Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy

Yang, 2020, Engineering prodrug nanomedicine for cancer immunotherapy, Adv Sci, 7, 10.1002/advs.202002365 Syn, 2017, De-novo and acquired resistance to immune checkpoint targeting, Lancet Oncol, 18, E731, 10.1016/S1470-2045(17)30607-1 Goldberg, 2019, Improving cancer immunotherapy through nanotechnology, Nat Rev Cancer, 19, 587, 10.1038/s41568-019-0186-9 Buss, 2020, Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics, Proc Natl Acad Sci U S A, 117, 13428, 10.1073/pnas.2001569117 Yang, 2019, Synergetic functional nanocomposites enhance immunotherapy in solid tumors by remodeling the immunoenvironment, Adv Sci, 6, 10.1002/advs.201802012 Binnewies, 2018, Understanding the tumor immune microenvironment (TIME) for effective therapy, Nat Med, 24, 541, 10.1038/s41591-018-0014-x Peng, 2022, Tumor-microenvironment-responsive nanomedicine for enhanced cancer immunotherapy, Adv Sci, 9, 10.1002/advs.202103836 Li, 2019, A three-in-one immunotherapy nanoweapon via cascade-amplifying cancer-immunity cycle against tumor metastasis, relapse, and postsurgical regrowth, Nano Lett, 19, 6647, 10.1021/acs.nanolett.9b02923 Wang, 2021, Cooperative self-assembled nanoparticle induces sequential immunogenic cell death and Toll-like receptor activation for synergistic chemo-immunotherapy, Nano Lett, 21, 4371, 10.1021/acs.nanolett.1c00977 Ovais, 2019, Tailoring nanomaterials for targeting tumor-associated macrophages, Adv Mater, 31, 10.1002/adma.201808303 Cassetta, 2018, Targeting macrophages: therapeutic approaches in cancer, Nat Rev Drug Discov, 17, 887, 10.1038/nrd.2018.169 Ginhoux, 2016, New insights into the multidimensional concept of macrophage ontogeny, activation and function, Nat Immunol, 17, 34, 10.1038/ni.3324 Zhao, 2021, Charge-switchable nanoparticles enhance Cancer immunotherapy based on mitochondrial dynamic regulation and immunogenic cell death induction, J Control Release, 335, 320, 10.1016/j.jconrel.2021.05.036 Komohara, 2016, Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy, Adv Drug Deliv Rev, 99, 180, 10.1016/j.addr.2015.11.009 Noy, 2014, Tumor-associated macrophages: from mechanisms to therapy, Immunity, 41, 49, 10.1016/j.immuni.2014.06.010 Lin, 2019, Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications, J Hematol Oncol, 12, 76, 10.1186/s13045-019-0760-3 Zhang, 2020, Nanoparticle-enabled dual modulation of phagocytic signals to improve macrophage-mediated cancer immunotherapy, Small, 16, 10.1002/smll.202004240 Xia, 2020, Engineering macrophages for cancer immunotherapy and drug delivery, Adv Mater, 32, 10.1002/adma.202002054 Nywening, 2016, Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial, Lancet Oncol, 17, 651, 10.1016/S1470-2045(16)00078-4 Zhao, 2021, Nanomedicine enables spatiotemporally regulating macrophage-based cancer immunotherapy, Biomaterials, 268, 10.1016/j.biomaterials.2020.120552 Sylvestre, 2020, Progress on modulating tumor-associated macrophages with biomaterials, Adv Mater, 32, 10.1002/adma.201902007 Yue, 2021, Biomimetic nanoparticles carrying a repolarization agent of tumor-associated macrophages for remodeling of the inflammatory microenvironment following photothermal therapy, ACS Nano, 15, 15166, 10.1021/acsnano.1c05618 Xie, 2021, Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance, Biomaterials, 275, 10.1016/j.biomaterials.2021.120891 Jain, 2015, Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis, Biomaterials, 61, 162, 10.1016/j.biomaterials.2015.05.028 Shobaki, 2020, Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy, J Control Release, 325, 235, 10.1016/j.jconrel.2020.07.001 Feng, 2019, Phagocytosis checkpoints as new targets for cancer immunotherapy, Nat Rev Cancer, 19, 568, 10.1038/s41568-019-0183-z Liu, 2015, CD47 blockade triggers T cell-mediated destruction of immunogenic tumors, Nat Med, 21, 1209, 10.1038/nm.3931 Chen, 2021, Recent advancements in nanomedicine for 'cold' tumor immunotherapy, Nanomicro Lett, 13, 92 Duan, 2019, Nanoparticle-mediated immunogenic cell death enables and potentiates cancer immunotherapy, Angew Chem Int Ed Engl, 58, 670, 10.1002/anie.201804882 Chen, 2019, Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses, Chem Soc Rev, 48, 5506, 10.1039/C9CS00271E Rong, 2019, Iron chelated melanin-like nanoparticles for tumor-associated macrophage repolarization and cancer therapy, Biomaterials, 225, 10.1016/j.biomaterials.2019.119515 Huang, 2021, Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer, Nat Commun, 12, 4310, 10.1038/s41467-021-24564-0 Chen, 2019, Nanoparticle-enhanced radiotherapy to trigger robust cancer immunotherapy, Adv Mater, 31, 10.1002/adma.201802228 Chao, 2018, Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses, Nat Biomed Eng, 2, 611, 10.1038/s41551-018-0262-6 Saeed, 2019, Engineering nanoparticles to reprogram the tumor immune microenvironment for improved cancer immunotherapy, Theranostics, 9, 7981, 10.7150/thno.37568 Dai, 2020, Eliciting immunogenic cell death via a unitized nanoinducer, Nano Lett, 20, 6246, 10.1021/acs.nanolett.0c00713 Mosquera, 2019, Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome-mediated metabolic syndrome, Sci Adv, 5, eaav9788, 10.1126/sciadv.aav9788 Yu, 2019, Multifunctional nanoregulator reshapes immune microenvironment and enhances immune memory for tumor immunotherapy, Adv Sci, 6, 10.1002/advs.201900037 De Henau, 2016, Overcoming resistance to checkpoint blockade therapy by targeting PI3K gamma in myeloid cells, Nature, 539, 443, 10.1038/nature20554 Zhang, 2019, Inhibiting PI3 kinase-gamma in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors, J Control Release, 309, 173, 10.1016/j.jconrel.2019.07.039 Klinman, 2004, Immunotherapeutic uses of CpG oligodeoxynucleotides, Nat Rev Immunol, 4, 249, 10.1038/nri1329 Liu, 2019, Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal, Nat Immunol, 20, 265, 10.1038/s41590-018-0292-y Liu, 2020, Core-shell nanosystems for self-activated drug-gene combinations against triple-negative breast cancer, ACS Appl Mater Interfaces, 12, 53654, 10.1021/acsami.0c15089 Shen, 2016, Interfacial cohesion and assembly of bioadhesive molecules for design of long term stable hydrophobic nanodrugs toward effective anticancer therapy, ACS Nano, 10, 5720, 10.1021/acsnano.5b07276 Liu, 2021, Metal-phenolic networks for cancer theranostics, Biomater Sci, 9, 2825, 10.1039/D0BM02064H Schrimpf, 2016, Investigation of the co-dependence of morphology and fluorescence lifetime in a metal-organic framework, Small, 12, 3651, 10.1002/smll.201600619 Wang, 2019, A stable zirconium based metal-organic framework for specific recognition of representative polychlorinated dibenzo-p-dioxin molecules, Nat Commun, 10, 3861, 10.1038/s41467-019-11912-4 Jiang, 2020, Tumor-targeted delivery of silibinin and IPI-549 synergistically inhibit breast cancer by remodeling the microenvironment, Int J Pharm, 581, 10.1016/j.ijpharm.2020.119239 Liu, 2018, Ferrous-supply-regeneration nanoengineering for cancer-cell-specific ferroptosis in combination with imaging-guided photodynamic therapy, ACS Nano, 12, 12181, 10.1021/acsnano.8b05860 Song, 2021, Macrophage-targeted nanomedicine for chronic diseases immunotherapy, Chin Chem Lett, 33, 597, 10.1016/j.cclet.2021.08.090 Krieg, 2006, Therapeutic potential of Toll-like receptor 9 activation, Nat Rev Drug Discov, 5, 471, 10.1038/nrd2059 Qu, 2020, Template-mediated assembly of DNA into microcapsules for immunological modulation, Small, 16, 10.1002/smll.202002750 McWhorter, 2013, Modulation of macrophage phenotype by cell shape, Proc Natl Acad Sci U S A, 110, 17253, 10.1073/pnas.1308887110 Biswas, 2010, Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm, Nat Immunol, 11, 889, 10.1038/ni.1937 Shan, 2020, Targeted ferritin nanoparticle encapsulating CpG oligodeoxynucleotides induces tumor-associated macrophage M2 phenotype polarization into M1 phenotype and inhibits tumor growth, Nanoscale, 12, 22268, 10.1039/D0NR04520A Tumeh, 2014, PD-1 blockade induces responses by inhibiting adaptive immune resistance, Nature, 515, 568, 10.1038/nature13954 Topalian, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, 366, 2443, 10.1056/NEJMoa1200690 Zhang, 2020, The progress and perspective of nanoparticle-enabled tumor metastasis treatment, Acta Pharm Sin B, 10, 2037, 10.1016/j.apsb.2020.07.013