Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity
Tóm tắt
Metastasis can be inhibited by asialo-GM1-positive spleen cells, and in this paper we show that there are two such spleen cell populations. One population is adherent and non-cytotoxic to YAC cells, whereas the other population is non-adherent and cytotoxic to YAC cells. Both cell populations exert an antimetastatic activity in cyclophosphamide-treated mice that are inoculated with LL2 Lewis lung carcinoma cells. We conclude that the antimetastatic activity is not only exerted by cytotoxic asialo-GM1-positive cells (apparently natural killer cells), but also by adherent, non-cytotoxic asialo-GM1+, Thy1.2−, IgG− cells. This means that the latter exert their antimetastatic activity by a non-cytotoxic mechanism.
Tài liệu tham khảo
Alexander P, Senior PV, Murphy P, Clarke R (1986) Role of the growth stimulatory factors in determining the sites of metastasis. In: Mechanisms of cancer metastasis. Martinus Nijhoff Publishing, Boston, p 173
Bishop CJ, Whiting VA (1983) The role of the natural killer cells in the intravascular death of intravenously injected murine tumour cells. Br J Cancer 48: 441
Budzynski W, Chirigos M, Gruys E (1987) Augmentation of natural cell activity in tumour bearing and normal mice by MVE-2. Cancer Immunol Immunother 24: 253
Dus D, Budzynski W, Radzikowski C (1985) LL2 cell line derived from transplantable murine Lewis lung carcinoma — maintainance in vitro and growth characteristics. Arch Immunol Ther Exp (Warsz) 33: 831
Fidler IJ (1970) Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with125I-5-iodo-2-deoxyuridine. J Natl Cancer Inst 45: 773
Gorelik E, Wiltrout R, Okumura K, Habu S, Herberman RN (1982) Role of NK cells in the control of metastatic spread and growth of tumor cells in mice. Int J Cancer 30: 107
Gorelik E, Beere WW, Herberman RB (1984) Role of the NK cells in the anti-metastatic effect of anti-coagulant drug. Int J Cancer 33: 87
Hanna N (1987) Review of evidence for role of NK cells in immunoprophylaxis of metastasis. In: Immune responses to metastases. CRC Press, Boca Raton, Florida, p 13
Hanna N, Fidler IJ (1980) Role of natural killer cells in the destruction of circulating tumour emboli. J Natl Cancer 65: 801
Hanna N, Burton RC (1981) Definitive evidence that natural killer (NK) cells inhibit experimental tumour metastasis in vivo. J Immunol 127: 1754
Hanna N, Schneider M (1983) Enhancement of tumour metastasis and suppression of natural killer cell activity by β-estradiol treatment. J Immunol 130: 974
Janik P, Szaniawska B (1984) Indirect effect of cyclophosphamide on the lung colony formation and on the conditioned media activity. Neoplasm 31: 37
Kawano YI, Taniguchi K, Karre K, Toshitani A, Nomoto K (1988) Host H-2 genotype regulates the metastatic ability of H-2 associated variants of B16 melanoma: defence system screening for absence of self H-2 components by natural killer cells and host-associated homing barrier. Cell Immunol 111: 341
Kisielow P, Draber P (1981) Expression of T-cell differentiation antigens on activated thymocytes. Cell Immunol 65: 180
Milas L, Peters LI (1984) Conditioning of tissue for metastasis formation by radiation and cytotoxic drug. In: Cancer invasion and metastasis: biological and therapeutic aspects. Raven Press, New York, p 321
Milas L, Malenica B, Allegretti N (1979) Enhancement of artificial lung metastases caused by cyclophosphamide. I. Participation of impairment of host anti-tumour resistance. Cancer Immunol Immunother 6: 191
Mercurio AM, Schwarting GA, Robbins PW (1984) Glycolipids of mouse peritoneal macrophages. J Exp Med 160: 1114
Orr FW, Warner DJA (1987) Effects of neutrophil-mediated pulmonary endothelial injury on the localization and metastasis of circulating Walker carcinoma cells. Invasion Metastasis 7: 183
Orr FW, Adamson IYR, Young L (1986) Promotion of pulmonary metastasis in mice by bleomycin induced endothelial injury. Cancer Res 46: 891
Ruiter I, Smink T, Van Putten LM (1976) Studies on the enhancement by cyclophosphamide of artificial lung metastases after labeled cell inoculation. Cancer Treat Rep 60: 465
Sieman DW, Macler L, Penney DP (1986) Cyclophosphamide-induced pulmonary cytotoxicity. Br J Cancer 55: 343
Stitz L, Baenziger J, Pircher H, Hengarter H, Zinkernagel RM (1986) Effect of rabbit anti-asialo-GM1 treatment in vivo or with anti-asialo-GM1 plus complement in vitro on cytotoxic T cell activities. J Immunol 136: 4674
Stout RD, Scharting GA (1987) Evidence that expression of asialo-GM1 may be associated with cell activation. J Immunol 139: 2123
Strzadala L, Rak J, Kusnierczyk H (1985) Enhancement by cycophosphamide of experimental pulmonary metastasis formation of Lewis lung carcinoma. I. Dose dependence and kinetics of cyclophosphamide effect. Arch Immunol Ther Exp (Warsz) 33: 825
Strzadala L, Rak J, Kusnierczyk H (1985) Enhancement by cyclophosphamide of experimental pulmonary metastasis formation of Lewis lung carcinoma. II. Reduction of the cyclophosphamide effect by repopulation with cells from lymphoid organs. Arch Immunol Ther Exp (Warsz) 33: 831
Strzadala L, Rak J, Ziolo E, Kusnierczyk H, Radzikowski C (1989) Potentiation of cyclophosphamide-induced enhancement of experimental metastasis by splenectomy. Arch Immunol Ther Exp (Warsz) (in press)
Suttles J, Schwarting GA, Hougland MW, Stout RD (1987) Expression of asialo-GM1 on a subset of adult murine thymocytes: histological localization and demonstration that the asialo GM-1 positive subset contains both the functionally mature and the proliferating thymocyte subpopulations. J Immunol 138: 364
Van Putten LM, Kram LKJ, Van Dierendonck HHC, Smink T, Fuzy M (1975) Enhancement by drug of metastatic lung nodule formation after intravenous tumour cell injection. Int J Cancer 15: 588
Wexler H (1966) Accurate identification of experimental pulmonary metastases. J Natl Cancer Inst 36: 641
Wiltrout RH, Talmadge JE, Herberman RB (1987) Role of NK cells in prevention and treatment of metastases by biological response modifiers. In: Immune response to metastases. CRC Press, Boca Raton, Florida, p 25
Yang JC, Mulé JJ, Rosenberg SA (1986) Lymphokine-activated killer (LAK) cells: phenotypic characterization of the precursor and effector cells. J Immunol 137: 715
Young WW, Haomori SI, Durdik JM, Henney CS (1980) Identification of ganglio-N-tetrasylceramide as a new marker for murine natural killer (NK) cells. J Immunol 124: 199