Các Bệnh Granuloma Không Nhiễm Khuẩn Tại Da và Những Bệnh Hệ Thống Có Liên Quan

American Journal of Clinical Dermatology - Tập 11 Số 3 - Trang 171-181 - 2010
Hawryluk, Elena Balestreire1, Izikson, Leonid1, English, Joseph C.1
1Department of Dermatology, University of Pittsburgh, School of Medicine University of Pittsburgh Medical Center, Pittsburgh, USA

Tóm tắt

Các bệnh granuloma không nhiễm khuẩn của da là một nhóm rộng lớn các tình trạng viêm phản ứng riêng biệt, có những điểm tương đồng quan trọng. Nhìn chung, chúng tương đối khó chẩn đoán và phân biệt cả về lâm sàng lẫn mô học. Nhiều rối loạn trong số này có mối liên hệ đáng kể với các bệnh hệ thống có ảnh hưởng đến tiên lượng tổng thể của bệnh nhân. Trong bản cập nhật này, chúng tôi sẽ thảo luận về các khái niệm mới nổi và các tranh cãi trong lĩnh vực này, thông qua các câu trả lời dựa trên bằng chứng cho bảy câu hỏi lâm sàng quan trọng liên quan đến các granuloma dạng tầng và biểu mô. Những câu hỏi này cung cấp cơ hội để xem xét mười tình trạng granuloma không nhiễm khuẩn có ảnh hưởng đến bệnh hệ thống: granuloma annulare, granuloma tế bào khổng lồ elastolytic hình vòng, necrobiosis lipoidica, nodule dạng thấp do methotrexate dẫn đến, xanthogranuloma necrobiotic, viêm da granuloma kẽ, phản ứng thuốc granuloma kẽ, viêm da granuloma dạng tầng tế bào neutrophil, sarcoidosis, và bệnh Crohn di căn. Các nghiên cứu lâm sàng, dịch tễ học và phòng thí nghiệm gần đây đã giúp làm sáng tỏ một số vấn đề liên quan đến các bệnh này, sự liên hệ của các tình trạng này với các rối loạn hệ thống, và tiên lượng tổng thể của chúng.

Từ khóa

#granulomatous diseases #skin #systemic diseases #diagnosis #clinical questions

Tài liệu tham khảo

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