Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing

Ounzain, 2015, The promise of enhancer-associated long noncoding RNAs in cardiac regeneration, Trends cardiovasc. Med., 25, 592, 10.1016/j.tcm.2015.01.014 Frank, 2016, A lncRNA perspective into (Re)Building the heart, Front. Cell Dev. Biol., 4, 128, 10.3389/fcell.2016.00128 Aguirre, 2013, Reprogramming toward heart regeneration: stem cells and beyond, Cell Stem Cell, 275, 10.1016/j.stem.2013.02.008 Giacca, 2015, Harnessing the microRNA pathway for cardiac regeneration, J. Mol. Cell. Cardiol., 68, 10.1016/j.yjmcc.2015.09.017 Itou, 2012, Life-long preservation of the regenerative capacity in the fin and heart in zebrafish, Biol. Open, 1, 739, 10.1242/bio.20121057 Poss, 2002, Heart regeneration in zebrafish, Science (80-. ), 298, 2188, 10.1126/science.1077857 Jopling, 2010, Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation, Nature, 464, 606, 10.1038/nature08899 Chablais, 2011, The zebrafish heart regenerates after cryoinjury-induced myocardial infarction, BMC Dev. Biol., 11, 21, 10.1186/1471-213X-11-21 González-Rosa, 2011, Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish, Development, 138, 1663, 10.1242/dev.060897 Schnabel, 2011, Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation, PLoS One, 6 Wang, 2011, The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion, Development, 138, 3421, 10.1242/dev.068601 Parente, 2013, Hypoxia/reoxygenation cardiac injury and regeneration in zebrafish adult heart, PLoS One, 8, 10.1371/journal.pone.0053748 Porrello, 2011, Transient regenerative potential of the neonatal mouse heart, Science, 331, 1078, 10.1126/science.1200708 Senyo, 2012, Mammalian heart renewal by pre-existing cardiomyocytes, Nature, 493, 433, 10.1038/nature11682 Aguirre, 2014, In vivo activation of a conserved microRNA program induces mammalian heart regeneration, Cell Stem Cell., 15, 589, 10.1016/j.stem.2014.10.003 Mercer, 2013, Structure and function of long noncoding RNAs in epigenetic regulation, Nat. Struct. Mol. Biol., 20, 300, 10.1038/nsmb.2480 Seeger, 2013, MicroRNAs in stem cell function and regenerative therapy of the heart, Arter. Thromb. Vasc. Biol., 33, 1739, 10.1161/ATVBAHA.113.300138 Grote, 2014, The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse, Dev. Cell., 24, 206, 10.1016/j.devcel.2012.12.012 Klattenhoff, 2013, Braveheart, a long noncoding RNA required for cardiovascular lineage commitment, Cell, 152, 570, 10.1016/j.cell.2013.01.003 Kurian, 2015, Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development, Circulation, 131, 1278, 10.1161/CIRCULATIONAHA.114.013303 Ounzain, 2015, CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis, J. Mol. Cell. Cardiol., 89, 98, 10.1016/j.yjmcc.2015.09.016 Ounzain, 2015, Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs, Eur. Heart J., 36, 353, 10.1093/eurheartj/ehu180 Ounzain, 2014, Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease, J. Mol. Cell. Cardiol., 76, 55, 10.1016/j.yjmcc.2014.08.009 Han, 2014, A long noncoding RNA protects the heart from pathological hypertrophy, Nature, 514, 102, 10.1038/nature13596 Michalik, 2014, Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth, Circ. Res., 114, 1389, 10.1161/CIRCRESAHA.114.303265 Yap, 2010, Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a, Mol. Cell., 38, 662, 10.1016/j.molcel.2010.03.021 Wang, 2014, CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation, Nat. Commun., 5, 3596, 10.1038/ncomms4596 Devaux, 2015, Long noncoding RNAs in cardiac development and ageing, Nat. Rev. Cardiol., 12, 415, 10.1038/nrcardio.2015.55 Ounzain, 2013, Small and long non-coding RNAs in cardiac homeostasis and regeneration, Biochim. Biophys. Acta - Mol. Cell Res., 923, 10.1016/j.bbamcr.2012.08.010 Uchida, 2015, Long noncoding RNAs in cardiovascular diseases, Circ. Res., 737, 10.1161/CIRCRESAHA.116.302521 Van Rooij, 2008, Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis, Proc. Natl. Acad. Sci. U. S. A., 105, 13027, 10.1073/pnas.0805038105 Kikuchi, 2015, Dedifferentiation, transdifferentiation, and proliferation: mechanisms underlying cardiac muscle regeneration in zebrafish, Curr. Pathobiol. Rep., 3, 81, 10.1007/s40139-015-0063-5 Kikuchi, 2010, Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes, Nature, 464, 601, 10.1038/nature08804 Kikuchi, 2011, Tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration, Development, 138, 2895, 10.1242/dev.067041 Gomes, 2016, “Young at heart”: regenerative potential linked to immature cardiac phenotypes, J. Mol. Cell. Cardiol. Authors, 92, 105, 10.1016/j.yjmcc.2016.01.026 Porrello, 2011, MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes, Circ. Res., 109, 670, 10.1161/CIRCRESAHA.111.248880 Porrello, 2013, Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family, Proc. Natl. Acad. Sci. U. S. A., 110, 187, 10.1073/pnas.1208863110 Hullinger, 2012, Inhibition of miR-15 protects against cardiac ischemic injury, Circ. Res., 110, 71, 10.1161/CIRCRESAHA.111.244442 Chen, 2006, The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation, Nat. Genet., 38, 228, 10.1038/ng1725 Liu, 2008, microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart, Genes Dev., 22, 3242, 10.1101/gad.1738708 Carè, 2007, microRNA-133 controls cardiac hypertrophy, Nat. Med., 13, 613, 10.1038/nm1582 Yin, 2012, Regulation of zebrafish heart regeneration by miR-133, Dev. Biol., 365, 319, 10.1016/j.ydbio.2012.02.018 Eulalio, 2012, Functional screening identifies miRNAs inducing cardiac regeneration, Nature, 492, 376, 10.1038/nature11739 Roush, 2008, The let-7 family of microRNAs, Trends Cell Biol., 505, 10.1016/j.tcb.2008.07.007 Coppola, 2014, Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications, Stem Cell Res. Authors, 12, 323, 10.1016/j.scr.2013.11.008 Shyh-Chang, 2013, XLin28 enhances tissue repair by reprogramming cellular metabolism, Cell, 155 Ventura, 2008, Targeted deletion reveals essential and overlapping functions of the miR-17-92 family of miRNA clusters, Cell, 132, 875, 10.1016/j.cell.2008.02.019 Wang, 2010, Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism, Dev. Cell., 19, 903, 10.1016/j.devcel.2010.10.022 Chen, 2013, Mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts, Circ. Res., 112, 1557, 10.1161/CIRCRESAHA.112.300658 Iekushi, 2012, Regulation of cardiac MicroRNAs by bone marrow mononuclear cell therapy in myocardial infarction, Circulation, 125, 1765, 10.1161/CIRCULATIONAHA.111.079699 Yamakuchi, 2008, miR-34a repression of SIRT1 regulates apoptosis, Proc. Natl. Acad. Sci. U. S. A., 105, 13421, 10.1073/pnas.0801613105 Bernardo, 2012, Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function, Proc. Natl. Acad. Sci. U. S. A., 109, 17615, 10.1073/pnas.1206432109 Ito, 2010, microRNA-34a regulation of endothelial senescence, Biochem. Biophys. Res. Commun., 398, 735, 10.1016/j.bbrc.2010.07.012 Boon, 2013, MicroRNA-34a regulates cardiac ageing and function, Nature, 495, 107, 10.1038/nature11919 Matsumoto, 2013, Circulating p53-responsive MicroRNAs are predictive indicators of heart failure after acute myocardial infarction, Circ. Res., 113, 322, 10.1161/CIRCRESAHA.113.301209 Tian, 2015, A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice, Sci. Transl. Med., 7, 10.1126/scitranslmed.3010841 Heallen, 2013, Hippo signaling impedes adult heart regeneration, Development, 140, 4683, 10.1242/dev.102798 Wackerhage, 2014, The Hippo signal transduction network in skeletal and cardiac muscle, Sci. Signal, 7, 10.1126/scisignal.2005096 Von Gise, 2012, YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy, Proc. Natl. Acad. Sci. U. S. A., 109, 2394, 10.1073/pnas.1116136109 Xin, 2011, Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size, Sci. Signal, 4, ra70, 10.1126/scisignal.2002278 Xin, 2013, Hippo pathway effector Yap promotes cardiac regeneration, Proc. Natl. Acad. Sci., 110, 13839, 10.1073/pnas.1313192110 Heallen, 2011, Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size, Science (80-. ), 332, 458, 10.1126/science.1199010 Pan, 2010, The hippo signaling pathway in development and cancer, Dev. Cell, 491, 10.1016/j.devcel.2010.09.011 Tao, 2015, Small RNA: from development to regeneration, Sci. Transl. Med., 7, 10.1126/scitranslmed.aaa7538 Yang, 2015, MIR-206 mediates YAP-induced cardiac hypertrophy and survival, Circ. Res., 117, 891, 10.1161/CIRCRESAHA.115.306624 Beltrami, 2003, Adult cardiac stem cells are multipotent and support myocardial regeneration, Cell, 114, 763, 10.1016/S0092-8674(03)00687-1 Bearzi, 2007, Human cardiac stem cells, Proc. Natl. Acad. Sci. U. S. A., 104, 14068, 10.1073/pnas.0706760104 Messina, 2004, Isolation and expansion of adult cardiac stem cells from human and murine heart, Circ. Res., 95, 911, 10.1161/01.RES.0000147315.71699.51 Martin, 2004, Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart, Dev. Biol., 265, 262, 10.1016/j.ydbio.2003.09.028 Oh, 2003, Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction, Proc. Natl. Acad. Sci. U. S. A., 100, 12313, 10.1073/pnas.2132126100 Laugwitz, 2005, Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages, Nature, 433, 647, 10.1038/nature03215 Chong, 2013, Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart, Stem Cells Dev., 22, 1932, 10.1089/scd.2012.0542 Santini, 2016, Developmental origin and lineage plasticity of endogenous cardiac stem cells, Development, 143, 1242, 10.1242/dev.111591 Keith, 2015, “String theory” of c-kit(pos) cardiac cells: a new paradigm regarding the nature of these cells that may reconcile apparently discrepant results, Circ. Res., 116, 1216, 10.1161/CIRCRESAHA.116.305557 Wilson, 2010, Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499, Circ. Cardiovasc. Genet., 3, 426, 10.1161/CIRCGENETICS.109.934281 Van Rooij, 2007, Control of stress-dependent cardiac growth and gene expression by a microRNA, Science (80-. ), 316, 575, 10.1126/science.1139089 Fu, 2011, Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes, PLoS One, 6, e27417, 10.1371/journal.pone.0027417 Jayawardena, 2012, MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes, Circ. Res., 110, 1465, 10.1161/CIRCRESAHA.112.269035 Nam, 2013, Reprogramming of human fibroblasts toward a cardiac fate, Proc. Natl. Acad. Sci. U. S. A., 110, 5588, 10.1073/pnas.1301019110 Rumyantsev, 1966, Autoradiographic study on the synthesis of DNA, RNA, and proteins in normal cardiac muscle cells and those changed by experimental injury, Folia Histochen Cytochem, 4, 397 Sulima, 1968, On the regeneration of the myocardium in various injuries to the cardiac wall of reptiles, Arkh Anat. Gistol. Embriol, 55, 56 Rumyantsev, 1973, Post-injury DNA synthesis, mitosis and ultrastructural reorganization of adult frog cardiac myocytes. An electron microscopic-autoradiographic study, Z Zellforsch Mikrosk Anat., 139, 431, 10.1007/BF00306596 Bergmann, 2009, Evidence for cardiomyocyte renewal in humans, Science, 324, 98, 10.1126/science.1164680 Beltrami, 2001, Evidence that human cardiac myocytes divide after myocardial infarction, N. Engl. J. Med., 344, 1750, 10.1056/NEJM200106073442303