shen, 2016, Decorating nanoparticle surface for targeted drug delivery: Opportunities and challenges, Polymers (Basel)., 10.3390/polym8030083 Sanità, 2020, Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization, Front. Mol. Biosci., 10.3389/fmolb.2020.587012 Pathak, 2019, Surface Modification of Nanoparticles for Targeted, Drug Delivery Mitchell, 2021, Engineering precision nanoparticles for drug delivery, Nat. Rev. Drug Discov., 10.1038/s41573-020-0090-8 Zhao, 2020, Targeting Strategies for Tissue-Specific Drug Delivery, Cell., 181, 151, 10.1016/j.cell.2020.02.001 Moore, 2020, Injectable, Ribbon-Like Microconfetti Biopolymer Platform for Vaccine Applications, ACS Appl. Mater. Interfaces., 10.1021/acsami.0c10276 Lu, 2020, Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy, Sci. Transl. Med., 12, 1, 10.1126/scitranslmed.aaz6606 Koshy, 2018, Injectable nanocomposite cryogels for versatile protein drug delivery, Acta Biomater., 65, 36, 10.1016/j.actbio.2017.11.024 Kuai, 2017, Designer vaccine nanodiscs for personalized cancer immunotherapy, Nat. Mater., 10.1038/nmat4822 Moon, 2012, Engineering Nano- and microparticles to tune immunity, Adv. Mater., 10.1002/adma.201200446 Mhatre, 2019, Pharmaceutical feasibility and flow characteristics of polymeric non-spherical particles, Nanomedicine Nanotechnology, Biol. Med. Champion, 2007, Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers, J. Control. Release., 121, 3, 10.1016/j.jconrel.2007.03.022 Tao, 2003, Microfabricated drug delivery systems: From particles to pores, Adv. Drug Deliv. Rev., 55, 315, 10.1016/S0169-409X(02)00227-2 Nejati, 2020, Role of particle shape on efficient and organ-based drug delivery, Eur. Polym. J., 10.1016/j.eurpolymj.2019.109353 Blanco, 2015, Principles of nanoparticle design for overcoming biological barriers to drug delivery, Nat. Biotechnol., 33, 941, 10.1038/nbt.3330 Wang, 2011, More effective nanomedicines through particle design, Small., 10.1002/smll.201100442 Truong, 2015, The importance of nanoparticle shape in cancer drug delivery, Expert Opin. Drug Deliv., 12, 129, 10.1517/17425247.2014.950564 Clegg, 2019, Modular fabrication of intelligent material-tissue interfaces for bioinspired and biomimetic devices, Prog. Mater. Sci., 10.1016/j.pmatsci.2019.100589 Metherell, 2018, Binding of Hydrophobic Guests in a Coordination Cage Cavity is Driven by Liberation of “High-Energy” Water, Chem. - A Eur. J., 10.1002/chem.201704163 Cao, 2019, Molecular Programming of Biodegradable Nanoworms via Ionically Induced Morphology Switch toward Asymmetric Therapeutic Carriers, Small., 15, 1, 10.1002/smll.201901849 Zheng, 2017, Shape-Shifting Patchy Particles, Angew. Chemie - Int. Ed., 56, 5507, 10.1002/anie.201701456 Kempe, 2016, Preparation of non-spherical particles from amphiphilic block copolymers, J. Polym. Sci. Part A Polym. Chem., 10.1002/pola.27927 Isely, 2020, Fabrication of biodegradable particles with tunable morphologies by the addition of resveratrol to oil in water emulsions, Int. J. Pharm., 10.1016/j.ijpharm.2020.119917 Vatankhah, 2019, One-step fabrication of low cytotoxic anisotropic poly(2-hydroxyethyl methacrylate-co-methacrylic acid) particles for efficient release of DOX, J. Drug Deliv. Sci. Technol., 10.1016/j.jddst.2019.101332 Geng, 2007, Shape effects of filaments versus spherical particles in flow and drug delivery, Nat. Nanotechnol., 2, 249, 10.1038/nnano.2007.70 Devarajan, 2010, Particle shape: A new design parameter for passive targeting in splenotropic drug delivery, J. Pharm. Sci., 99, 2576, 10.1002/jps.22052 Zhao, 2017, A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics, Sci. Rep., 7, 1 Li, 2020, Silk-coated dexamethasone non-spherical microcrystals for local drug delivery to inner ear, Eur. J. Pharm. Sci. Engstrom, 2009, Templated open flocs of nanorods for enhanced pulmonary delivery with pressurized metered dose inhalers, Pharm. Res., 10.1007/s11095-008-9707-z C.W. Shields, M.A. Evans, L.L. Wang, N. Baugh, D. Wu, Z. Zhao, A. Pusuluri, A. Ukidve, D.C. Pan, Cellular Backpacks for Macrophage Immunotherapy, Sci. Adv. (2020). Swiston, 2008, Surface functionalization of living cells with multilayer patches, Nano Lett., 10.1021/nl802404h Champion, 2006, Role of target geometry in phagocytosis, Proc. Natl. Acad. Sci., 103, 4930, 10.1073/pnas.0600997103 Mohraz, 2005, Direct visualization of colloidal rod assembly by confocal microscopy, Langmuir., 10.1021/la046908a Meyer, 2018, Anisotropic biodegradable lipid coated particles for spatially dynamic protein presentation, Acta Biomater., 72, 228, 10.1016/j.actbio.2018.03.056 Meyer, 2015, An automated multidimensional thin film stretching device for the generation of anisotropic polymeric micro- and nanoparticles, J. Biomed. Mater. Res. - Part A., 10.1002/jbm.a.35399 Garapaty, 2019, Shape of ligand immobilized particles dominates and amplifies the macrophage cytokine response to ligands, PLoS One., 14, 12, 10.1371/journal.pone.0217022 Kumar, 2015, Shape and size-dependent immune response to antigen-carrying nanoparticles, J. Control. Release., 220, 141, 10.1016/j.jconrel.2015.09.069 Dong, 2014, Pushing the resolution of photolithography down to 15nm by surface plasmon interference, Sci. Rep. del Barrio, 2019, Light to Shape the Future: From Photolithography to 4D Printing, Adv. Opt. Mater., 10.1002/adom.201900598 Dendukuri, 2007, Stop-flow lithography in a microfluidic device, Lab Chip., 10.1039/b703457a Dendukuri, 2006, Continuous-flow lithography for high-throughput microparticle synthesis, Nat. Mater., 10.1038/nmat1617 Shum, 2010, Droplet microfluidics for fabrication of non-spherical particles, Macromol. Rapid Commun., 10.1002/marc.200900590 Baah, 2012, Microfluidic synthesis and post processing of non-spherical polymeric microparticles, Microfluid. Nanofluidics., 12, 657, 10.1007/s10404-011-0874-6 Hwang, 2008, Microfluidic-based synthesis of non-spherical magnetic hydrogel microparticles, Lab Chip., 10.1039/b805176c Rolland, 2005, Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials, J. Am. Chem. Soc., 10.1021/ja051977c Enlow, 2011, Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings, Nano Lett., 10.1021/nl104117p Galloway, 2013, Development of a nanoparticle-based influenza vaccine using the PRINT® technology, Nanomedicine Nanotechnology, Biol. Med. Gratton, 2007, Nanofabricated particles for engineered drug therapies: A preliminary biodistribution study of PRINTTM nanoparticles, J. Control. Release., 10.1016/j.jconrel.2007.05.027 Merkel, 2010, Scalable, shape-specific, top-down fabrication methods for the synthesis of engineered colloidal particles, Langmuir., 10.1021/la903890h Perry, 2011, PRINT: A novel platform toward shape and size specific nanoparticle theranostics, Acc. Chem. Res., 10.1021/ar2000315 Rolland, 2004, Solvent-Resistant Photocurable “Liquid Teflon” for Microfluidic Device Fabrication, J. Am. Chem. Soc., 10.1021/ja031657y Anselmo, 2015, Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: A generalized strategy to deliver drugs to treat inflammation, J. Control. Release., 199, 29, 10.1016/j.jconrel.2014.11.027 Klyachko, 2017, Macrophages with cellular backpacks for targeted drug delivery to the brain, Biomaterials., 140, 79, 10.1016/j.biomaterials.2017.06.017 Sunshine, 2014, Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells, Biomaterials., 35, 269, 10.1016/j.biomaterials.2013.09.050 Bookstaver, 2018, Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation, Small., 10.1002/smll.201802202 Perry, 2012, PEGylated PRINT nanoparticles: The impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics, Nano Lett., 10.1021/nl302638g Mathaes, 2014, Influence of particle geometry and PEGylation on phagocytosis of particulate carriers, Int. J. Pharm., 465, 159, 10.1016/j.ijpharm.2014.02.037 Da Silva-Candal, 2019, Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions, J. Control. Release., 309, 94, 10.1016/j.jconrel.2019.07.026 Stefanick, 2013, A systematic analysis of peptide linker length and liposomal polyethylene glycol coating on cellular uptake of peptide-targeted liposomes, ACS Nano., 10.1021/nn305663e Yoo, 2010, Polymer particles that switch shape in response to a stimulus, Proc. Natl. Acad. Sci. U. S. A., 107, 11205, 10.1073/pnas.1000346107 Culver, 2017, Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery, Acc. Chem. Res., 10.1021/acs.accounts.6b00533 Peltonen, 2018, Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry, Adv. Drug Deliv. Rev., 131, 101, 10.1016/j.addr.2018.06.009 de Haan, 2019, Resolution enhancement in scanning electron microscopy using deep learning, Sci. Rep., 10.1038/s41598-019-48444-2 Danino, 2012, Cryo-TEM of soft molecular assemblies, Curr. Opin. Colloid Interface Sci. Kuntsche, 2011, Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems, Int. J. Pharm., 10.1016/j.ijpharm.2011.02.001 Thorn, 2016, A quick guide to light microscopy in cell biology, Mol. Biol. Cell., 10.1091/mbc.e15-02-0088 Hell, 2004, Concepts for nanoscale resolution in fluorescence microscopy, Curr. Opin. Neurobiol., 10.1016/j.conb.2004.08.015 Huang, 2009, Super-resolution fluorescence microscopy, Annu. Rev. Biochem., 10.1146/annurev.biochem.77.061906.092014 Pepperkok, 2006, High-throughput fluorescence microscopy for systems biology, Nat. Rev. Mol. Cell Biol., 10.1038/nrm1979 Polak, 2015, Liposome-Loaded Cell Backpacks, Adv. Healthc. Mater., 4, 2832, 10.1002/adhm.201500604 Zhou, 2017, Progress in the correlative atomic force microscopy and optical microscopy, Sensors (Switzerland). Carvalho, 2018, Application of light scattering techniques to nanoparticle characterization and development, Front. Chem., 10.3389/fchem.2018.00237 Hourahine, 2012, Accurate light scattering for non spherical particles from Mie-type theory, J. Phys. Conf. Ser., 10.1088/1742-6596/367/1/012010 Maguire, 2018, Characterisation of particles in solution–a perspective on light scattering and comparative technologies, Sci. Technol. Adv. Mater., 10.1080/14686996.2018.1517587 Wyatt, 1993, Light scattering and the absolute characterization of macromolecules, Anal. Chim. Acta., 10.1016/0003-2670(93)80373-S Fuentes, 2018, Application of asymmetric flow field-flow fractionation (AF4) and multiangle light scattering (MALS) for the evaluation of changes in the product molar mass during PVP-b-PAMPS synthesis, Anal. Bioanal. Chem., 10.1007/s00216-018-1039-1 Tarazona, 2003, Combination of SEC/MALS experimental procedures and theoretical analysis for studying the solution properties of macromolecules, J. Biochem. Biophys. Methods., 56, 95, 10.1016/S0165-022X(03)00075-7 Mage, 2019, Shape-based separation of synthetic microparticles, Nat. Mater., 10.1038/s41563-018-0244-9 Mathaes, 2013, Application of different analytical methods for the characterization of non-spherical micro- And nanoparticles, Int. J. Pharm., 10.1016/j.ijpharm.2013.05.046 Zhang, 2018, Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation, Nat. Cell Biol., 10.1038/s41556-018-0040-4 Zhang, 2019, Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization, Nat. Protoc. Correia, 2018, Detection of nanoplastics in food by asymmetric flow field-flow fractionation coupled to multi-angle light scattering: possibilities, challenges and analytical limitations, Anal. Bioanal. Chem., 410, 5603, 10.1007/s00216-018-0919-8 Romanski, 2012, Production and characterization of anisotropic particles from biodegradable materials, Langmuir., 10.1021/la2044834 Chalikwar, 2012, Formulation and evaluation of Nimodipine-loaded solid lipid nanoparticles delivered via lymphatic transport system, Colloids Surfaces B Biointerfaces., 10.1016/j.colsurfb.2012.04.027 Patil, 2020, Fabrication and Characterization of Non-spherical Polymeric Particles, J. Pharm. Innov. Schmitt, 2020, Anisotropic mesoporous silica/microgel core–shell responsive particles, RSC Adv., 10, 25393, 10.1039/D0RA02278K Cao, 2020, Drug-Directed Morphology Changes in Polymerization-Induced Self-Assembly (PISA) Influence the Biological Behavior of Nanoparticles, ACS Appl. Mater. Interfaces., 12, 30221, 10.1021/acsami.0c09054 Donatan, 2016, Loading Capacity versus Enzyme Activity in Anisotropic and Spherical Calcium Carbonate Microparticles, ACS Appl. Mater. Interfaces., 10.1021/acsami.6b03492 Serov, 2020, One-pot synthesis of template-free hollow anisotropic CaCO3structures: Towards inorganic shape-mimicking drug delivery systems, Chem. Commun., 10.1039/D0CC05502F Gong, 2014, Thermally activated reversible shape switch of polymer particles, J. Mater. Chem. B., 2, 6855, 10.1039/C4TB01155D Champion, 2008, Role of particle size in phagocytosis of polymeric microspheres, Pharm. Res., 25, 1815, 10.1007/s11095-008-9562-y Sharma, 2010, Polymer particle shape independently influences binding and internalization by macrophages, J. Control. Release., 147, 408, 10.1016/j.jconrel.2010.07.116 Champion, 2009, Shape induced inhibition of phagocytosis of polymer particles, Pharm. Res., 26, 244, 10.1007/s11095-008-9626-z Richards, 2017, How cells engulf: a review of theoretical approaches to phagocytosis, Rep. Prog. Phys., 80, 10.1088/1361-6633/aa8730 Kelley, 2018, PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils, Acta Biomater., 79, 283, 10.1016/j.actbio.2018.09.001 Safari, 2020, Neutrophils preferentially phagocytose elongated particles-An opportunity for selective targeting in acute inflammatory diseases, Sci. Adv., 6, 10.1126/sciadv.aba1474 Heinrich, 2015, Controlled One-on-One Encounters between Immune Cells and Microbes Reveal Mechanisms of Phagocytosis, Biophys. J., 10.1016/j.bpj.2015.06.042 May, 2001, Phagocytosis and the actin cytoskeleton, J. Cell Sci., 10.1242/jcs.114.6.1061 Unger, 2002, In vitro expression of the endothelial phenotype: Comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R, Microvasc. Res., 10.1006/mvre.2002.2434 Pan, 2009, Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions, Mol. Cell. Proteomics., 10.1074/mcp.M800258-MCP200 Agarwal, 2013, Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms, Proc. Natl. Acad. Sci. U. S. A., 110, 17247, 10.1073/pnas.1305000110 Parakhonskiy, 2015, The influence of the size and aspect ratio of anisotropic, porous CaCO3 particles on their uptake by cells, J. Nanobiotechnology., 13, 1, 10.1186/s12951-015-0111-7 Yoo, 2010, Endocytosis and intracellular distribution of PLGA particles in endothelial cells: Effect of particle geometry, Macromol. Rapid Commun., 31, 142, 10.1002/marc.200900592 Meng, 2011, Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small gtpase-dependent macropinocytosis mechanism, ACS Nano., 5, 4434, 10.1021/nn103344k Huang, 2010, The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function, Biomaterials., 31, 438, 10.1016/j.biomaterials.2009.09.060 Hao, 2012, The shape effect of PEGylated mesoporous silica nanoparticles on cellular uptake pathway in Hela cells, Microporous Mesoporous Mater., 162, 14, 10.1016/j.micromeso.2012.05.040 Herd, 2013, Nanoparticle geometry and surface orientation influence mode of cellular uptake, ACS Nano., 7, 1961, 10.1021/nn304439f Huang, 2013, Role of nanoparticle geometry in endocytosis: Laying down to stand up, Nano Lett., 13, 4546, 10.1021/nl402628n Shen, 2019, Membrane Wrapping Efficiency of Elastic Nanoparticles during Endocytosis: Size and Shape Matter, ACS Nano., 13, 215, 10.1021/acsnano.8b05340 Jin, 2009, Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes: Single particle tracking and a generic uptake model for nanoparticles, ACS Nano., 3, 149, 10.1021/nn800532m Hinde, 2017, Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release, Nat. Nanotechnol., 12, 81, 10.1038/nnano.2016.160 Castoldi, 2019, Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents, Pharm. Res., 36, 1, 10.1007/s11095-018-2521-3 Doshi, 2010, Needle-shaped polymeric particles induce transient disruption of cell membranes, J. R. Soc. Interface., 7, 10.1098/rsif.2010.0134.focus Zhang, 2020, Cellular fate of deformable needle-shaped PLGA-PEG fibers, Acta Biomater., 112, 182, 10.1016/j.actbio.2020.05.029 Duan, 2013, Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking, Small., 9, 1521, 10.1002/smll.201201390 Adriani, 2012, The preferential targeting of the diseased microvasculature by disk-like particles, Biomaterials., 33, 5504, 10.1016/j.biomaterials.2012.04.027 Decuzzi, 2005, A theoretical model for the margination of particles within blood vessels, Ann. Biomed. Eng., 33, 179, 10.1007/s10439-005-8976-5 Tan, 2013, The influence of size, shape and vessel geometry on nanoparticle distribution, Microfluid. Nanofluidics., 14, 77, 10.1007/s10404-012-1024-5 Gavze, 1998, Motion of inertial spheroidal particles in a shear flow near a solid wall with special application to aerosol transport in microgravity, J. Fluid Mech., 371, 59, 10.1017/S0022112098002109 Gentile, 2008, The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows, J. Biomech., 41, 2312, 10.1016/j.jbiomech.2008.03.021 Lee, 2009, Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows, Nanotechnology., 20, 10.1088/0957-4484/20/49/495101 Decuzzi, 2009, Intravascular delivery of particulate systems: Does geometry really matter?, Pharm. Res., 26, 235, 10.1007/s11095-008-9697-x Gavze, 1997, Particles in a shear flow near a solid wall: Effect of nonsphericity on forces and velocities, Int. J. Multiph. Flow., 23, 155, 10.1016/S0301-9322(96)00054-7 Park, 2010, Analysis of the migration of rigid polymers and nanorods in a rotating viscometric flow, Macromolecules., 43, 2535, 10.1021/ma901369a Toy, 2014, Shaping cancer nanomedicine: The effect of particle shape on the in vivo journey of nanoparticles, Nanomedicine., 9, 121, 10.2217/nnm.13.191 Jurney, 2017, Unique size and shape-dependent uptake behaviors of non-spherical nanoparticles by endothelial cells due to a shearing flow, J. Control. Release., 245, 170, 10.1016/j.jconrel.2016.11.033 Cooley, 2018, Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale, Nanoscale., 10, 15350, 10.1039/C8NR04042G Fish, 2017, Exploring deformable particles in vascular-targeted drug delivery: Softer is only sometimes better, Biomaterials., 10.1016/j.biomaterials.2017.02.002 Christian, 2009, Flexible filaments for in vivo imaging and delivery: Persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage, Mol. Pharm., 6, 1343, 10.1021/mp900022m Huang, 2011, The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo, ACS Nano., 5, 5390, 10.1021/nn200365a Zhou, 2013, Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery, Biomaterials., 34, 5722, 10.1016/j.biomaterials.2013.04.012 Arnida, 2011, Ghandehari, Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages, Eur. J. Pharm. Biopharm., 77, 417, 10.1016/j.ejpb.2010.11.010 Park, 2009, Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting, Small., 5, 694, 10.1002/smll.200801789 Wang, 2014, High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties, ACS Nano., 8, 12437, 10.1021/nn505126b Peiris, 2012, Enhanced delivery of chemotherapy to tumors using a multicomponent nanochain with radio-frequency-tunable drug release, ACS Nano., 6, 4157, 10.1021/nn300652p Muro, 2008, Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers, Mol. Ther., 16, 1450, 10.1038/mt.2008.127 Ben-Akiva, 2020, Biomimetic anisotropic polymeric nanoparticles coated with red blood cell membranes for enhanced circulation and toxin removal, Sci. Adv., 6, 1, 10.1126/sciadv.aay9035 Anselmo Aaron, 2014, Platelet-like nanoparticles: mimicking shape, flexibility, and surface biology of platelets to target vascular injuries, ACS Nano., 8, 11243, 10.1021/nn503732m Namdee, 2014, In vivo evaluation of vascular-targeted spheroidal microparticles for imaging and drug delivery application in atherosclerosis, Atherosclerosis., 237, 279, 10.1016/j.atherosclerosis.2014.09.025 Decuzzi, 2010, Size and shape effects in the biodistribution of intravascularly injected particles, J. Control. Release., 141, 320, 10.1016/j.jconrel.2009.10.014 Li, 2015, Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape, Nanomedicine Nanotechnology, Biol. Med., 11, 1915 Barua, 2013, Particle shape enhances specificity of antibody-displaying nanoparticles, Proc. Natl. Acad. Sci. U. S. A., 110, 3270, 10.1073/pnas.1216893110 Tjandra, 2020, Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display, Adv. Healthc. Mater., 2000261, 1 Wang, 2019, Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres, Nano Res., 12, 2451, 10.1007/s12274-019-2488-3 Cao, 2019, Development of PLGA micro- and nanorods with high capacity of surface ligand conjugation for enhanced targeted delivery, Asian J. Pharm. Sci., 14, 86, 10.1016/j.ajps.2018.08.008 Doshi, 2011, Cell-based drug delivery devices using phagocytosis-resistant backpacks, Adv. Mater., 23, 10.1002/adma.201004074 Gilbert, 2013, Orientation-specific attachment of polymeric microtubes on cell surfaces, Adv. Mater., 25, 5948, 10.1002/adma.201302673 Chauhan, 2011, Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration, Angew. Chemie - Int. Ed., 50, 11417, 10.1002/anie.201104449 Liu, 2007, In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice, Nat. Nanotechnol., 2, 47, 10.1038/nnano.2006.170 Harris, 2012, Particle shape effects in vitro and in vivo, Front. Biosci. (Schol. Ed)., 4, 1344 Van De Ven, 2012, Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution, J. Control. Release., 158, 148, 10.1016/j.jconrel.2011.10.021 Godin, 2012, Discoidal porous silicon particles: Fabrication and biodistribution in breast cancer bearing mice, Adv. Funct. Mater., 22, 4225, 10.1002/adfm.201200869 Chu, 2013, Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft, Nanomedicine Nanotechnology, Biol. Med., 9, 686 Wibroe, 2017, Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes, Nat. Nanotechnol., 10.1038/nnano.2017.47 Roberts, 2013, Analysis of the Murine Immune Response to Pulmonary Delivery of Precisely Fabricated Nano- and Microscale Particles, PLoS One. Shen, 2015, Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery, Pharm. Res., 10.1007/s11095-015-1701-7 Collier, 2016, Saquinavir Loaded Acetalated Dextran Microconfetti – a Long Acting Protease Inhibitor Injectable, Pharm. Res., 10.1007/s11095-016-1936-y Tazaki, 2018, Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines, RSC Adv., 10.1039/C8RA01690A Shukla, 2017, Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers, Biomaterials., 10.1016/j.biomaterials.2016.12.030 Hassani Najafabadi, 2020, Cancer Immunotherapy via Targeting Cancer Stem Cells Using Vaccine Nanodiscs, Nano Lett., 10.1021/acs.nanolett.0c03414 Kuai, 2020, Robust Anti-Tumor T Cell Response with Efficient Intratumoral Infiltration by Nanodisc Cancer Immunotherapy, Adv. Ther., 10.1002/adtp.202000094 Scheetz, 2020, Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy against Gliomas, Clin. Cancer Res., 10.1158/1078-0432.CCR-20-0341 Spiller, 2015, Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds, Biomaterials., 10.1016/j.biomaterials.2014.10.017 Wofford, 2020, Biomaterial-mediated reprogramming of monocytes via microparticle phagocytosis for sustained modulation of macrophage phenotype, Acta Biomater., 101, 237, 10.1016/j.actbio.2019.11.021 Hettiaratchi, 2019, Modulated Protein Delivery to Engineer Tissue Repair, Tissue Eng. - Part A., 10.1089/ten.tea.2019.0066 He, 2020, Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases, Adv. Drug Deliv. Rev., 165–166, 15, 10.1016/j.addr.2019.12.001 Fan, 2017, A general strategy to synthesize chemically and topologically anisotropic Janus particles, Sci. Adv., 3, 1, 10.1126/sciadv.1603203 Haryadi, 2019, Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting, Adv. Healthc. Mater., 8, 11, 10.1002/adhm.201900352 Kirch, 2012, Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge-an ex vivo and in silico approach, J. Control. Release., 10.1016/j.jconrel.2011.12.015