Nitric oxide signaling in pregnancy and preeclampsia

Nitric Oxide - Tập 95 - Trang 55-62 - 2020
Elizabeth F. Sutton1,2, Mary Gemmel1,2, Robert W. Powers3,2
1Magee-Womens Research Institute, Pittsburgh, PA 15213, USA
2Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA
3Magee-Womens Research Institute, Pittsburgh, PA, 15213, USA

Tài liệu tham khảo

Taylor Duley, 2009, The global impact of pre-eclampsia and eclampsia, Semin. Perinatol., 33, 130, 10.1053/j.semperi.2009.02.010 V Ananth, 2013, Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis, BMJ, 347, f6564, 10.1136/bmj.f6564 American College of Obstetricians and Gynecologists, 2013, Task force on hypertension in pregnancy, hypertension in pregnancy. Report of the American college of obstetricians and gynecologists' task force on hypertension in pregnancy, Obstet. Gynecol., 122, 1122 Davison, 2004, New aspects in the pathophysiology of preeclampsia, J. Am. Soc. Nephrol., 15, 2440, 10.1097/01.ASN.0000135975.90889.60 Broughton Pipkin, 2001, Risk factors for preeclampsia, N. Engl. J. Med., 344, 925, 10.1056/NEJM200103223441209 Roberts, 1998, Endothelial dysfunction in preeclampsia, Semin. Reprod. Endocrinol., 16, 5, 10.1055/s-2007-1016248 Bodnar, 2005, The risk of preeclampsia rises with increasing prepregnancy body mass index, Ann. Epidemiol., 15, 475, 10.1016/j.annepidem.2004.12.008 Roberts, 2005, Preeclampsia: recent insights, Hypertension (Dallas), 46, 1243, 10.1161/01.HYP.0000188408.49896.c5 VanWijk, 2000, Vascular function in preeclampsia, Cardiovasc. Res., 47, 38, 10.1016/S0008-6363(00)00087-0 Waite, 2002, Preeclampsia, an implantation disorder, Rev. Endocr. Metab. Disord., 3, 151, 10.1023/A:1015411113468 Wolf, 2001, 96, 78 Zunker, 2001, Pathophysiology of pre-eclampsia/eclampsia syndrome, J. Neurol., 248, 437, 10.1007/s004150170193 Dietl, 2005, Maternal obesity and complications during pregnancy, J. Perinat. Med., 33, 100, 10.1515/JPM.2005.018 Sibai, 2005, Pre-eclampsia, Lancet (London, England), 365, 785, 10.1016/S0140-6736(05)17987-2 Duckitt, 2005, Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies, BMJ, 330, 565, 10.1136/bmj.38380.674340.E0 Maul, 2003, Nitric oxide and its role during pregnancy: from ovulation to delivery, Curr. Pharmaceut. Des., 9, 359, 10.2174/1381612033391784 Ghimire, 2017, Nitric oxide: what's new to NO?, Am. J. Physiol. Cell Physiol., 312, C254, 10.1152/ajpcell.00315.2016 Murohara, 2002, Nitric oxide and angiogenesis in cardiovascular disease, Antioxidants Redox Signal., 4, 825, 10.1089/152308602760598981 Tejero, 2019, Sources of vascular nitric oxide and reactive oxygen species and their regulation, Physiol. Rev., 99, 311, 10.1152/physrev.00036.2017 Garcia, 2019, Endothelial NOS: perspective and recent developments, Br. J. Pharmacol., 176, 189, 10.1111/bph.14522 Zullino, 2018, Nitric oxide and the biology of pregnancy, Vasc. Pharmacol., 110, 71, 10.1016/j.vph.2018.07.004 Khalil, 2015, The role of arginine, homoarginine and nitric oxide in pregnancy, Amino Acids, 47, 1715, 10.1007/s00726-015-2014-1 Wang, 1997, Effects of diet on measurement of nitric oxide metabolites, Clin. Exp. Pharmacol. Physiol., 24, 418, 10.1111/j.1440-1681.1997.tb01212.x Choi, 2002, Iron deficiency anemia increases nitric oxide production in healthy adolescents, Ann. Hematol., 81, 1, 10.1007/s00277-001-0409-4 Davidge, 1996, Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia, Am. J. Obstet. Gynecol., 174, 1008, 10.1016/S0002-9378(96)70341-1 Choi, 2002, Nitric oxide production increases during normal pregnancy and decreases in preeclampsia, Ann. Clin. Lab. Sci., 32, 257 Hodžić, 2017, Nitric oxide biosynthesis during normal pregnancy and pregnancy complicated by preeclampsia, Med. Glas., 14, 211 Shaamash, 2000, Maternal and fetal serum nitric oxide (NO) concentrations in normal pregnancy, pre-eclampsia and eclampsia, Int. J. Gynaecol. Obstet., 68, 207, 10.1016/S0020-7292(99)00213-1 Valtonen, 2008, Serum L-homoarginine concentration is elevated during normal pregnancy and is related to flow-mediated vasodilatation, Circ. J., 72, 10.1253/circj.CJ-08-0240 Nelson, 2000, Increased nitric oxide synthase activity and expression in the human uterine artery during pregnancy, Circ. Res., 87, 406, 10.1161/01.RES.87.5.406 Bird, 2000, Pregnancy-dependent changes in cell signaling underlie changes in differential control of vasodilator production in uterine artery endothelial cells, Endocrinology, 141, 1107, 10.1210/endo.141.3.7367 Krause, 2011, Role of nitric oxide in placental vascular development and function, Placenta, 32, 797, 10.1016/j.placenta.2011.06.025 Rossmanith, 1999, Expression and functional analysis of endothelial nitric oxide synthase (eNOS) in human placenta, Mol. Hum. Reprod., 5, 487, 10.1093/molehr/5.5.487 Wieczór, 2018, Asymmetric dimethylarginine and angiogenesis: biological significance, Int. Angiol., 37, 431, 10.23736/S0392-9590.18.04017-8 Alpoim, 2015, Asymmetric Dimethylarginine (ADMA) in cardiovascular and renal disease, Clin. Chim. Acta, 440, 36, 10.1016/j.cca.2014.11.002 Caplin, 2012, Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators?, Arterioscler. Thromb. Vasc. Biol., 32, 1343, 10.1161/ATVBAHA.112.247726 Böger, 2003, Association of asymmetric dimethylarginine and endothelial dysfunction, Clin. Chem. Lab. Med., 41, 1467, 10.1515/CCLM.2003.225 Feliers, 2015, Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells, Cell. Signal., 27, 1, 10.1016/j.cellsig.2014.09.024 Mangoni, 2009, The emerging role of symmetric dimethylarginine in vascular disease, Adv. Clin. Chem., 48, 73, 10.1016/S0065-2423(09)48003-X Holden, 1998, Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia, Am. J. Obstet. Gynecol., 178, 551, 10.1016/S0002-9378(98)70437-5 Kaitu’u-Lino, 2012, Serum concentrations of soluble Flt-1 are decreased among women with a viable fetus and no symptoms of miscarriage destined for pregnancy loss, PLoS One, 7 Nejabati, 2017, Placental growth factor (PlGF) as an angiogenic/inflammatory switcher: lesson from early pregnancy losses, Gynecol. Endocrinol., 33, 668, 10.1080/09513590.2017.1318375 Zafer, 2018, Second trimester maternal serum-amniotic fluid nitric oxide and vascular endothelial growth factor levels in relation to uterine artery Doppler indices in pregnancies with normal outcome, J. Obstet. Gynaecol., 38, 1088, 10.1080/01443615.2018.1454409 Osol, 2008, Placental growth factor is a potent vasodilator of rat and human resistance arteries, Am. J. Physiol. Heart Circ. Physiol., 294, H1381, 10.1152/ajpheart.00922.2007 Nevzati, 2015, Estrogen induces nitric oxide production via nitric oxide synthase activation in endothelial cells, Acta Neurochir. Suppl., 120, 10.1007/978-3-319-04981-6_24 Hayashi, 1995, Estrogen increases endothelial nitric oxide by a receptor-mediated system, Biochem. Biophys. Res. Commun., 214, 847, 10.1006/bbrc.1995.2364 Lee, 2015, 2-Methoxyestradiol regulates VEGFR-2 and sFlt-1 expression in human placenta, Placenta, 36, 125, 10.1016/j.placenta.2014.11.013 Hall, 2011, [The heart during pregnancy], Rev. Esp. Cardiol., 64, 1045, 10.1016/j.recesp.2011.07.009 Moutquin, 1985, A prospective study of blood pressure in pregnancy: prediction of preeclampsia, Am. J. Obstet. Gynecol., 151, 191, 10.1016/0002-9378(85)90010-9 MacGillivray, 1969, Blood pressure survey in pregnancy, Clin. Sci., 37, 395 Macdonald-Wallis, 2011, Established preeclampsia risk factors are related to patterns of blood pressure change in normal term pregnancy, J. Hypertens., 29, 1703, 10.1097/HJH.0b013e328349eec6 Friedman, 1976, Pregnancy, outcome as related to hypertension, edema, and proteinuria, Perspect. Nephrol. Hypertens., 5, 13 De Haas, 2017, Cardiac remodeling in normotensive pregnancy and in pregnancy complicated by hypertension: systematic review and meta-analysis, Ultrasound Obstet. Gynecol., 50, 683, 10.1002/uog.17410 Mandala, 2012, Physiological remodelling of the maternal uterine circulation during pregnancy, Basic Clin. Pharmacol. Toxicol., 110, 12, 10.1111/j.1742-7843.2011.00793.x Osol, 2009, Maternal uterine vascular remodeling during pregnancy, Physiology, 24, 58, 10.1152/physiol.00033.2008 Carbillon, 2000, Pregnancy, vascular tone, and maternal hemodynamics: a crucial adaptation, Obstet. Gynecol. Surv., 55, 574, 10.1097/00006254-200009000-00023 Nelson, 1998, Pregnancy augments nitric oxide-dependent dilator response to acetylcholine in the human uterine artery, Hum. Reprod., 13, 1361, 10.1093/humrep/13.5.1361 Schiessl, 2006, Plasma- and urine concentrations of nitrite/nitrate and cyclic Guanosinemonophosphate in intrauterine growth restricted and preeclamptic pregnancies, Arch. Gynecol. Obstet., 274, 150, 10.1007/s00404-006-0149-8 Martin, 2009, A novel method to remotely measure food intake of free-living individuals in real time: the remote food photography method, Br. J. Nutr., 101, 446, 10.1017/S0007114508027438 Seligman, 1994, The role of nitric oxide in the pathogenesis of preeclampsia, Am. J. Obstet. Gynecol., 171, 944, 10.1016/S0002-9378(94)70064-8 Curtis, 1995, Nitric oxide metabolites in normal human pregnancy and preeclampsia, hypertens, Pregnancy, 14, 339, 10.3109/10641959509015680 Cameron, 1993, Relationship between nitric oxide synthesis and increase in systolic blood pressure in women with hypertension in pregnancy, hypertens, Pregnancy, 12, 85, 10.3109/10641959309031055 Silver, 1996, Evaluation of nitric oxide as a mediator of severe preeclampsia, Am. J. Obstet. Gynecol., 175, 1013, 10.1016/S0002-9378(96)80044-5 Smárason, 1997, Elevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre-eclampsia, Br. J. Obstet. Gynaecol., 104, 538, 10.1111/j.1471-0528.1997.tb11528.x Nobunaga, 1996, Plasma nitric oxide levels in pregnant patients with preeclampsia and essential hypertension, Gynecol. Obstet. Investig., 41, 189, 10.1159/000292266 Pathak, 1999, Estimation of oxidative products of nitric oxide (nitrates, nitrites) in preeclampsia, Aust. N. Z. J. Obstet. Gynaecol., 39, 484, 10.1111/j.1479-828X.1999.tb03139.x Noris, 2004, L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species, Hypertension (Dallas), 43, 614, 10.1161/01.HYP.0000116220.39793.c9 Sankaralingam, 2010, Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia, Cardiovasc. Res., 85, 194, 10.1093/cvr/cvp277 Böger, 2009, Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk, Pharmacol. Res., 60, 481, 10.1016/j.phrs.2009.07.001 Cooke, 2005, ADMA: its role in vascular disease, Vasc. Med., 10, S11, 10.1177/1358836X0501000103 Fickling, 1993, Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia, Lancet (London, England), 342, 242, 10.1016/0140-6736(93)92335-Q Rizos, 2012, Levels of asymmetric dimethylarginine throughout normal pregnancy and in pregnancies complicated with preeclampsia or had a small for gestational age baby, J. Matern. Fetal Neonatal Med., 25, 1311, 10.3109/14767058.2011.632037 Savvidou, 2003, Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia, Lancet, 361, 1511, 10.1016/S0140-6736(03)13177-7 Holden, 1998, Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia, Am. J. Obstet. Gynecol., 178, 551, 10.1016/S0002-9378(98)70437-5 Goulopoulou, 2015, Molecular mechanisms of maternal vascular dysfunction in preeclampsia, Trends Mol. Med., 21, 88, 10.1016/j.molmed.2014.11.009 Taysi, 2019, Radicals, oxidative/nitrosative stress and preeclampsia, Mini Rev. Med. Chem., 19, 178, 10.2174/1389557518666181015151350 Tsukimori, 1993, The superoxide generation of neutrophils in normal and preeclamptic pregnancies, Obstet. Gynecol., 81, 536 Roggensack, 1999, Evidence for peroxynitrite formation in the vasculature of women with preeclampsia, Hypertension (Dallas), 33, 83, 10.1161/01.HYP.33.1.83 Li, 2018, QSOX1 regulates trophoblastic apoptosis in preeclampsia through hydrogen peroxide production, J. Matern. Fetal Neonatal Med., 1 Aris, 2009, Potential biomarkers of preeclampsia: inverse correlation between hydrogen peroxide and nitric oxide early in maternal circulation and at term in placenta of women with preeclampsia, Placenta, 30, 342, 10.1016/j.placenta.2009.01.003 Lv, 2018, Hydrogen peroxide promotes the activation of preeclampsia peripheral T cells, Innate Immun., 24, 203, 10.1177/1753425918767305 Chiarello, 2018, Oxidative stress: normal pregnancy versus preeclampsia, Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. Sánchez-Aranguren, 2014, Endothelial dysfunction and preeclampsia: role of oxidative stress, Front. Physiol., 5, 372, 10.3389/fphys.2014.00372 Bainbridge, 2009, Increased xanthine oxidase in the skin of preeclamptic women, Reprod. Sci., 16, 468, 10.1177/1933719108329817 Myatt, 1996, Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action, Hypertension (Dallas), 28, 488, 10.1161/01.HYP.28.3.488 Kossenjans, 2000, Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia, Am. J. Physiol. Cell Physiol., 278, H1311, 10.1152/ajpheart.2000.278.4.H1311 Shaamash, 2001, Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia, Int. J. Gynaecol. Obstet., 72, 127, 10.1016/S0020-7292(00)00314-3 Myatt, 1997, Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies, Hum. Reprod., 12, 167, 10.1093/humrep/12.1.167 Davidge, 1995, NOS expression is increased in endothelial cells exposed to plasma from women with preeclampsia, Am. J. Physiol. Cell Physiol., 269, H1106, 10.1152/ajpheart.1995.269.3.H1106 Baker, 1995, Plasma from women with preeclampsia increases endothelial cell nitric oxide production, Hypertension (Dallas), 26, 244, 10.1161/01.HYP.26.2.244 Roggensack, 1999, Evidence for peroxynitrite formation in the vasculature of women with preeclampsia, Hypertension (Dallas), 33, 83, 10.1161/01.HYP.33.1.83 Taylor, 1990, Women with preeclampsia have higher plasma endothelin levels than women with normal pregnancies, J. Clin. Endocrinol. Metab., 71, 1675, 10.1210/jcem-71-6-1675 Maynard, 2003, Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia, J. Clin. Investig., 111, 649, 10.1172/JCI17189 Venkatesha, 2006, Soluble endoglin contributes to the pathogenesis of preeclampsia, Nat. Med., 12, 642, 10.1038/nm1429 Kleinrouweler, 2012, Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis, BJOG An Int. J. Obstet. Gynaecol., 119, 778, 10.1111/j.1471-0528.2012.03311.x James, 2010, Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces, J. Pathol., 221, 363, 10.1002/path.2719 Aalkjaer, 1985, Abnormal vascular function and morphology in pre-eclampsia: a study of isolated resistance vessels, Clin. Sci. (Lond.), 69, 477, 10.1042/cs0690477 Pascoal, 1998, Preeclampsia selectively impairs endothelium-dependent relaxation and leads to oscillatory activity in small omental arteries, J. Clin. Investig., 101, 464, 10.1172/JCI557 McCarthy, 1993, Abnormal endothelial cell function of resistance arteries from women with preeclampsia, Am. J. Obstet. Gynecol., 168, 1323, 10.1016/0002-9378(93)90389-Z Ashworth, 1997, Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia, Br. J. Obstet. Gynaecol., 104, 1152, 10.1111/j.1471-0528.1997.tb10939.x Myers, 2005, Preeclampsia, the circulating factors capable of altering in vitro endothelial function precede clinical disease, Hypertension, 45, 258, 10.1161/01.HYP.0000153461.58298.a4 Malhotra, 2018, Serial profile of flow-mediated dilatation in primigravida for prediction of preeclampsia and gestational hypertension, Hypertens. Pregnancy, 37, 212, 10.1080/10641955.2018.1524480 Weissgerber, 2015, Impaired Flow-Mediated Dilation before, during, and after Preeclampsia, Hypertension, vol. 67 Davis, 2001, Re: glyceryl trinitrate (GTN) patches are unsuitable in hypertensive pregnancy, Aust. N. Z. J. Obstet. Gynaecol., 41, 474 Lees, 1998, The efficacy and fetal-maternal cardiovascular effects of transdermal glyceryl trinitrate in the prophylaxis of pre-eclampsia and its complications: a randomized double-blind placebo-controlled trial, Ultrasound Obstet. Gynecol., 12, 334, 10.1046/j.1469-0705.1998.12050334.x Gui, 2014, Arginine supplementation for improving maternal and neonatal outcomes in hypertensive disorder of pregnancy: a systematic review, J. Renin-Angiotensin-Aldosterone Syst. JRAAS, 15, 88, 10.1177/1470320313475910 Vadillo-Ortega, 2011, Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial, BMJ, 342, 10.1136/bmj.d2901 Camarena Pulido, 2016, Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: a double-blind, randomized, clinical trial, Hypertens, Pregnancy, 35, 217, 10.3109/10641955.2015.1137586 Trapani, 2016, Perinatal and hemodynamic evaluation of sildenafil citrate for preeclampsia treatment, Obstet. Gynecol., 128, 253, 10.1097/AOG.0000000000001518 Paauw, 2017, Sildenafil during pregnancy, Hypertension, 70, 998, 10.1161/HYPERTENSIONAHA.117.09690 Roberts, 2010, Shriver national institute of child health and human development maternal-fetal medicine units network, vitamins C and E to prevent complications of pregnancy-associated hypertension, N. Engl. J. Med., 362, 1282, 10.1056/NEJMoa0908056 Crews, 2000, Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat, Hypertension (Dallas), 35, 367, 10.1161/01.HYP.35.1.367 Alexander, 2001, Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide, Hypertension (Dallas), 37, 1191, 10.1161/01.HYP.37.4.1191 Gilbert, 2007, Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression, Hypertension, 50, 1142, 10.1161/HYPERTENSIONAHA.107.096594 Molnár, 1992, Nω-Nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents, Am. J. Obstet. Gynecol., 166, 1560, 10.1016/0002-9378(92)91634-M Kulandavelu, 2012, Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placental oxygenation in pregnant mice, Hypertension (Dallas), 60, 231, 10.1161/HYPERTENSIONAHA.111.187559 Huang, 1995, Hypertension in mice lacking the gene for endothelial nitric oxide synthase, Nature, 377, 239, 10.1038/377239a0 Shesely, 2001, Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy, Am. J. Obstet. Gynecol., 185, 1198, 10.1067/mob.2001.118142 Kusinski, 2012, eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype, Am. J. Physiol. Integr. Comp. Physiol., 303, R86, 10.1152/ajpregu.00600.2011 Kanasaki, 2008, Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia, Nature, 453, 1117, 10.1038/nature06951 Davisson, 2002, Discovery of a spontaneous genetic mouse model of preeclampsia, Hypertension (Dallas), 39, 337, 10.1161/hy02t2.102904 Dokras, 2006, Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia, Biol. Reprod., 75, 899, 10.1095/biolreprod.106.053603 Szalai, 2015, Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice, PLoS One, 10, 10.1371/journal.pone.0119547 LaMarca, 2005, Hypertension produced by reductions in uterine perfusion in the pregnant rat, Hypertension, 46, 1022, 10.1161/01.HYP.0000175476.26719.36 Zenclussen, 2004, Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice, Eur. J. Immunol., 34, 377, 10.1002/eji.200324469 Faas, 1994, A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats, Am. J. Obstet. Gynecol., 171, 158, 10.1016/0002-9378(94)90463-4 Singh, 2011, Role of complement component C1q in the onset of preeclampsia in mice, Hypertension, 58, 716, 10.1161/HYPERTENSIONAHA.111.175919 Garrett, 2018, Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice, JCI Insight, 3, 10.1172/jci.insight.120147