Non-coding RNAs as key players in the neurodegenerative diseases: Multi-platform strategies and approaches for exploring the Genome’s dark matter

Journal of Chemical Neuroanatomy - Tập 129 - Trang 102236 - 2023
Hailah M. Almohaimeed1, Rasha Assiri2, Eman Hillal Althubaiti3, Waheeb S. Aggad4, Sameerah Shaheen5, Marwa Y. Shaheen6, Munirah A. Batarfi7,8, Nada Abdullah Alharbi9,2, Areej Mohammed Alshehri10, Basal sulaiman M. Alkhudhairy11
1Department of Basic Science, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
2Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
3Department of Biotechnology, College of Science, Taif University, P.O.BOX 11099, Taif 21944, Saudi Arabia
4Department of Anatomy, College of Medicine, University of Jeddah, P.O. Box 8304, Jeddah, 23234, Saudi Arabia
5Anatomy Department and Stem Cell Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia
6Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11451, Saudi Arabia
7Department of Anatomy, Basic medical Sciences, College of Medicine King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia
8King Abdulaziz Medical City (National Guard Health Affairs), Riyadh, Saudi Arabia
9Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Qassim, Saudi Arabia
10Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
11College of Medicine, Shaqra University, P.O. Box 13343, Riyadh 7396, Saudi Arabia

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Abrishamdar, M., Jalali, M., Rashno, M.J.M.N., 2022, MALAT1 lncRNA and Parkinson’s Disease: The role in the Pathophysiology and Significance for Diagnostic and Therapeutic Approaches. 1–10. Ajroud-Driss, 2015, Sporadic and hereditary amyotrophic lateral sclerosis (ALS), Biochim. Et. Biophys. Acta (BBA)-Mol. Basis Dis., 1852, 679, 10.1016/j.bbadis.2014.08.010 Alieva, 2015, miRNA expression is highly sensitive to a drug therapy in Parkinson's disease, Park. Relat. Disord., 21, 72, 10.1016/j.parkreldis.2014.10.018 Allemailem, 2021, Single nucleotide polymorphisms (SNPs) in prostate cancer: its implications in diagnostics and therapeutics, Am. J. Transl. Res., 13, 3868 Almatroudi, 2022, Non-coding RNAs in tuberculosis epidemiology: platforms and approaches for investigating the Genome’s dark matter, Int. J. Mol. Sci., 23, 4430, 10.3390/ijms23084430 Ansari, 2021, Prospective therapeutic potential of Tanshinone IIA: An updated overview, Pharmacol. Res., 164, 10.1016/j.phrs.2020.105364 Baby, 2020, MicroRNA‐134–5p inhibition rescues long‐term plasticity and synaptic tagging/capture in an Aβ (1–42)‐induced model of Alzheimer’s disease, Aging Cell, 19, 10.1111/acel.13046 Bahonar, 2022, New correlations to predict oil viscosity using data mining techniques, J. Pet. Sci. Eng., 208, 10.1016/j.petrol.2021.109736 Bastías-Candia, 2019, Revisiting the paraquat-induced sporadic Parkinson’s disease-like model, Mol. Neurobiol., 56, 1044, 10.1007/s12035-018-1148-z Bavelloni, 2017, MiRNA-210: a current overview, Anticancer Res., 37, 6511 Beermann, 2016, Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches, Physiol. Rev., 10.1152/physrev.00041.2015 Bennett, 2019, Front. Neurosci., 13, 235, 10.3389/fnins.2019.00235 Bennett, 2005, The role of α-synuclein in neurodegenerative diseases, Pharmacol. Ther., 105, 311, 10.1016/j.pharmthera.2004.10.010 Bhattacharyya, N., Pandey, V., Bhattacharyya, M., Dey, A.J.A.Jo.P.S., 2021, Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies. 16, 533–550. Biscarini, 2018, Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS, Stem Cell Res., 27, 172, 10.1016/j.scr.2018.01.037 Bonnal, 2015, miRiadne: a web tool for consistent integration of miRNA nomenclature, Nucleic Acids Res., 43, W487, 10.1093/nar/gkv381 Bucchia, 2015, Therapeutic development in amyotrophic lateral sclerosis, Clin. Ther., 37, 668, 10.1016/j.clinthera.2014.12.020 Cai, L.-J., Tu, L., Huang, X.-M., Huang, J., Qiu, N., Xie, G.-H., Liao, J.-X., Du, W., Zhang, Y.-Y., Tian, J.-Y.J.Mb, 2020, LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease. 13, 1–15. Cai, 2019, Downregulation of lncRNA UCA1 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson's disease through the inhibition of the PI3K/Akt signaling pathway, Int. Immunopharmacol., 75, 10.1016/j.intimp.2019.105734 Calabresi, 2013, New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease, Lancet Neurol., 12, 811, 10.1016/S1474-4422(13)70118-2 Cao, 2020, Overexpression of microRNA-9a-5p ameliorates NLRP1 inflammasome-mediated ischemic injury in rats following ischemic stroke, Neuroscience, 444, 106, 10.1016/j.neuroscience.2020.01.008 Carrettiero, 2009, The cochaperone BAG2 sweeps paired helical filament-insoluble tau from the microtubule, J. Neurosci., 29, 2151, 10.1523/JNEUROSCI.4660-08.2009 Chakravarty, 2014, The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer, Nat. Commun., 5, 1, 10.1038/ncomms6383 Chen, 2019, MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice, Int. J. Mol. Med., 43, 91 Chen, 2017, LincRNa-p21: function and mechanism in cancer, Med. Oncol., 34, 1, 10.1007/s12032-017-0959-5 Chen, 2016, circRNADb: a comprehensive database for human circular RNAs with protein-coding annotations, Sci. Rep., 6, 1 Chen, 2013, Novel human lncRNA–disease association inference based on lncRNA expression profiles, Bioinforma. (Oxf., Engl. ), 29, 2617 Chen, 2018, LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells, Neurotoxicology, 68, 212, 10.1016/j.neuro.2017.12.001 Cheng, 2022, ViRBase v3. 0: a virus and host ncRNA-associated interaction repository with increased coverage and annotation, Nucleic Acids Res., 50, D928, 10.1093/nar/gkab1029 Cheng, 2022, Comparative transcriptome profiles of Schistosoma japonicum larval stages: Implications for parasite biology and host invasion, PLoS Negl. Trop. Dis., 16, 10.1371/journal.pntd.0009889 Cheng, 2014, Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy, Neurology, 82, 1707, 10.1212/WNL.0000000000000403 Choonara, 2009, Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders, Int. J. Mol. Sci., 10, 2510, 10.3390/ijms10062510 Chu, Y., Kaushik, A.C., Wang, X., Wang, W., Zhang, Y., Shan, X., Salahub, D.R., Xiong, Y., Wei, D.-Q.J.Bi.B., 2021, DTI-CDF: a cascade deep forest model towards the prediction of drug-target interactions based on hybrid features. 22, 451–462. Ciarlo, 2013, An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples, Dis. Models Mech., 6, 424 Cloutier, 2015, MicroRNAs as potential circulating biomarkers for amyotrophic lateral sclerosis, J. Mol. Neurosci., 56, 102, 10.1007/s12031-014-0471-8 Cohen, 2011, MicroRNA regulation of homeostatic synaptic plasticity, Proc. Natl. Acad. Sci., 108, 11650, 10.1073/pnas.1017576108 Cohen, 2007, The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming, J. Biol. Chem., 282, 33752, 10.1074/jbc.M706268200 Coronel, 2018, Role of amyloid precursor protein (APP) and its derivatives in the biology and cell fate specification of neural stem cells, Mol. Neurobiol., 55, 7107, 10.1007/s12035-018-0914-2 Coupland, 2016, Role of the long non-coding RNA MAPT-AS1 in regulation of microtubule associated protein tau (MAPT) expression in Parkinson's disease, PLoS One, 11, 10.1371/journal.pone.0157924 Cui, 2019, Perspectives of small molecule inhibitors of activin receptor‑like kinase in anti‑tumor treatment and stem cell differentiation, Mol. Med. Rep., 19, 5053 Curtis, 2012, Mirtrons, an emerging class of atypical miRNA, Wiley Interdiscip. Rev.: RNA, 3, 617, 10.1002/wrna.1122 Das, 2021, Non-coding RNAs and their bioengineering applications for neurological diseases, Bioengineered, 12, 11675, 10.1080/21655979.2021.2003667 De Paoli-Iseppi, 2022, Using long-read RNA sequencing to decipher the role of RNA isoforms in disease, Pathology, 54, S17, 10.1016/j.pathol.2021.12.063 Delay, 2011, Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function, Mol. Neurodegener., 6, 1, 10.1186/1750-1326-6-70 Diamantopoulos, 2022, Identification and expression analysis of ten novel small non-coding RNAs (sncRNAs) in cancer cells using a high-throughput sequencing approach, Gene, 809, 10.1016/j.gene.2021.146025 Diling, 2019, Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice, Aging (Albany NY), 11, 12002, 10.18632/aging.102529 Ding, 2016, Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease, Park. Relat. Disord., 22, 68, 10.1016/j.parkreldis.2015.11.014 Ding, 2019, Long non-coding RNA-p21 regulates MPP+-induced neuronal injury by targeting miR-625 and derepressing TRPM2 in SH-SY5Y cells, Chem. -Biol. Interact., 307, 73, 10.1016/j.cbi.2019.04.017 Dinger, 2009, NRED: a database of long noncoding RNA expression, Nucleic Acids Res., 37, D122, 10.1093/nar/gkn617 Dixit, 2008, Differential regulation of dynein and kinesin motor proteins by tau, Science, 319, 1086, 10.1126/science.1152993 Dolinar, 2019, Circular RNAs as potential blood biomarkers in amyotrophic lateral sclerosis, Mol. Neurobiol., 56, 8052, 10.1007/s12035-019-1627-x Donaghy, 2014, The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis, Alzheimer'S. Res. Ther., 6, 1, 10.1186/alzrt274 Du, 2018, Alzheimer’s disease hypothesis and related therapies, Transl. Neurodegener., 7, 1, 10.1186/s40035-018-0107-y Duarte, 2022, gga-miRNOME, a microRNA-sequencing dataset from chick embryonic tissues, Sci. Data, 9, 1, 10.1038/s41597-022-01126-7 Dube, 2019, An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations, Nat. Neurosci., 22, 1903, 10.1038/s41593-019-0501-5 Dwight, 2022, 264 Edbauer, 2010, Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132, Neuron, 65, 373, 10.1016/j.neuron.2010.01.005 Fan, 2020, New insights into the pathogenesis of Alzheimer's disease, Front. Neurol., 10, 1312, 10.3389/fneur.2019.01312 Feng, 2019, Triptolide inhibits preformed fibril-induced microglial activation by targeting the microRNA155-5p/SHIP1 pathway, Oxid. Med. Cell. Longev., 2019 Feng, 2020, Circular RNA circDLGAP4 exerts neuroprotective effects via modulating miR-134-5p/CREB pathway in Parkinson’s disease, Biochem. Biophys. Res. Commun., 522, 388, 10.1016/j.bbrc.2019.11.102 Ferre, 2016, Revealing protein–lncRNA interaction, Brief. Bioinforma., 17, 106, 10.1093/bib/bbv031 Fiore, 2014, Mi R‐134–dependent regulation of P umilio‐2 is necessary for homeostatic synaptic depression, EMBO J., 33, 2231, 10.15252/embj.201487921 Gámez-Valero, 2021, Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease, Biomedicines, 9, 1272, 10.3390/biomedicines9091272 Gan, 2013, Functional roles of histone modification, chromatin remodeling and microRNAs in Arabidopsis flower development, Int. Rev. Cell Mol. Biol., 305, 115, 10.1016/B978-0-12-407695-2.00003-2 Garofalo, 2020, Alzheimer’s, parkinson’s disease and amyotrophic lateral sclerosis gene expression patterns divergence reveals different grade of RNA metabolism involvement, Int. J. Mol. Sci., 21, 9500, 10.3390/ijms21249500 Garofalo, 2021, Advances with long non-coding rnas in alzheimer’s disease as peripheral biomarker, Genes, 12, 1124, 10.3390/genes12081124 Geng, 2018, Inhibition of miR-128 abates Aβ-mediated cytotoxicity by targeting PPAR-γ via NF-κB inactivation in primary mouse cortical neurons and Neuro2a cells, Yonsei Med. J., 59, 1096, 10.3349/ymj.2018.59.9.1096 Gentile, 2022, Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases, J. Pers. Med., 12, 770, 10.3390/jpm12050770 Georgakilas, G., Vlachos, I.S., Zagganas, K., Vergoulis, T., Paraskevopoulou, M.D., Kanellos, I., Tsanakas, P., Dellis, D., Fevgas, A., Dalamagas, T., 2016, DIANA-miRGen v3. 0: accurate characterization of microRNA promoters and their regulators. Nucleic acids research 44, D190-D195. Ghosal, 2013, Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits, Front. Genet., 4, 283, 10.3389/fgene.2013.00283 Gkirtzou, 2010, MatureBayes: a probabilistic algorithm for identifying the mature miRNA within novel precursors, PloS One, 5, 10.1371/journal.pone.0011843 Glažar, 2014, circBase: a database for circular RNAs, Rna, 20, 1666, 10.1261/rna.043687.113 Granados-Riveron, 2016, The complexity of the translation ability of circRNAs, Biochim. Et. Biophys. Acta (BBA)-Gene Regul. Mech., 1859, 1245, 10.1016/j.bbagrm.2016.07.009 Green, 2022, Analysis of RNA by northern blotting, Cold Spring Harb. Protoc., 2022, 10.1101/pdb.top101741 Green, 2022, Preparation of labeled DNA, RNA, and oligonucleotide probes, Cold Spring Harb. Protoc., 2022, 10.1101/pdb.top100578 Guglas, 2017, lncRNA in HNSCC: challenges and potential, Contemp. Oncol. /Współczesna Onkol., 21, 259, 10.5114/wo.2017.72382 Gupta, S.C., Challagundla, K.B., 2022, Clinical Applications of Noncoding RNAs in Cancer. Gutiérrez-García, 2021, Identification of microRNAs from medicinal plant Murraya koenigii by high-throughput sequencing and their functional implications in secondary metabolite biosynthesis, Plants, 11, 46, 10.3390/plants11010046 Hackenberg, 2009, miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments, Nucleic Acids Res., 37, W68, 10.1093/nar/gkp347 Han, 2020, Mechanism of microRNA‐22 in regulating neuroinflammation in Alzheimer’s disease, Brain Behav., 10, 10.1002/brb3.1627 Hanan, 2017, CircRNAs in the brain, RNA Biol., 14, 1028, 10.1080/15476286.2016.1255398 Hardy, 1991, Amyloid deposition as the central event in the aetiology of Alzheimer's disease, Trends Pharmacol. Sci., 12, 383, 10.1016/0165-6147(91)90609-V Hardy, 1992, Alzheimer's disease: the amyloid cascade hypothesis, Science, 256, 184, 10.1126/science.1566067 Harrach, 2019, Adenoviruses across the animal kingdom: a walk in the zoo, FEBS Lett., 593, 3660, 10.1002/1873-3468.13687 He, 2017, Downregulation of miR‐7116–5p in microglia by MPP+ sensitizes TNF‐α production to induce dopaminergic neuron damage, Glia, 65, 1251, 10.1002/glia.23153 Heman-Ackah, 2013, RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis, Front. Mol. Neurosci., 40 Hu, 2015, MicroRNA-34c downregulation ameliorates amyloid-β-induced synaptic failure and memory deficits by targeting VAMP2, J. Alzheimer'S. Dis., 48, 673, 10.3233/JAD-150432 Huang, 2018, Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model, Aging (Albany NY), 10, 253, 10.18632/aging.101387 Huang, 2018, Identification of differentially expressed profiles of Alzheimer's disease associated circular RNAs in a Panax notoginseng saponins-treated Alzheimer's disease mouse model, Comput. Struct. Biotechnol. J., 16, 523, 10.1016/j.csbj.2018.10.010 Huarte, 2010, A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response, Cell, 142, 409, 10.1016/j.cell.2010.06.040 Hutchinson, 2007, A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains, BMC Genom., 8, 1, 10.1186/1471-2164-8-39 Jara, 2018, Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus, Redox Biol., 18, 279, 10.1016/j.redox.2018.07.010 Jellinger, 2018, Dementia with Lewy bodies and Parkinson’s disease-dementia: current concepts and controversies, J. Neural Transm., 125, 615, 10.1007/s00702-017-1821-9 Jeng, 2009, Profiling muscle-specific microRNA expression after peripheral denervation and reinnervation in a rat model, J. Neurotrauma, 26, 2345, 10.1089/neu.2009.0960 Jiang, 2020, LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson’s disease via the HPRT1-mediated Wnt/β-catenin signaling pathway, Aging (Albany NY), 12, 8820, 10.18632/aging.102877 Jiang, 2018, Micro-RNA-137 inhibits tau hyperphosphorylation in Alzheimer’s disease and targets the CACNA1C gene in transgenic mice and human neuroblastoma SH-SY5Y cells, Med. Sci. Monit.: Int. Med. J. Exp. Clin. Res., 24, 5635, 10.12659/MSM.908765 Johnson, R.J.Nod, 2012, Long non-coding RNAs in Huntington's disease neurodegeneration. 46, 245–254. Junn, 2009, Repression of α-synuclein expression and toxicity by microRNA-7, Proc. Natl. Acad. Sci., 106, 13052, 10.1073/pnas.0906277106 Juźwik, 2019, microRNA dysregulation in neurodegenerative diseases: A systematic review, Prog. Neurobiol., 182, 10.1016/j.pneurobio.2019.101664 Kawaguchi, 2015, SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies, Proc. Natl. Acad. Sci., 112, 4304, 10.1073/pnas.1423819112 Kiaei, 2013, New hopes and challenges for treatment of neurodegenerative disorders: Great opportunities for young neuroscientists, Basic Clin. Neurosci., 4, 3 Kim, 2007, A MicroRNA feedback circuit in midbrain dopamine neurons, Science, 317, 1220, 10.1126/science.1140481 Kim, 2015, microRNA-33 regulates ApoE lipidation and amyloid-β metabolism in the brain, J. Neurosci., 35, 14717, 10.1523/JNEUROSCI.2053-15.2015 Kim, 2014, miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling, Neurobiol. Aging, 35, 1712, 10.1016/j.neurobiolaging.2014.01.021 Kimura, 2014, Physiological and pathological phosphorylation of tau by Cdk5, Front. Mol. Neurosci., 7, 65, 10.3389/fnmol.2014.00065 Kiskinis, 2014, Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1, Cell stem Cell, 14, 781, 10.1016/j.stem.2014.03.004 Kong, 2015, High throughput sequencing identifies microRNAs mediating α-synuclein toxicity by targeting neuroactive-ligand receptor interaction pathway in early stage of drosophila Parkinson's disease model, PLoS One, 10, 10.1371/journal.pone.0137432 Kopec, 2020, Non-invasive brain delivery and efficacy of BDNF in APP/PS1 transgenic mice as a model of Alzheimer’s disease, Med. Res. Arch., 8 Kouli, 2018, Parkinson’s disease: etiology, neuropathology, and pathogenesis, Exon Publ., 3 Kozomara, 2019, miRBase: from microRNA sequences to function, Nucleic Acids Res., 47, D155, 10.1093/nar/gky1141 Kraus, 2015, Identification of stably expressed lncRNAs as valid endogenous controls for profiling of human glioma, J. Cancer, 6, 111, 10.7150/jca.10867 Kraus, 2017, Altered long noncoding RNA expression precedes the course of Parkinson’s disease—a preliminary report, Mol. Neurobiol., 54, 2869, 10.1007/s12035-016-9854-x Kuhn, 2008, Experimental validation of miRNA targets, Methods, 44, 47, 10.1016/j.ymeth.2007.09.005 Kumar, 2018, Functional characterization of novel circular RNA molecule, circzip-2 and its synthesizing gene zip-2 in C. elegans model of Parkinson’s disease, Mol. Neurobiol., 55, 6914, 10.1007/s12035-018-0903-5 Lamptey, 2022, A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics, Int. J. Mol. Sci., 23, 1851, 10.3390/ijms23031851 Lang, 2012, Dynamic roles of microRNAs in neurogenesis, Front. Neurosci., 6, 71, 10.3389/fnins.2012.00071 Lee, 2022, Role of microRNAs and long non-coding RNAs in sarcopenia, Cells, 11, 187, 10.3390/cells11020187 Lee, 2012, miR‐206 regulates brain‐derived neurotrophic factor in Alzheimer disease model, Ann. Neurol., 72, 269, 10.1002/ana.23588 Levsky, J.M., Singer, R.H., 2003, Fluorescence in situ hybridization: past, present and future. Journal of cell science 116, 2833–2838. Li, 2016, Molecular microevolution and epigenetic patterns of the long non-coding gene H19 show its potential function in pig domestication and breed divergence, BMC Evolut. Biol., 16, 1, 10.1186/s12862-016-0657-5 Li, 2018, MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3, Hum. Cell, 31, 106, 10.1007/s13577-017-0187-5 Li, 2020, MicroRNA‐150 serves as a diagnostic biomarker and is involved in the inflammatory pathogenesis of Parkinson's disease, Mol. Genet. Genom. Med., 8 Li, 2014, starBase v2. 0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data, Nucleic Acids Res., 42, D92, 10.1093/nar/gkt1248 Li, 2019, miR‐219–5p inhibits tau phosphorylation by targeting TTBK1 and GSK‐3β in Alzheimer's disease, J. Cell. Biochem., 120, 9936, 10.1002/jcb.28276 Li, 2018, CircMarker: a fast and accurate algorithm for circular RNA detection, BMC Genom., 19, 79, 10.1186/s12864-018-4926-0 Liehr, 2017 Lin, 2008, Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism, Mol. Cell. Biol., 28, 3008, 10.1128/MCB.01800-07 Liu, 2017, Targeting the HDAC2/HNF-4A/miR-101b/AMPK pathway rescues tauopathy and dendritic abnormalities in Alzheimer’s disease, Mol. Ther., 25, 752, 10.1016/j.ymthe.2017.01.018 Liu, 2016, MicroRNA‑26b is upregulated in a double transgenic mouse model of Alzheimer's disease and promotes the expression of amyloid‑β by targeting insulin‑like growth factor 1, Mol. Med. Rep., 13, 2809, 10.3892/mmr.2016.4860 Liu, 2016, miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease, Biochem. Biophys. Res. Commun., 478, 852, 10.1016/j.bbrc.2016.08.037 Liu, 2016, Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores, Nature, 535, 153, 10.1038/nature18629 Long, 2012, MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients, J. Biol. Chem., 287, 31298, 10.1074/jbc.M112.366336 Long, 2014, MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects, J. Biol. Chem., 289, 5184, 10.1074/jbc.M113.518241 Lu, 2019, Circular HDAC9/microRNA-138/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in Alzheimer’s disease, Neurosci. Bull., 35, 877, 10.1007/s12264-019-00361-0 Lu, 2007, Differentiation of adipose stem cells by nucleus pulposus cells: configuration effect, Biochem. Biophys. Res. Commun., 359, 991, 10.1016/j.bbrc.2007.06.002 Lukiw, 2013, Circular RNA (circRNA) in Alzheimer's disease (AD), Front. Genet., 4, 307, 10.3389/fgene.2013.00307 Luo, 2016, Long noncoding RNAs and Alzheimer’s disease, Clin. Interv. Aging, 11, 867, 10.2147/CIA.S107037 Lv, 2020, Role of long noncoding RNAs in Parkinson’s disease: putative biomarkers and therapeutic targets, Parkinson’s Dis., 2020 Ma, 2015, MiR-206, a key modulator of skeletal muscle development and disease, Int. J. Biol. Sci., 11, 345, 10.7150/ijbs.10921 Ma, 2019, LncBook: a curated knowledgebase of human long non-coding RNAs, Nucleic Acids Res., 47, D128, 10.1093/nar/gky960 Manual, I. 2020, miRStar™ Human Cancer Focus miRNA & Target mRNA PCR Array (Instruction Manual Version). Manzine, 2018, microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer’s Disease, J. Alzheimer'S. Dis., 61, 113, 10.3233/JAD-170592 Massone, 2012, NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion, Biochim. Et. Biophys. Acta (BBA)-Mol. Cell Res., 1823, 1170, 10.1016/j.bbamcr.2012.05.001 Melissari, 2016, Roles for long non-coding RNAs in physiology and disease, Pflüg. Arch. -Eur. J. Physiol., 468, 945, 10.1007/s00424-016-1804-y Memon, 2019, In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival, Sci. Rep., 9, 1 Militello, 2018, A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1, J. Mol. Cell Biol., 10, 102, 10.1093/jmcb/mjy025 Moncini, 2017, The miR-15/107 family of microRNA genes regulates CDK5R1/p35 with implications for Alzheimer’s disease pathogenesis, Mol. Neurobiol., 54, 4329, 10.1007/s12035-016-0002-4 Mouradian, 2012, MicroRNAs in Parkinson's disease, Neurobiol. Dis., 46, 279, 10.1016/j.nbd.2011.12.046 Muddapu, 2020, Neurodegenerative diseases–is metabolic deficiency the root cause?, Front. Neurosci., 14, 213, 10.3389/fnins.2020.00213 Mulder, 2010, BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology, J. Alzheimer'S. Dis., 20, 253, 10.3233/JAD-2010-1367 Mumtaz, 2022, Expression of lncRNAs in response to bacterial infections of goat mammary epithelial cells reveals insights into mammary gland diseases, Microb. Pathog., 162, 10.1016/j.micpath.2021.105367 Mus, 2007, Dendritic BC200 RNA in aging and in Alzheimer's disease, Proc. Natl. Acad. Sci., 104, 10679, 10.1073/pnas.0701532104 Naganuma, 2012, Alternative 3′‐end processing of long noncoding RNA initiates construction of nuclear paraspeckles, EMBO J., 31, 4020, 10.1038/emboj.2012.251 Naphade, 2022, Systematic comparative analysis of strand-specific RNA-seq library preparation methods for low input samples, Sci. Rep., 12, 1, 10.1038/s41598-021-04583-z Nederlof, P., Van der Flier, S., Wiegant, J., Raap, A., Tanke, H., Ploem, J., Van der Ploeg, M., 1990, Multiple fluorescence in situ hybridization. Cytometry: The Journal of the International Society for Analytical Cytology 11, 126–131. Nelson, 2018, MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls, Brain Res., 1678, 374, 10.1016/j.brainres.2017.11.009 Nelson, 2015, The reduced genomes of Parcubacteria (OD1) contain signatures of a symbiotic lifestyle, Front. Microbiol., 6, 713, 10.3389/fmicb.2015.00713 Nguyen, 2022, MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases, Int. J. Mol. Sci., 23, 4718, 10.3390/ijms23094718 Nishimoto, 2013, The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis, Mol. brain, 6, 1, 10.1186/1756-6606-6-31 Ouyang, 2017, Microarray expression profile of circular RNAs in peripheral blood mononuclear cells from rheumatoid arthritis patients, Cell. Physiol. Biochem., 42, 651, 10.1159/000477883 Pamudurti, 2017, Translation of circRNAs, Mol. Cell, 66, 9, 10.1016/j.molcel.2017.02.021 Paraskevopoulou, 2013, DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs, Nucleic Acids Res., 41, D239, 10.1093/nar/gks1246 Parasramka, 2016, Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma, Pharmacol. Ther., 161, 67, 10.1016/j.pharmthera.2016.03.004 Parenti, 2007, A natural antisense transcript against Rad18, specifically expressed in neurons and upregulated during β‐amyloid‐induced apoptosis, Eur. J. Neurosci., 26, 2444, 10.1111/j.1460-9568.2007.05864.x Parisi, 2013, Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation, Cell death Dis., 4, 10.1038/cddis.2013.491 Parisi, 2016, MicroRNA-125b regulates microglia activation and motor neuron death in ALS, Cell Death Differ., 23, 531, 10.1038/cdd.2015.153 Pathania, 2012, miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons, PloS One, 7, 10.1371/journal.pone.0038174 Peng, 2019, RETRACTED ARTICLE: Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson’s disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation, Artif. Cells, Nanomed., Biotechnol., 47, 2764, 10.1080/21691401.2019.1636805 Piccolo, 2017, RNAi of arcRNA hsrω affects sub-cellular localization of Drosophila FUS to drive neurodiseases, Exp. Neurol., 292, 125, 10.1016/j.expneurol.2017.03.011 Pietrzak, 2016, Gene expression profiling of brain samples from patients with Lewy body dementia, Biochem. Biophys. Res. Commun., 479, 875, 10.1016/j.bbrc.2016.09.114 Pizza, 2011, Neuroinflamm-aging and neurodegenerative diseases: an overview, CNS Neurol. Disord. -Drug Targets (Former. Curr. Drug Targets-CNS Neurol. Disord. ), 10, 621 Ponomarev, 2011, MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU. 1 pathway, Nat. Med., 17, 64, 10.1038/nm.2266 Przedborski, 2003, Series Introduction: Neurodegeneration: What is it and where are we?, J. Clin. Investig., 111, 3, 10.1172/JCI200317522 Qamar, 2020, Pan-genome: A promising resource for noncoding RNA discovery in plants, Plant Genome, 13 Qian, 2019, Downregulated lncRNA-SNHG1 enhances autophagy and prevents cell death through the miR-221/222/p27/mTOR pathway in Parkinson's disease, Exp. Cell Res., 384, 10.1016/j.yexcr.2019.111614 Quinodoz, 2014, Long noncoding RNAs: an emerging link between gene regulation and nuclear organization, Trends Cell Biol., 24, 651, 10.1016/j.tcb.2014.08.009 Ramachandran, 2011, Sirt1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets, FEBS J., 278, 1167, 10.1111/j.1742-4658.2011.08042.x Renton, 2014, State of play in amyotrophic lateral sclerosis genetics, Nat. Neurosci., 17, 17, 10.1038/nn.3584 Renton, 2011, A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD, Neuron, 72, 257, 10.1016/j.neuron.2011.09.010 Rizzo, 2014, Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis, Cell. Mol. Life Sci., 71, 999, 10.1007/s00018-013-1480-4 Ruffo, 2021, Deregulation of ncRNA in neurodegenerative disease: Focus on circRNA, lncRNA and miRNA in amyotrophic lateral sclerosis, Front. Genet., 2492 Russell, 2013, Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis, Neurobiol. Dis., 49, 107, 10.1016/j.nbd.2012.08.015 Rybak-Wolf, 2015, Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed, Mol. Cell, 58, 870, 10.1016/j.molcel.2015.03.027 Salta, 2016, miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain, EMBO Mol. Med., 8, 1005, 10.15252/emmm.201606520 Santa-Maria, 2015, Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau, J. Clin. Investig., 125, 681, 10.1172/JCI78421 Sarkar, 2019, Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer’s disease-like pathology, Brain Res., 1721, 10.1016/j.brainres.2019.146327 Schulhofer, 1987, Reconsidering Miranda, Univ. Chic. Law Rev., 54, 435, 10.2307/1599796 Scorza, 2022, Sudden unexpected death in Parkinson's disease: Insights from clinical practice, Clinics, 77 Shah, 2022, Systematic screening of penetratin’s protein targets by yeast proteome microarrays, Int. J. Mol. Sci., 23, 712, 10.3390/ijms23020712 Sharma, 2022, Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges, Int. J. Oncol., 60, 1, 10.3892/ijo.2022.5346 Shelkovnikova, 2018, Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis, Mol. Neurodegener., 13, 1, 10.1186/s13024-018-0263-7 Shi, 2017, The circular RNA ci RS‐7 promotes APP and BACE 1 degradation in an NF‐κB‐dependent manner, FEBS J., 284, 1096, 10.1111/febs.14045 Simchovitz, 2019, NEAT1 is overexpressed in Parkinson's disease substantia nigra and confers drug‐inducible neuroprotection from oxidative stress, FASEB J., 33, 11223, 10.1096/fj.201900830R Slaby, 2016, Vol 937 Sorensen, 2016, miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimers disease and other types of dementia-an exploratory study, Transl. Neurodegener., 5 Sun, 2013, Long non-coding RNA expression profiling of mouse testis during postnatal development, PloS One, 8 Sun, 2019, MicroRNA‐190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP‐induced Parkinson's disease mouse model, J. Cell. Physiol., 234, 23379, 10.1002/jcp.28907 Surmeier, 2010, What causes the death of dopaminergic neurons in Parkinson’s disease?, Prog. brain Res., 183, 59, 10.1016/S0079-6123(10)83004-3 Tang, 2009, A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression, Mol. Biol. Cell, 20, 1120, 10.1091/mbc.e08-07-0759 Tang, 2017, MicroRNA-139 modulates Alzheimer’s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2, Genet. Mol. Res, 16, 10.4238/gmr16019166 Tatura, 2016, Parkinson's disease: SNCA-, PARK2-, and LRRK2-targeting microRNAs elevated in cingulate gyrus, Park. Relat. Disord., 33, 115, 10.1016/j.parkreldis.2016.09.028 Taylor, 2010, A practical approach to RT-qPCR—publishing data that conform to the MIQE guidelines, Methods, 50, S1, 10.1016/j.ymeth.2010.01.005 Thome, 2016, microRNA-155 regulates alpha-synuclein-induced inflammatory responses in models of Parkinson disease, J. Neurosci., 36, 2383, 10.1523/JNEUROSCI.3900-15.2016 Toden, 2022, Non-coding RNAs as liquid biopsy biomarkers in cancer, Br. J. Cancer, 126, 351, 10.1038/s41416-021-01672-8 Tollervey, 2011, Characterizing the RNA targets and position-dependent splicing regulation by TDP-43, Nat. Neurosci., 14, 452, 10.1038/nn.2778 Torii, 2022, Comparison of five polyethylene glycol precipitation procedures for the RT-qPCR based recovery of murine hepatitis virus, bacteriophage phi6, and pepper mild mottle virus as a surrogate for SARS-CoV-2 from wastewater, Sci. Total Environ., 807, 10.1016/j.scitotenv.2021.150722 Trask, 1991, Fluorescence in situ hybridization: applications in cytogenetics and gene mapping, Trends Genet., 7, 149, 10.1016/0168-9525(91)90103-W Tung, C.-W., Huang, P.-Y., Chan, S.C., Cheng, P.-H., Yang, S.-H.J.Jobs, 2021, The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease. 28, 1–11. Vallelunga, 2014, Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy, Front. Cell. Neurosci., 8, 156, 10.3389/fncel.2014.00156 Vickers, 2017, Animal communication: when i’m calling you, will you answer too?, Curr. Biol., 27, R713, 10.1016/j.cub.2017.05.064 Volders, 2013, LNCipedia: a database for annotated human lncRNA transcript sequences and structures, Nucleic Acids Res., 41, D246, 10.1093/nar/gks915 Wang, 2022, A chemoresistance lncRNA signature for recurrence risk stratification of colon cancer patients with chemotherapy, Mol. Ther. -Nucleic Acids, 27, 427, 10.1016/j.omtn.2021.12.015 Wang, 2016, LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations, Nucleic Acids Res., 44 Wang, 2013, Metabolic stress modulates Alzheimer’s β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons, Cell Metab., 17, 685, 10.1016/j.cmet.2013.03.016 Wang, 2020, miR‐29c‐3p inhibits microglial NLRP3 inflammasome activation by targeting NFAT5 in Parkinson's disease, Genes Cells, 25, 364, 10.1111/gtc.12764 Wang, 2017, The long noncoding RNA HOTAIR promotes Parkinson’s disease by upregulating LRRK2 expression, Oncotarget, 8, 24449, 10.18632/oncotarget.15511 Wang, 2015, MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha, FEBS Lett., 589, 726, 10.1016/j.febslet.2015.02.001 Wei, 2020, MicroRNAs in Alzheimer’s disease: function and potential applications as diagnostic biomarkers, Front. Mol. Neurosci., 13, 160, 10.3389/fnmol.2020.00160 Williams, 2018, Phase determination using chromosomal microarray and fluorescence in situ hybridization in a patient with early onset Parkinson disease and two deletions in PRKN, Mol. Genet. Genom. Med., 6, 457, 10.1002/mgg3.386 Wilson, 1995, Polymerization of microtubule-associated protein tau under near-physiological conditions, J. Biol. Chem., 270, 24306, 10.1074/jbc.270.41.24306 Winter, 2009, Many roads to maturity: microRNA biogenesis pathways and their regulation, Nat. Cell Biol., 11, 228, 10.1038/ncb0309-228 Withanage, 2022, RNA-Seq experiment and data analysis, 405 Wu, D.M., Wen, X., Wang, Y.J., Han, X.R., Wang, S., Shen, M., Fan, S.H., Zhuang, J., Zhang, Z.F., Shan, Q. 2018, Retracted: Effect of microRNA‐186 on oxidative stress injury of neuron by targeting interleukin 2 through the janus kinase‐signal transducer and activator of transcription pathway in a rat model of Alzheimer’s disease (Wiley Online Library). Wu, 2013, mirTools 2.0 for non-coding RNA discovery, profiling, and functional annotation based on high-throughput sequencing, RNA Biol., 10, 1087, 10.4161/rna.25193 Wu, 2020, Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases, J. Biomed. Sci., 27, 1, 10.1186/s12929-020-00636-z Xiong, 2014, MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration, Neurobiol. Aging, 35, 705, 10.1016/j.neurobiolaging.2013.09.027 Xu, 2007, A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease, Mol. Cell. Neurosci., 36, 313, 10.1016/j.mcn.2007.06.009 Xu, W., Yang, W., Zhang, Y., Chen, Y., Zhang, Q., Wang, X., Song, K., Jin, W., Chen, X., 2022, ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells. bioRxiv. Xu, 2020, Long noncoding RNA GAS5 promotes microglial inflammatory response in Parkinson's disease by regulating NLRP3 pathway through sponging miR-223-3p, Int. Immunopharmacol., 85, 10.1016/j.intimp.2020.106614 Xu, 2018, LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson’s Disease through Activating-Synuclein Expression, BioMed. Res. Int., 2018 Yamanaka, 2015, Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2, Cell Rep., 11, 967, 10.1016/j.celrep.2015.04.011 Yan, 2014, Targeting the β secretase BACE1 for Alzheimer's disease therapy, Lancet Neurol., 13, 319, 10.1016/S1474-4422(13)70276-X Yang, 2014, LncRNA: a link between RNA and cancer, Biochim. Et. Biophys. Acta (BBA)-Gene Regul. Mech., 1839, 1097, 10.1016/j.bbagrm.2014.08.012 Yang, 2019, Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer’s disease, Cell Cycle, 18, 2197, 10.1080/15384101.2019.1629773 Ye, 2019, PACAP attenuates optic nerve crush-induced retinal ganglion cell apoptosis via activation of the CREB-Bcl-2 pathway, J. Mol. Neurosci., 68, 475, 10.1007/s12031-019-01309-9 Yiu, E.M., Kornberg, A.J.J.Jop, health, c, 2015, Duchenne muscular dystrophy. 51, 759–764. You, 2019, Royal jelly alleviates cognitive deficits and β-amyloid accumulation in APP/PS1 mouse model via activation of the cAMP/PKA/CREB/BDNF pathway and inhibition of neuronal apoptosis, Front. Aging Neurosci., 10, 428, 10.3389/fnagi.2018.00428 Yu, 2022, Next-generation sequencing markup language (NGSML): A medium for the representation and exchange of NGS data, IEEE/ACM Trans. Comput. Biol. Bioinforma., 10.1109/TCBB.2022.3144170 Zhang, 2016, Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease, Aging (Albany NY), 8, 272, 10.18632/aging.100887 Zhang, 2018, RETRACTED ARTICLE: MicroRNA-322 cluster promotes tau phosphorylation via targeting brain-derived neurotrophic factor, Neurochem. Res., 43, 736, 10.1007/s11064-018-2475-1 Zhang, 2019, miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease, Biochem. Biophys. Res. Commun., 519, 740, 10.1016/j.bbrc.2019.08.140 Zhang, 2019, Dopaminergic neuron injury in Parkinson’s disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/α-synuclein pathway, Aging (Albany NY), 11, 9264, 10.18632/aging.102330 Zhang, 2021, The emerging role of circular RNAs in Alzheimer’s disease and Parkinson’s disease, Front. Aging Neurosci., 13 Zhang, 2016, Beta-asarone protects against MPTP-induced Parkinson’s disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression, Biomed. Pharmacother., 83, 153, 10.1016/j.biopha.2016.06.017 Zhang, 2019, Systematic characterization of circular RNA-associated CeRNA network identified novel circRNA biomarkers in Alzheimer's disease, Front. Bioeng. Biotechnol., 7, 222, 10.3389/fbioe.2019.00222 Zhang, 2021, The role of non-coding RNAs in Alzheimer’s disease: from regulated mechanism to therapeutic targets and diagnostic biomarkers, Front. Aging Neurosci., 384 Zhang, Y., Zhao, Y., Ao, X., Yu, W., Zhang, L., Wang, Y., Chang, W.J.Fi.A.N., 2021b, The role of non-coding RNAs in Alzheimer’s disease: from regulated mechanism to therapeutic targets and diagnostic biomarkers. 384. Zhang, 2014, miR-16-1 promotes the aberrant α-synuclein accumulation in parkinson disease via targeting heat shock protein 70, Sci. World J., 2014 Zhao, 2019, The long-non-coding RNA NEAT1 is a novel target for Alzheimer’s disease progression via miR-124/BACE1 axis, Neurol. Res., 41, 489, 10.1080/01616412.2018.1548747 Zhao, 2016, Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer’s disease (AD) is linked to deficits in a natural circular miRNA-7 sponge (circRNA; ciRS-7), Genes, 7, 116, 10.3390/genes7120116 Zhao, 2016, NONCODE 2016: an informative and valuable data source of long non-coding RNAs, Nucleic Acids Res., 44, D203, 10.1093/nar/gkv1252 Zhou, 2021, Long non-coding RNAs in pathogenesis of neurodegenerative diseases, Front. Cell Dev. Biol., 9 Zhou, 2016, MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease, Mol. Neurodegener., 11, 1, 10.1186/s13024-016-0094-3 Zhou, Y., Wang, Z.F., Li, W., Hong, H., Chen, J., Tian, Y., Liu, Z.Y. 2018, Retracted: Protective effects of microRNA‐330 on amyloid β‐protein production, oxidative stress, and mitochondrial dysfunction in Alzheimer's disease by targeting VAV1 via the MAPK signaling pathway (Wiley Online Library). Zhu, 2016, Modulation of miR-19 in aluminum-induced neural cell apoptosis, J. Alzheimer'S. Dis., 50, 1149, 10.3233/JAD-150763 Ziukelis, 2022, Fractal dimension of the brain in neurodegenerative disease and dementia: a systematic review, Ageing Res. Rev., 10.1016/j.arr.2022.101651 Zong, 2015, miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer׳ s disease, Brain Res., 1624, 95, 10.1016/j.brainres.2015.07.022