Nitric oxide releasing acetaminophen (nitroacetaminophen)

Moncada, 1975, Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint, Eur J Pharmacol, 31, 250, 10.1016/0014-2999(75)90047-3

Moncada, 1979, Mode of action of aspirin-like drugs, Adv Intern Med, 24, 1

Al-Swayeh, 1999, Anti-oedema and anti-nociceptive effect of nitroprednisone and nitroflurbiprofen, Br J Pharmacol, 127, 84

al-Swayeh, 2000, A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin, Br J Pharmacol, 129, 343, 10.1038/sj.bjp.0703064

Prescott, 2000, Paracetamol, past, present, and future, Am J Ther, 7, 143, 10.1097/00045391-200007020-00011

Glenn, 1977, Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen, Agents Actions, 7, 513, 10.1007/BF02111123

Seegers, 1981, The anti-inflammatory, analgesic and antipyretic activities of non-narcotic analgesic mixtures in rats, Arch Int Pharmacodyn Ther, 251, 1265

Lokken, 1980, Analgesic and anti-inflammatory effects of paracetamol evaluated by bilateral oral surgery, Br J Clin Pharmacol, 10, 253S, 10.1111/j.1365-2125.1980.tb01808.x

Stern, 1984, Protective effect of acetaminophen against aspirin- and ethanol-induced damage to the human gastric mucosa, Gastroenterology, 86, 728, 10.1016/S0016-5085(84)80123-7

Routledge, 1999, Paracetamol (acetaminophen) poisoning. No need to change current guidelines to accident departments, Br Med J, 317, 1609

Fiourucci, 2002, A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway, Br J Pharmacol, 135, 589, 10.1038/sj.bjp.0704500

Fujihara, 1998, Nitroflurbiprofen: a new nonsteroidal anti-inflammatory ameliorates structural injury in the remnant kidney, Am J Physiol, 274, F573

Wallace, 1995, Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative, J Clin Invest, 96, 2711, 10.1172/JCI118338

Yamamoto, 2000, The effect of aspirin and two nitric oxide donors on the infracted heart in situ, Life Sci, 67, 839, 10.1016/S0024-3205(00)00678-0

Muscara, 2001, Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats, Br J Pharmacol, 133, 1314, 10.1038/sj.bjp.0704209

Muscara, 2000, Antihypertensive properties of a nitric oxide releasing naproxen derivative in two kidney, one-clip rat, Am J Physiol, 279, H528

Carini, 2001, Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin, in vitro and in vivo studies in the rat by ESR spectroscopy, J Pharm Biomed Anal, 26, 509, 10.1016/S0731-7085(01)00478-2

Keeble, 2001, Vasorelaxant effect of nitric oxide releasing steroidal and nonsteroidal anti-inflammatory drugs, Br J Pharmacol, 133, 1023, 10.1038/sj.bjp.0704161

Al-Swayeh, 2000, Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity, Br J Pharmacol, 130, 1453, 10.1038/sj.bjp.0703509

Paul-Clerk, 2001, Nitroparacetamol (NCX-701) exhibits anti-inflammatory activity in the zymosan air pouch, Inflamm Res, 50, S158

Bippi, 1990, Effects of acetylsalicylic acid and paracetamol alone and in combination on prostanoid synthesis in man, Br J Clin Pharmacol, 29, 305, 10.1111/j.1365-2125.1990.tb03640.x

Seppala, 1983, Comparative study on the effects of acetylsalicylic acid, indomethacin and paracetamol on metabolites of arachidonic acid in plasma, serum and urine in man, Int J Clin Pharmacol Res, 3, 265

Itoh, 2001, Cisapride raises the bioavailability of paracetamol by inhibiting its glucuronidation in man, J Pharm Pharmacol, 53, 1041, 10.1211/0022357011776298

Rayburn, 1986, Acetaminophen pharmacokinetics, comparison between pregnant and nonpregnant women, Am J Obstet Gynecol, 155, 1353, 10.1016/0002-9378(86)90173-0

Kosonen, 1998, Inhibition by nitric oxide-releasing compounds of prostacyclin production in human endothelial cells, Br J Pharmacol, 125, 247, 10.1038/sj.bjp.0702042

Zou, 1996, Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase, FEBS Lett, 382, 101, 10.1016/0014-5793(96)00160-3

Churchman, 2001, Regulation of COX-2 and iNOS expression by novel NO-NSAIDs, Inflamm Res, 50, S211

Cui, 2001, Inhibition of NF-κB activation by nitro-paracetamol and nitro-aspirin in J774 macrophages, Inflamm Res, 50, S152

Makarov, 2000, NF-kappaB as a therapeutic target in chronic inflammation, recent advances, Mol Med Today, 6, 441, 10.1016/S1357-4310(00)01814-1

Baeuerle, 1998, Pro-inflammatory signaling, last pieces in the NF-kappaB puzzle?, Curr Biol, 8, R19, 10.1016/S0960-9822(98)70010-7

Zhang, 2001, Nitric oxide differentially regulates induction of type II nitric oxide synthase in rat vascular smooth muscle cells versus macrophages, Arterioscler Thromb Vasc Biol, 21, 529, 10.1161/01.ATV.21.4.529

von Knethen, 1999, Superoxide attenuates macrophage apoptosis by NF-kappa B and AP-1 activation that promotes cyclooxygenase-2 expression, J Immunol, 163, 2858, 10.4049/jimmunol.163.5.2858

Peng, 1995, Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells, J Biol Chem, 270, 17050, 10.1074/jbc.270.28.17050

Matthews, 1996, Inhibition of NF-kappaB DNA binding by nitric oxide, Nucleic Acids Res, 24, 2236, 10.1093/nar/24.12.2236

Dimmeler, 1997, Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease (CPP)-32-like proteases, J Exp Med, 185, 601, 10.1084/jem.185.4.601

Fiorucci, 2000, NO-aspirin protects from T cell mediated liver injury by inhibiting caspase-dependent processing of Th-1 like cytokines, Gastroenterology, 118, 404, 10.1016/S0016-5085(00)70223-X

Creamer, 2000, Osteoarthritis pain and its treatment, Curr Opin Rheumatol, 12, 450, 10.1097/00002281-200009000-00019

Reid, 2001, Acute postoperative pain management, a review, Can J Urol, 8, 1394

Romero-Sandovai, 2002, NCX-701 (nitroparacetamol) is an effective anti-nociceptive agent in rat withdrawal reflexes and wind up, Br J Pharmacol, 135, 1556, 10.1038/sj.bjp.0704589

Dionne, 2001, Analgesia and COX-2 inhibition, Clin Exp Rheumatol, 19, S63

Lane, 1997, Pain management in osteoarthritis, the role of COX-2 inhibitors, J Rheumatol, 49, 20

Bannwath, 1989, Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in cerebrospinal fluid, Biomed Pharmacother, 43, 121, 10.1016/0753-3322(89)90140-6

Sousa, 2001, The dual effect of a nitric oxide donor in nociception, Brain Res, 897, 9, 10.1016/S0006-8993(01)01995-3

Kurihara, 1996, The excitatory and inhibitory modulation of primary afferent fibre-evoked responses of ventral roots in the neonatal rat spinal cord exerted by nitric oxide, Br J Pharmacol, 118, 1743, 10.1111/j.1476-5381.1996.tb15600.x

Colasanti, 2000, The dual personality of NO, Trends Pharmacol Sci, 21, 249, 10.1016/S0165-6147(00)01499-1

Bjorkman, 1994, Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P, Pain, 1, 259, 10.1016/0304-3959(94)90001-9

Haley, 1992, Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat, Neuropharmacology, 31, 251, 10.1016/0028-3908(92)90175-O

Stanfa, 1996, Amplification of spinal nociceptive transmission depends on the generation of nitric oxide in normal and carrageenan rats, Brain Res, 737, 92, 10.1016/0006-8993(96)00629-4

Moore, 1993, Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles, anti-nociceptive and cardiovascular effects, Br J Pharmacol, 110, 219, 10.1111/j.1476-5381.1993.tb13795.x

Plevris, 1998, The management of acute liver failure, Aliment Pharmacol Ther, 12, 405, 10.1046/j.1365-2036.1998.00320.x

Bridger, 1998, Deaths from low dose paracetamol poisoning, Br Med J, 316, 1724, 10.1136/bmj.316.7146.1724

Townsend, 2001, Substances used in deliberate self-poisoning 1985–1997, trends and associations with age, gender, repetition and suicide intent, Soc Psychiatry Psychiatr Epidemiol, 36, 228, 10.1007/s001270170053

Futter, 2001, A comparison of the effect of nitroparacetamol and paracetamol on liver injury, Br J Pharmacol, 132, 10, 10.1038/sj.bjp.0703837

Boulares, 1998, Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen, inhibition of c-myc expression. NF-κB activation and RAF kinase activity, Toxicol Sci, 316, 1724

Blazka, 1995, Role of proinflammatory cytokines in acetaminophen hepatoxicity, Toxicol Appl Pharmacol, 133, 43, 10.1006/taap.1995.1125

Gardner, 1998, Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat, Hepatology, 27, 748, 10.1002/hep.510270316

Michael, 1999, Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species, Hepatology, 30, 186, 10.1002/hep.510300104

Farghali, 1999, The amelioration of hepatocyte oxidative stress injury by nitric oxide released from S-nitroso-N-acetyl penicillamine, a study in immobilised perfused hepatocytes, Methods Fundam Exp Clin Pharmacol, 21, 395, 10.1358/mf.1999.21.6.541919

Kuo, 1997, Nitric oxide and acetaminophen-mediated liver injury, modulation of interleukin-1 induced nitric oxide synthesis in cultured rat hepatocytes, J Pharmacol Exp Ther, 282, 1072

Young-Myeong, 1997, Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms, J Biol Chem, 272, 31138, 10.1074/jbc.272.49.31138

Zhang, 2000, Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis, Nature Biotechnol, 18, 862, 10.1038/78475