News from the “5th international meeting on inflammatory bowel diseases” CAPRI 2010

Kappelman, 2007, The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States, Clin Gastroenterol Hepatol, 5, 1424, 10.1016/j.cgh.2007.07.012 Thia, 2008, An update on the epidemiology of inflammatory bowel disease in Asia, Am J Gastroenterol, 103, 3167, 10.1111/j.1572-0241.2008.02158.x de Silva, 2008, Emergence of inflammatory bowel disease ‘beyond the West’: do prosperity and improved hygiene have a role?, Trans R Soc Trop Med Hyg, 102, 857, 10.1016/j.trstmh.2008.03.016 Bernstein, 2008, Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases, Gut, 57, 1185, 10.1136/gut.2007.122143 Shivananda, 1996, Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? 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2009, Low counts of Faecalibacterium prausnitzii in colitis microbiota, Inflamm Bowel Dis, 15, 1183, 10.1002/ibd.20903 Willing, 2009, Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease, Inflamm Bowel Dis, 15, 653, 10.1002/ibd.20783 Sokol, 2008, Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients, Proc Natl Acad Sci USA, 105, 16731, 10.1073/pnas.0804812105 Packey, 2009, Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases, Curr Opin Infect Dis, 22, 292, 10.1097/QCO.0b013e32832a8a5d Ley, 2008, Evolution of mammals and their gut microbes, Science, 320, 1647, 10.1126/science.1155725 Salzman, 2010, Enteric defensins are essential regulators of intestinal microbial ecology, Nat Immunol, 11, 76, 10.1038/ni.1825 Haller, 2010, Nutrigenomics and IBD: The Intestinal Microbiota at the Cross-road Between Inflammation and Metabolism, J Clin Gastroenterol, 10.1097/MCG.0b013e3181dd8b76 Pospisilik, 2007, Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes, Cell, 131, 476, 10.1016/j.cell.2007.08.047 Kaser, 2008, XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease, Cell, 134, 743, 10.1016/j.cell.2008.07.021 Kaser, 2010, Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis, Curr Opin Gastroenterol, 26, 318, 10.1097/MOG.0b013e32833a9ff1 Beltrán, 2010, Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohn's disease, Inflamm Bowel Dis, 16, 76, 10.1002/ibd.21027 Werner, 2009, Intestinal epithelial cell proteome from wild-type and TNFDeltaARE/WT mice: effect of iron on the development of chronic ileitis, J Proteome Res, 8, 3252, 10.1021/pr800772b Nakamura, 2010, Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis, Cell, 140, 338, 10.1016/j.cell.2010.01.001 Todd, 2008, The endoplasmic reticulum stress response in immunity and autoimmunity, Nat Rev Immunol, 8, 663, 10.1038/nri2359 Kaser, 2010, Endoplasmic reticulum stress and intestinal inflammation, Mucosal Immunol, 3, 11, 10.1038/mi.2009.122 Kaser, 2010, Inflammatory bowel disease, Annu Rev Immunol, 28, 573, 10.1146/annurev-immunol-030409-101225 Huett, 2010, A systems biology viewpoint on autophagy in health and disease, Curr Opin Gastroenterol, 26, 302, 10.1097/MOG.0b013e32833ae2ed Huett, 2010, Xavier RJ.Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases, Inflamm Bowel Dis, 16, 152, 10.1002/ibd.20991 Lapaquette, 2010, Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly, Cell Microbiol, 12, 99, 10.1111/j.1462-5822.2009.01381.x Cooney, 2010, NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation, Nat Med, 16, 90, 10.1038/nm.2069 Travassos, 2010, Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry, Nat Immunol, 11, 55, 10.1038/ni.1823 Mota, 2005, The bacterial injection kit: type III secretion systems, Ann Med, 37, 234, 10.1080/07853890510037329 Huett, 2009, A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy, J Immunol, 182, 4917, 10.4049/jimmunol.0803050 Mariathasan, 2007, Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation, Nat Rev Immunol, 7, 31, 10.1038/nri1997 Brodsky, 2009, NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens, Semin Immunol, 21, 199, 10.1016/j.smim.2009.05.007 Maloy, 2008, IL-23 and Th17 cytokines in intestinal homeostasis, Mucosal Immunol, 1, 339, 10.1038/mi.2008.28 Rakoff-Nahoum, 2008, Innate immune recognition of the indigenous microbial flora, Mucosal Immunol, 1, S10, 10.1038/mi.2008.49 Liu, 2009, In vivo analysis of dendritic cell development and homeostasis, Science, 324, 392, 10.1126/science.1170540 Bogunovic, 2009, Origin of the lamina propria dendritic cell network, Immunity, 31, 513, 10.1016/j.immuni.2009.08.010 Xiang, 2010, Accumulation of DC in lamina propria induced by FMS-like tyrosine kinase 3 ligand aggravates the intestinal inflammatory response during endotoxemia, Inflammation, 33, 34, 10.1007/s10753-009-9156-9 Varol, 2009, Intestinal lamina propria dendritic cell subsets have different origin and functions, Immunity, 31, 502, 10.1016/j.immuni.2009.06.025 Liu, 2010, Origin and development of dendritic cells, Immunol Rev, 234, 45, 10.1111/j.0105-2896.2009.00879.x Lotze, 2007, The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity, Immunol Rev, 220, 60, 10.1111/j.1600-065X.2007.00579.x Davé, 2009, Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis, J Leukoc Biol, 86, 633, 10.1189/jlb.1008662 Sims, 2010, HMGB1 and RAGE in inflammation and cancer, Annu Rev Immunol, 28, 367, 10.1146/annurev.immunol.021908.132603 Yanai, 2009, HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses, Nature, 462, 99, 10.1038/nature08512 Kazama, 2008, Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein, Immunity, 29, 21, 10.1016/j.immuni.2008.05.013 Rubartelli, 2007, Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox, Trends Immunol, 28, 429, 10.1016/j.it.2007.08.004 Bjornsson, 2004, An integrated epigenetic and genetic approach to common human disease, Trends Genet, 20, 350, 10.1016/j.tig.2004.06.009 Murrell, 2005, From genome to epigenome, Hum Mol Genet, 14, 10.1093/hmg/ddi110 Bäckdahl, 2009, Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation, Int J Biochem Cell Biol, 41, 176, 10.1016/j.biocel.2008.08.023 Wilson, 2009, Epigenetic control of T-helper-cell differentiation, Nat Rev Immunol, 9, 91, 10.1038/nri2487 Littman, 2010, Th17 and regulatory T cells in mediating and restraining inflammation, Cell, 140, 845, 10.1016/j.cell.2010.02.021 Zhou, 2008, TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function, Nature, 453, 236, 10.1038/nature06878 Ivanov, 2008, Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine, Cell Host Microbe, 4, 337, 10.1016/j.chom.2008.09.009 Ivanov, 2009, Induction of intestinal Th17 cells by segmented filamentous bacteria, Cell, 139, 485, 10.1016/j.cell.2009.09.033 Ivanov, 2010, Segmented filamentous bacteria take the stage, Mucosal Immunol, 3, 209, 10.1038/mi.2010.3 Ahern, 2008, The interleukin-23 axis in intestinal inflammation, Immunol Rev, 226, 147, 10.1111/j.1600-065X.2008.00705.x Izcue, 2009, Regulatory lymphocytes and intestinal inflammation, Annu Rev Immunol, 27, 313, 10.1146/annurev.immunol.021908.132657 Izcue, 2008, Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis, Immunity, 28, 559, 10.1016/j.immuni.2008.02.019 Buonocore, 2010, Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology, Nature, 464, 1371, 10.1038/nature08949 Neurath, 2009, Translating inflammatory bowel disease research into clinical medicine, Immunity, 31, 357, 10.1016/j.immuni.2009.08.016 Kanai, 2009, Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease, Curr Opin Gastroenterol, 25, 306, 10.1097/MOG.0b013e32832bc627 Zenewicz, 2009, CD4 T-cell differentiation and inflammatory bowel disease, Trends Mol Med, 15, 199, 10.1016/j.molmed.2009.03.002 Waldner, 2009, Novel cytokine-targeted therapies and intestinal inflammation, Curr Opin Pharmacol, 9, 702, 10.1016/j.coph.2009.07.005 Waldner, 2009, Colitis-associated cancer: the role of T cells in tumor development, Semin Immunopathol, 31, 249, 10.1007/s00281-009-0161-8 Atreya, 2008, Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer, Curr Drug Targets, 9, 369, 10.2174/138945008784221116 Weigmann, 2008, The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis, J Exp Med, 205, 2099, 10.1084/jem.20072484 Mudter, 2008, The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6, J Clin Invest, 118, 2415 Mudter, 2009, IRF4 selectively controls cytokine gene expression in chronic intestinal inflammation, Arch Immunol Ther Exp (Warsz), 57, 369, 10.1007/s00005-009-0046-5 Leppkes, 2009, RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F, Gastroenterology, 136, 257, 10.1053/j.gastro.2008.10.018 D'Haens, 2009, IOIBD Membership. Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease, Inflamm Bowel Dis, 15, 1599, 10.1002/ibd.21034 D'Haens, 2007, Risks and benefits of biologic therapy for inflammatory bowel diseases, Gut, 56, 725, 10.1136/gut.2006.103564 Rahier, 2009, The European (ECCO) Consensus on infection in IBD: what does it change for the clinician?, Gut, 58, 1313, 10.1136/gut.2008.175950 Sokol, 2009, Inflammatory bowel disease and lymphoproliferative disorders: the dust is starting to settle, Gut, 58, 1427, 10.1136/gut.2009.181982 Beaugerie, 2009, Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study, Lancet, 374, 1617, 10.1016/S0140-6736(09)61302-7 Shale, 2008, Hepatosplenic T cell lymphoma in inflammatory bowel disease, Gut, 57, 1639, 10.1136/gut.2008.163279 Weersma, 2009, Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort, Gut, 58, 388, 10.1136/gut.2007.144865 Zhou, 2009, Plasticity of CD4+ T cell lineage differentiation, Immunity, 30, 646, 10.1016/j.immuni.2009.05.001 Lu, 2009, Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein, Immunity, 30, 80, 10.1016/j.immuni.2008.11.010