New molecular and biochemical insights of doxorubicin-induced hepatotoxicity

Life Sciences - Tập 250 - Trang 117599 - 2020
Pureti Lakshmi Prasanna1, Kaviyarasi Renu1, Abilash Valsala Gopalakrishnan1
1Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu 632014, India

Tài liệu tham khảo

Rivankar, 2014, An overview of doxorubicin formulations in cancer therapy, J. Cancer Res. Ther., 10, 853, 10.4103/0973-1482.139267 Thorn, 2011, Doxorubicin pathways: pharmacodynamics and adverse effects, Pharmacogenet. Genomics, 21, 440, 10.1097/FPC.0b013e32833ffb56 Arcamone, 2000, Adriamycin, 14-Hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius, Biotechnol. Bioeng., 67, 704, 10.1002/(SICI)1097-0290(20000320)67:6<704::AID-BIT8>3.0.CO;2-L Cortes-Funes, 2007, Role of anthracyclines in the era of targeted therapy, Cardiovasc. Toxicol., 7, 56, 10.1007/s12012-007-0015-3 N.I.o. Health, 2017 Renu, 2019, Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu, Reprod. Biol., 19, 22, 10.1016/j.repbio.2019.02.004 Renu, 2019, Elevated lipolysis in adipose tissue by doxorubicin via PPARα activation associated with hepatic steatosis and insulin resistance, Eur. J. Pharmacol., 843, 162, 10.1016/j.ejphar.2018.11.018 Renu, 2018, Molecular mechanism of doxorubicin-induced cardiomyopathy–an update, Eur. J. Pharmacol., 818, 241, 10.1016/j.ejphar.2017.10.043 Henninger, 2012, The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity, Toxicol. Appl. Pharmacol., 261, 66, 10.1016/j.taap.2012.03.012 Gabizon, 2003, Pharmacokinetics of pegylated liposomal doxorubicin, Clin. Pharmacokinet., 42, 419, 10.2165/00003088-200342050-00002 Hilmer, 2004, The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin, Drug Metab. Disposition., 32, 794, 10.1124/dmd.32.8.794 Fornari, 1994, Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells, Mol. Pharmacol., 45, 649 Momparler, 1976, Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells, Cancer Res., 36, 2891 Sasame, 1979, Superoxide and hydrogen peroxide production and NADPH oxidation stimulated by nitrofurantoin in lung microsomes: possible implications for toxicity, Life Sci., 24, 1091, 10.1016/0024-3205(79)90042-0 Quiles, 2002, Antioxidant nutrients and adriamycin toxicity, Toxicology, 180, 79, 10.1016/S0300-483X(02)00383-9 Doroshow, 1986, Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones, Proc. Natl. Acad. Sci. U. S. A., 83, 4514, 10.1073/pnas.83.12.4514 Choudhari, 2013, Nitric oxide and cancer: a review, World J. Surg. Oncol., 11, 118, 10.1186/1477-7819-11-118 Hickok, 2010, Nitric oxide and cancer therapy: the emperor has NO clothes, Curr. Pharm. Des., 16, 381, 10.2174/138161210790232149 Subapriya, 2002, Oxidant-antioxidant status in patients with oral squamous cell carcinomas at different intraoral sites, Clin. Biochem., 35, 489, 10.1016/S0009-9120(02)00340-5 Wink, 1998, Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide, Free Radic. Biol. Med., 25, 434, 10.1016/S0891-5849(98)00092-6 Patel, 1999, Biological aspects of reactive nitrogen species, Biochim. Biophys. Acta, 1411, 385, 10.1016/S0005-2728(99)00028-6 Yagmurca, 2007, Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats, Arch. Med. Res., 38, 380, 10.1016/j.arcmed.2007.01.007 Shivakumar, 2012, A study on the toxic effects of doxorubicin on the histology of certain organs, Toxicol. Int., 19, 241, 10.4103/0971-6580.103656 Mansouri, 2017, Protective effect of pravastatin on doxorubicin-induced hepatotoxicity, Bratisl. Lek. Listy, 118, 273 Lamas, 2015, Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models, Cell death discov, 1, 1, 10.1038/cddiscovery.2015.59 Mete, 2016, Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats, Toxicol. Ind. Health, 32, 551, 10.1177/0748233713504807 Kalender, 2005, Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: the effects of vitamin E and catechin, Toxicology, 209, 39, 10.1016/j.tox.2004.12.003 Yao, 2018, Alleviation of doxorubicin-induced hepatic toxicity with fermented Cordyceps sinensis via regulating hepatic energy metabolism in rats, Pharmacogn. Mag., 14, 283, 10.4103/pm.pm_354_17 Djabir, 2017, Potential roles of Kleinhovia hospita L. leaf extract in reducing doxorubicin acute hepatic, cardiac and renal toxicities in rats, Pharm. Res., 9, 168 Nagai, 2015, Theanine prevents doxorubicin-induced acute hepatotoxicity by reducing intrinsic apoptotic response, Food Chem. Toxicol., 78, 147, 10.1016/j.fct.2015.02.009 Asensio-Lopez, 2017, Doxorubicin-induced oxidative stress: the protective effect of nicorandil on HL-1 cardiomyocytes, PLoS One, 12, 10.1371/journal.pone.0172803 Barakat, 2018, Protective effect of boswellic acids against doxorubicin-induced hepatotoxicity: impact on Nrf2/HO-1 defense pathway, Oxidative Med. Cell. Longev., 2018, 10.1155/2018/8296451 Zhao, 2012, Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice, Biol. Pharm. Bull., 35, 796, 10.1248/bpb.35.796 Indu, 2014, Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids, J. Cancer Res. Ther., 10, 62, 10.4103/0973-1482.131370 Damodar, 2014, An evaluation of hepatotoxicity in breast cancer patients receiving injection doxorubicin, Ann Med Health Sci Res, 4, 74, 10.4103/2141-9248.126619 Kwiecień, 2006, The selective effect of cystathionine on doxorubicin hepatotoxicity in tumor-bearing mice, Eur. J. Pharmacol., 550, 39, 10.1016/j.ejphar.2006.09.001 Pieniążek, 2013, Oxidative stress induced in rat liver by anticancer drugs doxorubicin, paclitaxel and docetaxel, Adv. Med. Sci., 58, 104, 10.2478/v10039-012-0063-1 Bulucu, 2009, Effects of N-acetylcysteine, deferoxamine and selenium on doxorubicin-induced hepatotoxicity, Biol. Trace Elem. Res., 132, 184, 10.1007/s12011-009-8377-y Gotama, 2019, Hepatoprotective effects of l-citrulline against doxorubicin-induced liver damage in rats: an analysis of serum biomarkers, Int. J. App. Pharm., 11, 230, 10.22159/ijap.2019.v11s1.19099 Nagai, 2016, Protective effects of taurine on doxorubicin-induced acute hepatotoxicity through suppression of oxidative stress and apoptotic responses, Anti-Cancer Drugs, 27, 17, 10.1097/CAD.0000000000000299 Zolfagharzadeh, 2013, Pretreatment hepatoprotective effect of regular aerobic training against hepatic toxicity induced by doxorubicin in rats, Asian Pac. J. Cancer Prev., 14, 2931, 10.7314/APJCP.2013.14.5.2931 Bagchi, 1995, Adriamycin-induced hepatic and myocardial lipid peroxidation and DNA damage, and enhanced excretion of urinary lipid metabolites in rats, Toxicology, 95, 1, 10.1016/0300-483X(94)02867-T Ashrafi, 2012, Cardioprotective effects of aerobic regular exercise against doxorubicin-induced oxidative stress in rat, Afr. J. Pharm. Pharmacol, 6, 2380, 10.5897/AJPP12.617 Injac, 2008, Potential hepatoprotective effects of fullerenol C60 (OH) 24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas, Biomaterials, 29, 3451, 10.1016/j.biomaterials.2008.04.048 Kassner, 2008, Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver, Drug Metab. Disposition., 36, 2113, 10.1124/dmd.108.022251 Betteridge, 2000, What is oxidative stress?, Metabolism-Clinical and Experimental, 49, 3, 10.1016/S0026-0495(00)80077-3 Lin, 2007, Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress, J. Biol. Chem., 282, 20621, 10.1074/jbc.M607954200 Enomoto, 2001, High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes, Toxicol. Sci., 59, 169, 10.1093/toxsci/59.1.169 Tacar, 2013, Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems, J. Pharm. Pharmacol., 65, 157, 10.1111/j.2042-7158.2012.01567.x Wang, 2012, Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl, PLoS One, 7 Cox, 2016, Mechanisms of doxorubicin resistance in hepatocellular carcinoma, Hepatic oncology, 3, 57, 10.2217/hep.15.41 Lee, 2002, Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines, Cancer Chemother. Pharmacol., 49, 78, 10.1007/s00280-001-0376-4 Zheng, 2013, Telekin induces apoptosis associated with the mitochondria-mediated pathway in human hepatocellular carcinoma cells, Biol. Pharm. Bull., b13 Candé, 2002, Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?, J. Cell Sci., 115, 4727, 10.1242/jcs.00210 Saelens, 2004, Toxic proteins released from mitochondria in cell death, Oncogene, 23, 2861, 10.1038/sj.onc.1207523 Fulda, 2006, 5-Aza-2′-deoxycytidine and IFN-γ cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8, Oncogene, 25, 5125, 10.1038/sj.onc.1209518 Walczak, 2000, The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems, Exp. Cell Res., 256, 58, 10.1006/excr.2000.4840 Chen, 2019, Protective effects of dioscin against doxorubicin-induced hepatotoxicity via regulating Sirt1/FOXO1/NF-κB signal, Front. Pharmacol., 10, 1030, 10.3389/fphar.2019.01030 Dai, 2016, Different growth promoting effects of endophytic bacteria on invasive and native clonal plants, Front. Plant Sci., 7, 706, 10.3389/fpls.2016.00706 Takahashi, 2008, Hepatic failure and enhanced oxidative stress in mitochondrial diabetes, Endocr. J., 0804280123 Guven, 2018, Mitochondrial dysfunction associated with doxorubicin, Mitochondrial Diseases, 323 Barogi, 2000, Effect of the oxidative stress induced by adriamycin on rat hepatocyte bioenergetics during ageing, Mech. Ageing Dev., 113, 1, 10.1016/S0047-6374(99)00089-5 Taskin, 2015, Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium, Cytotechnology, 67, 977, 10.1007/s10616-014-9736-x Dirks-Naylor, 2014, Doxorubicin alters the mitochondrial dynamics machinery and mitophagy in the liver of treated animals, Fundam. Clin. Pharmacol., 28, 633, 10.1111/fcp.12073 Qian, 2011, Curcumin enhanced adriamycin-induced human liver-derived Hepatoma G2 cell death through activation of mitochondria-mediated apoptosis and autophagy, Eur. J. Pharm. Sci., 43, 125, 10.1016/j.ejps.2011.04.002 Santos-Alves, 2019, Physical exercise positively modulates DOX-induced hepatic oxidative stress, mitochondrial dysfunction and quality control signaling, Mitochondrion, 47, 103, 10.1016/j.mito.2019.05.008 Siddiqui, 2011, Boswellia serrata, a potential antiinflammatory agent: an overview, Indian J. Pharm. Sci., 73, 255 Lv, 2013, Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme, Food Chem. Toxicol., 59, 657, 10.1016/j.fct.2013.07.012 Zanwar, 2014, Antioxidant role of catechin in health and disease, 267 Dechant, 1996, Erdosteine, Drugs, 52, 875, 10.2165/00003495-199652060-00009 Mohamad, 2009, The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats, J. Med. Food, 12, 394, 10.1089/jmf.2007.0715 Sakr, 2011, Protective effect of ginger (Zingiber officinale) on adriamycin-induced hepatotoxicity in albino rats, J. Med. Plant Res., 5, 133 El-Moselhy, 2014, Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity, Biomed. Pharmacother., 68, 101, 10.1016/j.biopha.2013.09.001