Ni‐free Zr–Cu–Al–Nb–Pd bulk metallic glasses with different Zr/Cu ratios for biomedical applications

Journal of Biomedical Materials Research - Part B Applied Biomaterials - Tập 100B Số 6 - Trang 1472-1482 - 2012
Lu Huang1,2, Yoshihiko Yokoyama3, Wei Wu1, Peter K. Liaw1, Shujie Pang2, Akihisa Inoue3, Tao Zhang2,4,5, Wei He1,6,4,5
1Department of Materials Science and Engineering, The University of Tennessee, Knoxville, Tennessee 37996-2200
2Key Laboratory of Aerospace Materials and Performance (Ministry of Education), School of Materials Science and Engineering, Beihang University, Beijing 100191, China
3Advanced Research Center of Metallic Glasses, Institute for Materials Research (IMR), Tohoku University, Sendai 980-8577, Japan
4Tao Zhang, Key Laboratory of Aerospace Materials and Performance (Ministry of Education), School of Materials Science and Engineering, Beihang University, Beijing 100191, China
5Wei He, Department of Materials Science and Engineering, The University of Tennessee, Knoxville, Tennessee 37996-2200
6Department of Mechanical, Aerospace and Biomedical Engineering, The University of Tennessee, Knoxville, Tennessee 37996-2200

Tóm tắt

AbstractZr‐based bulk metallic glasses (BMGs) possess attractive properties for prospective biomedical applications. The present study designs Ni‐free Zr–Cu–Al–Nb–Pd BMGs and investigates their in vitro biocompatibility by studying mechanical properties, bio‐corrosion resistance, and cellular responses. The Ti–6Al–4V alloy is used as a reference material. It is found that the Zr‐based BMGs exhibit good mechanical properties, including high strengths above 1600 MPa, high hardness over 4700 MPa, and low elastic moduli of 85–90 GPa. The Zr‐based BMGs are corrosion resistant in a simulated body environment, as revealed by wide passive regions, low passive current densities, and high pitting overpotentials. The formation of ZrO2‐rich surface passive films of the Zr‐based BMGs contributes to their high corrosion resistance, whereas their pitting corrosion in the phosphate buffered saline solution can be attributed to the sensitivity of the ZrO2 films to the chloride ion. The general biosafety of the Zr‐based BMGs is revealed by normal cell adhesions and cell morphologies. Moreover, the Zr/Cu content ratio in the alloy composition affects the biocompatibility of the Zr‐based BMGs, by increasing their corrosion resistance and surface wettability with the increase of the Zr/Cu ratio. Effects of Zr/Cu ratios can be used to guide the future design of biocompatible Zr‐based BMGs. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1472–1482, 2012.

Từ khóa


Tài liệu tham khảo

10.1016/B978-012582460-6/50002-5

Yaszemsk MJ, 2004, Biomaterials in Orthopedics

10.1007/s11837-010-0038-2

10.1007/s11837-009-0128-1

10.1016/j.actbio.2010.08.002

10.1002/jbm.a.31425

He W, 2011, Biocompatibility study of zirconium‐based bulk metallic glasses for orthopedic applications, Metall Mater Trans A, 41, 1726, 10.1007/s11661-009-0150-5

10.1557/S0883769400053252

10.1016/S0966-9795(03)00046-3

10.1002/adma.200902776

10.1016/j.mser.2004.03.001

10.1007/978-0-387-48921-6

10.1557/jmr.2007.0040

Ma MZ, 2004, Wear resistance of Zr‐based bulk metallic glass applied in bearing rollers, Mater Sci Eng A, 386, 326, 10.1016/S0921-5093(04)00973-6

10.1016/j.actamat.2007.01.052

10.1016/j.intermet.2009.01.017

10.1016/j.jallcom.2006.01.048

10.1063/1.110520

10.2320/matertrans.43.2316

Migliori A, 1997, Resonant Ultrasound Spectroscopy: Applications to Physics, Materials Measurements, and Nondestructive Evaluation

10.1002/app.1969.070130815

10.1016/j.intermet.2008.07.020

10.1016/j.jallcom.2004.01.043

10.1557/JMR.2003.0227

10.2320/matertrans1989.41.1490

10.1016/S0010-938X(78)80087-0

10.1016/S0001-8686(97)00040-7

10.1016/0927-7765(94)80066-9

10.1016/j.actbio.2008.03.012

10.1016/B978-012369413-3/50078-1

10.1016/S0142-9612(03)00440-X

10.1002/jbm.b.31937

10.1016/0043-1648(74)90102-1

10.1520/STP1173-EB

10.1016/j.jmbbm.2007.07.001

10.1016/S0966-9795(99)00155-7

10.1016/j.actamat.2005.12.006

10.1016/j.msea.2007.03.106

10.1016/j.jallcom.2010.02.080

10.1038/nmat2542

10.1016/j.actamat.2007.12.030

10.1103/PhysRevLett.95.195501

Thông tin
Thông tin xuất bản

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Tập 100B Số 6

1472-1482

Thông tin tác giả